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Quote from: Woodman on November 12, 2010, 06:10:19 PMIts all a read tape game to get the drug approved to get it on the market. They pick the best of the best candidates so they can prove the drug effective. End the end most likely it will go along the lines of the VIs with effective rates from one end of the spectrum to the other. Far as the ethical aspect, the drug company can give two hoots about sticking a man with the placebo to get there drug to pass the FDA even though it mite cause further damage. Remember in the end this is all about money and profits! Iam worried that the attention that Xiaflex has gained for us Peyronies Disease suffers will turn against our cause when it does not live up to the hype that has been advertised about its wonderful effects of reversing the disorder. Then other drug companies will not want to even try to develop a Peyronies Disease drug in hind site for there short comings. They have a lot of money and resources riding on this drug if it fails to live up to its hype I am afraid its just going to turn others off to investing into a cure.I hope I am wrong and it really does work in the end but my experience in the world tends to lean in the opposite direction. If it did work where real men were getting exceptional results or fully cured then I would pay the 12K without thinking twice about it.
Quote from: Woodman on November 12, 2010, 06:10:19 PMFar as the ethical aspect, the drug company can give two hoots about sticking a man with the placebo to get there drug to pass the FDA even though it mite cause further damage. Remember in the end this is all about money and profits!
Quote from: skunkworks on November 13, 2010, 05:10:15 AMNot only that, but a placebo that could worsen the condition is no placebo at all. This would completely invalidate the whole study.
Quote from: Kempenstein on February 24, 2012, 01:29:14 PMYes I know James but if you read the first page after the abstract that is available on line it gives a very good description of the actions of collagenase.And no I am not an agent for the publisher. LOL.Most places I have consulted seem to talk about C "breaking down" or "softening" plaque. As I understood it removing the plaque in Peyronies just leaves a gap that won't be healed naturally. That is why in the Nesbit Surgery Proceedure it is necessary to remove a graft from the other side of the penis to the one you are removing the plaque from thus shortening it by a minimum of about 2cm depending on the extent of the plaque.
QuoteThere is No accepted solution yet ... even the uro´s know anything about this disease
QuoteYou dont know what you are talking about - all is BS!
QuoteMost places I have consulted seem to talk about C "breaking down" or "softening" plaque
Quote from: james1947 on February 24, 2012, 05:12:54 PMIn all the surgeries for Peyronie's today the doctors are making grafting to fill the removed plaque area. Some surgeries are not shortening the penis as the Nesbit procedure. Have a lot of information on the forum regarding surgeries for Peyronie's. James
QuoteAnd I personally know guys who did have excision and grafting and did not lose any length.
Quotethe two surgery types most doctors are using today for people with Peyronie's that lost length to the disease are Incision with Grafting and Excision with Grafting or a combination of both.
Quote from: lwillisjr on February 25, 2012, 04:58:52 PMKempenstein,I'm sure many have read the article you have linked to including myself. It is an interesting study and it is always good to see new approaches to treating Peyronies Disease. I don't understand thiswontwork's comment to your post, but don't let one person's opinion shoot you down.
Quote from: nycsurfer on December 30, 2011, 12:34:22 AMMy piece of not-so-good news is I just got through with the Xiaflex trial last month and I came out looking even WORSE (!) than when I went in both with the hourglassing and curvature. Had high hopes and now not too sure WHAT to do...