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Author Topic: Should Xiaflex shot be this painful?  (Read 461 times)

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male_patient

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Should Xiaflex shot be this painful?
« on: April 29, 2021, 01:12:04 PM »


I got two shots of (in 2 separate days) Xiaflex and the pain during the shots was unbearable. I was screaming bloody murder. I could never imagine pain like this in my life. Is this normal?   If I have to do the second sets, I'm not sure I'll be able to tolerate it. I can deal with pain, but this is something out of nightmares. 
   
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57,Peyronies started in 2018 with pebble size hardening, but no curvature. Late 2020, sudden (within  weeks) 50-60 degrees of upward bend and hourglassing while erect.  1 round Xiaflex without numbing, without ultrasound, without endused erection

LWillisjr

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Re: Should Xiaflex shot be this painful?
« Reply #1 on: April 29, 2021, 01:41:22 PM »

They always gave me 2 injections for pain blocking with a much smaller needle first. Then after 10 minutes or soo came in with  the big needle for the Xiaflex. I assume it is really dependent on your doctor.
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Developed peyronies 2007 - 70 degree dorsal
Traction/MEDs/Injections/Surgery 2008
65y/o  13 years Peyronies free
My History

male_patient

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Re: Should Xiaflex shot be this painful?
« Reply #2 on: April 29, 2021, 02:08:41 PM »


The second time I was there, I asked if they could numb it. The doctor said, Nah, it would be just as painful.   
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57,Peyronies started in 2018 with pebble size hardening, but no curvature. Late 2020, sudden (within  weeks) 50-60 degrees of upward bend and hourglassing while erect.  1 round Xiaflex without numbing, without ultrasound, without endused erection

Shane43

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Re: Should Xiaflex shot be this painful?
« Reply #3 on: April 29, 2021, 02:34:59 PM »

I have had 6 injections. Each was painful for just 5-10 seconds and then it was fine. No numbing shot either. Now the swelling that happened later, especially after my 6th shot, was a bit scary and more painful.
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60YO, hourglass indent/hinging at base 30deg bend up 3cmx2cm hard plaque at dorsal base. No Erectile Dysfunction. 3 rounds Xiaflex decreased plaque/indent/hinge/bend by ~50%. Can now have careful sex, but now getting worse. Saw Dr. Levine, will start PMP for 6 months

male_patient

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Re: Should Xiaflex shot be this painful?
« Reply #4 on: April 30, 2021, 10:06:38 AM »


Per govenment website : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708590/

"... not uncomfortable to receive.."   lies lies lies     >:(


Pain
Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period. Verapamil is more painful to receive, likely due to the volume of fluid, but is not significantly painful thereafter.
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57,Peyronies started in 2018 with pebble size hardening, but no curvature. Late 2020, sudden (within  weeks) 50-60 degrees of upward bend and hourglassing while erect.  1 round Xiaflex without numbing, without ultrasound, without endused erection

BadLuck

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Re: Should Xiaflex shot be this painful?
« Reply #5 on: April 30, 2021, 10:37:01 PM »

I went through 6 rounds of Verapamil injections and I just had my 5th Xiaflex injection this week.  Each of the Verapamil injections was preceded by a numbing injection.  With Xiaflex, there is no such injection.  I believe the needle gauge is larger for Verapamil than it is for the Xiaflex injections.
Honestly, I though they were all pretty painless.  I would equate it to a wasp sting. 
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Xavier99

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Re: Should Xiaflex shot be this painful?
« Reply #6 on: May 01, 2021, 07:54:32 AM »

Badluck did you have any results from verapamil? Is there anywhere you can still get those these days. Nobody around me would shoot me w/ it
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35 yrs old
Onset 05/01/20 diagnosed 05/14/20. Taking Pentox, trental, multivitamin, Zoloft & Tylenol
Traction was painful and made it worse
Lateral plaque by glands 20 degrees left/ narrowing
Lost about 2cm length

Hawk

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Re: Should Xiaflex shot be this painful?
« Reply #7 on: May 01, 2021, 08:21:05 AM »

Guys,

We work hard here to make a forum that gives support to men and couples.  All we ask is cooperation.

Please fill in your signature line with the basic information about your case, so readers have some clue what your background is and why you are posting or trying a treatment.  Here are clear instruction. ----> https://www.peyroniesforum.net/index.php/topic,10819.0.html

I will gladly take my time and help if you have trouble figuring it out.

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Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

Mikel7

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Re: Should Xiaflex shot be this painful?
« Reply #8 on: May 01, 2021, 12:58:26 PM »

I would have responded to this but I am exhausted from trying to go back and read about the posters history.     :-\
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Lump April 2020, age 60 , Dr Levine 6-26-20,
Dorsal Curve 11-1-20 , Peyronies
Vit E400mg, COQ10, ALCAR, Heat Therapy, Penimaster, Pentox, Cialis
had SNHL 7-31-20 - Stopped all Meds because ototoxicity  Heat/traction/VED are working.

chas

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Re: Should Xiaflex shot be this painful?
« Reply #9 on: May 04, 2021, 02:18:45 AM »

I'd  like to add that I received a numbing injection and didn't feel a thing from the Xiaflex.
One of the anaesthetics wasn't 100% effective and the Xiaflex was damn uncomfortable.
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Mild bend in 2013, Stabilised at 40 degrees in 2017
6 Xiaflex shots 2020 - 2021.
Now more or less straight.

john.doe.550

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Re: Should Xiaflex shot be this painful?
« Reply #10 on: July 14, 2021, 09:40:52 PM »

Everyone has different pain threshold. A few injections hurt a little for me, but the majority did not.  No numbing or pain killing was used on me.
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Age: 62;  Peyronies Disease diagnoses: MAR 2019;  Onset: Immediate & severe;  Treatment: Xiaflex, APR 2019 to present, slow & steady improvement. Notable Xiaflex improvement through early 2021. Potentially good enough for late 2021 plication surgery.

Flatten_the_curve

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Re: Should Xiaflex shot be this painful?
« Reply #11 on: July 14, 2021, 11:30:05 PM »

I received the penile block (lidocaine anaesthetic) and felt nothing but some pressure during injections. The evening of my second injection I had excruciating pain and massive swelling.
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33 yo
Committed Partner
Onset late 2020
60 degree leftward bend
One Xiaflex course (2 injections) 6/23/21, 6/29/21
Painful swelling & hematoma following injection 2
Results unknown but unlikely to continue treatment

BrettC

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Re: Should Xiaflex shot be this painful?
« Reply #12 on: July 15, 2021, 02:11:09 PM »

I have been through a full series of XIAFLEX treatments.  I found them uncomfortable, but never outright painful.  I did use a numbing cream that I got online... and whenever they administered the shots I grabbed on to something very tightly as they administered.  I would liken it to a small bee sting or less.  I think the real variable is where your plaque is located too.  They usually try to inject right into your plaque.  Mine was dorsal or on top and near the base.  Also I went to a urologist practice that specializes in Peyronie's.  The PA who gave it to me does these all day every day.  He has it down. 
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50 years old
Diagnosed just over a year and a half with 40-45 degree upward bend after starting with 60-65 degrees.
Completed one full round of treatments with Xiaflex (8 injections) 
Using Restorex and oral medications as well (Pentox, Cialis)
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