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Author Topic: Tissue Engineering  (Read 66737 times)

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popopo

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Re: Tissue Engineering
« Reply #150 on: January 19, 2018, 05:04:05 PM »

I agree it takes long alex, but consider this: cancer has been around for ages, it’s among the most deadly and well known diseases, people spend millions on research and there still is no fool proof cure for cancer. It’s not uncommon for these things to take some time and especially getting your treatment FDA approved and being able to start human trials takes time.
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Age: 25
Date of onset: 17
Symptoms: sharp pains, numbness, change in shape/size, hourglassing and discolaration from jelqing/VED usage as a teen. Diagnosed with a venous leak and possible scarring.
Treatments tried: cialis, pentox and VED didnt help

Werther

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Re: Tissue Engineering
« Reply #151 on: January 19, 2018, 08:17:19 PM »

[Full quote removed - Please read the forum rules for posting]

I had alreay read the article of The Guardian and I agree with you with regards to Wake Forest's trials for full penile transplantation: it has nothing to do with tissue engineering (in fact Peyronie's disease and Erectile Dysfunction are both mentioned as exclusion criteria for recipients).

There seems to be nothing new on their site or in the newspapers concerning the subject of penile erectile tissue engineering; I have just found this link about a conference that was held in Boston in May 2017: https://www.urotoday.com/conference-highlights/95611-aua-2017-regenerative-medicine-where-do-we-stand.html

Anyway the information are, again, vague. I quote what's written: "With respect to genitourinary organs, they have reverse engineered a vagina, from a remnant vagina biopsy, and successfully implanted it into a patient with vaginal agenesis. In patients with contracted, noncompliant bladders (end stage bladders) they have implanted bladders that over time increased in compliance and capacity. This is proof of the recipient truly “accepting” these refurbished organs. Following this, they moved on to the more complex solid organs. Their team has successfully regenerated a penile implant in a rodent model with the ability to sustain erection and ejaculate. Based on these studies, they are planning preliminary human studies".

The fact is, however, that a lot of people here tried to contact them and lately (beginning from last year) they have always been responded that they were just about to begin; but when they were asked for more precise details, they didn't answer. So, plain and simple, I think that they'll actually begin very soon (maybe this year), but we'll never know for sure if nobody's willing to go there in person and talk face to face with someone who's involved in this project (one of these people could be Dr. Terlecki, since he was mentioned in the response they sent to me). We could keep sending tons and tons of e-mails, but if they simply don't answer we'll keep remaining in a limbo.

Damn, isn't there a single North Carolina's man who have Peyronies Disease (except for "rellisacct") and is interested in discovering what the hell is going on with this study? It looks like North Carolina's male inhabitants are immune to this disease.
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Brunobald

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Re: Tissue Engineering
« Reply #152 on: January 21, 2018, 05:24:07 PM »

As far as I'm aware we are still a long way from regenerating, growing or printing a penis outside of the body for transplantation. I did find a company called polarityte that claims to use the body's own cell to make a healing matrix which they fill into a tissue void. This uses the body as a bio reactor. I contacted them and they say that fascia is also in their pipeline. There skin results should be published first half of 2018.
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Jack1909

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Re: Tissue Engineering
« Reply #153 on: January 22, 2018, 01:33:19 AM »

No one is in need to have something done it’s just about having a small piece of tunica replaced..
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

DELETED

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Re: Tissue Engineering
« Reply #154 on: January 22, 2018, 12:54:12 PM »

Jack1909,

I'm not agree. In some cases patients need in both tunical and cavernous tissue replacement, especially when we talking about patients with Erectile Dysfunction.
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Werther

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Re: Tissue Engineering
« Reply #155 on: February 19, 2018, 09:43:11 PM »

FYI

I wrote again to WFIRM asking for more precise details with regards to their trials and here's what they answered: "We are hoping to begin recruiting for the engineered corporal tissue study in May.  The study will be for a corpora injury/deformity of 5 cm or less in length.  There are 2 surgical procedures (a biopsy and then the implant) about 3-5 weeks apart, and follow-up visits at 1 week, 3 weeks, 6 months, 9 months and 1 year post-implant.  When the engineered corpora is ready for implant we will have about 2 days to get the implant surgery scheduled. This is a phase 1 safety study.  we have not performed this surgery before".

They had to begin recruiting last year (and maybe even the previous one) and now they "hope" to commence in May; well, I hope even more than them that this will be the time (but I have to say that I still didn't find any new record on ClinicalTrials.gov).

Anyway I think this is a positive progress, since they described the procedure and an exclusion criteria (plaque of 5 cm or less in lenght)... It kinda makes me hope that they're getting serious and they'll finally begin before the end of this year.
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diehardpatriot

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Re: Tissue Engineering
« Reply #156 on: February 20, 2018, 02:17:38 AM »

Holy ****, so you’re telling me WFIRM is going to do corporal replacements ?? That’s insane. I think we’re about 5 years,  10 tops from being able to replace a tunica or corpora
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Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

popopo

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Re: Tissue Engineering
« Reply #157 on: February 20, 2018, 02:45:16 AM »

Well, in 2016 they said they’d be able to replace whole penises in 5 years max, so let’s just wait and see about that.
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Age: 25
Date of onset: 17
Symptoms: sharp pains, numbness, change in shape/size, hourglassing and discolaration from jelqing/VED usage as a teen. Diagnosed with a venous leak and possible scarring.
Treatments tried: cialis, pentox and VED didnt help

Sadguy

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Re: Tissue Engineering
« Reply #158 on: February 20, 2018, 03:09:18 AM »

Can they cure Erectile Dysfunction ? I think for Erectile Dysfunction it would need a complete replacement of the penis ( corpus cavernosum, tunica and the fascias)

Do you see this possible? What it would take? 10 years maybe?
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Jack1909

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Re: Tissue Engineering
« Reply #159 on: February 20, 2018, 04:33:32 AM »

I might be super eligible for it as most of my problems come just from that fibrotic stitch. Probably the most eligible considering I’m not at risk of any flare up (don’t have peyronie).
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Werther

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Re: Tissue Engineering
« Reply #160 on: February 20, 2018, 12:32:03 PM »

I hope that people with Erectile Dysfunction caused by fibrosis (mainly venous leakage) will be recruited, so we can know if these surgeries actually restore sexual function, a part from straightening the dick. And I think it will work like this, since they declared that they aim at solving selected cases of erectile dysfunction with tissue engineering.

Hopefully we won't have to wait for other 5 or 10 years; maybe it will take these many years (or more) for whole tunica and/or corpora replacement, but these trials deal with partial replacement and they've been planning on beginning for a very long time.

I'm no doctor, but I think that partial replacement of engineered tissue could solve Erectile Dysfunction without having a whole new tunica and/or corpora, if Erectile Dysfunction onset is due to scarring.
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Re: Tissue Engineering
« Reply #161 on: March 01, 2018, 12:31:49 PM »

Today I received an update from Wake Forest

"Thank you for contacting use regarding lab-grown penile tissue.  We will be starting a clinical trial in the next few months for engineered corporal tissue mainly for men with Peyronie’s Disease.  This is a phase 1 study for safety.  If the study goes well, we hope to be able to advance to a Phase 2 study, looking at incorporating more penile tissue and for other indications.

Regards,
Mary-Clare Day

Mary-Clare Day, RN, BSN, CCRC
Research Nurse Manager"


P.S. @"rellisacct", where are you man?
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DELETED

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Re: Tissue Engineering
« Reply #162 on: March 07, 2018, 10:16:04 AM »

Does anybody else received any information about upcoming clinical trials in Wake Forest?
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jusirmi

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Re: Tissue Engineering
« Reply #163 on: March 16, 2018, 01:21:46 PM »

this clinical trial appeared to clinicaltrials.gov recently
https://clinicaltrials.gov/ct2/show/NCT03463239?cond=corpora+cavernosa&rank=5
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Werther

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Re: Tissue Engineering
« Reply #164 on: March 20, 2018, 07:03:54 PM »

Finally! It's the one people have been talking about since this thread had opened.
It looks like they are really moving forward.
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AlmostBlue

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Re: Tissue Engineering
« Reply #165 on: April 30, 2018, 10:48:29 PM »

Happy Phase 1 is beginning.

A little confused here... they constantly mention engineered corporal tissue. To me this means the spongey tissue, specifically the smooth muscle tissue, inside the corporas that relaxes to let blood in. There is no mention of engineered tunica nor replacement of pieces of the tunica by WF.

I get that replacement of corporal tissue can help Erectile Dysfunction, but what we really need is engineered tunica tissue in order to replace our plaques. Is WF not doing this yet?


*EDIT*
I stand corrected... Brief Summary:
"The primary objective of this clinical trial is to evaluate the safety of autologous engineered corpora cavernosa + albuginea constructs for treatment of complex penile deformities. Autologous endothelial and smooth muscle cells obtained from enrolled subjects' corpora cavernosa biopsy sample, will be culture expanded in vitro and used to seed decellularized corpora cavernosa + albuginea obtained from cadaveric-donors to create autologous bioengineered corpora cavernosa/albuginea constructs for repair of damaged penile tissues."

https://clinicaltrials.gov/ct2/show/NCT03463239

So they take the tissue from a cadaver, strip it off all its cells, so what's left is the structure/empty scaffold. Then they add your cells to it and they multiply them. Then they replace. Makes sense now. I am happy to find that they are doing the Tunica Albuginea and not just cavernosa tissue.
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diehardpatriot

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Re: Tissue Engineering
« Reply #166 on: April 30, 2018, 11:02:03 PM »

It’s a whole penis replacement bro. They take biopsy stem cells from the corpora , that’s what they use to regrow the penis. Can you post a link stating phase 1 is starting? How do you know? I wonder if any forum members were able to volunteer
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Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

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Re: Tissue Engineering
« Reply #167 on: May 01, 2018, 02:12:57 PM »

Does anybody contacted with WF? Any news or updates about upcoming human clinical trials?
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AphexTwin

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Re: Tissue Engineering
« Reply #168 on: May 10, 2018, 12:30:34 AM »

Im still interested in this. Any leads would be so appreciated
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Jack1909

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Re: Tissue Engineering
« Reply #169 on: July 08, 2018, 07:28:11 AM »

I actually went down there the last week and had a consultation with Terlecki who is the principal investigator of the trial. He got around the point, but basically we are not veterans injured so we are not considered as candidates  and don’t know when we will ever be. He didn’t give me any info about this. He just offered me the same treatments we all know they are knocking people’s penis out around the world. He told me it would be helpful getting into this in first place but lately I was not considered qualified for it (via mail).

Think we should turn ourselves  to something else, even if this would be pretty much a cure to me.
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Jack1909

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Re: Tissue Engineering
« Reply #170 on: July 08, 2018, 07:39:59 AM »

Alex Samo you posted this..



"Thank you for contacting use regarding lab-grown penile tissue.  We will be starting a clinical trial in the next few months for engineered corporal tissue mainly for men with Peyronie’s Disease.  This is a phase 1 study for safety.  If the study goes well, we hope to be able to advance to a Phase 2 study, looking at incorporating more penile tissue

...I think it’s not true that’s will be on veterans unless they wanna find veterans with peyronies..that answer is misleading unfortunately. Otherwise I wasn’t told how things are going..
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

hope794

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Re: Tissue Engineering
« Reply #171 on: July 08, 2018, 09:29:15 AM »

I didn't understand properly:
this studies which you all are talking about, the one which involves "veterans", aim to replace the penis TOTALLY (new penis from another guy) or only small parts of tissue?

I am not a doctor, but i can't understand why is so much complicated to grow with stem cells + 3D printer some little parts of tissue. For example, i have got some fibrosis in the TUNICA ALBUGINEA. Why should this be complicate to solve with actual technology?

I'ts only a matter of removing a small part of TA (some millimeters) and replace it. Am i missing something?
I read that there are many studies about growing parts of organs to replace only the 'bad parts' and not the entire organ, and they seem really promising. For some organs, it is still possible. So what's the matter with tissue engineering?

P.S. = Someone in this post said that, 10 years ago, we were "10 years from the target". Today i can't understand if we are near or not. What's the truth? Can someone REALLY well informed explain to me where we are now, please?
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26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
Erectile Dysfunction for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

swiss

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Re: Tissue Engineering
« Reply #172 on: July 08, 2018, 11:14:18 AM »

so...join the army. Claim you hurt your pee pee there and get new pee pee.
Problem solved.
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Jack1909

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Re: Tissue Engineering
« Reply #173 on: July 08, 2018, 12:03:20 PM »

They can but they don’t want to. That’s the fact. The technology already exists but we are not allowed to get there. Waiting for this to wild open in any clinic will take years.

I think I explained myself. They are sponsored and funded by the difence so they are focusing on them rather than people with “real” diseases.
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Jack1909

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Re: Tissue Engineering
« Reply #174 on: July 08, 2018, 12:07:38 PM »

Small parts for veterans..I know it sounds strange but that’s what I ve been told.
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Thomas2

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Re: Tissue Engineering
« Reply #175 on: July 08, 2018, 02:59:56 PM »

For what i remember, medical research through history has always gone through veteran studies... It's about standardization...
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hope794

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Re: Tissue Engineering
« Reply #176 on: July 12, 2018, 05:17:56 PM »

Hi all, i have got a question. I read in this post many people talking about a "total penis replacement", but IMHO only some people suffering from Peyronies Disease really needs this. For many people, a little piece of tunica replacement would be enough, and this doesn't seem so hard to do. (i'm talking about the piece of tunica which is covered by fibrosis)
So i'm writing this post because i would like to hear the opinion of someone in the forum which is expert in this field and is following the progresses of Tissue Engineering; it would be fantastic if someone could explain to me why a little piece of tunica albuginea, grown on a scaffold and then transplanted on a patient, is so hard to do, and which results you would obtain with this procedure.

Thank you very much
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26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
Erectile Dysfunction for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

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Re: Tissue Engineering
« Reply #177 on: October 01, 2018, 02:42:59 PM »

Alex Samo you posted this..

...I think it’s not true that’s will be on veterans unless they wanna find veterans with peyronies..that answer is misleading unfortunately. Otherwise I wasn’t told how things are going..

Yes, I was told exactly this. She mentioned that this trials would be available for Peyronies Disease patients. I don't know if she was wrong or something. It was half-year ago. You can ask her: [email protected]

They can but they don’t want to. That’s the fact. The technology already exists but we are not allowed to get there. Waiting for this to wild open in any clinic will take years.

Skip the fact that this is not available for us yet, but "The technology already exists"? Are you sure about this part of your message?
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Re: Tissue Engineering
« Reply #178 on: February 01, 2019, 02:15:45 PM »

Any news&updates?
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shrunken_dick

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Re: Tissue Engineering
« Reply #179 on: November 11, 2020, 10:05:41 AM »

Looking for an Update.
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gaussrifle

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Re: Tissue Engineering
« Reply #180 on: March 19, 2021, 12:02:45 AM »

Finally! The trials begin this month and we will have primary study completion by Summer of next year. This site was updated January 2021 so it is accurate.
https://clinicaltrials.gov/ct2/show/record/NCT03463239?cond=corpora+cavernosa
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26 year old
45-50 degree downward curve. Hourglassing when semi-erect
changes to indentation on one side only when erect.
Using RestoreX
Taking coq10 with daily Cialis 5mg.

Fubar94

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Re: Tissue Engineering
« Reply #181 on: March 19, 2021, 05:59:50 AM »

Finally some good news. I am doing PRP for now, keep fcking with viagra in my system as long as I can and hopefully will see this happening and get cured in my lifetime.
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Age 26
Did jelqing, pumping & clamping from abt age 15 until 17. Never had any real issues, until it was too late.
I got a change of shape, sensation, and a loss of volume.
it continues progressing

gaussrifle

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Re: Tissue Engineering
« Reply #182 on: March 26, 2021, 01:53:06 AM »

Fubar,  prp results ?
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26 year old
45-50 degree downward curve. Hourglassing when semi-erect
changes to indentation on one side only when erect.
Using RestoreX
Taking coq10 with daily Cialis 5mg.

Jack1909

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Re: Tissue Engineering
« Reply #183 on: March 26, 2021, 03:36:15 AM »

10 years away.....
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

Jack1909

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Re: Tissue Engineering
« Reply #184 on: March 26, 2021, 05:03:13 AM »

Why just no pursuing the cadaveric tissue implanting, building up a penile tissue bank...nowadays would be feasible and it would not require immuno suppressants. I read some articles urging this thing to be set up..
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

gaussrifle

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Re: Tissue Engineering
« Reply #185 on: March 26, 2021, 05:33:54 AM »

You can’t directly implant tissue from a dead body (cadaver). Your body will reject it without immunosuppression. You need to use it as a scaffold on top of which your cells grow and then implant. Hence the clinical trials.
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26 year old
45-50 degree downward curve. Hourglassing when semi-erect
changes to indentation on one side only when erect.
Using RestoreX
Taking coq10 with daily Cialis 5mg.

Jack1909

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Re: Tissue Engineering
« Reply #186 on: March 26, 2021, 12:52:12 PM »

That’s not necessary true, not nowadays at least..I know the overall purpose of the trial (I think I’m the only one went down in Notth Carolina to speak with the guy leading the trials), but the point is we are 10 years away..
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31 yrs old
Severe congenital curvature. 3 straightening surgeries
Big lump/stitch w/ left deviation after 2012 surgery
Severe Erectile Dysfunction after last one in 2014. Still crooked
Slightly improved w/ shockwave therapy
Looks like only one side of my penis works

gaussrifle

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Re: Tissue Engineering
« Reply #187 on: March 26, 2021, 01:06:01 PM »

10 years atleast ... lol
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26 year old
45-50 degree downward curve. Hourglassing when semi-erect
changes to indentation on one side only when erect.
Using RestoreX
Taking coq10 with daily Cialis 5mg.

Fix This

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Re: Tissue Engineering
« Reply #188 on: April 06, 2021, 02:23:11 PM »

This sounds very promising

Did they actually give a timescale when they were contacted ?

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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Godisreal

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Re: Tissue Engineering
« Reply #189 on: April 07, 2021, 05:23:24 PM »

I sincerely hope they are doing something. We all know this whole forum would come to a beautiful end if it worked, and the pain and suffering for us all, would be done.
Beautiful f*cking thought lol
But it’s far away. No doubt.
I can promise you that I will finance the entire research one day if a beautiful soul does not do it before me. I hope one does.
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Youngster with 30 degree dorsal bend.
Loss of girth is present too.
I have lot of faith but still a lot of work left to do.
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