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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: Peyronie disease treated with ultrasound and hydrocortisone.  (Read 589 times)

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keeblerellf

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Peyronie disease treated with ultrasound and hydrocortisone.
« on: August 14, 2021, 02:51:36 PM »

I was researching topical hydrocortisone on the penis but couldn't find much except this paper from 1983.
I also have been wondering about topical aspirin cream on the penis. Both aspirin and hydrocort art anti-inflammatory and anti-fibrotic, especially locally.
Anyone have any experience or knowledge regarding this?
The original paper is attached.

https://pubmed.ncbi.nlm.nih.gov/6868230/

Quote
Peyronie disease treated with ultrasound and hydrocortisone
H C Miller, J Ardizzone
PMID: 6868230 DOI: 10.1016/0090-4295(83)90197-8

Abstract

Thirty patients with Peyronie disease were treated with ultrasound using hydrocortisone ointment as the conducting vehicle. Twenty-five patients completed at least one course of treatment. Of those 25, 19 had at least some benefit with evidence that multiple courses of treatment were more beneficial than a single course. We conclude that ultrasound with hydrocortisone is beneficial in relieving pain, relieving deviation, and reducing the size of the fibrous plaque. It has the advantages of being noninvasive, repeatable, and without any side effects.

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nemo

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Re: Peyronie disease treated with ultrasound and hydrocortisone.
« Reply #1 on: August 14, 2021, 03:37:20 PM »

Given that this study is almost 40 years old and I've never heard anyone even trying hydrocortisone for Peyronies Disease, I doubt there's any hope here.

As to aspirin cream, etc., the problem with many topicals is getting them to penetrate all the way into the tunica, where the damage from Peyronies Disease is. Even topical verapamil solutions are of questionable abilities to penetrate effectively. So the notion that an OTC cream could somehow remedy Peyronies Disease is likely just wishful thinking. If it worked, everyone here would be using it and talking about it.

Check out the threads on Hirudoid cream - very similar proposition, very limited results.

Regards,
Nemo
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50 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred in 2013. Have now begun a third episode in 2021. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline.

keeblerellf

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Re: Peyronie disease treated with ultrasound and hydrocortisone.
« Reply #2 on: August 14, 2021, 06:27:13 PM »

Here's a study reporting success with injected hydrocortisone.

https://sti.bmj.com/content/sextrans/36/3/186.full.pdf

Pubmed has 13 hits for peyronies and hydrocortisone.
Age doesn't alter the quality of research.
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Lostandsad

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Re: Peyronie disease treated with ultrasound and hydrocortisone.
« Reply #3 on: August 14, 2021, 07:33:42 PM »

Agreed with nemo, everyone would be talking about it if it helped.
The only real hope at the moment seems to be advancement on stem cell therapy to heal the scar tissue
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MIA - nothing works after 5 months
supplements and pharmaceuticals I've tried:
cialis, pentox, magnesium chloride, dim, turmeric, hyaluronic acid, vitamin k2, paba, l-arginine, l-citrulline. either get surgery (and possible Erectile Dysfunction), get implant, or pray

nemo

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Re: Peyronie disease treated with ultrasound and hydrocortisone.
« Reply #4 on: August 14, 2021, 11:54:37 PM »

Age may not alter the quality of the research, but you have to ask yourself why the treatment has not been used if it was truly effective or produced results.

Nemo
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50 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred in 2013. Have now begun a third episode in 2021. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline.
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