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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: Hirudoid has helped me immensely  (Read 7502 times)

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Winter

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Re: Hirudoid has helped me immensely
« Reply #50 on: March 20, 2021, 11:39:46 AM »

Hi everyone. I should have posted on the introduce yourself first, but I was eager to report my experience on this topic.
I have been using the cream for the past 4 days and I am very excited with the progress.
day 1
A little growing burning sensation scared me at first, but it cooled down after a few minutes. I avoided the glans and testicles. It was a little itchy all night long.
day 2
No burning feeling or itching whatsoever. No changes on the lumps.
day 3
No burning or itching, but I started to few better about my penis. I noticed the lumps slightly softer. Maybe it was just an impression.
day 4
I am very happy today. Feeling the lumps noticeably softer. Less painful as well. Woke up with a huge morning erection that made me very happy.
I don't dismiss some sort of placebo effect, but I don't care.

Eager to use the cream another day. I don't know how long I will apply it. Perhaps 10 days an then rest a bit. Open for suggestions.
Praying for some permanent improvements.
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

Gabriel

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Re: Hirudoid has helped me immensely
« Reply #51 on: March 21, 2021, 07:04:03 AM »

Hey guys,

I've purposely waited before reporting here, but I'm vey excited too. This is a mid-term assesment; will do a full version after a 3 months-use use perspective. As many of you know, with my 3+years never-ending inflammation/pain syndrom, I've become quite an expert in trying everything under the sun to allieviate the suffering. Most of it didn't work, as I fully explained here (https://www.peyroniesforum.net/index.php/topic,14622.msg131841.html#msg131841).

And yet, buddies, oh Lord, I'm starting to think our friend Friedrich has found HELL OF A GAME CHANGER here. Here is the story so far: I've been applying hirudoid cream for approximately 7 weeks now, soaking my dick in it before bed and wrapping my penis with gaze in order to let it soak all night long (well at least until I get the 4-5 o'clock erection that makes the stuff disassemble, but anyway).

Well, bros: every since I applied this cream, and I do mean overnight, my pain has subsided to an all-time low. I never thought that would be even F^@$!ng possible. Plain and simple: I apply this cream at night, I almost get 0 pain during my nightly erection or during my daily erection while having sex or masturbation the next day. If I stop applying it for a few days though, the pain comes back slowly (if I dont have sex or masturbate or use my VED), or a little quicker (if I do have sex or masturbate or use VED), BUT 1) it stays on a quite low level (like 50% max of what I used to have), 2) it subsides in one or or two nights as soon as I go back to applying the cream again.

Guys, I don't want to jump on the gun either, and I do want to take a few more weeks of full assessment (applying the cream in the morning too to see if if pushes the effect further), but [email protected]< I don't have words to say how much I'm thrilled by this news. So far I see no improvement in diformity (I don't have proper "lumps" or palpable plaque anymore, although the denting/hourglass is still here), but honestly I don't care so much: if this magical a$$hole cream can make my dick pain go away and allows me to go back to at least a normal-ish sexual and psychological life, I'm the happiest man on earth.

See you in a few weeks for a whole narrative ;-)... And stay strong!!!

G
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- 33 yo, very healthy lifestyle, Peyronies Disease with pain, general hourglassing with girth and length loss since 09/01/17. Still acute.
- Treatments tried: almost everything; few things helped (see my big related post on december 2020), but pain still there...

markdubby

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Re: Hirudoid has helped me immensely
« Reply #52 on: March 21, 2021, 07:45:15 AM »

are you noting any side effects at all?

i am very tempted to try the cream with traction!
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30, discovered ~20-30 degrees right bend beginning of Feb 2021. Small plaque under gland on right side of the shaft

300 mg COQ10, 2-3 g Acetyl-L-Carnitine, , 6-8h traction daily with pmp,

new scar 26/04 on left side below glans, current curve < 5

Tortão Pra Direita

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Re: Hirudoid has helped me immensely
« Reply #53 on: March 21, 2021, 09:38:31 AM »

This is a very interesting thread...
keep updating it, guys

Hirudoid may have potential use in the acute phase
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1993 born. Brazil.
Peyronies since Sep 2019.
Penis developed curvature, lots of plaque, loss of size and axial rigidity. Severe peyronie.
Mar/21 TEP + Titan Touch 20 cm + 1.5 RTE.

Surgery done by Dr. Marco Tulio Cavalcanti, in São Paulo.

hope794

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Re: Hirudoid has helped me immensely
« Reply #54 on: March 21, 2021, 05:54:55 PM »

How many times a day do u put it and how much u put? I can give it a shot!
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26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
Erectile Dysfunction for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Winter

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Re: Hirudoid has helped me immensely
« Reply #55 on: March 21, 2021, 06:31:37 PM »

Thanks for the testimony Gabriel! It fills my heart with hope.
Your mega post about all your experiments is amazing! Thanks for sharing it. Strongly recommended for those who haven't read it.

I really would like to thank Friedrich for this discover. So far it was the quicker relief I had comparing to every other treatment I've tried. Let's see if it keeps improving.
Thanks a lot, man!!!

I'd like to share another day of good news.

Day 5 using the cream
I am, actually, starting to believe my lumps are getting a little softer and a little smaller. I am feeling less pain then I am used to feel during the day as well.
Not completely gone yet, but it is getting better by the day. Fingers crossed!

By the way, this is how I am doing: I am applying 1x daily, just before bed, so far. I am generously rubbing all the penis (without gaze or bandages), with the exception of the glans. I am still worried about causing some sort of burning feeling. Today I will try to rub it just a bit on the tip, since I have another lump, just at the base of the glans. I will report back if it was somehow uncomfortable. But so far, no side effects at all! I might try twice a day in the future.
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

Hricco

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Re: Hirudoid has helped me immensely
« Reply #56 on: March 22, 2021, 12:01:26 PM »

I have the cream

I ordered on ebay.  Took for ever to get here. 

Where do you guys get it from.  Can someone post a link?

Thanks
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Asphyxia

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Re: Hirudoid has helped me immensely
« Reply #57 on: March 22, 2021, 01:42:54 PM »

Ebay doesnt ship that product to my country  so i got it from eclipse pharmacy i think, took about a month though.
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Age:23. Onset of symptoms: september 2020.
Curve mostly semi erect about 60 degrees, slight pain
Tried short & prolonged fasts, keto,carnivore, traction and most of the supplements.
Severe digestive issues, probably an autoimmune disorder

TWalker

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Re: Hirudoid has helped me immensely
« Reply #58 on: March 26, 2021, 10:29:04 PM »

Any updates chaps?

Been massaging Hirudoid cream into the nodules twice a day for 2 weeks- nothing too dramatic but gun to my head I’d say my biggest nodule is actually a little smaller (or at least less inflamed). No clue if it’s the Hirudoid or VED or just the disease progressing naturally.

Curious if anyone else has had any results/seen no results!
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27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

french_boy

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Re: Hirudoid has helped me immensely
« Reply #59 on: March 27, 2021, 02:59:34 PM »

It is better to use the standard hirudoid 3% or the hirudoid forte 4,5? I just wonder
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markdubby

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Re: Hirudoid has helped me immensely
« Reply #60 on: March 28, 2021, 04:42:47 PM »

got 2 tubes of cream on the way

anyone tried the gel?
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30, discovered ~20-30 degrees right bend beginning of Feb 2021. Small plaque under gland on right side of the shaft

300 mg COQ10, 2-3 g Acetyl-L-Carnitine, , 6-8h traction daily with pmp,

new scar 26/04 on left side below glans, current curve < 5

TWalker

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Re: Hirudoid has helped me immensely
« Reply #61 on: March 28, 2021, 10:06:38 PM »

The cream & gel (I have both) are both 0.3% Heparinoid (the active ingredient) which seems to be the standard strength available in the UK.

Doubt there’s much difference between cream and gel but I have found the gel evaporates a bit quicker which has its advantages if you’re putting it on in the morning. On balance I suppose I’d pick the cream if I had to choose- because it doesn’t evaporate at the same speed, I figure it has a higher chance of being absorbed by the skin and tissues underneath. I also massage it in to the Peyronie’s areas for a few minutes.

In theory Hirudoid can reduce swelling, inflammation, scarring and even promote tissue regeneration. I believe it’s been proven to penetrate down at least to the Dermis layer of the skin but I have my doubts concerning its ability to reach the tunica- seems possible though!

My current opinion is it’s unlikely to do any harm to most people (freak allergic reactions and minor skin rashes aside) and at worst, even if it doesn’t reach the tunica, it helps improve the circulation of blood through the superficial veins which has got to be a good thing!

Keen to hear updates from anyone noticing any change!
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27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Hawk

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Re: Hirudoid has helped me immensely
« Reply #62 on: March 29, 2021, 12:19:33 AM »

I am questioning this entire topic.  Does it strike anyone as strange that:
1. A man would have Peyronies Disease for 10 years and never come on this site once in that 10 years.
2. but After two nights he would search out the forum
3. Then register and make his first post within minutes of registering about what cured him
4. AND that what cured him is something that no other member got results from

I am calling this non-sense


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Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

TWalker

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Re: Hirudoid has helped me immensely
« Reply #63 on: March 29, 2021, 03:03:42 PM »

Hawk- I know that wasn’t addressed at me but just a quick clarification a uestion about point 4. sorry if I haven’t searched the forum thoroughly enough but do you know many members who have tried Hirudoid and seen no results from using it? Or just haven’t heard of anyone posting about Hirudoid in general up until now? Wondering if you know it to be of no use or if you just haven’t seen any evidence for it’s utility yet?
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27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Hawk

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Re: Hirudoid has helped me immensely
« Reply #64 on: March 29, 2021, 09:35:47 PM »

A fair question,  I do NOT have any specific studies firmly establishing that it is not effective.  That is primarily because no competent medical or pharmaceutical company or even the manufacturer thought it was worthy of raising the question.

Similarly, I have no studies disproving Preparation H, Tinactin, or Vick Vapor Rub. 

If all it takes to gain a following is for an anonymous guy to register here, claim he just wanted to drop in for the first time after a decade of Peyronies Disease to announce he just had great improvement after 2 days from one of the above products which gave him great results - WE ARE PATHETICALLY VULNERABLE to every manner of prankster and scam on the planet.
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Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

Winter

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Re: Hirudoid has helped me immensely
« Reply #65 on: March 29, 2021, 11:18:39 PM »

My update on the subject.
First and foremost, I know Hawk’s message wasn’t for me but I would like to note that I take this forum very seriously. I am also very thankful about all the help and information you guys share. Having said that here I go.

I am using Hirudoid Cream 300 for 10 days or so. At first, I started to feel some mild relief on the pain and (I think) some softening on the rigidity of the lumps. On day 5, I had sex with my wife after 3 months without it. (She was pregnant and we were avoiding it, but, sadly, we lost him/her with 6 weeks).
Anyway, after 5 days of pleasant results with Hirudoid, my dick started to hurt again just after the day of having sex. I suspect I am in the middle of a secondary flare up on this acute phase. Probably the sex caused some damage, but is it enough to rule out Hirudoid? I don’t think so. But I don’t think it is the hidden miracle cure either. I really don’t know if Hirudoid has helped me to mitigate all the pain, but it appears to be safe.
Definitely I am not experiencing the same amazing results as Friedrich’s. But who knows if things won’t improve just a bit after some longer period?
I have read this interesting related article from Portugal (sorry guys, only in Portuguese, perhaps google translate can help it you wanna check it out. But beware, penis’s photos). It shows a case of a guy that had some inflamed veins on his penis after rough sex. They  prescribed Hirudoid along with vioxx and other treatments. I know we are talking about different diseases, but maybe, poor vascularization has some relation to Peyronies. I am noticing some swollen veins on the size of my dick. At least the article shows that it is not completely crazy to use Hirudoid  on the penis.
https://apurologia.pt/wp-content/uploads/2018/11/tromb-veia-dors.pdf

I totally understand Hawk’s skepticism. I probably would be considered some sort of naive dreamer, but I don’t have enough resolve to not try something just because it lacks proper evidence. I am going to try everything unless it is something that appears to make it worst. Obviously I am looking out for some effective treatment, but, otherwise, I would love to experience some placebo effect, so why not maximizing the chances of either one by trying alternative treatments? Call me whatever you want. I will accept all the criticism quietly. If it doens’t hurt, or if only helps just a tiny bit, why not?
I just bought another version of Hirudoid. This time gel and 500mg. Lets see if it leads to some improvement. I will try it for another two weeks and report back.
Good luck to you all and God bless.
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

Hawk

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Re: Hirudoid has helped me immensely
« Reply #66 on: March 30, 2021, 10:12:15 AM »

Look,  I am not saying don't give it a try if you are up for it but be objective.  The post that started this topic does not lend one ounce of evidence t\for Hirudoid use.  It was baseless and VERY suspect of a prankster.

Peyronies Disease is not a static condition.  Pain invariably lessens and stops.  There are often flare-ups and calm periods.  Plaque typically contracts and reduces in size.  Pain and plaque size reduction means nothing.  Because you try a "treatment," you cannot assume anything that follows is a result of that treatment. 

At best, it takes large, randomized, double-blind clinical trials. Every man here should understand those three criteria of a trial.

At the least, it takes very objective length and girth measurements and comparisons in size, bend, and erection on your penis.  If things get better, you stop, and things get worse, you start, and things get better, and you repeat that cycle a few times, then you have established a single anecdotal account of improvement. 

Please read https://peyroniessociety.info/index.php/weighing-the-evidence/
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Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

TWalker

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Re: Hirudoid has helped me immensely
« Reply #67 on: March 30, 2021, 10:28:13 AM »

Very fair points Hawk- can't really disagree with anything there... Apart from that Hirudoid is a medically proven treatment for swelling, inflammation and scarring of the skin so one presumes it has a greater chance at improving Peyronies symptoms than rubbing toothpaste on the plaque!

I have a similar approach to Winter regarding trying potential cures- if there's very little chance of something having a deleterious effect, it's not exceedingly expensive and it doesn't require hours of time a day then I'll give it a shot.

So on that basis I'd love to continue to hear updates from anyone who has used it and seen/not seen results! I will of course update everyone as and when I notice any change in symptoms myself.
Logged
27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Godisreal

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Re: Hirudoid has helped me immensely
« Reply #68 on: April 02, 2021, 10:02:02 AM »

I’m on day two of using Hirudoid. Obviously it’s too early to document any results but it feels good on the penis, and it’s not as harsh or aggressive on the tissue as Diclofenac (Voltaren).
Voltaren actually caused me random waves of pain so, to me, it didn’t work good.
I will apply Hirudoid for another week before I document any results.
Logged
30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

markdubby

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Re: Hirudoid has helped me immensely
« Reply #69 on: April 02, 2021, 10:17:33 AM »

same here, no adverse effects yet!
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30, discovered ~20-30 degrees right bend beginning of Feb 2021. Small plaque under gland on right side of the shaft

300 mg COQ10, 2-3 g Acetyl-L-Carnitine, , 6-8h traction daily with pmp,

new scar 26/04 on left side below glans, current curve < 5

Godisreal

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Re: Hirudoid has helped me immensely
« Reply #70 on: April 04, 2021, 11:37:06 AM »

Sorry for being off topic but am I the only one having thinning caused by A LOT of really small scars spread all over the tunica? Seems like I can relate to anyone on that?
Or what causes you guys thinning? There’s like 500 small speed bumps just everywhere completely strangling my penis’s girth.
This doesn’t effect curve but it’s devastating.
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30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

Winter

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Re: Hirudoid has helped me immensely
« Reply #71 on: April 05, 2021, 12:11:23 AM »

Godisreal, I have several dents all over my dick. Only when REALLY fully erect most of them disappear. Also some hourglassing at the middle and some sections that never completely fills up. It adds a dire fear of having a fragile mid section that would break under pressure.

Talking about Hirudoid. I just bought the Gel version. It is incredibly better. It gets completely absorbed much quicker!! It is also 500mg instead of 300mg like the cream (the only alternatives i’ve found here).

I totally understand Hawk’s points. They make a lot of sense! I must confess I was not expecting a prankster here for several reasons. First, this is a really obscure disease that usually only a patient knows. Often not even urologists knows very well! Second, someone would have to be really really evil to apply this prank. Because he would have to study the disease deeply, to make up this very elaborate, cunningly reasonable solution, based on a very convenient medicine, in order to build up this almost believable story of success. This guy would be a really clever and despicable prankster. Not that are not people like this. Hawk probably saw plenty of troublesome jerks here across all those years. But I would be really surprised on this case. Specially because Hirudoid apparently is quite safe.

I also agree completely with Hawk on the criteria to fully validate a treatment while testing with minimal rigor. Unfortunately I am definitely not a strong candidate for this protocol. It is important to clarify this not to induce my fellow colleagues to false hope. I think time is my enemy, and any day with pain could mean new inflammation leading to further damage. Therefore I will often proceed like TWalker, testing everything safe and reasonable, simultaneously, hoping for improvement. That’s why I cannot nail precisely what had effectively helped and what had not. I cannot even rule out spontaneous recover, although rather unlikely.

Hawk, with all your experience here, do you really think it is likely to be a prank?

My reports. I was starting to feel a very uncomfortable increasing pain on the past two week, to the point of hurting all day long. Therefore I switched to gel and started rubbing it generously twice a day, even over the glans. No bad reaction at all so far.
But since I was not getting much progress on the pain, I also started to take Celebrex pills twice a day, following the example of some guys from a very old post here from 2011. I don’t know if it was either the celebrex or the Hirudoid, but roughly 90% of the pain vanished after just two days. I am feeling much better! I only feel a tiny discomfort while getting erect, but it is going away rather quickly. Still not seeing any progress with the dents or lump sizes. But feeling a lot better overall. I will keep using celebrex once a day until finishing the whole box. But I will keep rubbing Hirudoid twice a day for a while. Let’s see how things will behave. Cheers!
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

Mikel7

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Re: Hirudoid has helped me immensely
« Reply #72 on: April 05, 2021, 06:23:12 AM »




But since I was not getting much progress on the pain, I also started to take Celebrex pills twice a day, following the example of some guys from a very old post here from 2011.

   Before SNHL I also took Celebrex and can attest to the fact that it does somewhat lessen the pain of peyronies and joint pain.  It is a Cox-2 inhibitor and works very well for some individuals. People got scared of it when it was temporarily taken off the market. It has newer studies to show it as safe as ibuprofen and aspirin.  When you combine your 2 types of treatment you never really know which one is working and to what degree.  I am skeptical of a cream penetrating the dermal layer of the skin and doing any good for peyronies. Several compounding pharmacists tried their best  to make me a penetrating cream for my hormone problem with no success. They told me our skin is very impermeable to a lot different substances.  Just my thoughts :)
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Lump April 2020, age 60 , Dr Levine 6-26-20,
Dorsal Curve 11-1-20 , Peyronies
Vit E400mg, COQ10, ALCAR, Heat Therapy, Penimaster, Pentox, Cialis
had SNHL 7-31-20 - Stopped all Meds because ototoxicity  Heat/traction/VED are working.

markdubby

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Re: Hirudoid has helped me immensely
« Reply #73 on: April 05, 2021, 08:02:00 AM »

I'm on day 5, I cant say I notice any difference in the lump size, but my penis definitely feels less inflamed, especially after masturbating.

i wrap a graze around the scar with a load of cream before going to bed. not sure if it's the best way however as the cream might get displaced at some point!
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30, discovered ~20-30 degrees right bend beginning of Feb 2021. Small plaque under gland on right side of the shaft

300 mg COQ10, 2-3 g Acetyl-L-Carnitine, , 6-8h traction daily with pmp,

new scar 26/04 on left side below glans, current curve < 5

Godisreal

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Re: Hirudoid has helped me immensely
« Reply #74 on: April 05, 2021, 08:54:08 AM »

I’m on day I don’t know lol, but pain hasn’t gone nowhere and it’s making me go insane, quite frankly.
If I apply a lot throughout the day, there’s a slight decrease in inflammation.
But nothing compared to an improved diet, I believe diet is way more important than these half-assed creams, unfortunately. I also jacked off two times in a row just to feel something (super depressed) and the second time definitely took damage on my dick.
Celebrex isn’t available prescription-free here so that’s a bit of a hassle.

I also wanna ask what natural oils can have potential to seep deeper?
I know DMSO will help with that but DMSO f*cked me up last time I used it, and I still have unexplained pain in between my penis raphe (bottom back) and my balls.
So I’m scarred for life on that one lol
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30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

Graggaxy

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Re: Hirudoid has helped me immensely
« Reply #75 on: April 07, 2021, 07:24:56 AM »

I just bought hirudoid but then I found this article https://www.researchgate.net/publication/262880027_Complete_Penile_Necrosis_in_a_Patient_With_Heparin-induced_Thrombocytopenia_A_Case_Report

What the fk? Necrosis ?! Is this post a scam? What kind of evil creature would post this? Am I being paranoid?

Is hirudoid really safe?!
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Tortão Pra Direita

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Re: Hirudoid has helped me immensely
« Reply #76 on: April 07, 2021, 09:47:02 AM »

Graggaxy
How are you linking this case report to Hirudoid topical use?

"A 75-year-old man presented with acute renal failure and experienced cardiac complications during the hospitalization. The patient was treated twice with intravenous heparin. He developed symptoms of penile necrosis 4 days after the reintroduction of heparin."

Yes, you're being very paranoid. You're linking 1 case report of a 75 years old man with a history of factor V Leiden, severe coronary atherosclerotic disease, and chronic renal failure because of diabetic nephropathy. He then got treated with intravenous heparin (a different drug).

 ???
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1993 born. Brazil.
Peyronies since Sep 2019.
Penis developed curvature, lots of plaque, loss of size and axial rigidity. Severe peyronie.
Mar/21 TEP + Titan Touch 20 cm + 1.5 RTE.

Surgery done by Dr. Marco Tulio Cavalcanti, in São Paulo.

Graggaxy

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Re: Hirudoid has helped me immensely
« Reply #77 on: April 07, 2021, 10:17:45 AM »

No, hirudoid is heparin. its the same active agent. they are substitutes
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Winter

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Re: Hirudoid has helped me immensely
« Reply #78 on: April 07, 2021, 11:06:27 PM »

I will side with Tortão on this one.
I know you are worried, but it appears to be a farfetched relation here. Even the article you’ve brought mentions that there were only two cases in the whole medical records of penile necrosis under those circumstances. One was a lung cancer patient and the other the one of the link. Both incredibly ill patients, with a myriad of dreadfully grim diseases. Also, the intravenous medicine operates on a much different scale, with different proposal, promoting much different reactions to different ends.

I have searched on several websites for any side effect related to topical Hirudoid.
The common answer is often like this:
There are no reported side effects for Hirudoid cream or gel. However, the cream and gel both contain additional ingredients that can cause allergic reactions.

They usually clear the main substance and blame the additional ones for a rash or something milder. Note that, even though they may be very similar substances (no, they are NOT completely identical), the intravenous one works very differently. On both gel and cream’s leaflet I have, on the side effects session, it doesn’t mention anything remotely similar to that, even on the rarest of cases group.

I have been using the 500mg, gel version, twice a day, even on the glans, for almost two weeks and I am feeling nothing wrong. All the way around! But I will give a couple of weeks before reporting back.

Obvioulsy this is a experimental test with no avail of any doctor. It is an unsanctioned leap of faith on the pursuit of an effective treatment. Feel free not to use if you don’t think it is safe. It is probably a wise and careful choice, specially if you are so deeply concerned with such a rare (almost unique) and radical side effect, happening so instantaneously you couldn’t even stop rubbing the cream before complete necrosis. Our mind is a powerful thing and it can promote not only placebo effects, but also psychosomatic disorders. Beware!
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

diehardpatriot

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Re: Hirudoid has helped me immensely
« Reply #79 on: April 29, 2021, 01:11:43 PM »

Where the heck are you guys ordering this stuff? It’s not at any local pharmacy for me. I see it on websites, but don’t know which one to trust 
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Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

markdubby

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Re: Hirudoid has helped me immensely
« Reply #80 on: April 29, 2021, 03:04:20 PM »

winter, would you recommend the gel over the cream?

been starting to put it regularly every night after a little break and am wondering if the gel gets absorbed quicker/better
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30, discovered ~20-30 degrees right bend beginning of Feb 2021. Small plaque under gland on right side of the shaft

300 mg COQ10, 2-3 g Acetyl-L-Carnitine, , 6-8h traction daily with pmp,

new scar 26/04 on left side below glans, current curve < 5

Winter

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Re: Hirudoid has helped me immensely
« Reply #81 on: April 29, 2021, 05:21:40 PM »

Hi there Mark.
Totally! The gel is so much better in terms of absorption. A lot quicker. In less than 5 min it is completely dry.
I hope the skin is absorbing mostly rather than the gel drying out, vanishing to the air.
Besides, where I live the Gel is 500mg, while the cream is 300mg.

diehardpatriot
Hi there! Here where I live I can pretty much find out at any given drugstore. Apparently things are different in US, oddly.
Perhaps you could find it through ebay.
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

diehardpatriot

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Re: Hirudoid has helped me immensely
« Reply #82 on: April 30, 2021, 05:19:42 PM »

On eBay, I can only find 100g “heparinoid” active ingredient. I see that your guys’s cream has 300mg-500mg of heparinoid , please tell me if I’m wrong? If this is true, I’ll have to figure out a way to get the good stuff. Perhaps on online pharmacy overseas
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Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

skunkworks

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Re: Hirudoid has helped me immensely
« Reply #83 on: May 01, 2021, 10:31:43 AM »

I will follow this with interest.

Logically though, if the original poster had Peyronie's before and it healed by itself, then he gets it again and applies a cream, it may have just healed by itself without the cream exactly as it did the first time around.
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

french_boy

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Re: Hirudoid has helped me immensely
« Reply #84 on: May 02, 2021, 04:15:23 AM »

hello is anyone else who tried hirudoid improved in curvature after used?
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Curvekiller94

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Re: Hirudoid has helped me immensely
« Reply #85 on: May 05, 2021, 09:38:23 AM »

I found this on another website from 2019. Apparently this guys urologist suggested hirudoid cream


I'm male, 27yrs. About 6 months ago, I had a lump on my
★★★★★
Hello,
I'm male, 27yrs.
About 6 months ago, I had a lump on my penis (on the right side of shaft close to the foreskin) with some veins around it and along the shaft. this happened after having an erection for a long period on time (2 to 3 hours). Then, this lump and the veins disappeared overnight. However, two months later the same thing happened again but this time the lump and the veins don't disappear. 4 days later I decided to get a feel of that lump while the penis is flaccid (I touched very hard), the lump then inflamed and grow bigger and became painful. I left it alone for about two weeks (during this period I had no erection) and the situation got better (the pain disappeared and the lump became very small). then I thought that it is gone, I started to have erection (maybe more than the usual) and the lump appeared back again with some pain too. It seem that the lump is associated with having an erection (it becomes very hard while the penis in erect and stay a bit hard after that and then it looks like it has disappeared). I still have normal erection and I have no pain while ejaculation or urinating. I asked a urologist and he said that this could be a inflamed vein and gave me Hirudoid cream, I have been using that for one week and I still no improvement. please help me with this matter and thank you very much
Logged
26 y/o
sex injury that gradually got worse
Hard flaccid, Indentation bottom left close to my body,  mild twist left
28° up 28° Left
official diagnosed peyronies w/pain
Pentox, restorex, l-arginine, cq10, NSAID, tramadol(as needed)
Gf is supportive

Kobegianna

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Re: Hirudoid has helped me immensely
« Reply #86 on: May 05, 2021, 04:41:17 PM »

😂😂 I’m on bird too!! Let’s go. Haven’t laughed in awhile. But love this board
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34 yrs Old, Healthy very active
Possibly injured penis or took too much Cialis
Symptoms starting January-February 2021
First dent seen April 4, 2021, painful erections

diehardpatriot

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Re: Hirudoid has helped me immensely
« Reply #87 on: May 05, 2021, 05:14:54 PM »

Curve killer , did he ever post a follow up? If he didnt, I take that as good news.
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Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

samsam

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Re: Hirudoid has helped me immensely
« Reply #88 on: June 08, 2021, 01:00:54 AM »

Also been using hirudoid for a few days now. Wow what an immense difference. Pain and inflammation has stopped almost completely. I get nightly erections again and the bump is a lot softer and almost gone. I’m not sure if this will help healing on the long term or if this is just a temporary effect of the cream. Did anyone discuss this with his urologist? Wonder if it could have negative long term effects.
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37yo. Started July 2020. Inflammation, pain and Erectile Dysfunction are the biggest issues. Small but almost unnoticable to left. Currently on Q10, Pentox and Ginko.

pauli

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Re: Hirudoid has helped me immensely
« Reply #89 on: July 04, 2021, 09:35:54 AM »

I will also try this hirudoid.

let's see if it does anything  ;D
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31 yrs old; in a supportiv relationship
first symptoms and diagnosed in february 2018
severe progression since spring 2020
several plaque/indentations and currently 40° up curve

Sanabo

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Re: Hirudoid has helped me immensely
« Reply #90 on: July 20, 2021, 09:17:58 AM »

I have used conservatively for a few days and I have to say it really does seem to help with pain. My penis feels better and he plaque might actually be a little softer or it could just be the foreskin is softer - tough to say.

Are there any negative experiences? So far I have found nothing worse than it didn't help.

My only fear is that if this is softening things up that that might lead to softer erections but so far I haven't read any reports on this.

Going to stop for a few days and compare to how I feel now.

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42, acute, began 2/21
30 degree curve left, 15 up, bottleneck
Carnitine, CoQ10, arginine, 5 mg Cialis, pentox
Moderate Erectile Dysfunction, getting worse

nemo

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Re: Hirudoid has helped me immensely
« Reply #91 on: July 29, 2021, 03:38:59 AM »

Hi guys. I've got some Hirudoid on order and intend to give it a try, if only to stop the constant (albeit mild) inflammation pain associated with my active lesion. That constant reminder that something is wrong is really unnerving!

I did try Hirudoid briefly back in 2008 or so when I was having a mild flare. At that time, I was thinking it might have actually been a thrombosed vein, so that's why I got Hirudoid. It wasn't a thrombosed vein - I think it was actually a mild Peyronies Disease flare - and I couldn't tell the Hirudoid was doing anything, so I didn't try it more than maybe a couple times.

But with this flare, I have definite inflammation feelings 24/7, and can feel the lesion, so I'm anxious to give it a try and see if it can at least shut down that inflammation. Especially as I'm not supposed to take Ibuprofen, due to my Ulcerative Colitis.

I've tried Voltaren, but it does nothing for me.

I'll report back here.

Nemo
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50 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred in 2013. Have now begun a third episode in 2021. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline.

NeoV

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Re: Hirudoid has helped me immensely
« Reply #92 on: July 29, 2021, 08:54:32 AM »

Hi guys, I have gone through 4 tubes already and it absolutely reduces penile swelling and discomfort.
It seems to make my penis more elastic. I would like to know why we should not put it on the glans (mucous membrane).

It also seems to interact with nattokinase, so please do not take/use them at the same time until I or someone else figures out what this means. Nattokinase is ultimately the best supplement IMO for penile pain and hinging / denting while flaccid, so that would be too bad if we couldn't use them together, but I want to be careful.

As I mentioned in my video on hirudoid, it does have some rationale to be used as an antifibrotic, but the science seems contradictory to me at this point,

The only potential fear I have about hirudoid would be a reaction, "Heparin-Induced Thrombocytopenia," but I do not know if this can happen with such a low dose of a heparin derivative.

https://www.ahajournals.org/doi/full/10.1161/circulationaha.106.632653

nemo

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Re: Hirudoid has helped me immensely
« Reply #93 on: July 29, 2021, 09:28:52 AM »

Hi NeoV, are you using this on an active case of inflammation, such as a nodule or lesion?  Just wondering.  Glad to hear you find it useful, regardless.

Regards,
Nemo
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50 yrs. old, multiple auto-immune conditions. First episode of Peyronies Disease in 2002. Recurred in 2013. Have now begun a third episode in 2021. Over the years I have tried Topical Verapamil, Iontophoresis, all the supps and Cialis + Pentoxifylline.

Winter

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Re: Hirudoid has helped me immensely
« Reply #94 on: July 29, 2021, 10:19:26 PM »

Hi NeoV
I use it on the glans regularly (both gel and cream) and it doesn't cause any discomfort whatsoever.
I suspect it helps to be absorbed deeper easier than over the rougher skin of the penis.

But honestly speaking, all the benefits of the Hirudoid, to me, stopped after the first few days. After that I have just been using it out of tradition and hope. My penis still hurts sometimes while getting erect, even after a whole year with this disease. To me, the pain “activation” is more a matter of getting aroused while under the wrong “conditions” like while using an underwear, or while seated.

I will look out this nattokinase supplement. Thanks for the tip!
I think another user questioned this trombose fear regarding heparin. But all that I’ve read it about it claims to be a problem of the injectable product, not the cream. But it is a valid fear.
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39 yo, married Onset on 07/20. Major flare up 07/21
Deep indentations on ventral and dorsal area while erect. No erectile dysfunction. 20° up congenital. It still hurts; Taking pentox, Cialis, Q10, Hirudoid, keto diet. Considering surgery
God bless

PeyroniKirai

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Re: Hirudoid has helped me immensely
« Reply #95 on: July 30, 2021, 05:02:20 AM »

Hirudoid is the brand name for heparinoid, which is designed to reduce inflammation of blood vessels just under the skin, specifically, "superficial thrombophlebitis".  There's no reason to assume it will work to dissolve plaque on the tunica.  I would warn again as other posters have that this is extremely experimental (as someone said "mad scientists") and I would definitely not think of it as something to slather all over the penis as if that would make more of it get absorbed by the afflicted area.  Your penis is not a like a sponge cake soaking up fruit sauce.  There are chemicals that will penetrate your skin and others which will just irritate it.  If the active ingredient of Hirudoid cream or gel can actually penetrate the skin deeply and do something on the plaque that causes Peyronie's, it would be most effective applied only on the exact region where the plaque is, and certainly not all over the whole penis.  Also, just because the skin of the glans may be more sensitive, that doesn't make it some kind of portal that will make drugs flow magically into the area where they might do some good. 
  So please, apply some caution and some logic here.  If people are going to try this, first start out small by applying to the area just over the plaque (where your dent or hourglassing or bend/hinge is).  Leave the rest of your member in peace in case this stuff doesn't actually help at all.  As the gentleman said, he had Peyronie's ten years ago and it healed spontaneously.  If he has it again and the cream is working, then maybe what he had then AND now was really an inflammation of some veins or capillaries in his member, and that is actually something which Hirudoid could be expected to help reduce.
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Age 60, Peyronie's history 10 months, left side hourglass, 20-degree bend to left, no Erectile Dysfunction

NeoV

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Re: Hirudoid has helped me immensely
« Reply #96 on: July 30, 2021, 07:57:40 AM »

I was using it to reduce swelling from some VED I had been doing, and just to see how it felt.

I have zero expectation of it helping the penile tissue, but there are papers on how heparin derivatives prevent fibrosis in lung tissue, that's all.
Now, it absolutely does help with swelling and vascular inflammation, it has been shown to do so in studies, and it got rid of my swelling and made some veins disappear that had been protruding a bit.

It probably does absorb better through the glans, but again, I wonder why the manual says "do not use on mucous membranes."

Sanabo

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Re: Hirudoid has helped me immensely
« Reply #97 on: August 01, 2021, 03:47:47 PM »

I am not sure if it is just my progression as my erections have been worsening for months, but I applied this a couple times a day for 3 days about 20 days ago. Since then I have not had a very good erection. They feel softer.

Has anyone else had this experience? I wish I hadn't tried this at all as NSAIDs basically took care of the pain already.
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42, acute, began 2/21
30 degree curve left, 15 up, bottleneck
Carnitine, CoQ10, arginine, 5 mg Cialis, pentox
Moderate Erectile Dysfunction, getting worse

Sanabo

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Re: Hirudoid has helped me immensely
« Reply #98 on: August 01, 2021, 03:52:03 PM »

Neo, did you really use 4 tubes and continue to get good erections?  If so,  I'll assume my condition isn't because of the hirudoid cream.

I'll be even more distraught if I made matters worse by experimenting.

Anyone else not have verections affected negatively?
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42, acute, began 2/21
30 degree curve left, 15 up, bottleneck
Carnitine, CoQ10, arginine, 5 mg Cialis, pentox
Moderate Erectile Dysfunction, getting worse

Juan

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Re: Hirudoid has helped me immensely
« Reply #99 on: August 01, 2021, 04:35:18 PM »

According to my personal experience, I’d say that your erection quality has not been altered because of the use of hirudoid.

I’ve been applying generous quantities of hirudoid for a long time with any issue.

I’ve never used it in the glans have to say. Only in the shaft.

At first I think it had more effect against the pain. Lately it seems it’s not as effective as at the beginning.
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39 yo. Onset Oct/20. 25º dorsal bend 1cm before glans + high erection angle.
Pentoxifiline 400x3. Tadalafil 2,5. Vit E, D3, K2. Zinc.Omega3. Ubiquinol. ALCAR.
Traction with PMP.
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