MWPC003 update and absurd question for forum

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samsung

This is for mediwound product in case anyone is wondering. I asked this guy many months ago if he had any updates. Just heard back. Sort of depressing, but expected.

Here is the whole exchange:

No updates, low priority program for the company as it focuses on its more urgent and later-stage NexoBrid and EscharEx programs.

On Jan 14, 2020

Hello Mr. Feffer. Please see below. If you have any updates, please let me know.

Best,

-------- Original message --------

From: "Jeremy Feffer (LifeSci Advisors)"

Date: 9/13/19

Subject: Re: MWPC003 updates?

Sorry for the delay in response. As the company has mentioned before, this program is still pre-clinical, but there should be updates next year.

On Sep 1, 2019

Hello,

Are there any updates about MWPC003? Please check out peyroniesforum.net. I would include links to where mediwound products are discussed but you don't know me, so I'm sure would not want to click on links in an email.

At any rate, many, many men are awaiting news of when any clinical trials might be taking place. Thanks in advance for any updates.

My question to the forum is this, and please excuse the absurdity of it.

Why not hire a hacker to breach their servers, steal the chemical formula and inject myself with it?

I realize this is illegal, but I am honestly asking everyone here. The chemical does exist. I know people who could do this. I have a fairly decent amount of money. I doubt it would cost more than 50K. I doubt I would get caught (other than the evidence I just posted).😁

And by no means am I saying I am going to do this. In fact, I absolutely would not. But it could be done.

Other than prison, can someone give me a reason why I should wait possibly 20 years for a research chemical to go through trials? Or never even get there.

Asking honestly. Why? Like I said, I realize the absurd nature of this question. But I am asking honestly. We are all desperate. There is no good reason to wait.

I know this post is stupid and immature. I am sort of just asking what you all think about this and about clinical trials in general.

There are probably 100 fibrosis research chemicals that exist right now and I would inject all of them into my dick because that is better than nothing. Who are they to hold them from us?
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

samsung

Hopefully everyone knows not to take my post too seriously. I was sharing an update on mediwound (they aren't going to do anything for a good long while or probably anything at all-bottom line being peyronie's is not a priority for them. He went further in a subsequent email) and just venting frustration.  
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

melting

Yeah waiting for a headline that reads:
"Man forces lab assistant to inject obscure drug into his bent penis" :D

I read Trump wants to lower the requirements to go through these endless phases or was it only for people on the brink of death for cancer drugs etc.?
I have another chronic condition that I contacted docs in the US for years and I stopped doing that. Too frustrating, sometimes they are close then the whole company is bought, funding shifted, everything is delayed indefinitely. But hey at least something is happening. Nothing is happening in the EU lol
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Hawk

I have no clue what Mediwound is.  I never even heard of it.  Which means this entire topic makes no sense to a majority of readers.
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
Hawk - Updated 10/27/18 - Peyronies Society Forums

samsung

There are a few threads on MWPC003. Here is one:

https://www.peyroniesforum.net/index.php/topic,9699.msg91836.html#msg91836

And again, I apologize for the stupid parts of this post. Merely trying to bring attention to the fact that a representative of the company emailed me back to basically say that they are not going to do anything with this drug for the foreseeable future.  
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Whyisthishappening

thank you samsung
do not apologize for anything
you did your best
i was looking forward to hear from them what a pitty we are so unlucky
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

samsung

Not a big deal imo. Drugs are not the future anyway. Doesn't matter. This would have just been another band aid, like xiaflex. They will never cure anything with drugs. It is tissue engineering/stem cells/crispr, etc. In about 50 years, you'll be fine. In the meantime God can continue to feast off our tears to run his machine.  
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

hope794

Thank you for the update, samsung. Well done.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Jack1909

Already got to the conclusion that i will not have an usable penis in my lifetime. Funny thing a real improver for us all is already here as autologous graft is nothing compared to what he have been hearing recently. But it's all about market logics and curing is not good for medicine.
31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe ED after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Jack1909

Thus, never understood why no one investigated cadaveric tissue. Nowadays a tissue bank is feasible, my uncle had a rib transplanted and he had to take anti suppressants for just a month or something.  
31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe ED after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Boar

Why not create a petition on the site and email them telling them your interested in the drug until we get thier attention. Or if they arent going to bother using the drug getting them to sell it to another Research and developement Company. Question: is this a publically traded company?
2, 5+ year old peyronie cords, one on each side
20-15 degree curve
Hourglassing under the old cords
New, third cord forming at base with pain Feburary 2020

samsung

Because that would take time and I am lazy :)

Don't know if public company or not.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

hope794

@Hawk,
what can we do to make MWPC003's clinical trials begin faster? Any idea guys?
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Boar

What I just mentioned, Ill be emailing and calling both companies and others should do the same
2, 5+ year old peyronie cords, one on each side
20-15 degree curve
Hourglassing under the old cords
New, third cord forming at base with pain Feburary 2020

Crooked_Stick

MWPC003 is essentially medical grade bromelain derived from the stems of pineapples. It can break down certain connective tissues like fibrous plaques without harming surrounding tissue and blood vessels. Bromelain has been used for years as a meat tenderizer. The problem with the do it yourself approach is that even if you could get the drug you wouldn't know the proper concentration to use. All of Mediwounds products contain the same active ingredient.  
Born 1960, Diagnosed 2013
Initial 40 degree bend, 1" loss, Xiaflex 3 rds of 2 injections
Current 25 degree bend, no palpable plaque, 1/4" loss
VED 5-6 days/week, traction daily,
TRT 20 ml twice weekly, Cialas 3 mg - No ED - Doing Well!

CrookedJohnson

I was watching a movie called "The fountain" with Hugh jackman where he cures dieases with experiemntal compounds, sort of life the tony stark of medicine. It is clear that this therapy shows promise, but obviously the company isnt focused on this drug at the moment, The active compounds are relatively easy to get (bromelain) , The best course of action would be to get ahold of Bromelain and inject it into rats with peyroines (similar to early trials of xiaflex), until we get a concentration that can break down the plaque. It is my understanding that this treatment is far less agressive than xiaflex (which is basically gangrene). So injecting this into a human penis after successful trials in rats seems relatively safe. Since the company isnt willing to do this, I think it is feasable to Tony Stark this thing. I dont think it would take that much money to accomplish, just alot of time and dedication and trial and error but lightspeed compared to waiting for a biotech to come out with a solution(other than xiaflex)
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melting

In the meantime, supplement Bromelain ? Some of it might reach the plaque.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

CrookedJohnson

They injected this stuff into Drutopyans cords ex vivo and achieved cord rupture, Bromelain has ~40% bioavialability when ingested orally

The body can absorb significant amount of bromelain; about 12 gm/day of bromelain can be consumed without any major side effects [13]. Bromelain is absorbed from the gastrointestinal tract in a functionally intact form; approximately 40% of labeled bromelain is absorbed from intestine in high molecular form

Looks like you can take up to 12 grams per day without side effects, 12 grams cost is about $40 USD

I imagine you would have to take a massive amount for it to reach the target area, but might be crazy enough to work  
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CrookedJohnson

I purcahased a massive amount of Bromelain. I am taking 1 gram every hour throughout the day. Will see what 7 days and 12g per day can do.  
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hope794

Wow bro, nice try!!!! Please keep us updated..!!!!
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Paolo

Quote from: CrookedJohnson on June 05, 2020, 05:10:00 PM
I purchased a massive amount of Bromelain. I am taking 1 gram every hour throughout the day. Will see what 7 days and 12g per day can do.

It has been shown that a substantial portion of orally administered bromelain is absorbed intact into the bloodstream, thereby elevating the proteolytic and fibrinolytic activity of the blood for hours.

Might be best taking it out of say an eight hour eating 'window', interesting and good luck  :)
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

melting

That's smart, talking it often. And yes, as I understand it interacts with proteins so don't take it with meals?

Also, some food for thought.. I'm a firm believer that these compounds often work with other compounds that go with it naturally.
Like vitamin C comes with flavonoids etc. You might take some pineapple juice and possible pieces with it.  
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Paolo

It is actually the 'stem' or 'core' of a pineapple that contains the most Bromelain, therefore blending the whole pineapple will give a concentrated amount. Commercial pineapple juice might be a poor substitute for fresh due to the juice missing the core and pasteurization  ?

Combine Bromelain with Quercetin for extra potency
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

hope794

26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

CrookedJohnson

I attemtped to take 12 grams daily, on day 2 i noticed some rather explosive side effects, kept going and by day 3, i was running to the bathroom every 10 minutes. At 12g per day, the laxative side effects caused me to stop treatment. this one is still up in the air. I may try it again but i would have to stock up on charmin first
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hope794

Wohaaa, sorry to hear this :/ What about trying with 6g a day?
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Paolo

Titrate the dose until GI abates, better still get 'whole' pineapples and blitz, consume away from meals.
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

drew67