Anybody else notice sleep affects peyronies A LOT?

[McChicken94]

Let's say I pull an all nighter, before I go to bed my dck is completely messed up, dark coloured, feels though like rubber, cold, etc. Not saying it's not messed up when I had a good night of rest, but somehow when I have had good sleep it looks better. Fuller, more fleshy, less wrinky and damaged. Anybody noticed the same? That said, it comes and goes even when I do get proper sleep.

[NeoV]

Yes. Shorter sleep seems to cause more inflammation and also less melatonin, which is an antifibrotic.

[TonySa]

I started melatonin again, and sleep if much better!

[Asphyxia]

Makes me consider cannabis again.
Isnt the body downregulating melatonin effects?

[Hawk]

This is not primarily an Erectile Dysfunction topic and probably belongs in the Peyronies Disease section of the forum.

I would take a Benadryl or maybe a 1/2 of a Benadryl if I had concerns about Peyronies Disease.

Melatonin strengthens the immune system a while that is great in general it is contraindicated in cases where any autoimmune disease is present (Rheumatoid Arthritis, Lupis, Peyronies Disease,
etc.)

I know of no direct evidence it can worsen Peyronies Disease but I would avoid the risk.

[postrocker]

Hawk, which other supplements could go against improving Peyronies Disease? Besides, possibly, melatonin.

[Asphyxia]

If we ought to avoid strengthening the immune system then how come nobody is talking about immunosuppressants?
Are they doing more harm than good?

[Hawk]

Probably because immune-suppressants are a radical unproven step in treating Peyronies Disease and come with a host of serious life-threatening risks.

There is little dispute, however, that Peyronies Disease is an auto-immune disease in which the wound healing procedure goes wrong.  The result is that it is often triggered by very minor micro-trauma and then over-runs healthy tissue.

[Hawk]

I would use Benadryl or a half of a 50 mg Trazadone for sleep as needed.  The latter promotes NTE's  

[Asphyxia]

Do you have a suggestion for an immunosuppressant incase i choose to take that route?
I doubt i can get it from my doctor though, is there something over the counter?
I wonder if its worth taking those medication for sleep, arent they causing withdrawal once you stop taking them and also you build tolerance to them? Maybe not in low doses? Thats why i mentioned im considering cannabis, but it may have negative aspects too so idk, Maybe its worth taking the pills while in acute phase and come off when entering stable phase

[Godisreal]

Peyronies Disease is an auto-immune disease in which the wound healing procedure goes wrong.  The result is that it is often triggered by very minor micro-trauma and then over-runs healthy tissue.

Yes Hawk, but I'd like to know what Chronic phase feels like to those who've reached it lol, because I'm personally in month 15 and I'm still acute, I think.
It's WEIRD. Why does the body keep attacking the healthy tissue for such an insanely extended amount of time? Does chronic phase mean no pain and no new issues?  

[Hawk]

Do you have a suggestion for an immunosuppressant in case i choose to take that route?
I doubt i can get it from my doctor though, is there something over the counter?
I wonder if its worth taking those medication for sleep, arent they causing withdrawal once you stop taking them and also you build tolerance to them? Maybe not in low doses? Thats why i mentioned im considering cannabis...

On your first question - There are no over-the-counter immune suppressants simply because suppressing the immune system has life-threatening consequences.  No doctor is going to prescribe immune suppressants for Peyronies Disease.

On your second point, it is difficult to absorb that someone is concerned about the dependency of generic over-the-counter Benadryl but casually ready to start smoking or ingesting marijuana.  I am not sure I am equipped to cover the basics in simple enough terms to address that question.

[Asphyxia]

Thanks for the response

Thats understandable, the strange reason as to why im not concerned about marijuana  is because it causes no physical withdrawl/dependency, only mentally addicting,if something causes withdrawal, doesnt that mean that whichever desired effect you were getting, is about to be"nullified" or be "undone" by giving you a hard time and undesired effects during your withdrawal? the withdrawal is counteracting the effectivness of the desired effect even if we are talking about low dosages that you barely feel, isnt your body still reacting in an undesired way once you stop with it?

The same is true even for coffee, the withdrawal symptoms are canceling the desired effects, you feel energized, but at a later point in your life you pay the price by having an headache and being lethargic.
Am i missing something here? Is the desired effect actually greater than the undesired effect(withdrawal)?
Im having a hard time trying to explain what i mean, hopefully you understand.

[Asphyxia]

This post inspired me to write a post with a big chunk of it dedicated to sleep and everything associated with it if anyone is interested
https://www.peyroniesforum.net/index.php/topic,14791.0.html?PHPSESSID=nuctk4jci2l2fqli3q7hr1c527

[Hawk]

There are ZERO withdrawal symptoms from stopping Melatonin, Benadryl (an allergy medication), or 1/2 of 50 MG Trazadone tablets.

Smoking marijuana might not have physical withdrawal symptoms, but it does have negative physical effects on the body, along with the possibility of negative psychological effects. Both are certainly far riskier than Benadryl.

[Tortão Pra Direita]

Melatonin strengthens the immune system a while that is great in general it is contraindicated in cases where any autoimmune disease is present (Rheumatoid Arthritis, Lupis, Peyronies Disease,
etc.)

The immune system is very complex. Some "immune boosters" aren't actually boosters, but regulators. I don't think it's wise to avoid vitamin D, C, garlic, onions, and other things that are known to "strengthen" the immune system.

Remember melatonin is also anti-inflammatory.  

[Asphyxia]

I was wondering exactly about the same thing actually, take garlic for example, its supposed to strenghten your immune systm and kill bacteria overgrowth or candida in your stomach, which in theory would help immensly with autoimmune disseases

Now if we take melatonin for example, say you get more sleep, your body heals and repairs, i dont know if it regulates the immune system or strenghtens it but even if it does strenghten the immune response for a while, maybe it would still be essential to consume a certain product in order to try to fix the cause of the autoimmune dissease.

[Hawk]

i dont know if it regulates the immune system or strenghtens it but even if it does strenghten the immune response for a while, maybe it would still be essential to consume a certain product in order to try to fix the cause of the autoimmune dissease.

Asphyxia you are precisely accurate when you say  "I don't know" and "maybe".  No one knows.  The human body, its processes, and the complications brought on by the differences from one individual to another make it impossible to know now or for decades to come.  That is why I said to be cautious.  I reiterate that.  

For instance, plaque is collagen and vitamin C is a collagen booster.  However, healthy tunica is another form of collagen so will vitamin C speed healing or will it speed plaque production or will it have no effect?  Will it do the same thing with each individual in each instance? Any discussion is nothing but pure speculation based on a hunch.

[Asphyxia]

I am interested in hearing your speculation regarding collagen and vitamin c,
And what in your opinion healing means, is it to replace scar tissue with healthy tissue or is the purpose of traction is to stretch the scar tissue and the only way to heal is to have a stretched scar, im really confused about it.

If healthy tissue could replace scar tissue then id assume peyronies is cureable but it isnt, this tells me that healthy tissue cant replace scar tissue and collagen is harmful,
but im interested in your speculation, im not expecting any clear evidence.

A simple google search shows me that there are 16 types of collagen, which makes me think maybe some types are builing essential for healthy tissue, and some are building scars, this link looks interesting and makes me think that this is worth exploring.
https://www.jomfp.in/articles/2016/20/2/images/JOralMaxillofacPathol_2016_20_2_276_185932_t3.jpg

It seems like we are steering the topic of this post, i will start a new post, if anyone chooses to answer or comment on the question please do so here.
https://www.peyroniesforum.net/index.php/topic,14806.0.html?PHPSESSID=0n3gk2373p1mjgsrp2ga385bh2
Hawk, that question was directed to you but i wanted to get more opinions and ideas
And i copied your comment on that post, hopefully im not breaking any rule.

[Rocodile]

On the immunosuppressant point, I have been on an immunosuppressant drug for the duration of my peyronies for about 9 months (prescribed for a different medical issue) and it had no positive effect on the peyronies.