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Author Topic: DMSO+X Revisited 2019  (Read 10962 times)

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pap

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Re: DMSO+X Revisited 2019
« Reply #50 on: November 20, 2019, 01:29:06 AM »

That’s great pap! And you only used the DMSO + Aloe Vera mix, if I understand it right?

No I didn't. I mix DMSO with Magnesium chloride and apply Castor oil afterwards to avoid drying.
Cialis in low dose (2.5mg) was also helpful to restore the blood circulation. Now I still have small lumps, but no problems.

There is not "the solution" to this sickness, I guess if someone comes with a simple treatment -> $$$
Be patient and gentle to your friend ;-)
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melting

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Re: DMSO+X Revisited 2019
« Reply #51 on: November 20, 2019, 04:32:44 PM »

I’ve ordered a DMSO + Aloe Vera mix that will arrive shortly... you were talking about the mix missing that extra  “punch”. What could you add into the mix, in order to add that extra punch? I’m starting experimenting as soon as I get it home. And should the DMSO + Aloe Vera mix be safe towards the skin? I think I’ve read about aloe Vera being very moisturizing.


My thought process is that the Aloe vera mix saturates the DMSO
This could mean anything else you add won't go transdermal as easily.
I wouldn't add anything extra to that but rather create another mix of DMSO+X.(you got several recomendations in this thread)

The DMSO+Aloe mix is probably the safest and skin friendliest DMSO mix you can buy.
I add Castor oil to my mixes cause it's great for the skin and mitigates possibly drying out from the DMSO(I wrote about castor oil on this thread prior)

As pap said, the DMSO alone can help and Aloe has some healty properties too.
I think other supplements like Ascorbic Acid etc.(I mentioned a lot prior) can give more "punch", as in more impact at the plaque site.

What I advocate for is to "flood" the Penis tissue at and around the plaque with supplements that are said to help with peyronies plaques, scar tissue,fibroids etc. 
The ways I described prior in this thread are in my opinion great to achieve that...

..I now have 6 different mixes that I apply at least 2 times a day.(sometimes all day every 30 minutes)
I circle them to "attack" the plaque from several "chemical angles". Mostly I focus with every application on one mix and use another with the next application(or day).
My skin is great(thx to castor oil in every mix) and the tissue feels very healthy and I "hang flushed".
The plaques are again feeling very soft. Soon I will start pumping, stretching etc. to stretch the tissue around it.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

melting

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Re: DMSO+X Revisited 2019
« Reply #52 on: November 20, 2019, 04:49:05 PM »

(DMSO+X) + Traction/VED/Tissue Modeling

I see big potential in combining both at the same time or in succession.

When using DMSO at the same time as traction or VED devices,.. you should be careful that the DMSO+X solution doesn't interact with plastics and metals while applied to your skin 

Using my VED I wrap the tissue lightly with a clean white cotton cloth over the area where I applied the DMSO+X to avodi any DMSO contact with the plastic of the VED.

The often observed softening of the plaque while using the DMSO+X is good but when you stretch the plaque, it can be a) easier stretched and b) the stretching could enable the DMSO+X to easier penetrate the plaque(for example microtears in the plaque).
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

dplookin

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Re: DMSO+X Revisited 2019
« Reply #53 on: November 21, 2019, 09:25:56 AM »

Godisreal..........I saw no change after using the DMSO with Aloe.  I have been working on trying to solve my problem for years and have gotten no where.  I have tried just about everything you can think of and nothing seems to help including Years of Traction and Years of VED, which I am still doing.  You can try the DMSO and Aloe, it may help you.  I lost 2 to 3 inches in length and have a 80 to 90 degree bend to the right.  Different things help Different People.  You need to give it a try.  I wish you Luck, and Sorry again for taking to long to get back to you.  Take Care, dplookin
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Godisreal

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Re: DMSO+X Revisited 2019
« Reply #54 on: November 21, 2019, 10:57:38 AM »

Thanks for all the input guys, really appreciate it.
I’m very sorry to hear about your situation dplookin.
When you say you lost inches, do you mean you lost inches because of the severe bend?
How else would you lose length?
Hope you find yourself curing soon man, we all should cure one day.
God bless you
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Youngster with Peyronie’s caused by repetitive micro trauma. Tried most things with little to no success, including Pentox.
Currently on Tadalafil (Cialis) and finally seeing improvements. Things are getting better.

melting

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Re: DMSO+X Revisited 2019
« Reply #55 on: November 22, 2019, 05:24:54 AM »

Please keep on topic DMSO + X to get good info collected.

DMSO+Aloe is great for the skin but I think the plaques need more active substances(as described prior) to soften and dissolve.
My guess is 1-2 times a day DMSO+Aloe won't do much to the plaque.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

TonySa

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Re: DMSO+X Revisited 2019
« Reply #56 on: November 24, 2019, 10:51:02 PM »

I agree, DMSO is only the carrier...need to add a therapeutic element.
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buzzin2

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Re: DMSO+X Revisited 2019
« Reply #57 on: November 30, 2019, 12:10:43 PM »

i dunno if i have some sort of injury or if i have pre peyronies, i went to the uro 3 times and they're annoyed with me and said nothings wrong.  im thinking of doing this dmso thing, would it be beneficial if im in acute stage?  i know it dissolves plaque but i dunno if it is beneficial if plaque hasn't formed.  at the same time i figure the dmso would penetrate and whatever else you add with the dmso would get right ot the tissue and heal.  so i figure this would also help for a general penis injury, what do you think?
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melting

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Re: DMSO+X Revisited 2019
« Reply #58 on: November 30, 2019, 03:58:03 PM »

Alright, several weeks in now and feeling great. Very flush, great hang, good circulation. Faulty tissue is very soft.
Clear difference to before applying DMSO+X but difficult to say if the faulty tissue is shrinking though.
I think the little bit of indentation I have is filling in better, especially days where I'm pumping.
Prepared to do this until it's fully dissolved. Surely will take some more months of daily application...
 

im thinking of doing this dmso thing, would it be beneficial if im in acute stage?

Sure, just focus on using anti-inflammatory supplements as X.

For example,.. DMSO + Iodine. DMSO + Vitamin E. There's more.. not my focus right now.. Just search for acute stage supplements and if you can use them with DMSO (compatible - molecular weight - I wrote about it prior page). You can list them here and I chime in.

You can't do much wrong in any stage by doing DMSO+Ascorbic acid(vitamin C). Hell, I would do it from time to time If I was healthy just to clear the tissue, arteries etc.

Read the first 1-2 pages on google about DMSO, this thread etc. to understand how to handle DMSO.
I wish I knew what I know now when I had the first Peyronies Disease symptoms.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

buzzin2

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Re: DMSO+X Revisited 2019
« Reply #59 on: November 30, 2019, 06:16:26 PM »

thats an awesome reply, thx

im reading that entire, long ass 10 page dmso thread from 2005.
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melting

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Re: DMSO+X Revisited 2019
« Reply #60 on: December 04, 2019, 07:07:35 PM »

All the talk about Aloe made me take some Aloe juice from the drugstore.   
I added the Aloe Vera juice to all the mixes. Just some drops. Can't hurt and it seems to improve the texture of the mix and feeling of skin after.   

I'm not sure about Aloe's impact in itself +DMSO. But there are several claims around that it helps with scars and fibrous tissue..
This is a nice compilation about Aloe:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/
A long list of healthy ingredients found in it.. many of them with low molecular weight.

Writing this I think it might be a good idea to have a DMSO+Aloe Vera mix in the circling of the various DMSO+X solutions. It certainly is great for the skin.
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melting

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Re: DMSO+X Revisited 2019
« Reply #61 on: December 04, 2019, 07:18:10 PM »

Shelf Life of the DMSO+X solutions..

DMSO + Vitamin C degrades rather fast for example. After 10-21 days the Vitamin C turns orange/yellow and into a "lesser biologically usable form".
Changing of smell is another indicator of degradation.
Observe changes and if in doubt just get rid of it and make a new batch.

What I do often is to add to my mixes fresh ingredients instead of making a new one. Takes some experience though.
Surely after some weeks any glass should be emptied, thoroughly cleaned and a new mix made.
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buzzin2

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Re: DMSO+X Revisited 2019
« Reply #62 on: December 04, 2019, 08:03:55 PM »

do you just order dmso on amazon?  any reliable brands?
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Godisreal

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Re: DMSO+X Revisited 2019
« Reply #63 on: December 05, 2019, 10:33:12 AM »

melting, is your plaque calcified? I seem to be the only one with a calcified thin scar, not a plaque.
I wonder if I will have the same success with DMSO anyway...
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Youngster with Peyronie’s caused by repetitive micro trauma. Tried most things with little to no success, including Pentox.
Currently on Tadalafil (Cialis) and finally seeing improvements. Things are getting better.

melting

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Re: DMSO+X Revisited 2019
« Reply #64 on: December 05, 2019, 06:31:35 PM »

do you just order dmso on amazon?  any reliable brands?

Several online shops in germany I ordered from over the years incl. amazon. Always satisfied..
I  read that jacoblab in the US is one of the best sources but so might be anyone with good reviews. Pharmacies or chemical supply stores might have good quality. Due diligence..

melting, is your plaque calcified? I seem to be the only one with a calcified thin scar, not a plaque.
I think it is calcified but softens after some days/weeks with DMSO.
It's a fibrous plaque that then gets en-capsuled and hard/calcified.
I think scar tissue can be positively impacted by DMSO+X too. I applied it to some smaller old scars on my legs and they soften too and then scab and turn more "fleshy"/pinker. You can try and observe... If you search Vitamin C + scars you'll find a lot on google and so might be other supplements.. ( search "X + scar tissue")
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buzzin2

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Re: DMSO+X Revisited 2019
« Reply #65 on: December 06, 2019, 02:00:49 PM »

i should get the 99%+  pure dmso right?
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melting

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Re: DMSO+X Revisited 2019
« Reply #66 on: December 08, 2019, 09:00:53 PM »

Right, 99,99% pharmaceutical grade DMSO
DMSO is a well researched product, used everyday in countless laboratories around the world.
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TonySa

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Re: DMSO+X Revisited 2019
« Reply #67 on: December 09, 2019, 04:28:44 PM »

Doesn’t one dilute DMSO for use?
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melting

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Re: DMSO+X Revisited 2019
« Reply #69 on: December 18, 2019, 12:24:58 PM »

One thing,.. if you use DMSO+Ascorbic Acid(Vitamin C) a lot then the skin might turn yellow/orange there.   
That's ascorbic acid trapped/accumulating in the skin layers "decaying". It goes away after some days not using Vitamin C.

I did now run through at least 1 batch of every mix but always have a big DMSO+Ascorbic Acid mix which I now run for a week straight 3-10 times a day and this visual gets apparent fast. Didn't happen when I cycled several mixes.

My tissue feels great. The hard sites feel now very soft but are still there. But the overall health of my penis is great. I'm having a very "flush" meaty hang all day everyday. Great blood circulation.
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melting

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Re: DMSO+X Revisited 2019
« Reply #70 on: December 30, 2019, 07:07:31 AM »

How to proceed after applying DMSO+X

It's recommended to let DMSO+X sit for at least 10 minutes. After 15 minutes most of the DMSO should be gone.
Depending on the "X" you wash it off, rub in the remains or apply an oil or a(healthy/bio) lotion over it. Ascorbic acid/vitamin C for example will stain clothes yellow/orange.
If I'm just around at home I will let it sit and wear some white cotton underwear that I don't worry about.
Just apply common sense. Don't wear heavily colored toxic underwear after applying DMSO ;)

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samsung

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Re: DMSO+X Revisited 2019
« Reply #71 on: December 30, 2019, 08:31:42 AM »

After the 15 minutes of letting it sit and then washing off, can you put on heavily colored underwear then?
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

melting

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Re: DMSO+X Revisited 2019
« Reply #72 on: January 03, 2020, 06:03:54 PM »

Yes, if there's no DMSO on your skin interacting with the underwear, nothing should happen.
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desmondthethird

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Re: DMSO+X Revisited 2019
« Reply #73 on: January 05, 2020, 11:36:17 AM »

Irishpeyroniecure, what else does your “cure” contain of?
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melting

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Re: DMSO+X Revisited 2019
« Reply #74 on: January 05, 2020, 12:35:19 PM »

Please don't clutter this thread with posts that have no value to others or add to the context of this thread, irish.
This is not a chat were you post several posts in succession. Please also don't answer to this post in this thread either.
(If a mod reads this please delete above posts and this one)
desmond, if you check his profile https://www.peyroniesforum.net/index.php?action=profile;u=22162 he has made some posts detailing his cure. It's in no relation to this thread though.
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samsung

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Re: DMSO+X Revisited 2019
« Reply #75 on: January 05, 2020, 01:31:46 PM »

This Irish guy has also called everyone here losers and said a transexual member is better off dead. Great guy. I'm sure all the rest of his posts are extremely worthy of being read by rational humans. He advocates marijuana and steroids too. Awesome.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

TonySa

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Re: DMSO+X Revisited 2019
« Reply #76 on: January 05, 2020, 08:19:02 PM »

I agree Sam, and when he said those things I requested he STOP!
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Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Hawk

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Re: DMSO+X Revisited 2019
« Reply #77 on: January 06, 2020, 12:28:35 AM »

Pfff...I have the only solution. Infrared and a few other gems

How absurd for someone to claim they have the only answers.  My experience with Peyronies Disease and life, in general, is that the more loudly a person proclaims they have the answer, the more ignorant they appear when you take a closer look.
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melting

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Re: DMSO+X Revisited 2019
« Reply #78 on: January 06, 2020, 05:28:16 AM »

Oh cool derailment of another thread so people have to wade through empty useless posts. The scourge of most forums on the internet.
Anyways..

DMSO + PENTOX

I got my hand on some Pentox from a relative. I crushed it, added some water and used the mixer.
There will be some left over materials which is most probably the filler from the tablet. I looked them up and they're harmless.(again: test every solution you make first on your arm with some drops) One could probably filter them out but that needs some research to make sure the pentox doesn't get filtered too. If you don't filter them they will remain on the skin if their molecular weight is high.

Molecular weight of Pentox: 278.31 g/mol
This means it's perfect for transdermal delivery with DMSO.

Pentox has various impacts on Peyronies Disease, it enables red blood cells to be more flexible which means they can get into places they couldn't before(scars, fibroids?). That is a rather systemic mechanism which can be easily created by oral medication but it also has effects that can work right in place..
It inhibits the formation of inflammatory agents.
For people out of the active phase it has still a function like inhibiting TGF-beta which is part of scar tissue and fibroids.
Quote
Pentoxifylline increases fibroblast collagenases and decreases the production of collagen, fibronectin and glycosaminoglycan.
It basically aids the production of healthy collagen and messes with the faulty collagenous fibroid structures of peyronies plaques.

I did use the same protocols to create an easy to apply solution like you can read about on the previous pages. 
Considering the amounts possible to apply transdermaly I don't worry much about dosage. I managed to dissolve about 8 tablets in a vial that would take me around 2 weeks to go through with 3 times a day applications. (now still be aware of how much Pentox you put into a given mix)



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goodluck

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Re: DMSO+X Revisited 2019
« Reply #79 on: January 08, 2020, 11:22:41 AM »

Can anyone comment on what DMSO's shelf life would be.?    I have a bottle that is about 7 years old.  It does not say on the label.  It does say if cloudy do not use.  It is not cloudy.  It looks and smells normal to me.  Just wondering if it loses something over time.  Thanks.
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melting

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Re: DMSO+X Revisited 2019
« Reply #80 on: January 09, 2020, 11:00:45 AM »

Depending on how it was stored about 2-5 years. If it's in the original storage container dark and cool it might still be good.. I wouldn't use it if it was some sort of premix and not the pure dmso.
I don't know how DMSO breaks down but DMSO will freeze/solidify in the refrigerator above 0°c / 32°F. If it doesn't do that anymore I'm sure it lost it's properties. I couldn't find a definite answer through several google links. DMSO is cheap. So if you have a good source, you might buy a new bottle.
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john.doe.550

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Re: DMSO+X Revisited 2019
« Reply #81 on: January 10, 2020, 02:16:30 AM »

There is a ton of info in this posted topic, with DMSO central to the conversation in terms of a carrying agent.  DMSO is an organosulphur compound (Dimethyl sulfoxide). Its formula is  (CH₃)₂SO.  That's carbon, hydrogen, sulphur, and oxygen. I'm emphasizing this due to the sulphur in this compound.

I'm allergic to sulphur and, especially, sulfa drugs. Sulfa prescriptions mess me up big time.  About 25 years ago, I used DMSO to transport a very high quality powdered vitamin mixture through my skin.  After 2 or 3 days, I had allergic reactions to the sulfur in the DMSO.  The primary symptom was pounding headache.  A secondary symptom was flushed or reddened face.  I stopped using DMSO and re-tried it again in 2 weeks.  Same symptoms were experienced.  I didn't use it again.

I share the information contained in this post to alert others they may experience similar symptoms.  Fortunately, not many people are allergic to sulfa drugs. But, if you are allergic to sulfa drugs and/or feel poorly using DMSO, then you are not alone.
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Age: 61;  Peyronies Disease diagnoses: MAR 2019;  Onset: Immediate & severe;  Treatment: Xiaflex, APR 2019 to present, slowly improving w/ much more to go

AlterEgo

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Re: DMSO+X Revisited 2019
« Reply #82 on: January 10, 2020, 04:17:57 AM »

Is it ok to use dmso + absorbic acid while on a dry fast and water fast?
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #83 on: January 10, 2020, 02:09:50 PM »

Hi,
looking for dmso on amazon us  , there was a dmso cream said for Dupuytren's syndrom what do you think about it?
thanks
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melting

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Re: DMSO+X Revisited 2019
« Reply #84 on: January 10, 2020, 04:01:39 PM »

Is it ok to use dmso + absorbic acid while on a dry fast and water fast?
I see no reason why not but I have no experience with "fasts".
dmso cream said for Dupuytren's syndrom
I don't know what cream you are talking about(you can send me the link via pm, don't post here). It's a similar disease so it might work.
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #85 on: January 10, 2020, 04:34:12 PM »

".I don't know what cream you are talking about(you can send me the link via pm, don't post here). It's a similar disease so it might work.
pm sent ;)
us amazon website +"health and beauty"  search  for "Dupuytren's"
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #86 on: January 13, 2020, 09:45:35 AM »

Hhi,
i found an interesting protocole on  vitamine wiki , about Dupuytren's and Mg,D3, Dmso , Boron , Aloe vera
not sure i am allowed to post url links but it's not a commercial one , have a look seems to be relevant about that topic
copy the whole link in your browser because clicking on it not going to the right page , perhaps beacause of the "+" symbols at its end


https://vitamindwiki.com/Dupuytren’s+Contracture+%28bent+finger%29+treated+by+Boron+and+DMSO+-+2016

https://vitamindwiki.com/tiki-index.php?page_id=7967 is the same page
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melting

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Re: DMSO+X Revisited 2019
« Reply #87 on: January 13, 2020, 02:16:44 PM »

Great find! D3 and MG I talked about earlier. Interesting is that they together with Boron seem to have synergistic effects.
Always interested in combining several supplements. I'm running 5 different glasses of DMSO+X right now.

Reading the article on your link it's clear how much more effective transdermal is. Person had no reaction to oral Boron initially.

BORON:
Molecular Weight: 10.81 g/mol
That is very low! Could get a lot of it through the dermal layers via DMSO..
But I'm unsure about it's solubility and toxicity especially in combination. Then again it seems to be readily used in some preparations.

Quote
Under normal circumstances boron does not react with water. However, for boron compounds may be the case. Boron salts are generally well water soluble. Boric acid has a water solubility of 57 g/L, borax of 25.2 g/L, and boron trioxide of 22 g/L. Boron trifluoride is the least water soluble boron compound, with a water solubility of 2.4 g/L.
Obviously mixed with MG it might change the solubility.

Quote
General: There is no Recommended Daily Allowance (RDA) for boron since an essential biological role for it has not been identified. The Tolerable Upper Intake Level (UL), the maximum dose at which no harmful effects would be expected, is 17 mg per day for adolescents

From your link:
Quote
Boric/Boric Acid (10 mg dailyseems to work),

Quote
It has been shown that boric acid has well-defined biological effects such as stimulation of wound healing in vivo, release of growth factors and cytokines, and increase of the extracellular matrice turn-over
https://link.springer.com/article/10.1385/BTER:85:1:23
A lot of impact on fibrosis talked in several studies. Also impact on collagen formation and angiogenesis. Both crucial in peyronies.

I will buy some boron and check how it reacts in my DMSO+X mix and then combine it with D3 and magnesium. Instead of aloe I'm using mostly Castor oil.
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #88 on: January 13, 2020, 03:03:36 PM »

Great find! D3 and MG I talked about earlier. Interesting is that they together with Boron seem to have synergistic effects.
Always interested in combining several supplements. I'm running 5 different glasses of DMSO+X right now.

Reading the article on your link it's clear how much more effective transdermal is. Person had no reaction to oral Boron initially.

BORON:
Molecular Weight: 10.81 g/mol
That is very low! Could get a lot of it through the dermal layers via DMSO..
But I'm unsure about it's solubility and toxicity especially in combination. Then again it seems to be readily used in some preparations.
Obviously mixed with MG it might change the solubility.
thank you another interesting link below  where it's said :

"The doctors of PDI and DCI wanted to use a DMSO product that contained several synergistic products that could be helpful for DC.    They soon learned that the discoverer of DMSO, Stanley Jacobs, MD, has been using a special formula of DMSO, vitamin E, methyl salicylate and urea for his own patients with great success.  To make it easy and economical to apply, he made the formula into a gel formulation.  Dr. Jacobs called his special DMSO formula DUSA-SAL Gel.  When used twice daily it can be effective, and when combined in a larger therapy plan such as described by DCI the results can be just that much better.  This particular product, Dusa-Sal Gel, was selected for use by DCI because of the encouraging reports and research behind each therapy. Our opinion is that this combination is a good way to get as much additional therapy into the local area of the lesion area as possible. We think you will not find a more effective, pure and safe DMSO product than Dusa-Sal Gel anywhere."
where is also a link to that famous dmso preparation

Dupuytren Contacture and DMSO - Dupuytren Contracture Institute

BORON:
Molecular Weight: 10.81 g/mol
That is very low! Could get a lot of it through the dermal layers via DMSO..
But I'm unsure about it's solubility and toxicity especially in combination. Then again it seems to be readily used in some preparations.
Obviously mixed with MG it might change the solubility.
From your link: https://link.springer.com/article/10.1385/BTER:85:1:23
A lot of impact on fibrosis talked in several studies. Also impact on collagen formation and angiogenesis. Both crucial in peyronies.
I will buy some boron and check how it reacts in my DMSO+X mix and then combine it with D3 and magnesium. Instead of aloe I'm using mostly Castor oil.
for the boron dosage he said :"Update Nov 13, 2016
Well now, that did not work!
Hand ached all of Nov 12.
Suspect that there was less Boron in the DMSO slurry due to having the MgCl
I have switched back to Boron + DMSO. No pain again
I have also purchased 1 lb of Boric Acid crystals from Amazon
Realized that I had been applying approximately 1 milligram of topical Boron at a time
Going to make my own Boric acid solution and see what happens when I apply 3 or so mg at a time."
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aquintance22

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Re: DMSO+X Revisited 2019
« Reply #89 on: January 13, 2020, 03:35:45 PM »

Anyone has tried DMSO + Serrapeptase or other enzymes or would it be not absorbable or only working in the intestines?
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melting

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Re: DMSO+X Revisited 2019
« Reply #90 on: January 13, 2020, 04:55:46 PM »

Serrapeptase

Molecular Weight‎: ‎345.9 g/mol
Should work. For some reason I made a post years ago declaring it has too high of a weight. Turns out Nattokinase, similar enzyme, is around 600g/mol which is rather big.

https://www.ncbi.nlm.nih.gov/pubmed/20582192
Quote
Serratiopeptidase, an enzyme derived from Serratia marcescences strain E-15 (ATCC 21074), present in the gut wall of the silk worm possesses anti-inflammatory properties, and can prove to be a suitable alternative to commonly used non steroidal antiinflammatory agents. Being sensitive to gastric degradation, serratiopeptidase is conventionally given orally in the form of enteric coated tablet formulations. Topical formulations of serratiopeptidase would be useful to treat local inflammations and may prove to be more effective compared to non steroidal antiinflammatory agents.

Quote
Solubility
Soluble in water forming a clear solution practically insoluble in alcohol and in solvent ether

I read it's quiet ineffective orally taken but there's some studies, especially asian, were it's proven to have an effect on fibrosis and scars.
So yes, another one to try with DMSO
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melting

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Re: DMSO+X Revisited 2019
« Reply #91 on: January 13, 2020, 05:15:00 PM »

Suspect that there was less Boron in the DMSO slurry due to having the MgCl
I have switched back to Boron + DMSO. No pain again
Yeah, to make sure the ingredients actually work I opted to use just 1 in every DMSO+X formulation and cycle them daily or with each application.
Of course quiet a hassle to have 10 brown glasses standing around and replacing them when they run out.
Dr. Jacobs called his special DMSO formula DUSA-SAL Gel.
They still sell that at jacobs labs.
https://jacoblab.com/!!!!!!!!!!!OrderDMSODusaSAL.html (remove-!)
Would be more convenient to apply DMSO+X formulations with a gel type carrier. Though I love to use castor oil(which is the carrier) as itself has many possible helpful agents in it and is great for the skin(but can smear clothes).
Methyl salicylate:
Molecular Weight‎: ‎152.15 g/mol
Quote
Methyl salicylate is used in high concentrations as a rubefacient and analgesic in deep heating liniments (such as Bengay) to treat joint and muscular pain. Randomised double blind trials report that evidence of its effectiveness is weak, but stronger for acute pain than chronic pain, and that effectiveness may be due entirely to counterirritation. However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID
Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Side effects depend on the specific drug but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease.
Not sure about that.

Urea:
Molecular Weight‎: ‎60.056 g/mol
There's lots of info about Urea helping with scars. Often used in cremes etc. so certainly could be a great addition.
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melting

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Re: DMSO+X Revisited 2019
« Reply #92 on: January 13, 2020, 05:25:28 PM »

Btw. regarding MOLECULAR WEIGHT.

It's proven that Insulin can't be used with DMSO to go transdermal. Insulin has a Molecular Weight‎ of: ‎5808 g/mol
Hard to say at what exact molecular weight the cut off point is but it seems to be below 1000 g/mol and I assume the higher the weight the less is transported transdermaly.
Ascorbic Acid with 176,12 g/mol is perfect and I can literally feel it going inside. Heck my penis sometimes gets yellow patches from the vitamin C pooling through the deeper skin layers. Saying that it especially pools for some reason in nails, so take care if you want to avoid the look, but nothing dangerous about it. Some days off and the body takes it all up.
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #93 on: January 14, 2020, 10:11:32 AM »

pm sent ;)
us amazon website +"health and beauty"  search  for "Dupuytren's"
i had been in contact with the customers service (via their website) for they cream and they kindly reply "We actually experimented with DMSO but it was to harsh of a solvent and we found aufficient absorption using natural ingredients.  "   so for Dupuytren's , but they said Peyronies Disease and Dupuytren's are quite similar
and they would be interested by any feedback ,
they are delivering only for usa residents 


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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #94 on: January 14, 2020, 10:18:44 AM »

I found that interesting study with Geranium essential oil (the Bourbon one) Perargonium Asperum

Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil:
https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-2-1
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melting

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Re: DMSO+X Revisited 2019
« Reply #95 on: January 14, 2020, 04:07:44 PM »

I found that interesting study with Geranium essential oil (the Bourbon one) Perargonium Asperum
Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil:
https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-2-1
Sounds like an interesting option for fresh penis injuries or early stage of peyronies.
Geranium essential oil
Molecular Weight:   154.25 g/mol

Quote
Essential oils are soluble in alcohol, ether, and fixed oils, but
Quote
only slightly soluble in water
.

So you would up the oil parts in such DMSO+Geranium essential oil mix. I would still add some water to react with the DMSO to get rid of the heat reaction.

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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #96 on: January 14, 2020, 04:47:30 PM »

Another interesting link :
Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc :
" Notes by Henry Lahore, founder of VitaminDWiki
I have successfully using low concentration DMSO in an aloe vera gel on my skin to get Magnesium and Boron into my body
Dupuytren’s Contracture (bent finger) treated by Boron and DMSO - 2016
  (alreay shared by myself)

The Dupuytren's becomes bothersome several times a year and goes away each time after 2 treatments
Magnesium Chloride water/oil added to DMSO cream treats sore muscles in about 10 minutes


239 products on Amazon for Transdermal Magnesium as of April 2019
The only one I tried caused my skin to rash after about a month, so I gave it up and made my own
I needed more than Vitamin D to treat my knee osteoarthritis Magnesium and Low Level Laser Therapy
In April 2019 I got a painful shoulder which I assumed was Calcium deposits, similar to my wife's which were diagnosed by MRI
I found a reference on the web to the use of an acid (Ascorbic Acid) to disolve Calcium

After just a few days my shoulder pain appears to have gone away

Calcium deposits melted by Ascorbic Acid and DMSO – 2010
He believes that that the slight acidification of the region under the skin disolved the Calcium deposits

The author describes exactly what he did to get his shoulder pain to go away
Interesting to note - after a few months his pain came back, and quickly went away after re-application of the mixture

Note: Suspect that my Vitamin K (Super K LEF) did not keep Calcium from accumulating in my soft tissues
Hard bones, soft arteries, rather than vice versa (Vitamin D and Vitamin K) – March 2016
Another person switched from Super K to another supplier and was able to remove Calcium which had bulit up in his artiries while taking Super K. I need to investigate (May 2019) "


https://vitamindwiki.com/tiki-index.php?page_id=10721

sources from : "The 500 Dalton Rule of Dermal Penetration and Cosmetic Science March 2017"
https://realizebeauty.wordpress.com/2017/03/27/cosmetic-science/
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melting

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Re: DMSO+X Revisited 2019
« Reply #97 on: January 14, 2020, 06:31:57 PM »

Yes all good links and supplements. 
I think I listed them all already in this thread(Reservatrol has not much use in peyronies).
Used DMSO+Vitamin K2-MK7 just today.

The basic and best in any case is Ascorbic Acid. Can't do much wrong with it and it has several impacts on plaques, tissue and the healthy formation of collagen.
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sinvanio13

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Re: DMSO+X Revisited 2019
« Reply #98 on: January 15, 2020, 06:45:19 AM »

Yes all good links and supplements. 
I think I listed them all already in this thread(Reservatrol has not much use in peyronies).
Used DMSO+Vitamin K2-MK7 just today.

The basic and best in any case is Ascorbic Acid. Can't do much wrong with it and it has several impacts on plaques, tissue and the healthy formation of collagen.
thanks for your "scientific" work and experimentations , of course for your sharings ;)
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melting

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Re: DMSO+X Revisited 2019
« Reply #99 on: January 15, 2020, 02:05:13 PM »

No worries, I love people chiming in, adding info. Any thread at some point will get double info etc. 
I hope some more people try it and we can learn and optimize this and then boil the info down in a new thread.

I'm now almost 2months in and my penis feels great, the plaques are soft and I imagine they're slowly getting smaller. I'm 100% sure that if I had never stopped applying DMSO+X years ago I would've no plaques or faulty tissue at all long ago.
No adverse effects at all and I did run aroun 10 different mixes since November. Anyone reading this thread and some links on google should be able to do it.
But I'm sure it can get easier, as in nailing down the exact amounts of the ingredients and finding the right X-supplements for different cases and stages of peyronies.
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