Red wine for Peyronie?

[peyroniesurprise]

I used to have a glass of red wine every now and then, sometimes before sex. I remember my erections were literally raging after that. I stopped drinking altogether a couple of years ago and 4 years later i got peyronies.

I picked up a glass of red wine the other days and i have to say that my erection improved and i got more feeling in my penis.

Since red wine is known to be a good vasodilator and known to help with sex and erections, wouldnt it be an ideal treatment? I glass every other day or so.

[NeoV]

I think any amount of alcohol is likely bad for Peyronie's, but that said, I have noticed this as well. Red wine has a lot of flavanoids besides the small amount of resveratrol. If I do drink, I tend to choose wine lately despite the small amount of carbs. Choose a "malbec" for the highest resveratrol and lower carbs.

Currently I take about 400mg a resveratrol a day and pine bark extract, so I can't really justify red wine in any way. But yes, some indulgent can be nice.

[peyroniesurprise]

I do think other types of alcohol are bad but red wine specifically, because of its composition, is more than an indulgence but rather a potentially potent cure.

I will be trying it for a month or two every 2-3 days and check back in with the results.

Carbs in red wine are completely negligible.

[NeoV]

I have compiled a large list of studies on resveratrol and penile health recently. I was saving it for a YouTube video, but here are just some of the studies. I started taking it after hearing all the hype from David Sinclair on aging and Ronda Patrick's video.

PLEASE BE AWARE that alcoholism is STRONGLY associated with Peyronie's disease and Dupuytren's. I think this may have to do with the liver and diabetes but I am not sure yet. Anyway, here are the studies, cheers!

NEW WARNING MARCH/2020: I have stopped taking resveratrol due to a few studies on it.

Studies

Tgf-beta and SIRT7
https://www.nature.com/articles/s41467-017-00396-9

EQ (rats)
2https://pubmed.ncbi.nlm.nih.gov/26755081-resveratrol-protects-and-restores-endothelium-dependent-relaxation-in-hypercholesterolemic-rabbit-corpus-cavernosum/?from_term=Resveratrol+erectile&from_sort=date&from_pos=8

EQ (rats)
3https://pubmed.ncbi.nlm.nih.gov/18277612-trans-resveratrol-relaxes-the-corpus-cavernosum-ex-vivo-and-enhances-testosterone-levels-and-sperm-quality-in-vivo/?from_term=Resveratrol+erectile&from_sort=date&from_page=2&from_pos=5

EQ (rats) "improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group."
4https://pubmed.ncbi.nlm.nih.gov/21269399-vardenafil-and-resveratrol-synergistically-enhance-the-nitric-oxidecyclic-guanosine-monophosphate-pathway-in-corpus-cavernosal-smooth-muscle-cells-and-its-therapeutic-potential-for-erectile-dysfunction-in-the-streptozotocin-induced-diabetic-rat-preliminary-findings/?from_term=Resveratrol+erectile&from_sort=date&from_page=2&from_pos=3

EQ (rats) The red wine compound resveratrol, but not quercetin, relaxes isolated mice CC concentration-dependently through mechanisms independent of the NO/sGC pathway. Resveratrol is a more potent antioxidant than quercetin, being able to restore decreased neuronal NO responses in mice CC.
5https://pubmed.ncbi.nlm.nih.gov/23792339-resveratrol-an-activator-of-sirt1-restores-erectile-function-in-streptozotocin-induced-diabetic-rats/?from_term=Resveratrol+erectile&from_sort=date&from_page=2&from_pos=2

Resveratrol improves diabetes-associated Erectile Dysfunction in rats. Combination therapies with resveratrol and sildenafil have a synergistic effect in improving Erectile Dysfunction. The mechanisms might be attributed to its anti-oxidative properties and NO-cGMP signaling pathway upregulation.
6https://pubmed.ncbi.nlm.nih.gov/26006044-resveratrol-and-sildenafil-synergistically-improve-diabetes-associated-erectile-dysfunction-in-streptozotocin-induced-diabetic-rats/?from_term=Resveratrol+erectile&from_sort=date&from_pos=10

These results demonstrate that RVT-induced relaxation is at least partly dependent on H2 S formation and acts independent of eNOS pathway. In phosphodiesterase 5 inhibitor (PDE-5i) nonresponder population, combination therapy with RVT may reverse erectile dysfunction via stimulating endogenous H2 S formation.
7https://pubmed.ncbi.nlm.nih.gov/26437677-resveratrol-stimulates-hydrogen-sulfide-h2-s-formation-to-relax-murine-corpus-cavernosum/?from_term=Resveratrol+erectile&from_sort=date&from_pos=9

Resveratrol and quercetin protect mouse corpora cavernosa from diabetic-induced damage to NO-mediated relaxant responses. This might rely on their antioxidant capacity.
8https://pubmed.ncbi.nlm.nih.gov/26993793-protective-effect-of-resveratrol-and-quercetin-on-in-vitro-induced-diabetic-mouse-corpus-cavernosum/?from_term=Resveratrol+erectile&from_sort=date&from_pos=7

RVT improves sildenafil-induced relaxations of corpus cavernosum in both diabetic and non-diabetic aged rats probably by potentiating the activity of NOS, and this effect seems to be more manifest in diabetic aged group.

9https://pubmed.ncbi.nlm.nih.gov/26993793-protective-effect-of-resveratrol-and-quercetin-on-in-vitro-induced-diabetic-mouse-corpus-cavernosum/?from_term=Resveratrol+erectile&from_sort=date&from_pos=7

[peyroniesurprise]

Quality stuff mate, thanks

[NeoV]

I wanted to add here that I have stopped taking resveratrol due to possible issues with it causing a worsening in my neuropathy. I also found two studies showing that it could damage the body under certain circumstances (such as when already low carb and already healthy as apposed to on the SAD diet).  

[peyroniesurprise]

That worsening should be happening because of alcohol, not reservatrol