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[healthyconsumption]

Has anyone looked into Ivermectin as a treatment for Peyronie's?

Article: Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts (HPS)

Points: The results demonstrated that ivermectin inhibited the proliferation of HPS fibroblasts and significantly decreased the production of type I collagen, α‑smooth muscle actin and cellular communication network factor 2, as determined by analyzing the mRNA and protein expression levels. In conclusion, the results of the present study suggested that ivermectin may be a promising therapeutic agent for HPS.

- α-Smooth muscle actin (α-SMA) is used as a marker for a subset of activated fibrogenic cells, myofibroblasts, which are regarded as important effector cells of tissue fibrogenesis

[Lostandsad]

I know it’s used for C19. Are you willing to try it and report back? I guess if I can find a doctor willing to prescribe it I would…

[Winter]

Cool! I could try this one. I can buy it in my country without prescription.

[Winter]

Those articles are pretty cool

https://pubs.acs.org/doi/pdf/10.1021/acsomega.8b01451

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576857/

[Lostandsad]

Those articles are pretty cool, thanks for sharing those, Winter.

The second article says it increases TGF-Beta in the first 7 days. That’s definitely not good for Peyronie’s.

But later in the article states, “As noted in the study on day 21 and also reported by other authors, the transition of the healing from the initial stage to the terminal stages is characterized by decreased expression TGF-β1”

And part of the conclusion states:
“Low doses of ivermectin cream have the potential to be used in treating wounds with minimal scar tissue formation.”

Maybe it could be used as a post exposure prevention, or in this case of Peyronie’s, post injury/acute onset. Just theorizing, not really sure about this.

[healthyconsumption]

I know it’s used for C19. Are you willing to try it and report back? I guess if I can find a doctor willing to prescribe it I would…

Hey Lostandsad, I think it is an over the counter drug in some countries. They are used as prophylactic (to prevent disease) for many types of infection. Relatively mild in side effects (stomach ache and discomfort, nausea feeling, etc).

I was going to get a hold of some and look up where to get some but this was wayyy before my Peyronie's started (not if it's just me but I wish they named this disease with a less mouthful name) for the reason you stated above.

They're not locally available without prescription here in Australia, so it's a bit hard for me to get one (unless I buy it online).

[healthyconsumption]

Thanks for the articles. The way it works reminds me of dose dependent response in many anti-inflammatory agents. Where too little (or too much of something) gives the opposite effect. Which makes it difficult when some studies were only done in mice.

Only if we could offset/counteract some of these negatives with something else (I think that's why the COMP-4 study was sccessful, because some of the things they used were probably to counteract the negative effects of another)

Anyway, if you look at (a) and (f) in these photos here. The differences are MASSIVE, but to be fair we should probably compare (b) and (f) which are both Ivermectic at different concentration.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576857/figure/Fig2/

[Lostandsad]

I’m a little confused at the pictures. So (f) has a lower concentration than (b), but a better result?

I’m willing to try whatever at this point, but at the same time to my understanding, once fibrosis has already set in, it’s pretty much irreversible, making all these oral therapies seem like a futile effort.

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