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We offer our most sincere condolences to Old Man who lost his wife of 59 years on Monday night to Pancreatic Cancer.   
He is in our sincere thoughts and prayers.

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Author Topic: Peptide P144 a TGF-β1 Antagonist Peptide, Synergizes with Sildenafil.  (Read 726 times)

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I came across this article a week ago. But I can't seem to find any clinical trials on human or where they are availble.

P144, A TGF-β1 Antagonist Peptide, Synergizes with Sildenafil and Enhances Erectile Response via Amelioration of Cavernosal Fibrosis in Diabetic Rats.

Treatment with P144 synergized sildenafil and significantly increased erectile response by the potential antifibrotic activity.


Topical Application of a Peptide Inhibitor of Transforming Growth Factor-β1 Ameliorates Bleomycin-Induced Skin Fibrosis

These data suggest that topical application of P144, a peptide inhibitor of TGF-beta1, is a feasible strategy to treat pathological skin scarring and skin fibrotic diseases for which there is no specific therapy.


Someone even patented this, search for peyronie on the page below.

 Method for the treatment of skin fibrosis and suitable compositions for such treatment

Age: 40's
What: Approx 30 degree left from mid shaft, 45 degree clockwise torsion.
How: PE (June 2021)

⁍ Pentox 400mg (3 x daily)
⁍ Tadalafil 10mg (2 x daily)
⁍ Verdanafil 100mg (1 x 2 days)
⁍ Arginine/NAC/Vit-E/Ginger/Berries/Kelp


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Re: Peptide P144 a TGF-β1 Antagonist Peptide, Synergizes with Sildenafil.
« Reply #1 on: November 08, 2021, 09:38:51 PM »

Please someone notice this post
20, late 2020 masturbation injury leads to semi erect hourglass, then try manual stretching leads to pudendal neuralgia like symptoms, corpus spongiosum and glans do not fill, severe Erectile Dysfunction- floppy unstable erections that feel like water balloon .


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Re: Peptide P144 a TGF-β1 Antagonist Peptide, Synergizes with Sildenafil.
« Reply #2 on: November 12, 2021, 11:53:19 PM »

Post has been noticed. Has anyone been able to find a current study on this drug? This is an 8 year old article apparently
24 yrs old    Descended from Heaven on 11/27/97

Severe pain and shape changes started on Nov 30th, 2020 from injury

Shape was back to normal by December 2021
Still have some pain but hoping that will eventually go away too =D

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