Topical collagenase

[Werther]

Is this even a thing?

If it does exist, how much is it different form the injectable analogue (in terms of therapeutic and adverse events for those wondering).

If it doesn't exist were would be ways to get this componud developed for topical use?

What's anyone input on this subjcet? Would topical collagenase be better than the injected one? Should we pursue this option if it's currently stil off the market? Ultimately, if this was the case, who would we have to address with these inquiries? Auxiulium, Pfizer or any other legal enitity that might be the current owner of the patent as of today?

Chime in as much as you can.

Thanks.

[Godisreal]

I certainly have never heard of it. Perhaps you could explain further what you mean.
There are a lot of topical treatments, some are with DMSO mixed with other supplements.
But I've never heard about collagenase in topical form  

[Werther]

This product is used to help the healing of burns and skin ulcers. Collagenase is an enzyme. It works by helping to break up and remove dead skin and tissue (https://www.webmd.com/drugs/2/drug-9993/collagenase-clostridium-histolyticum-topical/details).

The brand name of the drug appears to be "Santyl".

Maybe, if mixed with DMSO, it could be able to reach the plaque and do the same job it does when it's injected while causing less side effects... I don't know if it's actually like this... Just wondering.

If anyone ever tried this or something similar, I would really appreciate whatever the feedback might be.

[Fix This]

Did anyone try Santyl or similar?...

[melting]

The molecular weight of collagenase is too high.
Not possible for the known transdermal methods to get it to peyronies plaques.  

[projectpd]

There is an animal study on collagenase ointment reducing hypertrophic scarring from wound healing. There is also a study that showed transfer of serrapeptase across rat skin is possible for niosomal formulations. serrapeptase is 53kDa, very high. You could have a go at niosomal formulations by using a sonic cleaner or sonicator probe, which are quite affordable now. I've bought one myself and going to use it for trying to make ethosomes.

However what I imagine is worse for the idea, is normal skin tissue and scar tissue are both composed of the same collagens, so, presumably, the collagenase should destroy normal skin and tissues on its way (however far it got) to the scar.   Even worse, here is a finding that something about the collagen structure in scar tissue is more resistant to collagenase than normal tissue: https://www.ncbi.nlm.nih.gov/pubmed/15982305.  Perhaps if there could be something that could concentrate it or activate it more specifically to the scar . eg focused light on it, but I have no idea about that . I'm sure one of the reasons why xiapex is advised only to be injected intralesionally.

[Bent Ding Dong]

I tried Santyl a few years ago and went through an entire tube of it and it did nothing at all. It has a petroleum based gel in it that wont penetrate the skin at all so it's basically useless for peyronie's.

I also tried serrapeptase topically on the penis, also does nothing besides irritating the skin and making it red. It's very sticky almost like glue when it dries on the penis and it's not pleasant at all.

[melting]

projectpd, healthy tissue can recover fast from such impacts while faulty has no impetus to "recover"... I guess..
I doubt collagenas will just erase your tissue.. nor does Xiaflex destroy any tissue as far as I know.

[projectpd]

hello melting, what i read was that collagenase does digest necrotic (which means dead) tissue more, compared to normal tissue. It is turned into gelatine basically. This would explain the benefit for wound healing. But unfortunately scar tissue is not necrotic, and may be even more resistant than normal tissue.  

[melting]

Maybe.. but maintaining healthy tissue is a prime interest of the body. It works on that all the time.
That's why (obviously much more intrusive!) some cancer medicines work. They destroy all tissue but healthy tissue has much better chances to survive/heal. But I doubt collagenase is plain destroying healthy tissue. Then people using it like in the xiaflex version would just wilt away their tissue.