Topic: Please tell me: is finasteride safe ? (Read 390 times)

Graggaxy · « **on:** February 20, 2021, 09:01:14 AM »

I am only 23 years old and I have been diagnosed with mild Peyronies Disease after ultrasound.

I’ve talked to a few urologists. Some told me I shouldn’t take fin and others told me that it’s safe with Peyronies Disease.

What do I do from here? Should I maybe try topical finasteride on my scalp just to minimize potential systemic effects?

Bud luck · « **Reply #1 on:** February 20, 2021, 01:09:21 PM »

Finasteride blocks DHT, DHT is the most important male hormone for males, the Doctors that told you that is fine they are just plain ignorant, but is up to you.

pfract · « **Reply #2 on:** February 20, 2021, 01:20:41 PM »

Please DO NOT TAKE finasteride! It has very nasty side effects and most likely it will lead to Erectile Dysfunction. There are links all over the place because of this...

Graggaxy · « **Reply #3 on:** February 20, 2021, 01:23:29 PM »

There is no evidence that finasteride could make Peyronie’s worse

Bud luck · « **Reply #4 on:** February 20, 2021, 01:30:35 PM »

It won't make Peroynes worst, but your erections could get worst

Graggaxy · « **Reply #5 on:** February 20, 2021, 01:32:32 PM »

I‘m taking daily cialis 5mg anyway so I should be fine?

Graggaxy · « **Reply #6 on:** February 22, 2021, 04:17:39 PM »

Just started finasteride 2 days ago and so far no bad side effects

Tortão Pra Direita · « **Reply #7 on:** February 22, 2021, 05:08:01 PM »

A lot of people take and are ok with it.

But is it worth it? You're gonna mess with hormones and take the chance of developing post-finasteride syndrome.

Make some money, go to Turkey to travel a bit, and get a hair implant there. Much better and safer option. And you're gonna love that place.

matty1998 · « **Reply #8 on:** February 22, 2021, 06:22:29 PM »

Finasterid ist sehr umstritten, https://de.wikipedia.org/wiki/Finasterid

Mit Finasterid geht’s du ein bestimmtes Risiko ein. Mir wurde 2012 Finasterid verschrieben, aber ich weigerte mich, die Tabletten einzunehmen, weil ich von der Kontroverse gehört hatte.

Auf keinen Fall würde ich Finasterid nehmen. Ich hab mich stattdessen einer Haartransplantation unterzogen. Das Ergebnis war ausgezeichnet. Teuer, aber es ist das Geld wert. Aber Finasterid? Das kannst du vergessen.

Es gibt kein örtliches Finasterid, glaube ich. Nur, Minoxidil kann als eine örtliche Behandlungsmethode verwendet werden, so weit ich weiß.

gaussrifle · « **Reply #9 on:** February 22, 2021, 07:21:32 PM »

Please do not take Finasteride at any cost. I am on this forum because of it. My peyronies and curve worsened after 2 months of Finasteride use. I know what it feels like to go through hairloss at your age. Earlier hairloss forums were my obsession, now this forum is, you tell me which one is better. Just get a hair transplant/system if it comes to that, but do not take finasteride especially if you have peyronies. In mice, it was studied that finasteride reduced elasticity and encouraged fibrosis , which is exactly what peyronies is. You say you have no side effects on finasteride so far ( I did not either except less pleasurable orgasms ) , there is an underlying pathway of fibrosis that develops when you starve erectile tissue of DHT.

this_life · « **Reply #10 on:** February 23, 2021, 08:25:04 AM »

people now using animal mice studies when we all know just how worthless they are in peyromies disease is incredibly disimgenous and not very rigorous scientifically

Nolte94 · « **Reply #11 on:** February 23, 2021, 12:23:24 PM »

These studies with mice aren't useless at all.

this_life · « **Reply #12 on:** February 23, 2021, 12:28:44 PM »

why? peyronies was effectively cured in mice just as was cancer and alzheimers. but these meds have zero effect in a human model. zero. but suddenly giving rats the 100! fold dosis of dutasteride which results in fibrosis is of real value when this has not been observed in clinical trials? explain to me why that is. ratsare rats

Graggaxy · « **Reply #13 on:** February 24, 2021, 02:50:52 AM »

What about minoxidil ? Is it safe? Because I’ve been using both and maybe I can get away with one of them

gaussrifle · « **Reply #14 on:** February 24, 2021, 03:54:39 AM »

Graggaxy, yes minoxidil is safe and so far I have been using it with no problem. I use the foam version.

Graggaxy · « **Reply #15 on:** February 24, 2021, 06:57:54 AM »

Yeah maybe I will drop the finasteride and just keep applying minoxidil for now

this_life · « **Reply #16 on:** February 24, 2021, 07:14:19 AM »

minoxidil does not stop the minaturization process through dht, you will continue to lose hair, you just get a boost for the time being. onceminox is stopped everything will vanish

Juan · « **Reply #17 on:** February 24, 2021, 10:17:30 AM »

What about topical finasteride? Would it be safer?

gaussrifle · « **Reply #18 on:** February 24, 2021, 11:43:01 AM »

This life, minoxidil does increase Anagen phase and once you stop the benefit wanes, is true. I do agree that finasteride is much more effective for hair loss but with the side effect profile it is not for me. I tried topical finasteride and got the same sides. So topical finasteride is absorbed through bloodstream too. Waiting for breezula/ kintoor, next generation treatments. Till then using minoxidil, micro needling to stop and control.

this_life · « **Reply #19 on:** February 24, 2021, 11:54:19 AM »

sad thing is people have been waiting for the next gen hairloss drugs for 20 years now. it is very comparable to research in peyronies. nothing happens. there is no financial incentive in it(despite what people might think, many men do not treat their hair loss) and research is expensive and the condition is actually really complicated(just like fibrosis of the penis). the next gen drugs will still not be very effective. we all lived 50 years too early, in around 50-100 years scientific research will finally have progressed to the point where we can address diseases at the root and not just treat one factor of it. that will come in the form of stem cell research and genetic research. but that sadly might be a century away. at some point, nobody will ever have to go bald or have peyronies disease ever again

Graggaxy · « **Reply #20 on:** February 25, 2021, 03:09:53 AM »

Quote from: this_life on February 24, 2021, 11:54:19 AM

sad thing is people have been waiting for the next gen hairloss drugs for 20 years now. it is very comparable to research in peyronies. nothing happens. there is no financial incentive in it(despite what people might think, many men do not treat their hair loss) and research is expensive and the condition is actually really complicated(just like fibrosis of the penis). the next gen drugs will still not be very effective. we all lived 50 years too early, in around 50-100 years scientific research will finally have progressed to the point where we can address diseases at the root and not just treat one factor of it. that will come in the form of stem cell research and genetic research. but that sadly might be a century away. at some point, nobody will ever have to go bald or have peyronies disease ever again

Very true I had this thought as well in the past. We were all born 50-100 years too early. Do you recommend finasteride in my case? I know that minoxidil alone doesn’t fix the root problem..maybe I should try topical finasteride, I think naturally it must have fewer side effects. Or what about 0.5 mg oral every other day? I think there is a way to make it work even with Peyronie’s

gaussrifle · « **Reply #21 on:** February 25, 2021, 02:34:36 PM »

It seems you have already made up your mind. I have already given my opinion. I would recommend taking finasteride of any kind topical or not in two cases only
1) you do not have peyronies, srsly, why are you adamant in coming up in contact with that evil drug when you already have peyronies ? Are you trying to make things worse ? It definitely won’t be helping you fight peyronies and I can guarantee you that it’ll be making things worse. My words, might sounds harsh right now, but it is the truth that you don’t want to hear. You will thank me later.
2) you have a penile implant

People on this forum and other forums have misconception about finasteride dosing. They say, if I take 0.25 mg or 0.5 mg finasteride or in topical form , I’ll get less sides..wrong! Look at the dosing curve and you’ll see that almost 70 percent dht is inhibited even for less doses. In short wether you take 1 mg or 5 mg or 0.5 mg , you are definitely blocking more than 50 percent of your dht that your penis needs !

Bud luck · « **Reply #22 on:** February 25, 2021, 03:31:57 PM »

Gaussrifle is 100% accurate, Fin is a drug that affects male hormones, the only ones that disagree are the "Doctors" that make profit from it and obviously the manufacturer. If you go any testosterone replacement therapy site, there are plenty of guys that ended up taking Testosterone because of finasterrade side-effects

Graggaxy · « **Reply #23 on:** February 28, 2021, 02:47:58 PM »

Ok I dropped finasteride but is topical minoxidil at least safe??

this_life · « **Reply #24 on:** February 28, 2021, 04:04:55 PM »

yeah it is safr but not very effective. it is very interesting to me that the ones so severe opposed to finasteride have nothing in this fight and are bot balding extremely young. it is easy to demonize the drug when you are not affected by premature baldness. surethe risk is non zero but it never is in life with anything. facts are all this scare talk is just that, scare talk. scientificstudies have not found finasteride to be parziculariy dangerous

matty1998 · « **Reply #25 on:** February 28, 2021, 06:06:06 PM »

Minoxidil is safe and has been out since 1988, but it’s true that it’s not very effective. It only has a minor effect and when stopped whatever hair was gained, which was probably not much, just falls out, from what I’ve heard. I didn’t lose any hair till age 50, but minoxidil didn’t do anything for me. Plus you have to apply it every day. It used to be rather greasy but later came out in a foam i believe.

The debate over Finasteride is not new. It’s been raging strongly since at least 2010, if not earlier. And it’s the same claims made then as now. But, it never lost approval by prescription.

When I thought of hair replacement (I had no hair loss until I was 50) I just thought of hair transplants (I had 3000 follicular units in 2012). When I went to this woman hair transplant doctor she had prescriptions already filled out, a big stack of them, and gave them to every guy who came in and said to just fill your name in on the prescription. I thought that was kind of strange. When I looked up finasteride on Wikipedia and elsewhere I saw the raging debate going on (the alleged „post-Finasteride syndrome“) everything they are talking about today, so I decided not to take it. The hair transplants were expensive, like 3€ per follicular unit, and I did 3000 to start. So, they were like 9000€ . So they are pretty expensive. I could use another 3000 or even more but they cost a bit too much right now. (They they Turkey is the least expensive place to have them done.) I don’t have strong feelings about finasteride one way or the other. I know most guys who have taken it report not Ill effects. Some have.

Bud luck · « **Reply #26 on:** February 28, 2021, 08:37:19 PM »

Finasteride can affect some men, the same as vasectomy or Trimix ( I was screwed in both cases). Are you willing to take the risk to get worst erections?. Finasteride blocks DHT, and DHT is the MOST important male hormone for libido and erections, is your call.

this_life · « **Reply #27 on:** February 28, 2021, 10:24:08 PM »

I don't understand why you say "worst" when "worse" seems to be the gramatically correct term. besides, your "most important" claim is LITERALLY made up. studies have shown it. most men are fine on dutasteride which obliterates men. but without testosterone men cannot function. in fact it is well know that testosterone is much more important than dht. the correct term is "dht is the most androgenic in certain tissues" but when that is "most important hormone" which is just misinterpreting science as "most important" is not a scientific term. there is a huge conspiracy online against finasteride. it is everywhere and wild. btw dht is not even tested most of the time when you get a hormone panel. estrogen and testosterone are. why if dht is the most important? most attacked drug on the internet for sure

OP made a big mistake by posting here. bud luck is literally giving out false information and then attacking OP with "your call" passive aggressiveness. really annoying..

Bud luck · « **Reply #28 on:** February 28, 2021, 10:31:22 PM »

This_life, I'm been on the TRT site for 2 years now, there are a lot of men that end up there because of Finasteride side effects, and you said that DHT is not important for libido and erections? Well, DHT is the main male hormone for libido and erections alongside testosterone. And sorry if I had grammatical errors, English is not my native language.

gaussrifle · « **Reply #29 on:** February 28, 2021, 10:36:48 PM »

I agree that bud luck called out dht as most important. I think he meant most important androgen after testosterone. However, as I have said before it is clearly not a conspiracy that finasteride can worsen erections and cause fibrosis. I am sorry, that is not up for debate. Even the hair clinics I spoke to who sell prp injections and all were upfront about this. I did experience sides from personal experience, I had much less pleasurable orgasms along with weaker erections. It sort of felt numb. After that in the following months I developed peyronies, that is why I’m here on this forum. This life, stop disregarding people who are giving actual opinion. I a, not 100 percent saying, that you will get sides, but let me tell you getting sides on finasteride is not as rare as you think or how the statistics are made up. With peyronies, taking finasteride is like playing Russian roulette with a revolver loaded with all but one chamber.

matty1998 · « **Reply #30 on:** February 28, 2021, 10:57:11 PM »

You know, this debate about finasteride ruining men’s sex lives has been argued and alleged for at least 12 years, yet I’ve never seen any evidence anywhere that it is true. People have claimed it, I know, but there are those who also claimed that it had no effect on them. It clearly has no connection to Peyroines (and Bud Luck, what were you claiming vasectomy did? I had both a vasectomy and a vasectomy reversal operation (vasovasostomy) a year later, and i never noticed a difference either way).

I’ve read that finasteride is especially good in filling in hair lost in the crown, where I need hair and where transplants are harder, so in many ways I wish I hadn’t been scared off by the internet propaganda 12 years ago. I might have had more hair now.

this_life · « **Reply #31 on:** February 28, 2021, 11:01:09 PM »

and i am younger than you and have peyronies without any risk factor and i have never taken finasteride. so now does that support my argument? there is no evidence to support fibrosis caused by finasteride, none what so ever. a small percentage (around 5-10%) get worsened Erectile Dysfunction and libido lowering and that is where the science ends. if you do not want to accept the science that is your call however it is out there. if you think the statistics are made up while literally making up your own mind with non verified facts, thats not very consequential. also your russian roulette comparison.. you know it really does make me angry that such nonsense is even allowed on this forum. obviously it is reactionary nonsense. everything in life has risk involved albeit often very small. you think this is smart but what about "everytime you get in a car is like playing Russian roulette with a revolver loaded with all but one chamber." it is the same thing. but peoiple wont stop driving because of chance of accident. russian roullete is 1/10 chance, long lasting sides from fin (after discontinuing) is legit 1/1000, just like you can die any day anyway. but people love to be reactionary abotu this and not stick with the science

Tortão Pra Direita · « **Reply #32 on:** **Yesterday** at 08:08:16 AM »

Quote from: this_life on February 28, 2021, 11:01:09 PM

a small percentage (around 5-10%) get worsened Erectile Dysfunction and libido lowering

I don't know if these numbers are correct, but assuming it is, this is enough to stay away from finasteride or other drugs that inhibit 5 Alpha-reductase.

If you have Peyronie, you want to maximize the blood flow into your penis, not the contrary. This is one of the reasons pde5 inhibitors, like tadalafil, are prescribed to Peyronie patients.

this_life · « **Reply #33 on:** **Yesterday** at 09:23:21 AM »

Quote from: Tortão Pra Direita on Yesterday at 08:08:16 AM

I don't know if these numbers are correct, but assuming it is, this is enough to stay away from finasteride or other drugs that inhibit 5 Alpha-reductase.

If you have Peyronie, you want to maximize the blood flow into your penis, not the contrary. This is one of the reasons pde5 inhibitors, like tadalafil, are prescribed to Peyronie patients.

easy to say when you are not suffering from male pattern baldness at a young age. like seriously, do you think people are taking these medications because "yolo life poppn pills like there is no tomorrow"? even the people who take it wish they would not have to.

it is debilitating to lose your hair this young and in contrast to common believe a hair transplant is NOT an option for the vast majority as further hair loss will occur and you can actually get shock loss after the procedure which will result in an absolute disaster. just as most people do not understand what peyronies sufferers experience most people *here* will also not understand why it is horrible for a 20 year old to go bald. you are acting like OP is commiting a crime just by even thinking about it.

have some understanding and empathy? and the science is pretty clear 5-10% Erectile Dysfunction but when discontinued it goes away, some rare cases(sub 1%) that claim they have persistent(not permanent mind you) sides but again, you could die tomorrow in a car crash so if you want to run the maximum risk avoidance strategy in life, go right ahead

and in my case for example, i got peyronies and balding, i will never have sex the way i want to and the way i find it enjoyable. the last thing i need in this depressive spiral is looking like a 50yo creepy guy. and i am not on finasteride as i want to wait out the accute phase of my peyronies.

my doctor said you only get peyronies once based on his experience and the theory is that it is an auto immune disorder and the immune system "learns" to not overreact the next time a micro trauma occurs. i am not sure how much of this is true but he is a well know peyronies specialist and has treated many cases and even done a trail on xiaflex so he must have the experience to draw form i suppose

Tortão Pra Direita · « **Reply #34 on:** **Yesterday** at 04:41:46 PM »

Quote from: this_life on Yesterday at 09:23:21 AM

easy to say when you are not suffering from male pattern baldness at a young age. like seriously, do you think people are taking these medications because "yolo life poppn pills like there is no tomorrow"? even the people who take it wish they would not have to.

How this is related to the thread? The guy created this topic cause he was asking for others' opinions on the safety of Finasteride. Nobody is prohibiting no one to use. Stop playing the poor victim. What I wrote is reasonable: you want to encourage blood flow into your penis, not the contrary. So finasteride is a no-no for Peyronie patients. "Oh, but I'm bald bla bla bla" So take the drug! It's your choice, dude!

If I were bald, I'd make a hair transplant. Safer, better results, healthier, and not so expensive. Go to Turkey. There are a lot of excellent clinics there. I know one that was charging $2500 (including 5-star hotel, local guides, translator, etc) for a beard transplant. A hair transplant I'd estimate can go from this value to $5500, depending on how much hair you have.

Just stop polluting here. You don't want to be helped and don't want others to be helped too.

this_life · « **Reply #35 on:** **Yesterday** at 04:43:37 PM »

how does finasteride stop blood flow to the penis??

Tortão Pra Direita · « **Reply #36 on:** **Yesterday** at 04:50:17 PM »

Quote from: this_life on Yesterday at 04:43:37 PM

how does finasteride stop blood flow to the penis??

Directly, it does not stop blood flow to the penis.
It reduces some of the most important male hormones, DHT, and reduces significantly sex drive. So it lowers the number of erections you have along your day (and even NTE).

Some men are more affected than others, of course. If you take finasteride and feel no reduction in the number of erections and libido, then you're lucky and may take the drug without problems.

Bud luck · « **Reply #37 on:** **Yesterday** at 04:54:30 PM »

Tortao is 100 % right. Finasteride doesn't affect all men, if the guy is willing to take the risk....

this_life · « **Reply #38 on:** **Yesterday** at 05:00:21 PM »

science disagrees

https://pubmed.ncbi.nlm.nih.gov/7775644/

Bud luck · « **Reply #39 on:** **Yesterday** at 05:09:30 PM »

How science can explain the large group of men that got screwed up because of Finasteride? I trusted the guys that got Erectile Dysfunction because of Finasteride, not "science" articles

Tortão Pra Direita · « **Reply #40 on:** **Yesterday** at 05:34:35 PM »

Quote from: this_life on Yesterday at 05:00:21 PM

science disagrees

https://pubmed.ncbi.nlm.nih.gov/7775644/

I don't know how you're trying to fit this study in the conversation. And it's n=20, not so reliable.

Really, stop being stubborn. Just google "5-alpha reductase inhibitors and erectile dysfunction" or something like that, and you're gonna find a ton of studies proving the relationship between this kind of drug and a lower erectile function. I'm not saying it will for sure make you limp.
It has a great chance of causing decreased libido, consequently a lower number of erections, and this is, consequently, not good for a patient that has Peyronie.

"randomized controlled studies report the rates of erectile dysfunction to be between 0.8%–15.8%." lol. A wide gap, for sure.
https://onlinelibrary.wiley.com/doi/full/10.2164/jandrol.108.005025#b54

Again: if you take finasteride and think it's fine for you, then keep it. It's your choice.
I'd prefer my head bald and my head down here working, lol

this_life · « **Reply #41 on:** **Yesterday** at 05:39:59 PM »

Quote from: Bud luck on Yesterday at 05:09:30 PM

How science can explain the large group of men that got screwed up because of Finasteride? I trusted the guys that got Erectile Dysfunction because of Finasteride, not "science" articles

i trust personal anecdotes more than scientific studies(or "articles" how you call them lol)
-Bud Luck et al.

Graggaxy · « **Reply #42 on:** **Yesterday** at 06:47:03 PM »

I think finasteride can be safe if taken at low doses like 0.5 mg EOD and daily Tadalafil 5mg. What do you guys think?

Bud luck · « **Reply #43 on:** **Yesterday** at 07:32:51 PM »

Just take it, you may have side effects, you may not, is up to you. Nothing is 100% safe, and definitely not a medication that blocks DHT, DHT is the most important androgen for a man's libido and strong erections

pfract · « **Reply #44 on:** **Yesterday** at 10:42:50 PM »

Quote

i trust personal anecdotes more than scientific studies(or "articles" how you call them lol)
-Bud Luck et al.

hahah Now this was funny. Unfortunately people have a hard time believing evidence and disregard it, when they really want to do something... In this case, to him it's more important to have hair than to have a functional penis. Go figure!

Graggaxy · « **Reply #45 on:** **Today** at 09:02:38 AM »

Of course it’s not the best thing to block DHT but I think I could get a significant amount of QoL back if I start finasteride

Bud luck · « **Reply #46 on:** **Today** at 09:16:38 AM »

Then take it. I know two guys that are taking Finasteride for years and they keep their hair, however, the both told me that their libido is not as strong, neither their erections. One told me that he prefers to have hair than strong erections. In the meantime, the manufacturer of Finasteride and the "Doctors" that prescribed said that is totally safe, and all the cases is due to "other reasons"

Juan · « **Reply #47 on:** **Today** at 10:05:28 AM »

What about saw palmetto instead of finas?
Obviously for hair loss will not be as effective but, in terms of safety for peyronies?

I’ve read saw palmetto would be like the natural finas.

What’s the opinion about this supp?

this_life · « **Reply #48 on:** **Today** at 11:59:34 AM »

hard to find a drug more worthless than saw palmetto. it is considered a meme among people who know a lot about hair loss. zero effectiveness but also zero side effects. might as well pop sugar.

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