NSAIDS - nonsteroidal anti-inflammatory drugs

[hopeful_one]

I've had Peyronie's for about 10 months now and have been taking Pentox and Arginine for about 7 weeks, and Ubiquinol for about 1 week. There is a lingering pain (down from 8/10 during erection for the first few months to about 2/10 while flaccid since October) and two inflamed areas that weren't present 3 months ago. For obvious reasons, I'm concerned that the longer I'm in the acute stage the more damage will be done. Now, I understand that I need to give Pentox and Ubiquinol more time to work but I was thinking that it might be a good idea to ALSO start taking a standard NSAID like Ibuprofen to bring down the inflammation and hopefully minimize further damage. I'm not sure of the dosage or the number of times per day.

I mentioned this to a close friend who is a physician and an excellent pain management specialist (not a Peyronie's specialist or even a urologist). He knows that I'm also taking Pentox and said that since Pentox and Ibuprofen are both blood thinners that I might want to look into taking Celebrex instead of Ibuprofen. My goals with this move would be to get the tunica in a more relaxed state, reduce pain and inflammation, minimize further damage with regards to inflammation and scarring and exit the acute stage as soon as possible. I have no idea if Celebrex or Ibuprofen can help with all these goals but please chime in and let me know your thoughts. Also, let me know if anyone ever discussed the regular use of Ibuprofen or Celebrex for therapeutic benefit during the acute stage with a true Peyronie's specialist.

By the way, I took 2 x 200mg Ibuprofen yesterday morning and 1 x 200mg in the afternoon and it pretty much reduced pain to the bare minimum. I took 2 x 200mg Ibuprofen this morning and once again pain is reduced to a bare minimum. Inflammation also seems reduced but I can't gauge that as well.

I don't really have any faith in the Peyronie's specialists I have seen thus far to answer a question like this, and I'm in the process of making an appointment with Dr. Lue but the first available isn't until the end of March. I don't want to wait another 5 weeks before taking action so Im turning to you all for help. My full history can be seen here https://www.peyroniesforum.net/index.php/topic,1591.msg29635.html#msg29635.

Thanks!

hopeful_one

[GS]

When I was diagnosed with Peyronies Disease, my urologists recommended taking ibuprofen 3 times a day and discontinuing sex for 30 days to help with inflammation and pain.  I was not taking any blood thinners at the time, but that's something you probably should consider.

GS

[newguy]

My advice is TOPICAL Ibuprofen. It works just as well, and less in absorbed into your system.

[slowandsteady]

I'm about to try some cissus for a running injury, but it occurred to me that it might have benefits for Peyronies Disease too, perhaps especially for those in the acute phase dealing with pain.

Most of the studies I've seen relate to bone repair, but what caught my eye was that it might reduce tissue infiltration by immune cells ("Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats", PMID 16338111). There are also a lot of anecdotal reports of it helping with soft tissue injury due to weightlifting.

It also seems to have some metformin-like effects on blood sugar and aids in fat loss (PMID 18377661), so careful if you're monitoring your blood sugar since this might drop it.

[slowandsteady]

Oh, it also protects the liver against injury by a poison (isoniazid) and another poison (fructose ) (PMID 21189914, PMID 20450951).

[slowandsteady]

I'd be interested in hearing back from anyone trying cissus for pain relief (thread started here). Since ibuprofen and celebrex can damage the liver whereas cissus is hepatoprotective, it might be worth looking into.

[newguy]

Sounds like an interesting option. There are many messages here from people with long term (and short term) pain, and I can't help but think that there must be viable options to help them that we haven't stumbled across yet. CoQ10 shows some promise in that area, but it's good to keep searching. Please do let us know how you get on.  

[chefcasey]

That's interesting.  I did take cissus for a back injury I had from weightlifting a few years ago when it was all the rage amongst weightlifters.  However I didn't notice any benefit from it in terms of my back injury and I took the stuff for months.  My back ultimately healed up about a year later but was due to physical therapy that cured it.  I don't know if there's a good Peyronies Disease connection but I assume it can't hurt.

[George999]

DO let us know how this works out.  It sounds VERY interesting.  Bilberry is reputed to have a similar effect on neutrophils.  - George

[Woodman]

hopeful_one- Iam currently taking Celebrex along with my other supplements L Arginine, ALC & CoQ10. I have had on going pain for quite some time now. Ive been back on it for a little over a week now. Iam waiting to see at about the two week mark where Iam at with reducing pain and inflammation. Last time I was on it for about 3 months 1 to 2 200 mg tablets a day. I would take one in the morning and if the pain was real bad take another in the evening. This round I am taking just 1 200mg tablet a day. This time I am taking it with the CoQ10 hoping for a little more relief.

I do know Celebrex can have side effects but its my only choice at this time because I cannot take NSIDs. I also didnt have good luck with Pentox. I asked my MD about taking it long term and he told me if it was helping he would write me a script for it. I would really like to try the whole combination with Pentox but have not built up enough courage to try taking Pentox again.

Just wanted to type and let you know theres someone here trying Celebrex for there Peyronie's pain and inflammation.

[hopeful_one]

Thanks GS

newguy: that's an interesting idea. Have you used topical Ibuprofen for Peyronie's?

woodman: thanks for chiming in. Please let me know how everything works out with the Celebrex and good luck getting back on Pentox, I hope that works out for you.

[newguy]

Thanks GS

newguy: that's an interesting idea. Have you used topical Ibuprofen for Peyronie's?

woodman: thanks for chiming in. Please let me know how everything works out with the Celebrex and good luck getting back on Pentox, I hope that works out for you.

I did when I was experiencing moderate penis pain. I had been taking it orally, but was concerned that doing so for weeks/months on end wouldn't be safe. I found a few non peyronie's studies that seemed to suggest that when applied topically it is as effective, but less is absorded into your system. That seems like a good way to bypass some of the negative side effects. The only issue was slightly dry skin (due to the alcohol in the topical formula I assume).This is the brand I bought: http://www.mysupermarket.co.uk/sainsburys-price-comparison/Medicine/Tesco_Ibuprofen_Gel_35g.html?ShowSwitchSMBar=3 It's readily available in UK supermarkets, so I should think the same is true of other countries.

[hopeful_one]

I did when I was experiencing moderate penis pain. I had been taking it orally, but was concerned that doing so for weeks/months on end wouldn't be safe. I found a few non peyronie's studies that seemed to suggest that when applied topically it is as effective, but less is absorded into your system. That seems like a good way to bypass some of the negative side effects. The only issue was slightly dry skin (due to the alcohol in the topical formula I assume).This is the brand I bought: http://www.mysupermarket.co.uk/sainsburys-price-comparison/Medicine/Tesco_Ibuprofen_Gel_35g.html?ShowSwitchSMBar=3 It's readily available in UK supermarkets, so I should think the same is true of other countries.

thanks newguy. I've been using Ibuprofen tablets the last couple days. I may try Celebrex, but if I still need either after a couple weeks I'll look into getting some of this Ibuprofen gel.  

[lespleen]

i would go for it......honestly, i don't know why standard anti-inflammatories aren't part and parcel of the acute phase peyronie's regime......maybe  a lot of guys out there have blood pressure issues or perhaps the arsenal of peyronie's related meds developed outside of mainstream medicine have continued along non traditional lines to the detriment of more standardized/"traditional" methods of dealing with inflammatory processes generally. i don't know......  it just seems obvious to me.. i asked some guys on the forum about this in november but nobody had a response..........last summer i injured my back weightlifting ...... also around the same time I happened to have incurred the worst peyronie's related injury to date.The high power anti-inflammatories jettisoned me out of what would have been a dangerous place to linger. i wasn't taking pain killers rather i was taking steroidal/nonsteroidal anti-inflammatories. you can take 400 milligrams of celebrex for a month and 200 for a longer period of time so long as you take an antiacid at the end of every month.  i think finding a way to use celebrex safely long term at lower dosages would be great. it helped me with my pain like no other. you really need to remove inflammatory agents rapidly before they gain a foothold.

[Fredca]

Does anyone understand what Lespleen is trying to say here? I'm currently taking 2x2 naproxen/day just because im worried that Peyronies is on the way of returning. I want to get ahead on it.  

[George999]

I certainly understand what he is saying.  He is saying that, for example, Celebrex was helpful to him in getting his Peyronie's inflammation under control.  I think I have seen multiple posts around here to that effect.  Doctors don't seem to care about Peyronie's pain.  The standard answer is "it will go away".  I agree with Lespeen, that pain represents tissue damage underway and the right anti-inflammatory at the right time can potentially spare the Peyronie's patient more than pain.  I certainly wish I had treated my early Peyronie's pain more aggressively.  But the standard line from the doctors is to just leave it alone other than *maybe* some vitamin E, because MOST OF THE TIME IT GOES AWAY ON ITS OWN.  Yeah right!!!!  - George

Does anyone understand what Lespleen is trying to say here? I'm currently taking 2x2 naproxen/day just because im worried that Peyronies is on the way of returning. I want to get ahead on it.

[Woodman]

I agree with George and Lespleen. I ve taken Celebrex on 2 or 3 occasions last being from Feb to about June of this year. It helped me alot last March of 2010 I purchased a Fastsize used it for about 2 weeks approximately and hurt myself pretty good even following Dr. Levines instructions. I had pain from it all year. I started using Celebrex again and it helped thru the worst part of it. The pain is finally tapering off so I quit taking it about 4 weeks ago. I tend to lean towards Lespleens idea that its not good to take for long periods of time. This is just my thoughts and reading on the Celebrex website. I also have esophagus problems so I have to really watch how many pills I am taking at one time. I was taking 200 mg once a day. Uros should really prescribe it to us guys who have pain from the onset of Peyronies but a couple yrs ago I practically had to corner my uro in the examining room to get him to give me a script for it. Uros do not like to deal with pain issues and Peyronie's. I ve heard several people comment the same from there Uros too its always perplexed me why they skirt the issue.

[crashbandit]

Hey all,

Penis pain is horrible. I have no curve or lumps on my member but I have constant pain, which flares up to a 5 out of 10. So I've added Celebrex to combat this inflammation. I'm worried that NSAID's are more bad then good? I just don't want to cause more problems, you know what I mean. I've been reading the "Inflammation Syndrome", by Jack Challem and he mentions NSAID's are very bad.

So are NSAID's (Celebrex) bad for me? Should I just use the Celebrex till the pain goes away, then stop it?

I've been taking Celebrex with my lunch meal. Then I take my pentox (and ALC, which I'm just trying to finish the bottle) twice a day with breakfast and supper.

Thanks  

[crashbandit]

The Celebrex if working great for me so far. 3 days on it and what a difference.

I think I'm going to use up this one bottle I have of it and then stop it. Don't want to be using NSAID's for too long I don't think.

[Fred22]

Hi Woodman,

I thought you were on ubiquinol and receiving pain relief from that. Maybe I was thinking of someone else.

[crashbandit]

I have been taking Celebrex 200mg tabs every morning for a week now. And I must say it is helping tremendously. I have a problem with flaccid penis pain, expecially after ejaculation.

I'm hoping this NSAID will deter the "bad" inflammation long enough to get some really good healing done. Does Celebrex have the potential to hit my penis pain at the root and rid the pain once and for all? I really hope so.

From what I've read this drug takes 2 weeks to fully kick in, is this true? Is blocking the inflammation going to slow the healing? Because isn't inflammation suppose to be the body's way to heal itself? I hate the thought that while I'm on Celebrex, the tissue damage is progressing because I'm stopping my body's nature way to heal itself. You guys following me???

I don't know the exact mechanisms of Celebrex in the body but I just don't want to be turing off my bodies healing capabilities. My penis is fighting a big battle against Peyronies Disease, I'd hate to take it's troops away:)

Anyways I know you guys arn't doctors, although most doctors are clueless (except the specialists), but who here thinks Celebrex is a good thing for penis pain and inflammation from Peyronies Disease?  

[crashbandit]

Dang, 91 views and no reply's. Is no one using Celebrex?

Anyway I got some new stuff today since Celebrex was killing my stomach (all the alcohol I was drinking probably didn't help either). It's called Arthrotec 75. My pain seems to be nulinvoid lately (little bit of pain after ejaculation). But if it ever flares up again, I got the big guns again.

[chefcasey]

I had a prescription for it a few months ago and let me tell you...NOTHING kicked away acute pain like it.  I took 1 200mg tab and that completely cleared away any pain, even for days later.  I had to ration it out very carefully for when I really needed it because doctors don't like to give out a lot.  I don't know how it differs from other NSAIDS but ibuprofen is nothing compared to it.  I definitely recommend it if you get bad flare ups.

[GS]

I took Celebrex a few years ago for inflammation in my hip.  It worked like magic and the pain was gone almost completely by the 2nd day.  So, I know it works for inflammation and would think it would help in the acute stage of Peyronies.  I wish I would have taken it when I was originally diagnosed, but my doctor told me to take ibuprofen and I was too distraught to think of anything on my own at the time.    As for the chronic stage and the scar that goes along with it...I don't have a clue.  But, if it made sense, you would think some doctor somewhere would have thought of it.

GS

[LeftBendBoy]

Are Nsaid´s recommended for treating Peyronies syndrome?

I haven´t seen that much references to these medications on this forum. I was thinking of Diclolfenac, Ibuprofen eg.

Thanks,

LBB

[Skjaldborg]

Before going on pentox, my uro recommended ibuprofen. It did help with the pain while the medication was in effect, but it would wear off in a few hours. Pentox got rid of the pain permanently within a few months. NSAID will probably help with pain but I do not believe it would effect scar tissue development or resolution.

-Skjaldborg