Found some studies on how increasing Nitric oxide can actually cause Pey?

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Rambo

Not sure, someone linked me to these in another group, seems that Nitrix oxide rising can actually cause damage?? (Using L Cit / L Arg / Cialis / Viagra . Etc ).


"Peyronie's disease occurs due to the activation of nuclear factor kappa-B, that induces the production of inducible nitric oxide synthase (iNOS), with an increase of nitric oxide, leading to increased production of peroxynitrite anion. All these processes result in the proliferation of fibroblasts and myo-fibroblasts and excessive production of collagen between the layers of the tunica albuginea (penile plaque)."
https://pubmed.ncbi.nlm.nih.gov/22309083/



"More recently, it has been discovered that progesterone inhibits the expression of the enzyme nitric oxide synthase, while estrogen stimulates its expression. At the time of ovulation, when estrogen is high, a woman breathes out 50% more nitric oxide ("NO") than men do, but at other times, under the influence of increased progesterone and thyroid, and reduced estrogen, women exhale much less NO than men do. (Nitric oxide is a free radical, and it decomposes into other toxic compounds, including the free radical peroxynitrile, which damages cells, including the blood vessels. brain, and heart. Carbon dioxide tends to inhibit the production of peroxynitrile.)  "' Dr Peat PhD
Progesterone, not estrogen, is the coronary protection factor of women.
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smashin

So this would suggest every leading expert who has treated thousands of cases are all wrong?

Hawk

Pretty interesting.  What is your source of all of those statements?  Is the link you furnished or other material?  I will read it when I get a chance.
 
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

Rambo

Quote from: smashin on August 07, 2020, 07:04:00 PM
So this would suggest every leading expert who has treated thousands of cases are all wrong?

Look I'm not agreeing with it, That's why I've posted them here as to see what you guys think..

I've been interested in the work of Ray Peat for 4 years now, I don't agree with all of his stuff but he's got some a amazing points and really helped me in my journey with health. One thing he is adamant on is that anything that causes Nitrix oxide production is bad and attributes to ageing/cell death. His preferred thing is Co2 production which is has similar types of effects to NO but much healthier: according to him ..




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Paolo

Whenever you find yourself on the side of the majority, it is time to pause and reflect.

Rambo

I'll take a read of them now Paulo!


I just found another one in the meantime: This shows the mechanism of pentox and it's NO reducing effects

Biol Neonate. 1995;67(1):72-6.
Effect of pentoxifylline on nitric oxide released by murine macrophages
R Lauterbach 1, A Grabowska, J Marcinkiewicz
Abstract
The growing knowledge on the pathological role of tumor necrosis factor alpha (TNF-alpha) and nitric oxide in septic shock stimulated efforts to control their generation pharmacologically in clinical situations. Pentoxifylline (PTXF) is well known as an inhibitor of TNF synthesis, whereas information about its role in suppression of NO generation is much less available. In our study, we have shown that PTXF suppresses the synthesis of both mediators, TNF and NO, released by macrophages activated with different stimuli. However, in contrast to N-monomethyl-L-arginine (an inhibitor of NO synthase), PTXF influenced NO generation only during the induction phase. In conclusion, we suggest that a possible new therapeutic approach in septic shock may result from the inhibition of these two major mediators by simultaneous application of PTXF and a specific inhibitor of NO generation. Further experimental investigations and clinical trials are necessary to evaluate the safety and effectiveness of application of these inhibitors.
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P1992

Quote from: Paolo on August 08, 2020, 04:16:11 AM
Here is an article of interest if you have a moment;

https://men-elite.com/2020/04/03/erectile-dysfunction-part-3-nitric-oxide-oxidative-stress-and-insulin-resistance/

And this one is very, very scientific;
https://www.researchgate.net/publication/7371709_The_Nitric_Oxide_Theory_of_Aging_Revisited

Recently someone posted here on the Forum that the copper supplement would have a benefit for Peyronies Disease and what I understand in this last article, excess copper can cause more oxidative stress "which can damage critical cell membranes in and around the penis, causing Erectile Dysfunction". It is very complicated when trying to use something for this disease when you do not have the scientific and practical support that it will really help or make the situation worse.
54 years, self-induced peyronie
Upward curvature ~40º-50º, narrowing and retraction in flaccid and erect. Multiple plaques, loss of sensitivity, pain sometimes in a flaccid state and always on erection, axial instability and erectile dysfunction

peter123

Quote from: Rambo on August 08, 2020, 03:03:54 AM
Look I'm not agreeing with it, That's why I've posted them here as to see what you guys think..

I've been interested in the work of Ray Peat for 4 years now, I don't agree with all of his stuff but he's got some a amazing points and really helped me in my journey with health. One thing he is adamant on is that anything that causes Nitrix oxide production is bad and attributes to ageing/cell death. His preferred thing is Co2 production which is has similar types of effects to NO but much healthier: according to him ..

You do want detah though, the point is aptosis of fibro and myofibroblasts
THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.

Rambo

Can any body chime on this please? Really interested to know if these NO inducers are actually all their made out to be..
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jake12

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peter123

THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.