Salvianolic Acids

[Whyisthishappening]

Salvianolic Acids: Potential Source of Natural Drugs for the Treatment of Fibrosis Disease and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391314/
In vitro anti-fibrotic activities of herbal compounds and herbs
https://academic.oup.com/ndt/article/24/10/3033/1817256
Effects of Danshensu and Salvianolic Acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on cell proliferation and collagen and melanin production.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271020/
Salvianolic acid B attenuates experimental skin fibrosis of systemic sclerosis
https://www.sciencedirect.com/science/article/pii/S0753332218376686

[hope794]

Nice find. Love your attitude.

[Whyisthishappening]

 Salvia miltiorrhiza enhances the survival of mesenchymal stem cells under ischemic conditions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099286/
The inhibitory effect in vitro of salvia miltiorrhiza and tetramethyl pyrazine on the growth of fibroblasts
https://www.ncbi.nlm.nih.gov/pubmed/10437081
Compound Astragalus and Salvia miltiorrhiza Extract Suppresses Rabbits' Hypertrophic Scar by Modulating the TGF/Smad Signal
https://www.ncbi.nlm.nih.gov/pubmed/25171116
Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
https://www.hindawi.com/journals/ecam/2019/6479136/
Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587316/
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833382/

[Whyisthishappening]

i have started today Salvia miltiorrhiza tea 5g per day

[melting]

Interesting!

The solubility of salvianolic acid B in ethanol is approximately 10 mg/ml and approximately 20 mg/ml in DMSO and DMF, respectively.
H2O/Water : ≥ 45 mg/mL
Molecular weight:   718.6 g/mol  

It's a candidate for transdermal application just from these data points.
It's indication for fibrosis might point especially to active peyronies phases or soft plaques.

[projectpd]

thanks.  have ordered a Dan Shen alcoholic tincture, going try to make an ethosomal version +DMSO for transdermal.

[jj21]

WhyISThisHappening - keep us updated. I'm interested in alternative medicines as well and I'm gna try everything and not give up!