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Author Topic: Treatment with 50mg cyclophosphamide daily and 5mg dexamethasone twice weekly  (Read 2222 times)

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Michiganguy19

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I am on my 3rd day starting this treatment. Below is a link to a single study showing this treatment resolved peyronies disease completely in 8 months. Only one study to go off of and the cyclophosphamide has extreme side effects including hair loss. I have nothing to lose at this point so I am giving it a shot and will keep you updated if this actually works at all. Cyclophosphamide has been shown to break down and stop scar tissue from forming in a few different diseases including pulmonary fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037975/
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

Patientxyz1992

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Man ill be folowing your updates ad if even remotely helps i will consider using it, i would care less abaout the hair, thank you very much! Btw there are so manny treatmants in development like peptides and stuff who promote angiogenesis etc that i dont know where to look for.....and why arent they on market...
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samsung

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Please keep us all updated. And stay safe. Those drugs sound like serious stuff.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

skunkworks

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Is this being monitored by a doctor?
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Werther

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How did you get these things prescribed?

Was it a urologist?
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samsung

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In my participation in this thread I hope it is not mistaken that I advocate taking this course of action. Without doctor supervision this is very dangerous. All I meant to say was, stay safe. Nobody on this forum would recommend doing this without the supervision of a physician.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Michiganguy19

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To be quite honest it is not from the supervision of a doctor. I called a pharmacy in another country and ordered it. Then confirmed with a friend that is a pharmacist that I got legitimate cyclophosphamide.
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

Michiganguy19

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I also am taking the dexamethasone twice a week
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

skunkworks

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Pharmacists don't tend to have the equipment or skill to identify unknown substances... H-NMR, HPLC, Mass spec?

To be clear, I think this is a very bad idea. Dose is VERY important with cyclophosphamide, equally important is close monitoring.
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

samsung

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Any updates for us Michiganguy? We all hope you are o.k.  Please check in.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Michiganguy19

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13 days in, no change. Cyclophosphamide supposedly takes 6 weeks to begin working in the body. So I will update then.
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

Michiganguy19

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Saw the best urologist supposedly in the state of Michigan for Peyronies, Dana Ohl at U of M. Said even though I'm as bad as I am he won't consider surgery until my penis is half the size it was before. I was 7.2 before now 6.1. That seems ridiculous to me cause flaccid I am embarrassingly f'~c<+d now. Said he's seen worse at count myself lucky I was the most mild case of the day. And he said to stay off this forum cause people give wrong info and he hates this forum it's just a bad idea lol
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

skunkworks

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Yeah because most of them see surgery as the only option. Sad truth, they have a hammer so all they see is nails.
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This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

jj21

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Really interested in this. Keep us updated.
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Age:30 -
Symptoms since mid-2018. no improvement or worsening
Prominent Left + Upwards curve when half-erect
Fully erect - approx 20-25 degree curve.
No noticeable plaque. Waiting on Ultrasound results.
Mild Erectile Dysfunction..

Hontas

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Urologist are the dumbest of all sadly. I have a theory that they take in only the ones that performed worst overall in medicine masters test. Dont go to urologists, find yourself a smart rheumatologist. That is my experience 13/15. I found only two decent urologists both of whom offered me nothing instead of acting like the c*nts the other 13 urologists are
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Michiganguy19

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Urologist are the dumbest of all sadly. I have a theory that they take in only the ones that performed worst overall in medicine masters test. Dont go to urologists, find yourself a smart rheumatologist. That is my experience 13/15. I found only two decent urologists both of whom offered me nothing instead of acting like the c*nts the other 13 urologists are

What did the rheumatologist do for you?
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

samsung

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Re: Treatment with 50mg cyclophosphamide daily and 5mg dexamethasone twice weekly
« Reply #16 on: September 04, 2019, 01:54:23 PM »

Any updates Michigan? Worried about you. Please check in and let us know.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

jj21

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Re: Treatment with 50mg cyclophosphamide daily and 5mg dexamethasone twice weekly
« Reply #17 on: September 05, 2019, 11:07:32 PM »

Really interested in any update and what the side effects are like?

I'm also interested in trying this.
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Age:30 -
Symptoms since mid-2018. no improvement or worsening
Prominent Left + Upwards curve when half-erect
Fully erect - approx 20-25 degree curve.
No noticeable plaque. Waiting on Ultrasound results.
Mild Erectile Dysfunction..

peter123

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  • THIS USER HAS BEEN BANNED FOR REPEATED VIOLATIONS

Saw the best urologist supposedly in the state of Michigan for Peyronies, Dana Ohl at U of M. Said even though I'm as bad as I am he won't consider surgery until my penis is half the size it was before. I was 7.2 before now 6.1. That seems ridiculous to me cause flaccid I am embarrassingly f'~c<+d now. Said he's seen worse at count myself lucky I was the most mild case of the day. And he said to stay off this forum cause people give wrong info and he hates this forum it's just a bad idea lol

why do you make up so much crap? who would believe that a dr saud sucj a ridiculud thibg?
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THIS USER HAS BEEN BANNED FROM FORUM FOR REPEATED RULE VIOLATIONS He never had Peyronies Disease but has body dysmorphia and his pastime was to attack all treatments, medical resources, and opinions.

TWalker

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Any update Michiganguy19?

Very curious to hear how the rather experimental treatment went! Or if anyone else has tried something similar with either of the two drugs?
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27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Graggaxy

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How come no one is trying this out? This is the first time I’ve seen Peyronie’s getting cured
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Replace this text with critical info about your case
such as age
first symptoms (deformity, Erectile Dysfunction)
official diagnosis
treatments tried
relationship status
Etc

Godisreal

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Because there’s barely any logic. And it’s difficult to get your hands on it.
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30 degree dorsal curve, immobility and heavy loss of girth.
My body seems to get very inflamed when I masturbate too often or eat unhealthy.
Using antioxidants, Pentox and hirudoid cream, as well as manual traction, heat and Cialis.

TWalker

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I’d say almost impossible to get your hands on...

But there’s definitely a huge amount of logic in taking oral steroids such as dexamethasone during the acute phase to reduce inflammation. Whether it works for Peyronie’s or not is another question entirely!
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27, Peyronies Disease started 4 months ago after sex injury- still progressing. Dad had Peyronies Disease
1 plaque on each side opposite each other near base- causing indentations on side and top and thus hourglassing- could be 1 circumferential scar?
Pentox, Cialis, L-Citrulline

Curvekiller94

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Any results @michiganguy??
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26 y/o
sex injury that gradually got worse
Hard flaccid, Indentation bottom left close to my body,  mild twist left
28° up 28° Left
official diagnosed peyronies w/pain
Pentox, restorex, l-arginine, cq10, NSAID, tramadol(as needed)
Gf is supportive
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