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Author Topic: Tamoxifen + PDE5 breakthrough  (Read 371 times)

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Aboqor

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Tamoxifen + PDE5 breakthrough
« on: August 02, 2020, 06:36:21 PM »

Hi All,

I have been watching this forum for quite some time and I want to thank you all for providing so much information. I am feeling quite depressed and I am fearing my disease progressing through shortening and worsening erectile function.

My urologist told me Tamoxifen combined with a PDE5 inhibitor is more effective in reducing curvature than pentox. She used the following research as her basis: https://www.sciencedirect.com/science/article/pii/S0302283818307553

What do you guys think of this? It seems like this combination is more effective in the early stages. Would love to get your feedback.

Aboqor
Logged
07/03/20 noticed 40 degree bent upwards
01/07/20 started feeling pain when flaccid

Remedies: COQ10, ALCAR, Vitamins, Keto Diet, IF/OMAD, light traction.

Starting 03/08/20: VED. PDE5 + Tamoxifen

TonySa

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Re: Tamoxifen + PDE5 breakthrough
« Reply #1 on: August 02, 2020, 08:17:01 PM »

It’s worth a shot.  Any chance she would prescribe all three?  I’d def add traction and/or VED.  Be sure to read the survival guide; https://www.peyroniesforum.net/index.php/topic,3180.msg44057.html#msg44057
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PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Aboqor

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Re: Tamoxifen + PDE5 breakthrough
« Reply #2 on: August 03, 2020, 03:41:41 AM »

I'm not too sure how safe that'll be but I will ask her opinion on it! She said that pentox will mostly help with the pain but that this combination (with daily VED usage) will be more effective as shown in the research. I believe she even mentioned a research from march 2020 but I havent been able to find it.
Logged
07/03/20 noticed 40 degree bent upwards
01/07/20 started feeling pain when flaccid

Remedies: COQ10, ALCAR, Vitamins, Keto Diet, IF/OMAD, light traction.

Starting 03/08/20: VED. PDE5 + Tamoxifen

peter123

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Re: Tamoxifen + PDE5 breakthrough
« Reply #3 on: August 03, 2020, 04:49:09 AM »

Hi All,

I have been watching this forum for quite some time and I want to thank you all for providing so much information. I am feeling quite depressed and I am fearing my disease progressing through shortening and worsening erectile function.

My urologist told me Tamoxifen combined with a PDE5 inhibitor is more effective in reducing curvature than pentox. She used the following research as her basis: https://www.sciencedirect.com/science/article/pii/S0302283818307553

What do you guys think of this? It seems like this combination is more effective in the early stages. Would love to get your feedback.

Aboqor


one thing I learned over the last few months is the only thing that physicians are actually interested in when it comes to these things are rtcs, randomized controlled trials. thats it. sure, its neat that in an animal model or in an in vitro study something has proven to have some effect but over and over again it has been shown that this does not directly translate into efficiency when given directly to humans. thats why they always write "further studies are very much needed". its just that nobody really gives a [email protected]< about mens sexual health and since most peyornies sufferers are old already.. no studies will be conducted. xiaflex was only a lucky shot since it was being developed for duypitrens contracture.

think about how insane this is. this is something that affects 10% of men but nobody is even bothered developing a drug for it. its the exact same thing with male baldness. which I also have and desperately wait for treatment. but nobody cares, its just low evidence studies like this one that never translate sadly. thats also why in review papers you see those things as being not recommended. because for a clinician this is not evidence sadly. and most won't even want to try anything unless the disease is lethal. because as we all know, if its not lethal it can't ruin your life! /s

you seem to have found a decent one though who is not a massive retard like the "watchful waiting" idiot doctors whom I wish the worst peyronies on earth that eats them alive, daily
Logged
onset of symptoms in February 2020 initial pain when flaccid only which has since improved. 20deg left curvature, loss of girth indent
started oral treatment in march, currently on Potaba 12mg 1200mg Pentox, 2.5mg Taladafil and L-arginin
very depress

Aboqor

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Re: Tamoxifen + PDE5 breakthrough
« Reply #4 on: August 03, 2020, 06:34:18 AM »

Hello Peter,

Trust me, I have definitely spoken to at least 2 specialists who suggested just to wait and had to look on wikipedia during the consult. I do feel like the disease is getting more attention now than it did 10 years ago. After speaking to yet another GP (most of them are complete tools) he found a specialist in male sexual health.

She told me pentox is mainly provided for the pain and could potentially dimish the curvature, but argued Tamoxifen + Tadalafil to be more effective in preventing more scarring and reducing the curvature.

Just like you I am quite afraid and depressed. I'm a young man who just got an amazing appartment, amazing internship and has a beautiful girlfriend yet I am not able to enjoy any of it. However, I will try to keep fighting this and I am glad I finally found a specialist in my country who without question prescribed me these remedies.

Will start medication today and I will keep you posted. If anyone has any feedback I would be glad to hear it.
Logged
07/03/20 noticed 40 degree bent upwards
01/07/20 started feeling pain when flaccid

Remedies: COQ10, ALCAR, Vitamins, Keto Diet, IF/OMAD, light traction.

Starting 03/08/20: VED. PDE5 + Tamoxifen

peter123

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Re: Tamoxifen + PDE5 breakthrough
« Reply #5 on: August 03, 2020, 06:45:47 AM »

Hello Peter,

Trust me, I have definitely spoken to at least 2 specialists who suggested just to wait and had to look on wikipedia during the consult. I do feel like the disease is getting more attention now than it did 10 years ago. After speaking to yet another GP (most of them are complete tools) he found a specialist in male sexual health.

She told me pentox is mainly provided for the pain and could potentially dimish the curvature, but argued Tamoxifen + Tadalafil to be more effective in preventing more scarring and reducing the curvature.

Just like you I am quite afraid and depressed. I'm a young man who just got an amazing appartment, amazing internship and has a beautiful girlfriend yet I am not able to enjoy any of it. However, I will try to keep fighting this and I am glad I finally found a specialist in my country who without question prescribed me these remedies.

Will start medication today and I will keep you posted. If anyone has any feedback I would be glad to hear it.

Not just like me at all
Logged
onset of symptoms in February 2020 initial pain when flaccid only which has since improved. 20deg left curvature, loss of girth indent
started oral treatment in march, currently on Potaba 12mg 1200mg Pentox, 2.5mg Taladafil and L-arginin
very depress
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