Xiaflex: Is there a difference btwn dorsal plaque and side plaque

[norcal1970]

Regarding Xiaflex:  In my research I noticed results fluctuated with side plaque vs dorsal plaque.  Side plaque seems to do better.  In fact sometimes dorasal plaque is created or worsened via injections.

I have dorsal plaque.  Are both plaques considered the same?  I also have Dupuryens Contractures in my hands.  I spoke with Old Man and he educated me on the fact that Dupuryrens Contractures is the essentially the same as Peyronies Disease.  One is on the hands, one is one the dick.

So is the hereditary disease (Dupuryrens/Peyronies) type plaque different then the plaque one gets from just breaking your dick F^@$!ng?  My peronies came on slow, a spec of rice, out of nowhere.  I know.... micro fractures could have caused it.

I am just trying to educate myself as much as possible before I put a needle in my dick full of enzymes that could cause worse damage.

Also, my chunk of plaque seems to have migrated from the tip of my dick to more of the middle of the shaft.  Is this just my imagination?  It has not changed in looks, size or shape when erect in over a year.   Still hurts like crap to have a full erection.  That's the worst part, the pain.  I am used to the straight up bend and my orgasms are good so long as I am not fully erect.  Will the pain ever go away?  I am going on two years.

I greatly appreciate any feedback. Not sure if this was the correct area/section to make this post.  THANKS!  -Norcal1970

[TDix]

What degree of curve are you?  Is your scar tissue calcified?  Valid questions as yes, sticking a needle of collagenase in your dick is not something to take lightly.  Trust me

[Hawk]

Many of your questions will be answered if you very carefully read this document. ---> https://www.peyroniesforum.net/index.php/topic,3180.0.html

Plaque is scar tissue.  Scar tissue can spread but it does not migrate.

[TonySa]

Norcal, what are you taking for the pain?

[Shane43]

I have a dorsal plaque at the base of my penis, causing hourglass indentation and hinging (very little stability when I am hard). It was about 3 cm long, 2 cm wide, hard but not calcified yet. I have had 3 series of Xiaflex, just finished the third. After two series (4 injections on the right side of the plaque) the plague reduced to about 1.5 cm x 1.5 cm and the indentations are smaller. The bruising and pain gets worse with each series, but it is tolerable with ibuprofen and ice the first 1-2 days and heat a few times a day for 1-2 weeks. I will wait to see how things look in a few weeks to see if I will go withe the fourth series (and last one that my insurance will cover). I have read that Xiaflex is not recommended for hourglass indentation, but my urologist said there is simply not enough info to know - the original US FDA approval clinical trials specifically excluded hourglass indents from the trials - so it may or may not work. I have read that XIaflex should not be used for ventral (bottom side) plaques due to the proximity of the urethra. I will update my pervious post in a few weeks.

[norcal1970]

I am not taking anything for pain.  It just hurts when fully erect.  I am used to it.  It only takes me few minutes to orgasm since it hardly gets used these days. But when I get a deep sleep erection the pain usually wakes me up.

The plaque is hard so most likely calcified.  It a disc like shape about the size of a penny and 1/8in thick.  The plaque was hard from onset.  My upward dorsal curve is about 45-50 degrees. 

Maybe its just my imagination regarding the location change.   

[norcal1970]

I was planning on waiting until next year to start the injections, considering changing my health bennies to better plan. 

Anyway, how do you know if your plaque is calcified?   I don't want to miss the window of un-calcified plaque injections.    The sooner the better to get xialflex correct?   My plaque and penis have not changed in over 10 months.   My doctor wanted to wait six months to make sure that peyroines plaque is finished forming.  That date has come and gone.

[Shane43]

My plaque also is very hard and I feared it was calcified, but my urologist said it was not - just based on feel and he injected Xiaflex. If the needle penetrates, I guess it is not calcified. I guess sooner the better is true, but if my insurance was not paying 95% of the cost, I would have waited too. My plaque was more the size of a quarter and 1/4 inch thick, right at the base of the penis with an hourglass indentation just beyond it toward the tip causing hinging. The Xiaflex has reduced the size of the plaque and indentation and now my penis has more of a curve to the right where the bigger indentation is. Unfortunately, the instability/hinging is only a little better.

[peter123]

not indicated doesn't mean not useful. it just means that patients with ventral curvature, hour glassing etc have been excluded form the fda study. there have been newer studies showing that it is useful for other kinds fo deformities including lateral as well.
https://www.sciencedirect.com/science/article/abs/pii/S009042952030724X

[peter123]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920074/

full study

[Hawk]

This topic is now locked because it has exceeded the 10 post limit imposed on Introductory Topics.

Please continue to post below on the appropriate boards on the forum