Treatment with 50mg cyclophosphamide daily and 5mg dexamethasone twice weekly

Previous topic - Next topic

0 Members and 1 Guest are viewing this topic.

Michiganguy19

I am on my 3rd day starting this treatment. Below is a link to a single study showing this treatment resolved peyronies disease completely in 8 months. Only one study to go off of and the cyclophosphamide has extreme side effects including hair loss. I have nothing to lose at this point so I am giving it a shot and will keep you updated if this actually works at all. Cyclophosphamide has been shown to break down and stop scar tissue from forming in a few different diseases including pulmonary fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037975/
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Patientxyz1992

Man ill be folowing your updates ad if even remotely helps i will consider using it, i would care less abaout the hair, thank you very much! Btw there are so manny treatmants in development like peptides and stuff who promote angiogenesis etc that i dont know where to look for.....and why arent they on market...
29 years old with injury induced Peyronies Disease - 7 years ago
Straight erections but easy to lose and hard to fill with soft glans
No morning erections
been depressed but not anymore
The biggest problem with my Peyronies Disease is loss of sexual desire.

samsung

Please keep us all updated. And stay safe. Those drugs sound like serious stuff.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

skunkworks

This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Werther


samsung

In my participation in this thread I hope it is not mistaken that I advocate taking this course of action. Without doctor supervision this is very dangerous. All I meant to say was, stay safe. Nobody on this forum would recommend doing this without the supervision of a physician.  
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Michiganguy19

To be quite honest it is not from the supervision of a doctor. I called a pharmacy in another country and ordered it. Then confirmed with a friend that is a pharmacist that I got legitimate cyclophosphamide.
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

skunkworks

Pharmacists don't tend to have the equipment or skill to identify unknown substances... H-NMR, HPLC, Mass spec?

To be clear, I think this is a very bad idea. Dose is VERY important with cyclophosphamide, equally important is close monitoring.  
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

samsung

Any updates for us Michiganguy? We all hope you are o.k.  Please check in.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Michiganguy19

13 days in, no change. Cyclophosphamide supposedly takes 6 weeks to begin working in the body. So I will update then.
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

Saw the best urologist supposedly in the state of Michigan for Peyronies, Dana Ohl at U of M. Said even though I'm as bad as I am he won't consider surgery until my penis is half the size it was before. I was 7.2 before now 6.1. That seems ridiculous to me cause flaccid I am embarrassingly f'~c<+d now. Said he's seen worse at count myself lucky I was the most mild case of the day. And he said to stay off this forum cause people give wrong info and he hates this forum it's just a bad idea lol
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

skunkworks

Yeah because most of them see surgery as the only option. Sad truth, they have a hammer so all they see is nails.  
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

jj21

34 Years Old...Peyronies for 4 years. 20 Degree left and upwards curvature, major dents and narrowing, ED.

Implant + Tunica Expansion Procedure, 7th Feb 2023, Titan 22cm +1cm RTE, Partial revision 27th June 23 (fix pump, remove 10ml reservoir).

Hontas

Urologist are the dumbest of all sadly. I have a theory that they take in only the ones that performed worst overall in medicine masters test. Dont go to urologists, find yourself a smart rheumatologist. That is my experience 13/15. I found only two decent urologists both of whom offered me nothing instead of acting like the c*nts the other 13 urologists are

Michiganguy19

Quote from: Hontas on August 15, 2019, 09:14:16 PM
Urologist are the dumbest of all sadly. I have a theory that they take in only the ones that performed worst overall in medicine masters test. Dont go to urologists, find yourself a smart rheumatologist. That is my experience 13/15. I found only two decent urologists both of whom offered me nothing instead of acting like the c*nts the other 13 urologists are

What did the rheumatologist do for you?
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

samsung

Any updates Michigan? Worried about you. Please check in and let us know.
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

jj21

Really interested in any update and what the side effects are like?

I'm also interested in trying this.
34 Years Old...Peyronies for 4 years. 20 Degree left and upwards curvature, major dents and narrowing, ED.

Implant + Tunica Expansion Procedure, 7th Feb 2023, Titan 22cm +1cm RTE, Partial revision 27th June 23 (fix pump, remove 10ml reservoir).

peter123

Quote from: Michiganguy19 on August 13, 2019, 02:10:56 AM
Saw the best urologist supposedly in the state of Michigan for Peyronies, Dana Ohl at U of M. Said even though I'm as bad as I am he won't consider surgery until my penis is half the size it was before. I was 7.2 before now 6.1. That seems ridiculous to me cause flaccid I am embarrassingly f'~c<+d now. Said he's seen worse at count myself lucky I was the most mild case of the day. And he said to stay off this forum cause people give wrong info and he hates this forum it's just a bad idea lol

why do you make up so much crap? who would believe that a dr saud sucj a ridiculud thibg?
THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.

TWalker

Any update Michiganguy19?

Very curious to hear how the rather experimental treatment went! Or if anyone else has tried something similar with either of the two drugs?
27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Graggaxy

How come no one is trying this out? This is the first time I've seen Peyronie's getting cured  
Replace this text with critical info about your case
such as age
first symptoms (deformity, Erectile Dysfunction)
official diagnosis
treatments tried
relationship status
Etc

Godisreal

Because there's barely any logic. And it's difficult to get your hands on it.  
30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

TWalker

I'd say almost impossible to get your hands on...

But there's definitely a huge amount of logic in taking oral steroids such as dexamethasone during the acute phase to reduce inflammation. Whether it works for Peyronie's or not is another question entirely!
27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Curvekiller94

28 y/o
sex injury - gradually got worse
Hard flaccid, Indentation bottom left close to my body,  mild twist left
28° up 28° Left
official diagnosed @26 peyronies w/pain
Pentox, cialis, NSAID, tramadol(as needed)
Sciatic  pain radiates penis to foo

Seattleman

@Michiganguy19 did you get any results? please update whether good or bad.
Age 30
30 degree lateral curve.
Started Aug 2020 (age 28) after injury
Stable Feb 2021 - Sep 2021
Started traction June 2021. Got length back
Traction worsened bend September 2021
Sex worsened bend slowly throughout 2022
Using Diclofenac gel aftersex

Arthur

26 year old.

Had multiple penile fractures.

Tried Verapamil injections, Pentoxifylline, Tadalafil, Vitamin E, heat therapy, Castor oil, L-Citrulline, Shilajit, Shatavari, Gotu Kola, Velvet beans.

Lost more than 6 inches.