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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: What is the conclusion on Topical Verapamil?  (Read 1084 times)

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Anbil

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What is the conclusion on Topical Verapamil?
« on: August 02, 2021, 08:24:30 PM »

https://ur.booksc.eu/book/24003297/3343a0

I know there was a big study by martin about how it fails to reach the Tunica, but I just came across this rebuttal, which presents a pretty good argument as the Martin study seems pretty poorly designed with a small sample size.

Given the low amount of side effects from TV it seems like it wouldn't hurt to try especially as a component of multimodal therapy.

I know it doesn't exactly have a positive reputation but I want to try it because there seems to be little to no risk and only benefits.

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Onset of pain in March 2021
Progressed to loss of girth to dent under the glans left side

Been doing daily heat,traction,pentox,ved,cialis since initial onset of pain

Currently still experiencing pain and dent unchanged

Tobyg

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Re: What is the conclusion on Topical Verapamil?
« Reply #1 on: August 02, 2021, 09:03:46 PM »

I did the treatment with verapamil, it was very expensive and I did not see any improvement, it only took away the pain for a few days, I felt ripped off
Logged
30 years,injured at 25.
Slight curve, narrowing and retraction in flaccid and semi-erect.
Loss of sensitivity due to peyronie and circumcision  moderate erectile dysfunction, pain.
I improved the pelvic floor with kinesiology.

howtheheck

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Re: What is the conclusion on Topical Verapamil?
« Reply #2 on: August 03, 2021, 05:18:13 AM »

Tobyg,

How long did you take it? I am sorry it did not work.
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56 years old.  Westerner (Expat) living in China, Single, 4/21 start. Various natural topicals & orals, will use home ESWT machine.  05/24 started TCM with TCM herbs acupuncture.  06/02/21- Restorex, also noticed slight dorsal curve late 06/21

FlatteningTheCurve

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Re: What is the conclusion on Topical Verapamil?
« Reply #3 on: August 03, 2021, 08:31:27 AM »

Urologists overall seem to believe that there is no scientific evidence of topical Verapamil working. There may be anecdotal evidence, i.e. a few people claiming that it led to improving their case. That said, it cannot be concluded across a large sample that any improvement was due to topical Verapamil specifically, holding other variables constant.

The European association of urology:
"There is no sufficient and unequivocal evidence that topical treatments (verapamil, H-100 Gel [a compound with nicardipine, superoxide dismutase and emu oil] or steroids) applied to the penile shaft, with or without the use of iontophoresis (now known as transdermal electromotive drug administration), result in adequate levels of the active compound within the tunica albuginea. Therefore, the Panel does not support the use of topical treatments for Peyronies Disease applied to the penile shaft." https://uroweb.org/guideline/sexual-and-reproductive-health/#8

American association of urology:
"Uncertainty remains regarding the efficacy of topical verapamil given the existence of only one study and the fact that < 20 patients were administered verapamil; replication in a high-quality randomized design with a larger sample size is needed before it can be recommended as a Peyronies Disease treatment." https://www.auanet.org/guidelines/guidelines/peyronies-disease-guideline

It would trust these panels that consist of experts and with no interest in promoting expensive treatments more than individual urologists-online websites than may have dubious motives for all I know.

It is very expensive but also a non-invasive treatment. If you want to spend your money on something that is not a form of surgery and which may have an effect (although not very likely as the quotes above indicate), feel free to give it a go.
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Early 30s, diagnosed with Peyronies in 2017 after trauma during sex. Upward curvature, currently multiple plaques. Restorex, VED, 5mg Cialis, Pentox, L-arginine, Coq10, Bio -Pycnogenol, Propolis

Tobyg

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Re: What is the conclusion on Topical Verapamil?
« Reply #4 on: August 03, 2021, 01:25:29 PM »

howtheheck
I did it for 1 month and a half, (12 sessions) with the electric device.
Logged
30 years,injured at 25.
Slight curve, narrowing and retraction in flaccid and semi-erect.
Loss of sensitivity due to peyronie and circumcision  moderate erectile dysfunction, pain.
I improved the pelvic floor with kinesiology.

Bud luck

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Re: What is the conclusion on Topical Verapamil?
« Reply #5 on: October 23, 2021, 03:37:38 PM »

I'm applying topical Verapamil daily, is been two days
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My first symptoms started early in 2019
I tried Traction device, Pentofixiline, Q10, TRT, L-Argenine, cialis
I have narrowing/dent/hinge on the left side of my shaft
My Erectile Dysfunction is getting worse
Had a PRP shot Aug 2021
I have a girlfriend
Age 46

Anbil

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Re: What is the conclusion on Topical Verapamil?
« Reply #6 on: October 24, 2021, 07:13:32 PM »

howtheheck
I did it for 1 month and a half, (12 sessions) with the electric device.

can you please share what happened?

im very jealous honestly
Logged
Onset of pain in March 2021
Progressed to loss of girth to dent under the glans left side

Been doing daily heat,traction,pentox,ved,cialis since initial onset of pain

Currently still experiencing pain and dent unchanged

Bud luck

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Re: What is the conclusion on Topical Verapamil?
« Reply #7 on: October 24, 2021, 08:33:18 PM »

I had to quit the topical Verapamil because it was giving me side effects, like fainting and low blood pressure, but I felt my penis getting somehow thicker, I believe it can work but the side effects were terrible.
Logged
My first symptoms started early in 2019
I tried Traction device, Pentofixiline, Q10, TRT, L-Argenine, cialis
I have narrowing/dent/hinge on the left side of my shaft
My Erectile Dysfunction is getting worse
Had a PRP shot Aug 2021
I have a girlfriend
Age 46

Tobyg

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Re: What is the conclusion on Topical Verapamil?
« Reply #8 on: October 24, 2021, 11:17:34 PM »

Anbil, nothing happened ... it was just a waste of time and money.
Logged
30 years,injured at 25.
Slight curve, narrowing and retraction in flaccid and semi-erect.
Loss of sensitivity due to peyronie and circumcision  moderate erectile dysfunction, pain.
I improved the pelvic floor with kinesiology.

pen fifteen

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Re: What is the conclusion on Topical Verapamil?
« Reply #9 on: November 03, 2021, 11:19:45 AM »

Anbil, nothing happened ... it was just a waste of time and money.
Did you do the topical verapamil or the injections?
Logged
31 y/o. 30 degree upward, and slightly leftward curve. 3 rounds of Xiaflex completed and praying I don't have to do anymore.

Tobyg

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Re: What is the conclusion on Topical Verapamil?
« Reply #10 on: November 03, 2021, 07:46:35 PM »

I described it before, topical with the electrical device.
Logged
30 years,injured at 25.
Slight curve, narrowing and retraction in flaccid and semi-erect.
Loss of sensitivity due to peyronie and circumcision  moderate erectile dysfunction, pain.
I improved the pelvic floor with kinesiology.
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