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Tadalafil daily causing back pain

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MarkDS

I've stated taking tadalafil 5mg daily.  I'm getting pain in my lower back, which I am aware can be a common side effect.

Can this be relieved with common paracetamol or ibuprofen, or will I need to switch medication?

I have arthritis in my lower back, but this has been fairly good over recent weeks.  So not sure if the pain is from the arthritis or medication.  I'm off to a festival for a few days next week, and not sure I. Will be able to stand for too long with the pain as it is.
49 yrs old, Married
Peyronie's started 2016
Upward curve of 100 degrees  
Incision/grafting surgery in 6/2019.  Resulted in loss of length of around 1.5 inches, residual curve of over 40 degrees, some Erectile Dysfunction
12/2019 had failed skin anchoring procedure

Hawk

I took large single doses and got significant pain so I never tried to relieve it since by the time I felt the pain I knew it was of limited duration.  Unlike arthritis which is centered in the spine, my Tadalafil backaches were more centered over the kidney area on each side of the spine.
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
[url=http://www.peyroniesforum.net/index.php/topic,872.0.html]Hawk - Updated 10/27/18 - Peyronies Society Forums[/url]

MarkDS

Thanks for the response.  I'm reluctant to stop the medication, as really need to get things working again post incision and grafting (which doesn't appear to have gone well).  So I'll persist and take some over the counter pain relief and hope it's just temporary.

I feel the pain is lower down than my kidneys, but I'll monitor it.
49 yrs old, Married
Peyronie's started 2016
Upward curve of 100 degrees  
Incision/grafting surgery in 6/2019.  Resulted in loss of length of around 1.5 inches, residual curve of over 40 degrees, some Erectile Dysfunction
12/2019 had failed skin anchoring procedure

Hawk

Worst-case scenario, switch to another PDE5 inhibitor with or without L-Arginine.
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
[url=http://www.peyroniesforum.net/index.php/topic,872.0.html]Hawk - Updated 10/27/18 - Peyronies Society Forums[/url]

Saynotopyronie

Hi there,

I had the worst possible side effects when I took Cialis 5 mg for the first time. 3 days of extreme pain and agony through out the body, even mild fever. I could not take it anymore and stopped the dose. Waited for a week till I felt normal again and then started with Cialis again. Surprisingly second time around, I did not feel a thing. It has been a month now that I am taking it daily and I dont feel anything now. So I pretty glad about it.

Generally pain medication can be taken but I would suggest you to consult ur doc anyway. He would know your medical history and would be able to suggest you a better solution for your case. We all can only share our experiences.

Hope you feel better. 

Hawk

Quote from: Saynotopyronie on June 20, 2019, 04:54:25 AM
Hi there,

I had the worst possible side effects when I took Cialis 5 mg for the first time. 3 days of extreme pain and agony through out the body, even mild fever. I could not take it anymore and stopped the dose. Waited for a week till I felt normal again and then started with Cialis again. Surprisingly second time around, I did not feel a thing. It has been a month now that I am taking it daily and I don't feel anything now. So I pretty glad about it.

I know you are convinced otherwise, but based on the reaction not being listed side-effects and the fact it did not recure when you resumed the drug, I am convinced that was NOT a reaction to the drug but rather a bacterial or viral illness that just happened to hit you when you started the drug.
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
[url=http://www.peyroniesforum.net/index.php/topic,872.0.html]Hawk - Updated 10/27/18 - Peyronies Society Forums[/url]

james1947

Agree with Hawk on the diagnosis :)
On 5 mg daily Cialis had no side effects.
But 20 mg for sex gave me back pain, excessive sweating, no erection.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

zabavno

I tried Viagra and Cialis and both caused the same problem - back pain and stiff neck.
Moreover I'm 100% sure PDE5 inhibitors were the cause of several disk herniations in my chest-level back and neck.


samsung

How would they cause disk herniation? Are they known to do that?
45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Hawk

The basis for thinking they caused herniation is simple.

He took Viagra, he consumed, and did ten thousand other things, he got a disc herniation = the herniation was caused by Viagra.

Even though there has NEVER been a suggested link between the two,  "A" came before "B" so "A" caused "B".  It is exactly the kind of reasoning that keeps us all in the dark and the lack of logic the forum is here to correct.
Prostatectomy 2004, radiation 2009, currently 70 yrs old
After pills, injections, VED - Dr Eid, Titan 22cm implant 8/7/18
[url=http://www.peyroniesforum.net/index.php/topic,872.0.html]Hawk - Updated 10/27/18 - Peyronies Society Forums[/url]

LWillisjr

Developed peyronies 2007 - 70 degree dorsal
Traction/MEDs/Injections/Surgery 2008
66y/o  14 years Peyronies free
[URL="[url="http://www.peyroniesforum.net/index.php/topic,895.0.html"]http://www.peyroniesforum.net/index.php/topic,895.0.html[/url]"]My History

melting

Just take less and see if side effects get less too..

Is the tadalafil activating so much down there that it makes the area act up? Or is there a direct effect into the bones?

Daily Transdermals and Traction/VED solved my Peyronies Disease [url="https://www.peyroniesforum.net/index.php/topic,12587.0.html"]https://www.peyroniesforum.net/index.php/topic,12587.0.html[/url] (DMSO+X)

skunkworks

Cialis also inhibits pde type 11 which has (among other places) receptors in skeletal muscle, particularly in the neck and center of the back. That is the cause of the back/neck pain.

PDE 11 is present in the pituitary, pancreas, skeletal muscle, heart, testes, and corpus cavernosum.

Considering how incredibly wide spread the use of pde5 inhibitors has become and the decades they have been on the market, if there was any connection with disc hernation it would have come up by now. Beware of coming to conclusions about anything when n=1.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

[url=http://goo.gl/IOBhJr]Review of current treatment options by Levine and Sherer]

Crooked_Stick

I started with 5 mg but had redness, slight swelling and severe pain in one eye. My urologist noted it as a rare side effect. He reduced my dosage to 3 mg and I haven't had any problems.
Born 1960, Diagnosed 2013
Initial 40 degree bend, 1" loss, Xiaflex 3 rds of 2 injections
Current 25 degree bend, no palpable plaque, 1/4" loss
VED 5-6 days/week, traction daily,
TRT 20 ml twice weekly, Cialas 3 mg - No Erectile Dysfunction - Doing Well!

FlavioSousa

Cialis is a wonderful Erectile Dysfunction drug but I'm very skeptical of the daily regimen. I actually tried it for a couple of nights just to maintain vasculogenic health, but I had to quit because of side effects, incl. this weird pain in the back of my eyes that always freaked me out.
Psychogenic Erectile Dysfunction (coital anxiety), 40+yo. Current regimen: udenafil 200mg, oral phentolamine mesylate 40 mg, Seredyn.

Pixie1002

Hi all.  Just a quick update to say that I temporarily stopped taking 5mg daily, but I've now been taking it for a few months with no more back pain.

Age 47, incision and grafting surgery in May 2019 to correct 90 degree upward curve.  Post of residual curve of 40 degrees.  Partial ligament separation and skin anchoring December 2019 to correct daily discomfort - without success

Chimp2020

@Pixie
So you stopped taking it for how long before you started again?

Now you've been on it for a couple of months with no back pain?

I've been toying with idea of using 5mg tablet in 4 pieces so 1.25mg on evening just for NTE purposes as even 2.5mg a night gives me really bad back ache.
Age 47
Had Erectile Dysfunction all my life, tried all the meds
Dupuytren's with mild peyronies

Shane43

I have read elsewhere that many have less or no back pain cutting 5 mg pill to usually 2.5 mg or even 1.25 mg as chimp suggests. It is worth a try. Most people without arthritis or some other pre-existing back condition can tolerate 5 mg with little or no pain. I realize that you have a pre-existing back condition, but still worth trying.
62YO, hourglass indent/hinging at base 30deg bend up 3cmx2cm hard plaque at dorsal base. No Erectile Dysfunction. 3 rounds Xiaflex decreased plaque/indent/hinge/bend. 1 year later, penis went from 7.5 to 5.5 in, but only 15 degree bend and no hinging.

adamcooper

As you have mentioned that you are suffering from arthritis, why don't you try medications effective for arthritis like Tapentadol. It is tolerable and has a safe profile. However, you are also taking Tadalafil so you should consult your doctor before taking the arthritis medication or may be you can check this article. It is mentioned in detail how long Tapentadol stays in the system so that when the effect of the medicine wears out, you can take Tadalafil without any worries.

LWillisjr

Why are you posting in a topic nearly 2 years old??
Developed peyronies 2007 - 70 degree dorsal
Traction/MEDs/Injections/Surgery 2008
66y/o  14 years Peyronies free
[URL="[url="http://www.peyroniesforum.net/index.php/topic,895.0.html"]http://www.peyroniesforum.net/index.php/topic,895.0.html[/url]"]My History

adamcooper

Quote from: LWillisjr on November 19, 2022, 05:18:27 PM
Why are you posting in a topic nearly 2 years old??
Well, I can relate to the topic. And I am sure enough that a vast majority of people can relate and are still searching for a solution for the same.
I believe reviving this old thread might be helpful to them.