What's the Theory behind L-Arginine ?

[PeyroniKirai]

Hello experts, question for you.
What's the theory behind taking L-Arginine?  As someone with a clear dent and a 15-20 degree bend, and who has been diagnosed by a urologist as Peyronie's, but does not suffer ED, is there some scientific reason I should take L-Arginine?  
 Does someone think that it will stimulate circulation or increase blood flow in the penis, and thereby somehow "flush out" the plaque?
Would appreciate any guidance on this.
Thanks vm

[NeoV]

Increased blood flow, less inflammation, basically. That means the dent will have a reason and ability to fill out and slowly your penis can remodel itself. Same with Cialis, just works in a different way. You can't flush out plaque but you can create a healthier environment so that some fibrosis can be reversed and any actual hard plaques can lose their reason for being there.

[Deek]

I have found for myself that taking L-arginine + Cialis at the same time gives me positive aspects.
The blood circulation must always be good in our condition.
As Neo said - the environment should be ideal.
I highly recommend it

[BadLuck]

I thought the consensus was L-Citrulline was preferred over L-Arginine?  

[bustedchubb]

L-Arginine is no joke, it certainly helped me with blood flow and circulation.  Despite my 90 degree upbend and some narrowing, I can still get solid and maintained erection.  

[Anton36]

 l citrulline is better

[PeyroniKirai]

Both BadLuck and Anton36 have said L-Citrulline is "better" than L-Arginine.  Any background on this?  I've read a few articles on websites selling the stuff, but the only medical information I saw was that (a) the body manufactures L-Citrulline under normal conditions and (b) the kidneys change L-Citrulline into L-Arginine.
If anyone knows of any reputable studies or medical treatises on these supplements please introduce!
Thank you very much.

[Olive]

This article has all the information you need and then some.

https://www.fertstert.org/article/S0015-0282(10)00647-3/fulltext#sec15

[PeyroniKirai]

Thanks guys.  So from all I've read, it seems that if someone simply has a dent or a bend or both from Peyronies, but no actual difficulty in achieving or maintaining erection, there is no need to take either L-Arginine or L-Citrulline.  The Fertstert article talks about a host of different factors that influence Erectile Dysfunction by causing a decrease in the Nitric Oxide (NO) content of the blood.  Most of these are "poor lifestyle choices":  lack of exercise, smoking, drinking, fatty or sugary diet, obesity etc.  It explains that a multi-faceted approach to Erectile Dysfunction which addresses all these bad factors is the most effective, since each one of them decreases NO a little.  The article gives a justification based on the theory of evolution:  a fit, strong, healthy male is more likely to impregnate and protect his mate successfully and protect his progeny.  
 According to the article, both L-Arginine and L-Citrulline can increase blood NO.  The former seems to require very large doses - up to 5g/day.  The latter seems to work with more like 2g/day.  But in either case, we are talking about increasing NO, which contributes to erection.  If you have Peyronie's, it means you have a block in the spongy tissue, and no amount of NO is going to just act like Roto-Rooter and flush it out.  So yes, those supplements may help overall circulation and bring about a stronger, better erection, but they won't do anything for the plaque that's causing the dent and the bend.  
 At least that's how I understood it.  So if you have good strong erections and your only complaint is a dent/bend/hourglassing from Peyronie's, you don't need these supplements at all.  And in any case, improving the lifestyle (regular moderate to strenuous exercise, no cigarettes, much less alcohol, less fat and less sugar) is going to have a bigger effect than just chugging some pills.
Thoughts?  Anyone disagree?

[Kobegianna]

Agreed. But people need to feel like they are doing something actively to fight this condition  

[LWillisjr]

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