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Author Topic: Xiaflex Made My Curvature Worse?  (Read 201 times)

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johndoe

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Xiaflex Made My Curvature Worse?
« on: November 08, 2019, 05:31:43 PM »

Hey fellas,

So I'm about 3 weeks out of my 1st round (2 shots) of xiaflex treatment with my 2nd round (shots 3 and 4) coming up in a couple of weeks and I'm not sure if I should continue with the treatment or not.

My first shot of xiaflex was nearly painless and hardly any swelling, bruising or pain persisted. My second shot however was a completely different story. Severe pain, swelling and bruising occurred after and I now had painful erections which I didn't have before.

The good news is that all of the above symptoms are going away and getting better everyday. The bad news is that I had my first real 100% erection today and I noticed that there seems to be "more" plaque than before as well as slightly more curvature.

I've read through as many threads I could find of members who've gone down this path and the consensus seems to be that results range from significant improvement of curvature or little to none. I haven't really heard of any members stating that the xiaflex actually me there case worse.

I'm set to see me doc in a couple of weeks and tell him everything and want to see what he says and what my next step should be.

Meanwhile I'm looking for any members on here who have had a similar experience.

Thanks,
JD
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TDix

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Re: Xiaflex Made My Curvature Worse?
« Reply #1 on: November 08, 2019, 06:33:59 PM »

After my third shot I fractured during a morning erection.  Wouldn’t wish that on anyone.  That was after two days of extreme pain and large hematomas.
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46 yrs old, 3 yrs diagnosed, 3 shots of Xiaflex resulting in hematomas/burst dorsal vein or fracture at tip, excision/grafting surgery March 26th successfully performed by Dr Faysal Yafi, pelvic floor therapy with Laureen McVickers

samsung

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Re: Xiaflex Made My Curvature Worse?
« Reply #2 on: November 08, 2019, 09:11:11 PM »

Exactly and precisely similar to you johndoe. Except for the pain getting better part. Pain getting worse. And it does seem like I have more plaque now. Although I don't see how that is even possible it could form in a week. Curve doesn't seem worse, but pain amd plaque definitely.
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Torsion to left. flaccid. Xiaflex rd. 1 10/7 and 10/10. PMP traction, heat, VED, arginine, cialis, lipoic acid, vit. K2.

johndoe

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Re: Xiaflex Made My Curvature Worse?
« Reply #3 on: November 08, 2019, 09:23:35 PM »

@samsung I agree, I mean how can the plaque get worse?

So what should we do moving forward? Stay the course or and hope subsequent shots loosen up the plaque or should we cut our losses short here?

Veteran members feel free to chime in.
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shrugs

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Re: Xiaflex Made My Curvature Worse?
« Reply #4 on: November 09, 2019, 04:34:15 AM »

Okay, I'll try a plausible explanation... Maybe as the plaque breaks up, the first few shots affect it unevenly, so either a big plaque becomes more lopsided, or if the doc is targeting several plaques, they aren't all being reduced uniformly so that there are transitory periods where you'll be curving more to one side or another.

Over the course of eight injections, eventually that evens out and you straighten out as things improve.

Is that what's really happening?  I don't know.  I also don't know if I'm going on to round two myself because these shots are rough!

The first shot of round one gave me dramatic swelling and bruising and a bump (probably an internal hematoma) that's still around ten days later.

The second shot was much milder with the swelling/bruising but more painful and gave me a fever for the rest of the day.

These side effects are considerable. It's too early for me to tell how much improvement round one has gotten me but the best case would be enough that I don't see a need to continue.
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Early 40's. Peyronies and mild Erectile Dysfunction started during summer 2018. PDE's worked somewhat but it got worse. First round of Xiaflex Oct/Nov 2019... and ouch.

samsung

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Re: Xiaflex Made My Curvature Worse?
« Reply #5 on: November 09, 2019, 06:34:24 AM »

 My personal feeling is "phuck it." I am going forward. For me, this all heads toward an implant anyway so if more damage is done, good. It will speed up the process. And if not, good, then gains can be made. I don't care at this point. Well, I do, but totally powerless, so onward it is. Will call the doctor a few days before if still in pain and see what he thinks about proceeding. But if I can't do traction because of pain then xiaflex seems pointless.
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Torsion to left. flaccid. Xiaflex rd. 1 10/7 and 10/10. PMP traction, heat, VED, arginine, cialis, lipoic acid, vit. K2.

QuackAttack

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Re: Xiaflex Made My Curvature Worse?
« Reply #6 on: November 09, 2019, 08:26:41 AM »

John Doe,

I think I can offer as good a perspective as anybody on this forum considering I have likely had more needles stuck into my dick as anybody. Two full courses of Xiaflex (16 injections) and 12 rounds of Verapamil. With Xiaflex, your first round of each cycle is usually more mild than the second. Here is the best way to keep the swelling down. You will get wrapped with Coflex after the injection. Either ask your doctor for more Coflex and gauze or go to the drug store and get some. Keep your dick wrapped for 3-4 days. Not fun peeing with the gauze on, but it is amazing how much improvement there is in swelling. Moreover, it will help keep the morning wood down. After one of my cycles of Xiaflex I had an errection around 3am and though I heard a pop with some pain and was freaked out. This occurred before I learned of the gauze trick. I went back in a couple of days later for an ultrasound and there was no fracture. My URO, who was the Chief of Urology at Walter Reed, said Xiaflex will create micro tears, which is what they want. The micro tears is a sign of the plaque breaking up.  If you can use a Restorex concurrently with Xiaflex, I think your results will be better. The Restorex didn't come out until after my Xiaflex treatments were over. I used several extenders to little avail. I started around 60-70 degrees and am around 35-40 degrees now. It has always functioned and without pain. So, I don't know about the pain aspect, but if you are functional and pain-free you can chalk you dick up to a g-spot dildo because it will look pretty much like one.
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johndoe

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Re: Xiaflex Made My Curvature Worse?
« Reply #7 on: November 14, 2019, 02:20:05 AM »

Thanks @quackattack for chiming in. You truly are a road warrior with all the rounds of treatment you've received.

Thanks for the advice regarding the swelling. It's funny that you mention the coflex. I got the coflex wrap after my first injection but not after my second as the doctor (or his assistant) "forgot" to wrap it and nor did I. To say the least the swelling was intense!

I've had some raging hard-on's since my second injection with most of them being nocturnal. I did feel a lot of pain and a throbbing aching sensation on the entire left side of the penis (curved side) I've never felt before but the good news is that everyday it's getting better and better.

@quackattack, I hope you're right about the micro tears. I did hear my penis "crack" one day while I was modeling. The downside to that however is that I feel as if that xiaflex is possibly causing the plaque to get worse.

@samsung and I are having "similar" issues with painful erections post xiaflex and
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P47D

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Re: Xiaflex Made My Curvature Worse?
« Reply #8 on: Today at 03:11:45 AM »

YES!!!  In my case with the Xiaflex injections there was quite a bit of pain and it was not until the second round that I learned how to PROPERLY wrap my penis after the shots.  My Dr. was really good and he did do a light wrap with the coflex stretch tape on the first round, but it was a small piece and only right where the injection was placed.  With pretty bad swelling, hematoma, and ecchymosis in the first round and first shot of the second round I tried to wrap everything more securely and it worked GREAT!!!  Proper wrapping for me eliminated the post injection pain, prevented almost all of the swelling and hematoma, and there was only mild ecchymosis around the area of my circumcision scar and near the base of the shaft.  I have some very good pix that show this since I documented all my treatments extensively...however I'm still waiting for Hawk to give me picture posting privileges... :(

-P47D
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Trauma induced 74 degree vertical dorsal curve in OCT 1916 - after 3 years, success with plication.
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