Study with Diclofenac.

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Godisreal

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706125/#!po=0.769231

This study showed good results and it says patients used Diclofenac, twice daily. Among other things (blueberry, PTX-oral, propolis, PTX-shot & Vitamin E.
Interesting since many on here has been asking if Diclofenac perhaps could do something.
Well, in this study, they use it officially.

I do, however, want to put the question out there - what actually made the difference?
If you bother to read the study, you'll see that they administered a Pentoxfylline-shot (100mg) every other week, directly into the penis. Has anyone else here had this done?
Perhaps this was the reason for the success of the patients on the study, but who knows.
I feel like antioxidants are important but we all know the mega-dosage of Vitamin E is Stone Age treatment. Is anyone on blueberry and Propolis combined with Pentox?

I will personally start using Diclofenac more, excluding the glans this time.
Actually, I might put on Hirudoid-cream when I wake up and Diclofenac when I go to sleep.
I can barley afford the supplements I get on which leads to me not taking them for an extended period of time, which is awful. Physical & psychological pain combined is devastating.
- GIR
30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

Winter

In my case I wouldn't mix Diclofenac and Hirudoid. I would use on or another, isolated, for a week. See each one improves the best and then make a choice. But that is just me. I am usually all in for combining treatments, but I am quite cautious about skin's allergic reactions.
41 yo, married. Onset on 07/20. Flare up on 07/21. Brand new flare up 01/23. Indentations and hourglass. It still hurts sometimes; No erectile dysfunction. Taking Pentox, Cialis, Supplements, trying diets, fasting, VED and manual traction.
God bless

Godisreal

Yeah I hear you, man. My skin'a reaction to DMSO wasn't too bad until I washed it off with warm water... God what a mistake.
Nasty skin rash on my balls after that and still occasional discomfort and pain in scrotum area, 2 months later!!!
Watch out for that.
Hirudoid is nicer to the skin in my case, but Diclofenac is definitely more powerful.

I'm applying Hirudoid two times a day right now.
It's working, but I still feel a dull pain in my glans almost every day. Comes like a small wave.
Any suggestions to treat pain in the glans? I'm trying to avoid getting Hirudoid on there but it's difficult.
30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

Winter

If you have any reaction on your glans, do avoid it carefuly. On the Hirudoid's leaflet, it says to avoid using it on mucous membranes or sensitive areas. Same with diclofenac.

But obviously you may try both. The problem with trying them at same time is that, if you have an allergic reaction, you wouldn't know which one caused it.
Having said that, perhaps I will try Diclofenac as well after finishing my Hirudoid.

The study your posted is quite interesting. Specially because says that by doing nothing, you are very likely to experience noticeable worsening. What the heck people are teaching on the urology classes lately?

The main protagonist of this study is the perilesional injections of pentoxifiline. In my country I am 100% sure no urologist will agree on this!! I've visited 4 of them and 3 dismissed even oral pentox, with no room for arguments. The last one prescribed me, but only to get rid of me. Pentox injections? No chance at all. I also don't recall reading about any member here talking having taken pentox shots.
But the results on the B group are quite promising also. I see myself, more or less, followin the same protocol as they were.
41 yo, married. Onset on 07/20. Flare up on 07/21. Brand new flare up 01/23. Indentations and hourglass. It still hurts sometimes; No erectile dysfunction. Taking Pentox, Cialis, Supplements, trying diets, fasting, VED and manual traction.
God bless

BillyJynx

Quote from: Godisreal on April 08, 2021, 12:21:57 PM
Hirudoid is nicer to the skin in my case, but Diclofenac is definitely more powerful.

How do? Which strength hirudoid are you using? I've just run out of hirudoid forte (mucopolysulphate saccharide) which worked very well for me. I can buy Diclofenac at the shops would love to know if it could work better.

Godisreal

Thanks, lads. I just read a study where it was found that Diclofenac has a negative impact on sperm-quality and testosterone. Of course, lol. It's always something.
The study also concluded that Melantonin-supplementation eases the negative impacts on testicular health, caused by Diclofenac.

Just a heads up for people trying Diclofenac. I'm not gonna stop using it, since it's working.
I might ease up a little and I will also start Melatonin-supplementation soon, since it's also a powerful antioxidant.
But I guess try Hirudoid, first hand. Might be a little more easy on the body & especially testicles.
30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

bentoboy

26 y. o. Peyronie since 2020: upward congenital curvature from the bottom - 20*; twist and curve to the left - 25*; two visible dents on the left side; multiple plaques everywhere; no pain

Vitamins; Tadafil; traction/bending; VED - nothing worked

hope4thebest

I'm also planning to use topical diclofenac. I bought the same formulation that they used in the study. 4% gel spray. It has a lot of different names in different countries. It's supposed to be the most powerful of all topical diclofenac preparations and have superior penetration due to lecithin, I believe. They say they used two pumps twice a day.

Also, I wouldn't be concerend about testosterone as we won't be applying it to testicles and the amount absorbed into general circulation will be very low. There really doesn't seem to be any downsides to trying, since it's cheap and maybe will have at least some effect.

I'm hoping to convince mu urologist to do PTX injections, since I can't take tablets due to terrible digestive issues I have and very poor general health. Urologist, of course, redommended wait and see... as seems to be the usual.
Trauma 2022 August, first deformation seen 2022 November. Very mild curve to the right. Indentation on the right side below the glans. Looking for treatment options. Initially almost complete Erectile Dysfunction, fixed by treating nutritional deficienes.

YoungPrince

Quote from: Godisreal on April 12, 2021, 02:06:50 PM
Thanks, lads. I just read a study where it was found that Diclofenac has a negative impact on sperm-quality and testosterone. Of course, lol. It's always something.
The study also concluded that Melantonin-supplementation eases the negative impacts on testicular health, caused by Diclofenac.

Just a heads up for people trying Diclofenac. I'm not gonna stop using it, since it's working.
I might ease up a little and I will also start Melatonin-supplementation soon, since it's also a powerful antioxidant.
But I guess try Hirudoid, first hand. Might be a little more easy on the body & especially testicles.

Be care with melatonin, it does no good for dopamin and dopamin regulation affects testosteron.
Age:27
Self induced peyron 2022.04.?
Fibrous ring on the base, restricting bloodflow
unable to sit because of it.
Lost 0.5 inch in girth.
The ring keeps tightening.
Penis often goes cold and slugish.
Narrowing, Right side does not fill properly.

Sonic

I used it almost every day for a month or more. Be very careful with applying this on your penis since it is proven to penetrate skin. It definitely helped with some soreness/minor pain flare ups but it also quite drastically lowered my erectile quality for months.

Use at your own risk.
28 years. Started to develop a rightwards curve in June 2020.
narrowing on right side and about a 20-25° curve to the right.
Weakened erections and instability due to narrowing.

hope4thebest

@sonic, interesting. I actually wondered yesterday if it could be a potential problem with it. I've just did a quick google search and it seems that NSAIDs are mildly associated with erectile dysfunction after prolonged use. Makes me wonder if it's really such a good idea. Interestingly, no such effects were observed in study subjects.

These same researchers also used propolis cream in another study. Maybe that's a good alternative option. I'm just not sure if it can penetrate deep enough to affect the plaque.
Trauma 2022 August, first deformation seen 2022 November. Very mild curve to the right. Indentation on the right side below the glans. Looking for treatment options. Initially almost complete Erectile Dysfunction, fixed by treating nutritional deficienes.

hope4thebest

Actually it wasn't a study, just a three case report. Interestingly, one guy had complete regression even without pentoxi injections.

It's probably already been posted here, but here's the link:

Full Regression of Peyronie's Disease Plaque Following Combined Antioxidant Treatment: A Three-Case Report
https://pubmed.ncbi.nlm.nih.gov/36139736/
Trauma 2022 August, first deformation seen 2022 November. Very mild curve to the right. Indentation on the right side below the glans. Looking for treatment options. Initially almost complete Erectile Dysfunction, fixed by treating nutritional deficienes.

Cehaleddin

I am not a very educated reader but my understanding is that propolis creme and antioxidants were the thing in common that these patients used, no?

If so what were the antioxidants? I could not see a list of them perhaps its in the longer version of the report.

Either way do you think this is valid? Total remission, sounds very promising.
27
Narrowing below the glans, a bit of shortening
Not sure if Peyronie's disease or fibrosis
Symptoms have currently stabilised

hope4thebest

I think the report shows that is indeed possible. Whether it's possible in every case, that's a different question. The one thing authors enmphasize in every paper is that it takes a long time and commitment to the multimodal therapy to achieve that. Just open the full paper, it's free. You'll find all the supplements listed.

Going back to.diclofenac and possibility of Erectile Dysfunction, I dug a little deeper and there seems to be a possible mechanism that would explain it. It has been proven in animal models.

Functional inhibition of erectile process in rats by indomethacin

Abstract
Objectives
Despite the important role played by prostaglandins in the control of erection, the potential contribution of non-steroidal anti-inflammatory drugs in erectile dysfunction in experimental animals has not been investigated. We examined the effect of the selective COX-2 inhibitor, celexocib, and the non-selective COX-inhibitors, indomethacin and diclofenac on erectile process in vivo.

Methods
Erectile responses to electrical stimulation of the cavernous nerve in anesthetized male rats were recorded after single and repeated administration and intracavernosal pressure/mean arterial pressure (ICP/MAP) was calculated. The effect on blood pressure during erection and total plasma nitrite/nitrate level was also investigated.

Results
Single-dose administration of indomethacin significantly reduced erectile responses to electrical stimulation at all frequencies tested; 15 mg/kg further reduced ICP/MAP to 0.016 ± 0.005 compared to 0.064 ± 0.012 and 0.104 ± 0.035 for indomethacin (5 mg/kg) and control, respectively at 0.5 Hz. Longer-term treatment with indomethacin completely abolished erectile responses at low frequencies and significantly reduced ICP/MAP at higher frequencies, accompanied by significant reduction in total plasma nitrite/nitrate level. Diclofenac reduced erectile responses only at low frequencies in contrast to celexocib that failed to negatively affect erectile responses.

Conclusion
Indomethacin, and to a lower extent diclofenac, may adversely affect erectile responses in rats.



Here's the link to a full article foe those interested:
https://sci-hub.se/10.1007/s00345-010-0600-0

But then again, no such problems were reported in the study so this problem may not be very significant.
Trauma 2022 August, first deformation seen 2022 November. Very mild curve to the right. Indentation on the right side below the glans. Looking for treatment options. Initially almost complete Erectile Dysfunction, fixed by treating nutritional deficienes.