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Welcome to J Francois Eid, MD - Directly answering member questions in the "Medical Professionals" section below the Treatment boards.
https://www.peyroniesforum.net/index.php/topic,17819.0.html

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Author Topic: Madorno  (Read 680 times)

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Madorno

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Madorno
« on: May 01, 2020, 06:39:01 AM »

Test
To all the carriers of Peyronie.
I would like to know the result of a manual test of all peyronie carriers to try to find a common symptom.
The test consists of tightening from light to lateral and the back of the testicles groping the epididymis to feel if there is any pain.
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samsung

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Re: Madorno
« Reply #1 on: May 01, 2020, 08:29:24 AM »

More info please.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Madorno

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Re: Madorno
« Reply #2 on: May 02, 2020, 12:04:21 PM »

 
Gently tighten the side and back of the testicles, feeling the spermatic cords to detect any pain, even if it is mild, to know if there is chronic inflammation.
If the answer is positive, I publish more reports.
All peyronie carriers including me applied drugs to the penis and never got results, only minor improvements. Now I think the origin is not in the penis. And my first hypothesis is chronic inflammation in the epididymis. That's why I asked other patients to take the test to see if there's any pain in the testicles.
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samsung

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Re: Madorno
« Reply #3 on: May 02, 2020, 02:55:56 PM »

How could inflammation in the epididymis cause curvature? Curvature is a mechanical problem due to plaque.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

melting

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Re: Madorno
« Reply #4 on: May 02, 2020, 07:52:01 PM »

It's possible your peyronies plaques are near the spermatic cords or structures attached to thems which then inflames them.   
They can sit in places where they create nerve pain that goes into the pelvic floor.

Taking oral drugs is for many not working in solving the problem cause the drugs don't reach the site of the plaque in the amount necessary to do enough. (nonetheless they can help mitigate)
At best you would "bath" the plaques in an antagonistic solution to dissolve them. That's not possible. The easiest non medicinal(doctor) way to get near that, I found is transdermals via DMSO. Injecting xiaflex by a doctor is a nother way to do similar.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Madorno

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Re: Madorno
« Reply #5 on: May 14, 2020, 07:19:45 AM »

Fibrosis, a chronic stage of many diseases that affects millions of people of all racial and ages groups, is characterized by excessive deposition of extracellular matrix (ECM) and then leads to tissue structural damage and organ dysfunction (Zhang and Friedman, 2012; Krenkel and Tacke, 2017). Fibrosis is the end stage of chronic inflammatory responses caused by a variety of stimuli factors including chemical insults, autoimmune reactions, radiation, tissue injury, allergic responses, and persistent infections (Wynn, 2007). Fibrosis is the process that non-physiological scar formation which plays a crucial role in the destruction of the liver, kidney, heart, lung, and other parenchymal organs. More and more studies have shown that the development of cancer has an important relationship with fibrosis diseases. For instance, most lung cancer cases are found in the lung periphery and lower lobes, and changes in lung fibrosis also occur mainly in these areas (Nagai et al., 1992; Aubry et al., 2002). In addition, 80–90% of hepatocellular carcinomas (HCCs) develop toward cirrhosis or liver fibrosis (El-Serag, 2011)...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391314/
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