0 Members and 1 Guest are viewing this topic.
QuoteSafety and efficacy of coenzyme Q(10) supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study.Private Practice of Urology and Andrology, Tehran, Iran.AbstractNo oral medication has proved to be clearly beneficial for Peyronie's disease (Peyronies Disease). We investigated the safety and efficacy of coenzyme Q(10) (CoQ(10)) supplementation in patients with early chronic Peyronies Disease. We conducted a randomized clinical trial of 186 patients with chronic early Peyronies Disease. Patients were randomly assigned to either 300 mg CoQ(10) daily (n=93) or similar regimen of placebo (n=93) for 24 weeks. Erectile function (EF), pain during erection, plaque volume, penile curvature and treatment satisfaction using patient versions of the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire were assessed at baseline and every 4 weeks during study period. EF was assessed using International Index of Erectile Function (IIEF-5), and pain was evaluated with a visual analog scale (VAS, 0-10). All patients also responded to a Global Assessment Question, 'Has the treatment you have been taking during this study improved your erections?' After 24 weeks, mean IIEF-5 score, mean VAS score and mean EDITS score improved significantly in patients receiving CoQ(10) (all P<0.01). Mean plaque size and mean penile curvature degree were decreased in the CoQ(10) group, whereas a slight increase was noted in the placebo group (both P=0.001). Mean index of IIEF-5 in 24-week treatment period was 17.8+/-2.7 in the CoQ(10) group and 8.8+/-1.5 in the placebo group (P=0.001). Of the patients in CoQ(10) group, 11 (13.6%) had disease progression vs 46 (56.1%) in placebo group (P=0.01). In patients with early chronic Peyronies Disease, CoQ(10) therapy leads plaque size and penile curvature reduction and improves EF.International Journal of Impotence Research advance online publication, 19 August 2010; doi:10.1038/ijir.2010.20.
Quote from: al-hikmah.orgSome evidence indicates that CoQ10 supplements may offer benefit for individuals taking medications that interfere with the body's production of CoQ10, or partially block its action. It has been suggested (but not proven) that these effects on CoQ10 may play a role in the known side effects of these treatments, and that taking CoQ10 supplements might help. The best evidence is for the cholesterol-lowering drugs in the statin family, such as lovastatin (Mevacor), simvastatin (Zocor), and pravastatin (Pravachol). For several other categories of drugs, the evidence that they interfere with CoQ10 is provocative but less than solid. These include oral diabetes drugs (especially glyburide, phenformin, and tolazamide), beta-blockers (specifically propranolol, metoprolol, and alprenolol), antipsychotic drugs in the phenothiazine family, tricyclic antidepressants, methyldopa, hydrochlorothiazide, clonidine, and hydralazine.
Quote from: slowandsteady on September 09, 2010, 04:20:05 PMHere are the 200 mg ubiquinol offerings at iherb. namecostquantitycost per capsule Healthy Origins, Ubiquinol, 200 mg, 150 Softgels126.851500.85 Healthy Origins, Ubiquinol, 200 mg, 60 Softgels52.85600.88 Now Foods, Ubiquinol, Extra Strengtd, 200 mg, 60 Softgels57.36600.96 Jarrow Formulas, QH-absorb, 200 mg, 30 Softgels34.97301.17 Bluebonnet Nutrition, Ubiquinol, 200 mg, 60 Softgels71.96601.20Yeah, a bit pricey. Cheap though, if it works. s&s
Quote from: George999 on September 09, 2010, 09:11:11 PMMost, if not all, Ubiquinol is produced by ONE Japanese pharmaceutical company, Kaneka. See -> http://www.kanekaqh.com/ for more info including a list of vendors. The vendors repackage the Kaneka product, sometimes adding their own proprietary synergists. So when you pay extra, you are either paying for nothing or you are paying for additional ingredients included to enhance the Ubiquinol product.Kaneka is also the major producer of Ubiquinone. See -> http://www.kanekaq10.com/index.htm for more info.For the difference between Ubiquinol and the far less expensive Ubiquinone see -> http://www.lef.org/magazine/mag2007/jan2007_report_coq10_01.htm Note that younger guys might be wasting their money on Ubiquinol since younger bodies are still able to convert Ubiquinone to Ubiquinol very effectively. For those of us who are older however (over 40), Ubiquinol is really the only way to go. - George
Quote from: slowandsteady on September 10, 2010, 01:27:16 PMHealthy Origins has the cheapest 100 mg on iHerb too. All of the ubiquinol comes from the same source, as George wrote. I have started taking mine with d-limonene that I get separately.The Puritan's pride deal you mentioned comes out slightly ahead of the Heathy Origins on iHerb. If you in the iHerb VIP program though, you get an additional 10% off (12% for orders over $120, etc), tipping the scales to iHerb for me.
Quote from: George999 on September 18, 2010, 06:34:34 PMAnother source of Ubiquinol is here -> http://www.swansonvitamins.com/SWU377/ItemDetail?n=160
Quote from: slowandsteady on September 23, 2010, 09:16:41 AMGeorge, any thought that, for whatever reason, coenzyme Q10 might be more effective than ubiquinol? I haven't had much in the way of improvements after a week at 200 mg ubiquinol.
Quote from: George999 on September 09, 2010, 09:11:11 PMFor the difference between Ubiquinol and the far less expensive Ubiquinone see -> http://www.lef.org/magazine/mag2007/jan2007_report_coq10_01.htm Note that younger guys might be wasting their money on Ubiquinol since younger bodies are still able to convert Ubiquinone to Ubiquinol very effectively. For those of us who are older however (over 40), Ubiquinol is really the only way to go. - George
Quote from: newguy on September 24, 2010, 11:31:28 PMI started on Ubiquinone. hopefully due to my age (29) is will convert well, and as a result be useful/suitable. I've bought six months worth, so I will stick with it for that period of time, at which time I will draw a conclusion as to its effectiveness for me.
Quote from: GS on October 14, 2010, 09:56:36 AMFred,I have had MVP since I was a child and due to a lot of stress in my life, my condition got progressively worse about 6 years ago. It was so bad that I had to have open heart surgery to correct it. Since the surgery, everything has been fine with my mitral valve.I was taking CoQ10 before the surgery and have been taking it since without any complications.My suggestion would be to have your MVP checked out again by your cardiologist. It may have worsened over time and you may now be a candidate for a valve job. If so, they are now doing the repair roboticly and you may not have to have your chest opened up.Better safe than sorry.GS