Relaxin-2

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pey ron

Relaxin-2 is a peptide that seems to hold a lot of promise.

https://www.pnas.org/content/116/25/12183
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406285/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697124/

I found a cheap and reliable source for it, but I have never injected anything in my entire life and I am already very nervous when nurses inject me in an arm. I don't think I'd be ever capable of injecting myself, and let alone in my penis...
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P1992

It seems that her action is similar to xiaflex. It would be good for them to test her for peyronie's disease to see if the results are promising.
54 years, self-induced peyronie
Upward curvature ~40º-50º, narrowing and retraction in flaccid and erect. Multiple plaques, loss of sensitivity, pain sometimes in a flaccid state and always on erection, axial instability and erectile dysfunction

projectpd

interesting.. but only multiple intra artery injections had a benefit in the 1st study? ouch!.

this study used a subcutaneous infusion, but wasn't positive: https://pubmed.ncbi.nlm.nih.gov/19333948/

how cheap was your source ? i thought this kind of thing was super expensive.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

hope794

what about relaxin-2 + DMSO?
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

pey ron

My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.
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projectpd

Molecular weight about 6000 Da is far above usual supposed limit for DMSO of around 400. According to this, ML290 is also a relaxin agonist at 500 Da- and supposed to be low price?: (have no info on that) any thoughts?

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13656
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

pey ron

Peptides are extremely delicate. I am afraid DMSO is going to damage them.
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projectpd

This ML290 isn't a peptide. but are you planning multiple injections per day?
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

pey ron

sorry, didn't notice you were talking about that. Very interesting!
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hope794

Wow, nice find!!!!!!!
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Hontas

Quote from: pey ron on August 01, 2020, 03:59:09 PM
My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.

How did letrozole affect your penis?

Gregd

Quote from: pey ron on August 01, 2020, 03:59:09 PM
My source is 22.36 dollars for 10 milligrams. It's a website I trust, I have used their letrozole and enclomiphene before and they were very effective, bloodwork at hand. I also bought the relaxin-2 but I am keeping it in my freezer until one day I will learn how to self-inject.

Have you tried this out yet? I'm willing to try this out. Can you message me your source. Thanks for the info
58 yrs old
1st symptoms started after 2 years of using trimix
Developed scar tissue after injections.
Tried most things in the alternative section.
Have ED that somewhat responds to Cialis
Transplanted 6/2/21, Dr. Jonathan Clavell, 24cm Titan

LuisFernandez

Relaxin is also cited i the Penis Enlargement patent: https://patents.google.com/patent/US20050065159A1/en

It sounds very interesting but sounds hard to get and correctly inject.
Injury in April 2020. Onset of ED.
Started RestoreX and VED 2 months after injury.
Taking 10mg daily cialis, pentox, coq10, vit-e.
Traction (+1 inch)/VED/PGE-1/DMSO+X

pey ron

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LuisFernandez

So,

According to the patent there's 3 different ways to apply relaxin to your penis:

"Relaxin can be administered at a dosage of 0.02 to 10 micrograms/kg body weight/day by intracavernosal injection.
Relaxin might be for topical administration at a dosage of 25 to 400 micrograms/kg body weight/day.
The relaxin might be for administration at a dosage of 0.02 to 1 micrograms/kg body weight/day by injection into the dense connective tissue surrounding the erectile tissue of the penis."

I'm not sure that topical administration would be much help. I'm also not sure if you could mix it with DMSO, I'm not sure what relaxin's molecular weight is.

I'm not brave enough to inject relaxin to my penis. I'm not sure if one should avoid the Neuro Vascular Bundle or something. Even though i regularly inject PGE-1 and apply DMSO to my penis.

Would be interested to see how this works, just won't do it on myself.
Injury in April 2020. Onset of ED.
Started RestoreX and VED 2 months after injury.
Taking 10mg daily cialis, pentox, coq10, vit-e.
Traction (+1 inch)/VED/PGE-1/DMSO+X

pey ron

how about injecting the pube, close to the penis? the stuff is powerful.
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LuisFernandez

Not for me. I'd need to see other people try it and at least not have issues before i try it myself.
Injury in April 2020. Onset of ED.
Started RestoreX and VED 2 months after injury.
Taking 10mg daily cialis, pentox, coq10, vit-e.
Traction (+1 inch)/VED/PGE-1/DMSO+X

Gregd

Quote from: LuisFernandez on February 14, 2021, 08:37:09 PM
So,

According to the patent there's 3 different ways to apply relaxin to your penis:

"Relaxin can be administered at a dosage of 0.02 to 10 micrograms/kg body weight/day by intracavernosal injection.
Relaxin might be for topical administration at a dosage of 25 to 400 micrograms/kg body weight/day.
The relaxin might be for administration at a dosage of 0.02 to 1 micrograms/kg body weight/day by injection into the dense connective tissue surrounding the erectile tissue of the penis."

I'm not sure that topical administration would be much help. I'm also not sure if you could mix it with DMSO, I'm not sure what relaxin's molecular weight is.

I'm not brave enough to inject relaxin to my penis. I'm not sure if one should avoid the Neuro Vascular Bundle or something. Even though i regularly inject PGE-1 and apply DMSO to my penis.

Would be interested to see how this works, just won't do it on myself.

Have you heard of a place where it can be purchased as a topical cream?
58 yrs old
1st symptoms started after 2 years of using trimix
Developed scar tissue after injections.
Tried most things in the alternative section.
Have ED that somewhat responds to Cialis
Transplanted 6/2/21, Dr. Jonathan Clavell, 24cm Titan