Peyronie’s disease: is it genetic or not?

[Paolo]

This below article doesn't tell us much new, it is however an interesting read, if you have the time;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108984/

What is seems to indicate that it is (mostly) a Caucasian disease, happens (mostly) in older Men.

Guess with Peyronie's we can't truly identify the cause so to speak and that it is a hugely complicated issue because one guys Peyronie's can be manifestly different from other guys  

It all seems to center around Myofibroblasts
Paul

[Whyisthishappening]

Comparison of apoptotic gene expression profiles between Peyronie's disease plaque and tunica albuginea
https://pubmed.ncbi.nlm.nih.gov/23356197/
"Similar expressions in Peyronie's plaque and tunica albuginea suggest that Peyronie's plaque is not a localized disease of tunica albuginea, rather it develops from the vulnerable regions of TA exposed to deleterious factor(s), trauma being the prominent one"