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[FlatteningTheCurve]

Hi all,

Just wanted to share these guidances from two regional urological associations. It could be that they have been shared on the forum before, in that case I apologise for the reposting:

https://uroweb.org/guideline/sexual-and-reproductive-health/#8

https://www.auanet.org/guidelines/peyronies-disease-guideline

What are they useful for? Among other things they list a range of different oral, topical and sub-cutane treatments for Peyronies Disease, as well as VED and traction, and outline whether they are recommended or not, along with reasoning as to why that is. As far as I understand, this is based on the scientific studies at hand and have been agreed on by clinical professionals and academics. Do note that the US-guidelines are from 2015 but still provide some interesting stuff. I for one learned something new from it and hope that someone else might too.

[FlatteningTheCurve]

Some key takeaway points:

Scientific evidence of improvement of curvature:
P-5 Inhibitors;
CCH injections;
Interferon a-2b injections;
Verapamil + Diclofenac + Antioxidants combination injection;
Traction therapy, esp in combination with the above mentioned injections;
VED, esp in combination with the above mentioned injections;
Surgery;
Implants


No scientific evidence of improvement of curvature:
Vitamin E;
Topical Verapamil;
Topical H100;
Botox;
ESWT (except in terms of pain reduction);
Radiotherapy

[postrocker]

Thank you.

Also found these excerpts:

"A recent survey indicates that the prevalence of definitive and probable cases of Peyronies Disease in the US is 0.7% and 11%, respectively, suggesting that Peyronies Disease is an under-diagnosed condition"

"There is no convincing evidence supporting oral treatment with acetyl esters of carnitine, vitamin E, potassium para-aminobenzoate (potaba) and pentoxifylline.".

"One randomized study assessed hyperthermia (39 to 40 degrees C for 30 min twice weekly; the comparison group received intralesional verapamil) and reported curvature improvement and plaque reduction"

"Treatment with penile traction therapy alone or in combination with injectable therapy as part of a multimodal approach may reduce penile curvature and increase penile length, although studies have limitations."

Also, the results for PMP seem to be more promising than the with Restorex (at least for the European uro association), but that might be episodical due to methodological choices. Both are said to be the best devices.

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