Why not use anti fibrotic drugs used for PF?

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Michiganguy19

August 29, 2020, 10:35:27 PM
Lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie's?  
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Bent Ding Dong

#1
September 07, 2020, 04:48:34 AM
@Michiganguy19, are you taking any of these meds yet? Am interested to know if it does anything. What are the side effects?
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

projectpd

#2
September 07, 2020, 05:16:31 AM
@Michiganguy19, i think you mean losartan. interesting. Used to lower blood pressure but has some antifibrotic research results.  Low cost @ 6 x 28 100mg tablet(s) - £29.95. Needs monitoring for low blood pressure, potassium and kidney function, but mostly low side effects. Not an ACE inhibitor. Molecular weight 423.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

hope794

#3
September 07, 2020, 07:23:51 PM
Makes a lot of sense. Honestly, this is unexplainable to me.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

drew67

#4
September 09, 2020, 09:11:32 PM
losartan lowers dht so it can potentially make Peyronies Disease worse

projectpd

#5
September 14, 2020, 04:24:35 PM
@drew67 do you have a ref for the DHT effect?
I don't necessarily mind if it lowers DHT anyway, but I think if I tried this it would only be transdermal anyway.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

drew67

#6
September 14, 2020, 04:58:05 PM
you can find articles on pubmed

lowering DHT will also lower DHT in the penis where there are lots of DHT receptors

peter123

#7
September 19, 2020, 10:40:00 AM
Quote from: drew67 on September 09, 2020, 09:11:32 PM
losartan lowers dht so it can potentially make Peyronies Disease worse

No data to support this, in theory l Arginin and increased NO should thelp peyronies which is doesn't therefore the assumption thag lowering NO by lowering dht cannot be supported  
THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.

projectpd

#8
September 20, 2020, 12:32:59 PM
There are no references i could find on pubmed that find or suggest losartan lowers dht. There are a number of studies on losartan and valsartan in rats and humans looking for effects on male hormones & sexual function that found no adverse effects on them, but did improve sexual function & related parameters, at least in diabetic or hypertensive subjects.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

projectpd

#10
September 24, 2020, 01:49:35 PM
What was the relevance of this link?
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

Asphyxia

#11
April 11, 2021, 01:46:31 PM
Has anyone tried this?
Would it make sense to?
Age:23. Onset of symptoms: september 2020.
Curve mostly semi erect about 60 degrees, slight pain
Tried short & prolonged fasts, keto,carnivore, traction and most of the supplements.
Severe digestive issues, probably an autoimmune disorder

Mikel7

#12
April 11, 2021, 02:14:25 PM
I have been on losartan for BP for the past 7 years and it did nothing for my peyronies/fibrosis.  100mg QD.
Lump 4/2020, age 62 , Dr Levine 6-26-20, Dors Curve 11/2020, Peyronies
Vit E400mg, COQ10, Heat Therapy, Penimaster, Pentox, Cialis, Restorex
SNHL 7/2020 - Stopped all Meds because ototoxicity  Heat/traction/VED are working. CPPS Diagnosis - Stable :)

Dipstick

#13
April 29, 2021, 10:07:11 AM
I have perfenidone the raw powder from....

I am considering it a long with dmso!!!

It seems to be a preventive drug rather than restoring. None the less maybe worth while!  
If you want answers, Please help us by filling in your signature block

Click here for Directions

Hawk

#14
April 29, 2021, 10:28:58 AM
What is the molecular weight?

How certain are you it is pure?

Do you have any clinical studies that show it is effective for Peyronies Disease?
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums
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