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Author Topic: Mofetil article  (Read 1202 times)

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samsung

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Mofetil article
« on: December 01, 2019, 01:14:02 PM »

Anyone have access to this that can tell us the upshot of the study?

https://www.nature.com/articles/s41443-019-0138-7
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

TonySa

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Re: Mofetil article
« Reply #1 on: December 01, 2019, 04:29:32 PM »


Abstract
The aim of the present study was to evaluate the histological, histochemical, and stereological changes caused by mycophenolate mofetil (MMF) on the tunica albuginea of rat penises submitted to an injection of transforming growth factor beta (TGF-β) for the induction of Peyronie’s disease (Peyronies Disease). Twenty adult male Wistar rats were divided into four groups: Control group; TGF-β group (TGF-β injection); MMF-7d group (treated with MMF 7 days after induction with TGF-β); and MMF-30d group (treated with MMF 30 days after induction with TGF-β). The steorological evaluation included the relative volume of different types of connective fibres of the tunica albuginea. The histochemical analysis revealed the fragmentation and degradation of elastin in the tunica albuginea. This process was partially reversed in the MMF-7d group and a situation very close to normality was observed in the MMF-30d group. In the collagen III/collagen I ratio it was observed increase in this ratio in the TGF-β (59.4 ± 5.53) and MMF-7d (49 ± 18.2) groups and a decrease in the MMF-30d group (28.7 ± 4), approaching normality. The injection of TGF-β promoted fibrotic alterations in the penile tunica albuginea in Wistar rats corresponding to Peyronies Disease. In this model, MMF acts as a regenerating anti-fibrotic agent.
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PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

samsung

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Re: Mofetil article
« Reply #2 on: December 01, 2019, 04:31:35 PM »

Thank you sir.

I'm going to ask my doc to compound something with mofetil and DMSO. I don't know if he'll do it or not. So I will report back if anything.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

drew67

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Re: Mofetil article
« Reply #3 on: March 22, 2020, 08:45:29 PM »

This seems promising assuming the injection method mitigates at least the most serious side effects of taking the drug by mouth
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samsung

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Re: Mofetil article
« Reply #4 on: March 22, 2020, 10:16:39 PM »

Just an update. My doc did not want to prescribe mofetil after a lot of back and forth. Not sure it will happen for the foreseeable future with all the covid19 stuff. May revisit like 6 months from now.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

drew67

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Re: Mofetil article
« Reply #5 on: March 24, 2020, 01:29:38 PM »

This would be a very interesting clinical trial.
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Fix This

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Re: Mofetil article
« Reply #6 on: March 24, 2020, 07:14:28 PM »

Yes it would

I'd like to hear more about this as and when
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!
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