Vactosertib_ ALK5 inhibitor

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Paolo

Vactosertib induced significant regression of fibrotic plaques in Peyronies Disease rats in vivo through reduced infiltration of inflammatory cells and reduced expression of phospho-Smad2

https://www.ncbi.nlm.nih.gov/pubmed/31496148

Paul.
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

hope794

26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Werther

This is curious: this exact paper was already submitted on a different journal almost one year ago (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186741/) and I know this because it was reported on this forum (https://www.peyroniesforum.net/index.php/topic,11598.0.html).

Is there any reason for this? Do medical researchers usually submit their same work for different journals or is this rare? If so, would this mean that they really believe that what they found could be really working (and they'd subsequently try to get as much coverage as possible) instead of being the umpteenth self-promtion act within their own community?

Bent Ding Dong

I'm happy to be a guinea pig to try this out, where to get some?
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

james1947

From Werther
QuoteDo medical researchers usually submit their same work for different journals or is this rare?
Not rare. Researchers, not just medical.
Quote...they really believe that what they found could be really working...
May be
Quote....self-promtion act within their own community?
May be also.

It will be interesting to know if they have done some progress after one year, the first publication from August, 2018

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

pey ron

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age, date of onset, symptoms, treatments tried,
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Whyisthishappening

i have supplemented with boswellia serrata for two months this summer together with reishi powder and su mu tea after that i had an MRI and showed NO FIBROSIS at all but my dents are still there .
alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee

hope794

Quote from: Whyisthishappening on September 28, 2019, 06:49:23 AM
i have supplemented with boswellia serrata for two months this summer together with reishi powder and su mu tea after that i had an MRI and showed NO FIBROSIS at all but my dents are still there .

LOL bro, how is this even possible? DENTS = FIBROSIS.

This fact says everything that must be said on doctors and their stupid diagnostical instruments.
26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Werther

Quote from: james1947 on September 28, 2019, 12:47:12 AM
It will be interesting to know if they have done some progress after one year, the first publication from August, 2018

I bet that more than one year has passed since they have been experimenting with this. If the first paper was published in 2018, I think that these guys might have been testing the drug for Peyronie's at least since 2017. This would mean that at least two years have passed.

@Bent Ding Dong: this drug is an antitumoral based on my understanding (https://www.cancer.gov/publications/dictionaries/cancer-drug/def/alk5-inhibitor-tew-7197). Keep us posted if you manage to find a complacent oncologist who's willing to prescribe you this.