What does loss of heterozygosity mean in this paper?

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samsung

June 18, 2020, 03:56:11 PM
If I understand correctly are they saying anyone with peyronie's is becoming some sort of genetic mutant? If so, I didn't need to know this.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

pey ron

#1
July 04, 2020, 08:01:49 PM
which paper???
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TonySa

#2
July 05, 2020, 03:02:16 PM
Many conditions have a genetic predisposition w environmental factors.
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

samsung

#3
July 05, 2020, 06:37:49 PM
Sorry. I had a link when I originally posted this. Must have not copied it here by mistake. I can't find it now.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

projectpd

#4
July 06, 2020, 06:10:12 PM
yeah, it would probably be only suggesting that Peyronies Disease is predisposed by genetic faults , maybe inherited mostly but maybe not exclusively.
it comes from ideas about cancer , you originally lack, or acquire a lack of, a "backup" gene from the other parent so when the sole gene gets randomly damaged , chaos ensues.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

skunkworks

#5
July 06, 2020, 07:49:13 PM
Please find the study, otherwise this thread should really just be deleted.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

melting

#6
July 06, 2020, 08:01:07 PM
I think a very healthy person without genetic predisposition can get peyronies.  
Just have an injury to the penis and then bad blood flow oxygen etc. to it and voila..
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

samsung

#7
July 07, 2020, 05:52:13 AM
Skunk, I don't recall but it was probably this paper:

https://pubmed.ncbi.nlm.nih.gov/10953165/

And here is the definition of LOH:

"Loss of Heterozygosity. Loss of heterozygosity is defined as the loss of one parent's contribution to the cell and can be caused by deletion, gene conversion, mitotic recombination, or loss of a chromosome."
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

melting

#8
July 07, 2020, 07:21:49 AM
Unlikely but possible real for a low % of cases..
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

#9
July 07, 2020, 04:15:39 PM
they didn't say what the normal /control rates would be ( no control) which might have been of interest. Then again I believe it's no controversy that there is a genetic component.  The study seems kind of pointless.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

#10
July 07, 2020, 04:26:20 PM
Anyone with a considerable injury or trapped inflammation in the penis can get peyronies or peyronies symptoms rather easily.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

#11
July 07, 2020, 04:36:18 PM
have you got data on it. it might well be the case, not disputing.  the study is showing a link to genetics but not arguing against nongenetic causes.  should be part of sex ed if verifiable.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

#12
July 08, 2020, 07:27:22 AM
No, just based on logic. Any injury can result in faulty collagenous tissue(scars, fibroids). Everyone can develop scars.
Rarely injuries heal perfectly like before.
If you have a scar in your penis the chances are high you get peyronies symptoms. Faulty non elastic tissue in the penis means impaired erection.

Not saying there can't be a genetic predisposition.. Or co-factors like diabetes surely make it easier for any penis injury to heal badly.
I feel like sometimes we search for complicated reasons and miracle treatments while it's rather head on what's going on with Peyronies Disease..?
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)
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