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Welcome to J Francois Eid, MD - Directly answering member questions in the "Medical Professionals" section below the Treatment boards.
https://www.peyroniesforum.net/index.php/topic,17819.0.html

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Author Topic: What's the Theory behind L-Arginine ?  (Read 1057 times)

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PeyroniKirai

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What's the Theory behind L-Arginine ?
« on: September 30, 2020, 08:34:07 PM »

Hello experts, question for you.
What's the theory behind taking L-Arginine?  As someone with a clear dent and a 15-20 degree bend, and who has been diagnosed by a urologist as Peyronie's, but does not suffer Erectile Dysfunction, is there some scientific reason I should take L-Arginine
  Does someone think that it will stimulate circulation or increase blood flow in the penis, and thereby somehow "flush out" the plaque?
Would appreciate any guidance on this.
Thanks vm
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Age 63, Peyronie's history 3 years, left side hourglass, 20-degree bend to left, no Erectile Dysfunction

NeoV

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Re: What's the Theory behind L-Arginine ?
« Reply #1 on: September 30, 2020, 10:57:42 PM »

Increased blood flow, less inflammation, basically. That means the dent will have a reason and ability to fill out and slowly your penis can remodel itself. Same with Cialis, just works in a different way. You can’t flush out plaque but you can create a healthier environment so that some fibrosis can be reversed and any actual hard plaques can lose their reason for being there.

Deek

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Re: What's the Theory behind L-Arginine ?
« Reply #2 on: October 01, 2020, 07:31:11 AM »

I have found for myself that taking L-arginine + Cialis at the same time gives me positive aspects.
The blood circulation must always be good in our condition.
As Neo said - the environment should be ideal.
I highly recommend it

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age: 43
relationship: married
symptoms: ~45 degree bend / curve up
Started October 2019 with bent erection (dent/notch)
Daily Tadalafil
Traction with PMP
VED with one cylinder

BadLuck

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Re: What's the Theory behind L-Arginine ?
« Reply #3 on: October 01, 2020, 10:35:49 AM »

I thought the consensus was L-Citrulline was preferred over L-Arginine
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Mid 50's
Diagnosed with Peyronies in 2014.
Treatments have included Verapamil injections, Pentox, and Xiaflex.
Currently using RestoreX

bustedchubb

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Re: What's the Theory behind L-Arginine ?
« Reply #4 on: October 01, 2020, 01:52:49 PM »

L-Arginine is no joke, it certainly helped me with blood flow and circulation.  Despite my 90 degree upbend and some narrowing, I can still get solid and maintained erection. 
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45 Yrs old, Peyronies Disease Onset 11/2019, Stabilized 6/2020.

Dent/Hourglassing distal and dorsal side, lost length and girth.

Underwent Plication with Dr. Brian Christine in Birmingham, AL on 6/17/2021. Fully recovered with no complications.

Anton36

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Re: What's the Theory behind L-Arginine ?
« Reply #5 on: October 02, 2020, 03:51:54 AM »

 l citrulline is better
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age 25
first symptoms: Flaccid Pain
official diagnosis 2017 after ultrasound
treatments tried All oral drugs

PeyroniKirai

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Re: What's the Theory behind L-Arginine ?
« Reply #6 on: October 05, 2020, 06:50:45 AM »

Both BadLuck and Anton36 have said L-Citrulline is "better" than L-Arginine.  Any background on this?  I've read a few articles on websites selling the stuff, but the only medical information I saw was that (a) the body manufactures L-Citrulline under normal conditions and (b) the kidneys change L-Citrulline into L-Arginine.
If anyone knows of any reputable studies or medical treatises on these supplements please introduce!
Thank you very much.
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Age 63, Peyronie's history 3 years, left side hourglass, 20-degree bend to left, no Erectile Dysfunction

Olive

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Re: What's the Theory behind L-Arginine ?
« Reply #7 on: October 06, 2020, 05:56:10 AM »

This article has all the information you need and then some.

https://www.fertstert.org/article/S0015-0282(10)00647-3/fulltext#sec15
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PeyroniKirai

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Re: What's the Theory behind L-Arginine ?
« Reply #8 on: October 10, 2020, 11:08:02 AM »

Thanks guys.  So from all I've read, it seems that if someone simply has a dent or a bend or both from Peyronies, but no actual difficulty in achieving or maintaining erection, there is no need to take either L-Arginine or L-Citrulline.  The Fertstert article talks about a host of different factors that influence Erectile Dysfunction by causing a decrease in the Nitric Oxide (NO) content of the blood.  Most of these are "poor lifestyle choices":  lack of exercise, smoking, drinking, fatty or sugary diet, obesity etc.  It explains that a multi-faceted approach to Erectile Dysfunction which addresses all these bad factors is the most effective, since each one of them decreases NO a little.  The article gives a justification based on the theory of evolution:  a fit, strong, healthy male is more likely to impregnate and protect his mate successfully and protect his progeny. 
  According to the article, both L-Arginine and L-Citrulline can increase blood NO.  The former seems to require very large doses - up to 5g/day.  The latter seems to work with more like 2g/day.  But in either case, we are talking about increasing NO, which contributes to erection.  If you have Peyronie's, it means you have a block in the spongy tissue, and no amount of NO is going to just act like Roto-Rooter and flush it out.  So yes, those supplements may help overall circulation and bring about a stronger, better erection, but they won't do anything for the plaque that's causing the dent and the bend. 
  At least that's how I understood it.  So if you have good strong erections and your only complaint is a dent/bend/hourglassing from Peyronie's, you don't need these supplements at all.  And in any case, improving the lifestyle (regular moderate to strenuous exercise, no cigarettes, much less alcohol, less fat and less sugar) is going to have a bigger effect than just chugging some pills.
Thoughts?  Anyone disagree?
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Age 63, Peyronie's history 3 years, left side hourglass, 20-degree bend to left, no Erectile Dysfunction

Kobegianna

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Re: What's the Theory behind L-Arginine ?
« Reply #9 on: July 07, 2021, 10:35:00 PM »

Agreed. But people need to feel like they are doing something actively to fight this condition
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34 yrs Old, Healthy very active
Possibly injured penis or took too much Cialis
Symptoms starting January-February 2021
First dent seen April 4, 2021, painful erections

LWillisjr

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Re: What's the Theory behind L-Arginine ?
« Reply #10 on: July 08, 2021, 10:49:37 AM »

This topic is now locked as it as approached the amount of posts we allow for an introduction post. But feel free to create new topics/discussions in the other respective areas of the forum.
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Developed peyronies 2007 - 70 degree dorsal
Traction/MEDs/Injections/Surgery 2008
66y/o  14 years Peyronies free
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