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Author Topic: Risk of Topical Minoxidil  (Read 643 times)

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Eric_C

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Risk of Topical Minoxidil
« on: January 19, 2021, 10:12:28 AM »

I was wondering how many people here take topical minoxidil?

Although there have been past posts regarding this topic, there does not seem to be any consensus as to whether this treatment poses any significant risk to our condition.

What risk if any is there of worsening Peyronie's disease from topical minoxidil applied daily to the scalp?

Of course the hair specialist assures me there's no problem but if it can affect the heart why would it not affect elsewhere in the body? she tells me it only usually affects the heart in people with heart conditions and if they take minoxidil tablets. she tells me the science behind its effectiveness is that it's a vasodilator and increases the blood supply to the hair follicles.

There are accounts of people applying minoxidil to the penis to improve erectile dysfunction issues.

just wondering what your thoughts are on here because for me I have to decide this week otherwise I will lose my fringe permanently.
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Age: 39
Intermittent Hard-Flaccid
Peyronies Disease since April '19
Intermittent Vit E, CoQ10, Citrulline Malate powder (sensitive stomach)
VED didn't agree with me, too tender for Stretching
Beginning to suffer from mild Erectile Dysfunction - begun Cialis

Juan

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Re: Risk of Topical Minoxidil
« Reply #1 on: January 19, 2021, 02:43:52 PM »

Hi
I was on finasteride pills of 1 mg twice a week and topical lotion (1ml morning + 1 ml night) of: minox 3%+finas1%.

Quit from finas pills when started peyronies but I’m continuing with the lotion.

Don’t know if my lotion makes peyronie worse but I’d say no.
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39 yo. Onset Oct/20. 25º dorsal bend 1cm before glans + high erection angle.
Pentoxifiline 400x3. Tadalafil 2,5. Vit E, D3, K2. Zinc.Omega3. Ubiquinol. ALCAR.
Traction with PMP.

leaningtowerofpisa

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Re: Risk of Topical Minoxidil
« Reply #2 on: January 19, 2021, 11:51:38 PM »

Hello, I am using topical minoxidil and also did a bit of digging on this and in terms of side effects in general. I of course am not a doctor, but what I have noticed is that topical minoxidil is safe when used properly unless your sensitive to the alcohol or allergic, in which case you should just experience scalp irritation and then discontinue. The concern is when topical minoxidil goes system, such as using much more than the instructed amount or if you also using micro-needling and apply minoxidil immediately after, allowing it to enter your bloodstream. Use rogaine foam minoxidil, much easier to control application and not get on / in other places of your body. Of course no substitute for medical advice but I would not worry about it affecting Peyronies when used properly. You can reduce intake of it as well by doing 1 application daily, instead of 2, which is shown to be pretty much just as effective and also not applying and leaving in over night. Those are just a few tips of what I'm doing.
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20y old. Pentox, healthy anti-oxidant diet. Stable, but no progress either.

Juan

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Re: Risk of Topical Minoxidil
« Reply #3 on: January 20, 2021, 03:37:59 AM »

But even applying more than the instructed amount, what would be the connection with peyronies?

And what would be the difference leaving it over night rather than over day?
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39 yo. Onset Oct/20. 25º dorsal bend 1cm before glans + high erection angle.
Pentoxifiline 400x3. Tadalafil 2,5. Vit E, D3, K2. Zinc.Omega3. Ubiquinol. ALCAR.
Traction with PMP.

Eric_C

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Re: Risk of Topical Minoxidil
« Reply #4 on: January 21, 2021, 02:54:42 PM »

Hi
I was on finasteride pills of 1 mg twice a week and topical lotion (1ml morning + 1 ml night) of: minox 3%+finas1%.

Quit from finas pills when started peyronies but I’m continuing with the lotion.

Don’t know if my lotion makes peyronie worse but I’d say no.

I see what you're saying. Doesn't seem like the minoxidil is worsening the condition. Thank you for your input.

Hello, I am using topical minoxidil and also did a bit of digging on this and in terms of side effects in general. I of course am not a doctor, but what I have noticed is that topical minoxidil is safe when used properly unless your sensitive to the alcohol or allergic, in which case you should just experience scalp irritation and then discontinue. The concern is when topical minoxidil goes system, such as using much more than the instructed amount or if you also using micro-needling and apply minoxidil immediately after, allowing it to enter your bloodstream. Use rogaine foam minoxidil, much easier to control application and not get on / in other places of your body. Of course no substitute for medical advice but I would not worry about it affecting Peyronies when used properly. You can reduce intake of it as well by doing 1 application daily, instead of 2, which is shown to be pretty much just as effective and also not applying and leaving in over night. Those are just a few tips of what I'm doing.

Thanks for sharing your knowledge. I'm sure you can appreciate, Peyronie's is traumatic enough without rolling the dice on a new chemical that there is no 100% safe answer on. The doctors and hair specialists say it'll be safe, but it's not their penis that is being gambled with, right?

Micro-needling - good call. I totally forgot about that. I might start looking into that again. I saw one video aboiut it which seemed a little hard to believe to be honest. Looks like the guys just got a hair transplant.

Concentration of minoxidil is an interesting topic. The clinic speaking to me charge an exorbitant price - a price which seems a complete joke when there are companies online offering solutions for like £15 per month or something similar. Of course they throw in zoom calls, and supplements, and laser therapy etc...

No idea if I will try this chemical or not yet. Still undecided, but it looks the least risky option.

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Age: 39
Intermittent Hard-Flaccid
Peyronies Disease since April '19
Intermittent Vit E, CoQ10, Citrulline Malate powder (sensitive stomach)
VED didn't agree with me, too tender for Stretching
Beginning to suffer from mild Erectile Dysfunction - begun Cialis

leaningtowerofpisa

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Re: Risk of Topical Minoxidil
« Reply #5 on: January 27, 2021, 02:47:19 AM »

I see what you're saying. Doesn't seem like the minoxidil is worsening the condition. Thank you for your input.

Thanks for sharing your knowledge. I'm sure you can appreciate, Peyronie's is traumatic enough without rolling the dice on a new chemical that there is no 100% safe answer on. The doctors and hair specialists say it'll be safe, but it's not their penis that is being gambled with, right?

Micro-needling - good call. I totally forgot about that. I might start looking into that again. I saw one video aboiut it which seemed a little hard to believe to be honest. Looks like the guys just got a hair transplant.

Concentration of minoxidil is an interesting topic. The clinic speaking to me charge an exorbitant price - a price which seems a complete joke when there are companies online offering solutions for like £15 per month or something similar. Of course they throw in zoom calls, and supplements, and laser therapy etc...

No idea if I will try this chemical or not yet. Still undecided, but it looks the least risky option.



just buy regular rogaine, Kirkland, or walgreens minoxidal. don't buy from some bs clinic. there is no difference. I would highly recommend micro-needling or PRP especially if you don't use finasteride. male hair loss pathway, in simple terms, is when your scalp DHT is suffocating, miniaturizing and creating micro-inflammation and scaring of the follicles. Get a scalp biopsy if your able at a dermatologist, which will confirm this as the source of your hair loss. If it is not, you may want to get blood work to see you it is a deficiency, auto-immune, or thyroid issue. but most likely it is simple male pattern hair loss. If it is here's what I recommend. Finasteride, while being effective at blocking the source of hair loss, DHT production, does come with all the side effects and risks you've probably read at. What's left on the table is Minoxidil which works as a vasodilator, increasing blood flow to follicles. This will buy your existing hair time and supplement any other treatments such as PRP or micro needling. It will not be enough for a long-term hair loss solution if you want solid results. Micro needling and prp are promising to some what address the underlying cause of hairloss, but not entirely. PRP is shown in studies to reduce the yellow-dots or "follicular ostium" which typically mark hairloss (this is what a scalp biopsy will confirm), by inducing all the growth factors the PRP serum contains. However, this is a very expensive treatment and everyone will have their opinion on if they think it works or not. PPR, very low risk however, if you care about your hair greatly and have the means, try it. If not, use micro-needling, loads of people have tips on how to do pair with a rogaine routine. I would summarize from what I've read and experienced rogaine + micro-needling is the most effective non-surgical hair loss treatment without finasteride. Don't get roped into snake oils, vitamins, blah blah blah. Rogaine works for what it does, it's not a magical potion. Also maybe look into a Biotin x Collagen shampoo and Nizoral 2% shampoo, I haven't found where to acquire Nizoral 2% yet, but it is actually quite helpful from what i've read. Hope that helps, sounds like we are in a bit of the same boat with the Peyronies feat. hair loss concern, so hope my personal findings are of use to you.

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20y old. Pentox, healthy anti-oxidant diet. Stable, but no progress either.

Graggaxy

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Re: Risk of Topical Minoxidil
« Reply #6 on: February 20, 2021, 08:56:08 AM »

I have been using topical minoxidil for 1 month now. It doesn’t affect peyronies. It’s a vasodilator. In theory it should even help with Peyronie’s.


Now finasteride on the other hand is more complicated. I am very very tempted to start taking oral finasteride but I’m not sure if it could make my "mild" Peyronie’s worse. What do you think? Should I use topical finasteride just to be safe?
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Graggaxy

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Re: Risk of Topical Minoxidil
« Reply #7 on: March 22, 2021, 12:59:21 PM »

Can I add azelaic acid to the minoxidil? I read that it’s a 5AR inhibitor but there are literally zero reports of sexual side effects regarding azelaic acid
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Eric_C

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Re: Risk of Topical Minoxidil
« Reply #8 on: March 23, 2021, 08:25:18 AM »

just buy regular rogaine, Kirkland, or walgreens minoxidal. don't buy from some bs clinic. there is no difference. I would highly recommend micro-needling or PRP especially if you don't use finasteride. male hair loss pathway, in simple terms, is when your scalp DHT is suffocating, miniaturizing and creating micro-inflammation and scaring of the follicles. Get a scalp biopsy if your able at a dermatologist, which will confirm this as the source of your hair loss. If it is not, you may want to get blood work to see you it is a deficiency, auto-immune, or thyroid issue. but most likely it is simple male pattern hair loss. If it is here's what I recommend. Finasteride, while being effective at blocking the source of hair loss, DHT production, does come with all the side effects and risks you've probably read at. What's left on the table is Minoxidil which works as a vasodilator, increasing blood flow to follicles. This will buy your existing hair time and supplement any other treatments such as PRP or micro needling. It will not be enough for a long-term hair loss solution if you want solid results. Micro needling and prp are promising to some what address the underlying cause of hairloss, but not entirely. PRP is shown in studies to reduce the yellow-dots or "follicular ostium" which typically mark hairloss (this is what a scalp biopsy will confirm), by inducing all the growth factors the PRP serum contains. However, this is a very expensive treatment and everyone will have their opinion on if they think it works or not. PPR, very low risk however, if you care about your hair greatly and have the means, try it. If not, use micro-needling, loads of people have tips on how to do pair with a rogaine routine. I would summarize from what I've read and experienced rogaine + micro-needling is the most effective non-surgical hair loss treatment without finasteride. Don't get roped into snake oils, vitamins, blah blah blah. Rogaine works for what it does, it's not a magical potion. Also maybe look into a Biotin x Collagen shampoo and Nizoral 2% shampoo, I haven't found where to acquire Nizoral 2% yet, but it is actually quite helpful from what i've read. Hope that helps, sounds like we are in a bit of the same boat with the Peyronies feat. hair loss concern, so hope my personal findings are of use to you.

Hi Leaningtowerofpisa,

My apologies for such a late response, this is literally the first time I've been on here for months.

Yes, I do appreciate you sharing your findings with me. What you have discovered is indeed inline with what I have found myself. I have not really looked into microneedling much but I had read of some positive results. Yes, we do indeed have the hair and peyronie's issue in common, feel free to pop me over a PM if you ever wish to discuss a specific aspect.

With regard to the cause of my thinning/receding hairline it is definitely Male-pattern-hair-loss, had this diagnosed.

After some deliberation in the last couple of months I've decided to try minoxidil and having now read your rather in-depth post, I feel I should open the door to PrP and micro-needling perhaps.

The clinic that reviewed me over Skype is charging megabucks and also wanterd me to consider their laser device and vitamins etc... It was a very expensive package for what is essentially minoxidil but in a kind of gel instead of the regular liquid. I'm based in the UK so branding might be a little different to you. Although we do have Rogaine I believe. I can't recall what the concentrations were. But I feel I shoulod probably start off with a less concentrated one. 2% i think it is?

Cheers.

EC
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Age: 39
Intermittent Hard-Flaccid
Peyronies Disease since April '19
Intermittent Vit E, CoQ10, Citrulline Malate powder (sensitive stomach)
VED didn't agree with me, too tender for Stretching
Beginning to suffer from mild Erectile Dysfunction - begun Cialis

GaussRifle

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Re: Risk of Topical Minoxidil
« Reply #9 on: March 23, 2021, 01:33:17 PM »

2 percent minoxidil won’t do anything for men, it is meant for women. Male pattern baldness is more aggressive and require 5 percent.
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Eric_C

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Re: Risk of Topical Minoxidil
« Reply #10 on: March 26, 2021, 09:07:04 AM »

Yes, thanks I was looking at products yesterday and picked up on that.
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Age: 39
Intermittent Hard-Flaccid
Peyronies Disease since April '19
Intermittent Vit E, CoQ10, Citrulline Malate powder (sensitive stomach)
VED didn't agree with me, too tender for Stretching
Beginning to suffer from mild Erectile Dysfunction - begun Cialis
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