DMSO+X Revisited 2019

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MacMathuna

Since not a lot of people with Peyronies Disease are complaining about loss of sensation, I'm figuring that I may have some nerve damage in my penis.

I've skimmed some studies suggesting that DMSO on its own may be helpful in peripheral nerve regeneration.
I'm just wondering about DMSO+ mixes for peripheral nerve regeneration.

Wonder how any of this would mix with DMSO:
Hyaluronic acid, Tacrolimus, Cyclosporin A, Melatonin, Methylprednisolone, Vitamin B12, Riluzole, 4‐Aminopyridine, Verapamil.

27 yr/o
Symptoms presented August 20, 2019
Slight bend to the left and down
downward hinging
distal hourglassing
loss of sensation

melting

Sonigel:
QuoteUV purified water, triethanolamine, carbomer, edta disodium, propelyne glycol, diazolidinyl urea, iodopropynyl butylcarbamate  
(https://www.trtllc.com/store/p10/Sonigel_5_Liter_Jug_.html#/)

Mostly it seems compounds with a rather small molecular weight, if I understand correctly, which could mean they get into skin with dmso. That said also most of them seem fine but with dmso I don't know.

Sure would be nice to have a gel like dmso application. I'm sure some more research one could find how to make a dmso gel.. Need a pharmacist on board ;)
If someone tries, do it on the arm with low amounts...

Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

melting

Quote from: MacMathuna on July 01, 2020, 10:21:06 AM
Wonder how any of this would mix with DMSO:
Hyaluronic acid, Tacrolimus, Cyclosporin A, Melatonin, Methylprednisolone, Vitamin B12, Riluzole, 4‐Aminopyridine, Verapamil.

You need to know the molecular weight. (not more than ~1000 g/mol)
You need to know the solubility. Water or oil... (and then you either need to mix it with water or oil, before mixing it with dmso+water)

for example vitamin b12 with 1356.4 g/mol might be too much... Also obviously be aware of side effects toxicity etc. I think that Melatonin can have a lot of side effects.

But yeah surely might make sense to add into the peyronies regime if nerve problems are part of it, in whatever form.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

hope794

Hyaluronic Acid seems to be lacking in Peyronies Disease's patient: a study found that in the patients with Peyronies Disease, there is nearly 0% HA inside the harmed tunica albuginea. But i think that its molecular weight it's too big.

NEWS: I began since 4 days the DMSO+X experiment. I've started with DMSO+Vit C, just like melting suggested. I'm applying about 1mL each time, 3 times per day. After 10 minutes, i wash away the DMSO from the penis.

In the next days i'll give my penis to the science: i'll try a dangerous experiment. I've found some KETORALAC vials, and i will mix them with DMSO. Ketoralac is a REALLY POWERFUL antinflammatory and anti-pain drug. Doctors prescribe it after a surgery, to bear with the pain. It is really powerful and dangerous, if you inject vials, you can't use it more than 5 days, since it can cause systemic issues to the body. But the molecular weight is about 300 g/mol, so i will transport via DMSO.

I'll update.

P.S. = What about a DMSO+X Telegram group? So we can chat daily about the experiments.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

MacMathuna

Quote from: hope794 on July 02, 2020, 08:14:00 AM
Hyaluronic Acid seems to be lacking in Peyronies Disease's patient: a study found that in the patients with Peyronies Disease, there is nearly 0% HA inside the harmed tunica albuginea. But i think that its molecular weight it's too big.


Yes, the Molecular weight is too high. I'm unsure about hyaluronic acid. It's supposed to prevent collagen loss, which... I'm wondering if that would keep peyronie's plaque from reducing.

But, there are studies of HA injections being somewhat helpful with peyronie's disease. And it's sometimes used to fade scars, so that has to be good, right?  I don't understand how collagen works guh.  
27 yr/o
Symptoms presented August 20, 2019
Slight bend to the left and down
downward hinging
distal hourglassing
loss of sensation

melting

edit: Mac, 846.8 g/mol might still be ok.. but yeah it's towards the higher ceiling .. idk for sure..

Quote from: hope794 on July 02, 2020, 08:14:00 AM
Hyaluronic Acid seems to be lacking in Peyronies Disease's patient: a study found that in the patients with Peyronies Disease, there is nearly 0% HA inside the harmed tunica albuginea. But i think that its molecular weight it's too big.

846.8 g/mol could be good to go!
Insulin for example is impossible: 5808 g/mol
Ascorbic acid: 176,12 g/mol (one of the lowest weights from our supplements)

Interesting point.. You can post links or copy paste raw stuff it into this thread if you find something that might help..
I personally am not as motivated right now to dig very deep. I like to work with what I know about this topic right now.
I hope someone takes this whole topic further soon.

Search for "X+ scars" "X+fibrosis" one can find a lot of info that (possibly)can be 'translated' to peyronies. Cause penis specific stuff is rare.
hyaluronic acid sounds very good and is often in cremes and lotions too.

QuoteStudies show that hyaluronic acid works well as an anti-aging dermal filler. It also works very well as a treatment for acne scars. In a 2013 study, researchers found that patients with acne scars experienced an "immediate visual improvement" after getting hyaluronic acid injections.


QuoteIn the next days i'll give my penis to the science: i'll try a dangerous experiment. I've found some KETORALAC vials, and i will mix them with DMSO. Ketoralac is a REALLY POWERFUL antinflammatory and anti-pain drug. Doctors prescribe it after a surgery, to bear with the pain. It is really powerful and dangerous, if you inject vials, you can't use it more than 5 days, since it can cause systemic issues to the body. But the molecular weight is about 300 g/mol, so i will transport via DMSO.

I'll update.

Honestly that sounds awful! Has a lot of side effects. But if you know the risks and sideffects you can obviously do what you want..

Just note that peyronies mitigation is in most cases a marathon and steady wins that. If Ketoralac doesn't work with one application then you might need many more which will increase the side effect %.
Most of what we do here is still kind of bro science winging it.(that's why I hope a pharmacist joins us..)

Still interesting.. lol
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

Quote from: melting on June 19, 2020, 06:01:51 PM

This was a valuable thread but with a lot of confusion and talking ideas. It needs to be consolidated boiled down

I agree. Im starting to get lost in all these other ideas. Im listening to that DMSO book now and it is good. Im trying to hunt down the posts you have of your exact steps and ingredients so I can try. I believe DMSO, iodine and C should be most effective. just need to know the ins and outs like why not to have the solution touch metal and plastic etc. I feel almost overwhelmed by all these other suggestions.
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

Holistic

Hey guys,

I would recommend getting a copy of DMSO: Natures healer, that Melting came across. I'm listening to it now and it is really informative and demystifying for this compound.

I just came across a part in the book that claims DMSO 50-80% applied 2-3 times a day will help get rid of keloids. It was a general statement. But I'm about 2 hrs in out of 11hrs of the total book and I'm really liking it.

It discusses also how DMSO works by acting like water going through the skin and the blood brain barrier for other conditions etc. It discusses its molecular weight(which is beyond my grasp. I just look for functional application).

Worth checking it out
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

Holistic

Sixteen of DMSO's advantages and wide ranges in use against organic disease:

1 - Blocks pain by interrupting C-fibers
2 - anti-inflammatory
3 - bact/fung/viralstatic
4 - transports pharmaceuticals across membranes
5 - reduces platelet thrombi in blood vessels
6 - inhibits calcium to reduce workload of the heart
7 - acts as a tranq when rubbed into the skin
8 - enhances anti-fungel and anti bacterial agents when combined.
9 - Vasodilator
10 - inhibits release of coleresterase (sp)
11 - softens collagen by a cross linking effect
12 - scavenges hydroxel free radicals
13 - stimulates various types of immunity
14 - diuretic
15 - brings out interferon
16 - stimulates healing in wounds

Listed from, DMSO: Natures healer book
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

Holistic

Quote from: melting on July 01, 2020, 03:54:39 PM

Sure would be nice to have a gel like dmso application.
If someone tries, do it on the arm with low amounts...

This one is a gel with 70/30 of DMSO/distilled water.

https://www.amazon.com/DMSO-70-Gel-Unfragranced-Ounce/dp/B0014AU8MK -

This one is non-diluted pharmaceutical grade.

https://www.amazon.com/DMSO-99-995-Diluted-Dimethyl-Sulfoxide/dp/B01L2FQAPU/ref=pd_lpo_121_t_2/130-6945731-8422050?_encoding=UTF8&pd_rd_i=B01L2FQAPU&pd_rd_r=e526f452-f0ff-44ff-a9de-d64de7faba8c&pd_rd_w=VHBPX&pd_rd_wg=1CyAY&pf_rd_p=7b36d496-f366-4631-94d3-61b87b52511b&pf_rd_r=SXZJFXQC4QRV22FWKF2X&psc=1&refRID=SXZJFXQC4QRV22FWKF2X

Would this be more of what youre talking about? Also, if the product is labeled as 70/30 already. At 99%, would the product still need to be cut with distilled water? And is the product distribution of 70/30 the same as what youre talking about with your solution by cutting DMSO with water when you do it yourself? If the company does the water cutting, I would think that would take out half the work...or do you think it is not as effective or doesnt even matter? Im asking bc i wouldnt know how to measure a 70/30 ratio with no standard measurements with pure DMSO and distilled water.
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

melting

Quote from: Holistic on July 02, 2020, 10:23:32 PM
I believe DMSO, iodine and C should be most effective. just need to know the ins and outs like why not to have the solution touch metal and plastic etc. I feel almost overwhelmed by all these other suggestions.
I suggest to start with 1 and get used to it and then add other mixes. The basic (Water+DMSO)+(Water+Ascorbic acid) is easy and cheap (of course read the instructions and risk mentioned. you can search top right corner this thread with "ascorbic")
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

Quote from: melting on November 13, 2019, 08:14:11 PM

-2 Brown glasses with a glass eye dropper(pharmacy) or another cap that isn't made of harmful plastics(https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/d2650pis.pdf read - compatibility )

Just to be clear, when you say brown glasses, do you mean like this: https://www.amazon.com/Boston-Complimentary-Perfume-Calibrated-Dropper/dp/B073VD1421/ref=sr_1_46?dchild=1&keywords=4oz%2Bamber%2Bglass%2Bbottle%2Bwith%2Bglass%2Bdropper&qid=1594000112&sr=8-46&th=1

Also, I read the sigma sheet about the compatibility and incompatibility. I honestly have no clue how one would find if the plastic cap is harmful or not lol. I posted a question to the manufacturer... All those words are foreign to me except PVC.

Do you have a weblink or name brand of the glass bottle you used specifically? That would help since this method seems to require exact sterility and precision for handling. Otherwise id just by a big glass and mix it in. but since youre saying theres potentional issues with plastic...that changes things.

When you say mixer...all i can picture is the blender my mom uses to bake. so Im unsure what you mean. do you have an example of a mixer you are referring to? like a metalic mixer someone uses to froth milk for espressos or something more specific?

I apologize for my needing to clear up wording, I just want to make sure im on the same page.

32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

melting

Yes, pharmacy type brown bottle. I bought mine in pharmacy's around town. Never had an issue.
Btw. plastics that react immediately with DMSO they will get "cloudy" or change color rather fast.

I use a similar mixer: https://static.mueller.de/5540139056-PV-0/pdmain/bosch-stabmixer-set-msm6b150.jpg
"Stabmixer" in german. I never let it get in contact with dmso only to premix the "X" and water/oil and emulsifiers etc.

I warn to use any plastic or metal but in reality some plastic is no issue with dmso.
It's just that someone will use some very poisonous plastics with DMSO and blame me lol

For example: https://en.wikipedia.org/wiki/Polypropylene is compatible with dmso.. "PP"
This dropper is "PP": https://www.berlinpackaging.com/20-400-black-pp-plastic-graduated-dropper-cap-with-glass-pipette-x775grad/
I think most in pharmaceutical grade stuff is that kind cause other chemicals will react with the PVC type non-compatible too.
So I probably would not use some crap from China...

DMSO is often delivered in HDPE plastic bottles.

from the Link:

QuoteThe compatibility of DMSO with various materials is listed below: • Compatible:  LDPE, HDPE, polypropylene, PPCO (polypropylene copolymer), polymethylpentene, nylon, teflon FEP •  
Moderately compatible:  polystyrene, ECTFE/ETFE •  
Incompatible:  polysulfone, flexible and rigid PVC tubing, polycarbonate
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

Fantastic. I'll look more into it after work. Yeah I know what you mean about people not taking responsibility, I encounter it every day with some people. I'm just looking to get as concise as possible to get started. I'm pretty pumped to try it. I finally got C to dissolve so I've been applying C water and iodine on my shaft for now. Not sure if that is doing much but it's better than nothing while taking supps.
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

theone45

I've just started trying to use DMSO and am trying to get my own mix going.

Right now I'm just using Vitamin E, 70% DMSO, Aloe Vera Gel, and MSM.

Bought a liquid CoQ10 to add to the mix.

I don't see see anything in the ingredient list that I should be wary of, but wanted to check.

The mix consists of water; matrixyl 3000, ubiquinone, glycerin, hyaluronic acid, vitamin e, aloe barbadensis, benzylalcohol DHA.

I was trying to get a mix with as few chemicals as possible to limit side effects, and applying ubiquinone directly to the scar with dmso seems like a better idea than the oral version.
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melting

Quote from: theone45 on July 07, 2020, 01:04:28 PM
The mix consists of water; matrixyl 3000, ubiquinone, glycerin, hyaluronic acid, vitamin e, aloe barbadensis, benzylalcohol DHA.

I was trying to get a mix with as few chemicals as possible to limit side effects, and applying ubiquinone directly to the scar with dmso seems like a better idea than the oral version.

Sounds fine on first look...
Ubi has Molar weight: 863.34 g/mol which is probably good for trans-dermal delivery.
I think using oral and transdermal can be effective.., maybe at different times, watching out for how much you take altogether.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

@theone45 interesting ingredients list. I will look them up.  How did you discover them? I would say watch out for vit E. it has a history of neutral or even negative results in studies after its discovery. check out my posts or Barrie Tan.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

Holistic

Quote from: melting on July 06, 2020, 07:57:56 PM
Yes, pharmacy type brown bottle. I bought mine in pharmacy's around town.




For example: https://en.wikipedia.org/wiki/Polypropylene is compatible with dmso.. "PP"
This dropper is "PP": https://www.berlinpackaging.com/20-400-black-pp-plastic-graduated-dropper-cap-with-glass-pipette-x775grad/

And your pharmacy had 200ml bottles around? Lol I'll check mine around town. 7 oz is huge. I may have to order from a packaging place like you did. And your dropper was separate, correct? Bc it looks like I'll have to order a7-8 oz bottle with a PP cap and buy a dropper separately. I feel like I'm on a treasure hunt lol
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

melting

We lack a lot of stuff in germany but chemicals, vitamins and such glasses including glass eye droppers etc. are all easily available in pharmacy and Ascorbic Acid is sold in the grocery store.
The pharmacy can basically order anything and it's there the next day. (costs a lot more than buying online though)

Shouldn't be a problem in the US to find what you need though, getting delivered.. one search on google..
A much bigger problem for other countries in the EU or South America where it's sometimes hard to find plain Vitamin C powder offline and online.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

melting

So how do we create a gel that is infused with DMSO and X?
A gel would be even better than what was tried in this thread.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

At some point when I get started in my process I can mix w the ultrasound gel and see how that holds. The two brands we carry seem to be safe but I'll look more into specific ingredients.

Also, when you finish a bottle. In between replenishing your mixes...how do you go about cleaning things out, just regular soap and water or any specific cleaning solution?
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

melting

I always flush it in the end with water to clean any chemicals..
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

So you dont use any soap or anything, just rinse out with plain water? Even the glass dropper?


I feel my questions are taking away from the main purpose of the thread but I dont know where the appropriate thread would be to ask.
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

melting

You can use soap and then make sure no soap is on it before using dmso again.

Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

Holistic

ylang-ylang oil

Density 0.911 g/mL at 25 °C(lit.)

Use: enhances blood flow
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

DarrenBent

Apologies if this has been covered already - so much info here!

What are people's experiences/researches/thoughts on water soluble POTABA powder instead of (or in addition to) Vitamin C in the DMSO solution?

I'm currently taking 12g a day orally so have crap tons of the stuff.

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hope794

UPDATE: I am using DMSO 70% + a little bit of water (for the heat reaction) and castor  oil. Furthermore, i've added 150mg Diclofenac (In italy, the name is "Voltaren fiale -75mg/3mL).

What can i say? It's a good anti-inflammatory, and i can advice it to cope with inflammation sensation and pain.

I apply 1 mL of DMSO + Diclofenac, 2 times a day
and 1mL of DMSO + Vit. C, 1 times a day.

Nevertheless, i'm starting to think that melting had success because he said he applied DMSO+X like 3-20 times a day, let's say an average of 8-9 times per day. It's a lot!
Scaring as it seem, i'm starting to think that this guy had success because of this. 3 times a day look like more a "mantaining" rather than an "aggressive attack cure". You know what i mean?

The crap thing is that it takes about 15mins for DMSO to be absorbed. Multiply it for 8 times a day it's 2 long hours in the bathroom. WTF. Not everyone got so much time to do so everyday if you work or need some privacy :( . It will be an issue to do that. I'll raise to 6 times a day.

However, my next program will be:

DMSO 60% + Diclofenac (225mg) , 3 times a day
DMSO 60% + Verapamil (20mg) (In Italy, the name is "Isoptin fiale") 2 times a day
DMSO 80% + ALCAR until total diluition, 1 time a day

I'll update..  What do you think about it? May it work? Please notice that i downregulated the % of DMSO since these molecules have <300 g/mol weight.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

TonySa

Hope, if you're following melting protocol he also included traction and VED.  Combination treatments show better progress than single modalities.  Since you have less strong erections than before, I'd also consider adding low dose nightly cialis (2.5-5mg).  It helps with erections and remodeling plaque to healthy tissue.
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

melting

Quote from: woodstorm on July 12, 2020, 04:10:13 PM
What are people's experiences/researches/thoughts on water soluble POTABA powder instead of (or in addition to) Vitamin C in the DMSO solution?

I used it for some time, just Paba(almost same as potaba), along with other mixes. I didn't mix it with other supplements.
You can search the thread top right which gives this: ;)
https://www.peyroniesforum.net/index.php/topic,12587.msg115772/topicseen.html#msg115772
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

melting

Quote from: hope794 on July 12, 2020, 06:53:53 PM

Nevertheless, i'm starting to think that melting had success because he said he applied DMSO+X like 3-20 times a day, let's say an average of 8-9 times per day. It's a lot!
Scaring as it seem, i'm starting to think that this guy had success because of this. 3 times a day look like more a "mantaining" rather than an "aggressive attack cure". You know what i mean?

The crap thing is that it takes about 15mins for DMSO to be absorbed. Multiply it for 8 times a day it's 2 long hours in the bathroom. WTF. Not everyone got so much time to do so everyday if you work or need some privacy :( . It will be an issue to do that. I'll raise to 6 times a day.


Most days I probably used it ~ 3-5x too.
But on some days, when I was home alone, watching TV or on the PC, I would just sit on a clean white towel and apply it all day long over and over.
Of course if you have to use everytime the bathroom then this can turn into a very cumbersome exercise.

The whole purpose of this dmso thread was to find a mix that you can apply without it dripping. As I had no big issues anymore I neither had the motivation to sit around with a wet drippy penis.
So when you use the DMSO+X + Emulsifier + oil then it will be easier as it's more like a creme/lotion..

The original "Thackers Formula"(you can search and find a lot about it) was a "wrap" around the penis which one could "carry around"(the penis). If done right possible under clothes too. Still rather messy.

I did the same with the traction and VED.. Mostly 1-4 hours a day but if I had time I used it up to 16 hours.
In any case, it will take time. I noticed improvements after a few weeks this way but big improvements only months in. (I know it was related to the protocol cause whenever I stopped for a few days it got worse again.)

If you feel like your tissue is inflamed then the diclofenac is proabably a good idea. I wish you good patience in this, it's a marathon not sprint!
The reason why I recommend daily(while taking care of the skin! If skin is bad you have to pause) is cause I could feel the plaques getting hard fast after stopping. Within days.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

TonySa

Just FYI diclofenac gel is absorbable on its own.
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

melting

Quote from: TonySa on July 13, 2020, 03:41:11 PM
diclofenac gel is absorbable on its own.

If kept on the skin for hours or applied very often.. ineffective to penetrate into the plaques especially when deep in the penis tissue.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771745/

In vitro..
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

melting

I never had any commercial interests in helping with peyronies and never will have.
Everything I know is available for free and was told in my posts(albeit often quiet long and hard to read I guess..), and the means I used were mostly cheap to buy.
My motivation was to help people who suffered from this after going through it for years myself.  

That feeling seeing my penis "destroyed", being diagnosed and not helped by the urologists in Germany(socialized government medicine sucks! DONT do it America!) was devastating and I will never forget it and creates empathy for anyone suffering of it.
Also many young people have huge problems with their pelvic floor which creates ED. (due to unhealthy masturbation habits and stress) which many who ask for help here(sometimes along with Peyronies Disease cause it makes Peyronies Disease worse and sometimes only PF problems) suffer from. I think I understand that problem quiet good by now.(relax, balance and strengthen the PF..)

After the first time depressed and hopeless I'm glad I found this forum and get help from a lot of people. Thanks to everyone making this possible(incl. the admins)
Being forced to not have access to most of what the Americans on this board have in means to combat Peyronies Disease I focused on DIY solving my peyronies and dedicate a lot of time to it and succeeded. Great that this was possible here, many other forums would never allow any alternatives discussed.
Sadly I think my time on this forum is coming to an end for various reasons. Right now I'm "watched". Seeing others being "muted" it might happen to me too soon. What I always loved with Americans was Free Speech being number 1. Ironically that seems to deteriorate! I can be reached through peyronies_eu @gmx.net (it could be this post gets deleted.. so please share the email with others). I have family to care for so it's possible it takes some days or weeks to answer. All that's necessary to get improvements with Peyronies Disease even if you're in a bad health system is in my posts.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

hope794

Absolutely OUTRAGEOUS! You did NOTHING, literally ZERO to get banned. This forum is getting delusional to me, even if i've always been in love with it. Why to watch melting? He's always been respectful and gave A LOT to this community.

Admins, please, can you kindly provide some further insight about this story?
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

TonySa

He isn't banned.  Individuals may be put on watch after having been given several warnings to stop personally attacking others...name calling, etc.  it would have been helpful he had explain why he's on watch.  Also, posts aren't deleted...perhaps occasionally edited for content...removing copying complete posts one is responding to, name calling, etc.  
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Whyisthishappening

can  MODS make public the REASON forum member MELTING is been WATCHED ?
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

RandyPE

One of the MANY things I tried for the first 2 years after I was diagnosed was DMSO and Iodine.

It's impossible to say what worked and what didn't, but 4 years after diagnosing my curve is imperceptible and only the hourglassing remains.

"Peyronie's disease occurs when the tissue along the shaft of the penis thickens, causing erections to become increasingly curved and even painful. Applying SSKI to the thickened tissue twice a day over several months can soften it considerably and eventually allow for more normal functioning." from https://www.icnr.com/articles/wondersofiodine.html

Also:

"Naturopathic Approach to Treatment
Because of the common delay in seeking treatment, patients with Peyronies Disease frequently present with a continuum of pathology which must be assessed in order to develop a treatment plan. Most of the cases I have seen are of the type I, and II variety. Other treatments for type III Peyronies Disease will need to address the underlying cause of the erectile dysfunction, even with successful resolution of the pathology caused by the Peyronie's disease.

The goal of treatment is to stop the underlying inflammatory process while also providing therapy that allows the damaged tissue to remodel. To accomplish this, I use the following protocol:

1 Vitamin E: 1000 IU/day
2 Vitamin C: 3000-5000 mg/day
3 CoQ10: 300 mg/day
4 L-Arginine: 1000 mg/day
5 A homeopathic combination remedy of Arnica 30C, Bellis perennis 30C, and Calendula 30C: 10 drops BID
6 Topical potassium iodide applied at bedtime to the lesion
7 Wet shorts treatment at bedtime to increase blood flow
8 Pulsed ultrasound 2 to 3 times per week, initially with potassium iodide and DMSO, for 10 minutes in order to break up the underlying plaques and fibrous tissue. Pulsed ultrasound must be used, as continuous ultrasound will cause a burn."

from: https://ndnr.com/mens-health/peyronies-disease-therapeutic-considerations/



It certainly didn't hurt, and again - who's to say if it helped or not.  

Randy
Peyronie's since 2017
Have tried: X4Labs Extender; Phallosan; Jelqing; Manual Massage & Stretches; VED Pump; DMSO + Iodine, Vit E; Ultrasound.
Curve gone from 90 degrees to 20.
Still have hour glassing, which I HATE
Open to new suggestions & ideas.

projectpd

you wore wet shorts at bedtime to increase blood flow?
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

RandyPE

Quote from: projectpd on July 16, 2020, 12:49:05 PM
you wore wet shorts at bedtime to increase blood flow?

LOL, I did not.  That was part of a longer quote from the page I cited.  (The quote starts with "Naturopathic Approach to Treatment" and goes through the end of my post.)

I did the iodine with DMSO and ultrasound, though.  Have also done the high dose Vit E, CoQ10 and the L-Arg, although I had done those before I saw that website.
Peyronie's since 2017
Have tried: X4Labs Extender; Phallosan; Jelqing; Manual Massage & Stretches; VED Pump; DMSO + Iodine, Vit E; Ultrasound.
Curve gone from 90 degrees to 20.
Still have hour glassing, which I HATE
Open to new suggestions & ideas.

DarrenBent

Just hopped on the DMSO bandwagon and started day 1 of treatment.

I've made two mixtures in two Amber glass dropper bottles:

1) DMSO + Vit C (and water and castor oil and lecithin)
2) DMSO + Potaba powder (and water and castor oil and lecithin)

The aim is to put Vit C one on in the morning for 15 mins followed by some VED and hand stretching, then same with the Potaba in the evening.

Investigating getting a Restorex too.

So far the mix (50% DMSO - 50% supplement and oil solution) seems fine and no burning or rash.
Mixture does look cloudy with a bit of a froth on top but I guess that's the oil and lecithin?

Sound about right to you, melting?
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Holistic

Awesome! Keep us posted.

I too am jumping on, but am waiting for the gel stuff from natures gift on amazon that is 70/30. will fuse the gel with iodine...try that and then do the mix youre doing. I have all the equipment.

doubt youll get melting on here anymore, he left his contact info but you can view his past comments on how he organized everything. youll probably be on your own from here as far as the experiment goes.
32 yo. Unknown cause. 1st plaque proximal left base near pelvis 9/19. Expanded and shrunk after 8 mo by 50% (still working on it). Minor bend but malleable. 2nd small plaque 5/20 superficial distal right just under tip. Currently growing. No bend.

Paolo

Does any member have experience using Urea cream 10-25% for getting topicals into the penis?
Cheers
Paul.
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

Bent Ding Dong

@Paolo, yes I have used urea but I make the solution up myself. Using urea on it's own is great for better erections as it's 50% nitrogen and it's also very cheap. I have recently been experimenting with vitamin C taurine and sod with urea and am thinking about starting a thread about this as a DMSO alternative which doesn't make you smell like DMSO does or wrinkle up or discolor the penis.

In short, yes it does penetrate the skin.
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

DarrenBent

Has anyone else noticed their DMSO+X solutions smelling weird. My DMSO + Potaba mix smells fine, DMSO + Vit C mix is much cloudier and has a real gone off vegetables smell.  
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TonySa

Bent, you use urea on the penis and it helps w erections?  I understand this is a "digester" type solution good for callouses and such, what does it do to the skin?  What % is the urea?
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

hope794

I've began to use urea AFTER DMSO and i've noticed way better erections. Does anyone know why?
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Bent Ding Dong

@TonySa, with urea, there is a delayed reaction for better erections, if I apply it before bed I always wake up with better erections than I would if I didn't have it. It can have a drying effect on the skin but I just add a few drops of MCT oil to the solution and that stops the drying effect. Other than this, I notice no other negative effects from it. As for the %, I try to get half as much urea as water so 50%.

@hope794, I assume the better erections from urea comes from the high nitrogen in the urea, the one I use is 50% nitrogen.

Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

hope794

How does the nitrogen improve erections? i've found no articles / studies about it.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Bent Ding Dong

@hope794, you wont find articles on it as we are probably only a small few who have tried it. I can only go off my own anecdotal experiments.

Nitrates increase blood flow to the penis. Drugs like Viagra do this also. Viagra or Cialis do work better and quicker for erections than urea but a 4kg bag of urea from the hardware store will last you a lifetime and only cost $10.
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

projectpd

interesting.  not doubting it, but urea is the main component in urine, right? and some oils have transdermal properties. I am curious why this would not work/ or been common knowledge since ancient times.
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%