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Author Topic: VERAPAMIL Injections results (Positive & Negative)  (Read 30466 times)

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pvpey

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #50 on: May 17, 2011, 02:00:29 PM »

Thanks for the replies. I was beginning to think that nobody in this forum who got these injections showed any kind of improvement and bring that up to my urologist. Now I'm a little more optimistic and willing to give it a try. However I'm still not comfortable with a nurse administering them and will insist that the doctor do so himself.

I'm really just trying to stop the progression of the disease and perhaps decrease the curvature a bit. As previously mentioned I can still function sexually and even with length loss still measure about 6 1/2" in length with adequate girth size. So if I can at least slow down the process, I'll be happy for now being I'm 48 yo. Any other positive or negative replies are appreciated.

Also if anyone has had these injections coupled with other treatments and had success, I'd be very interesting in hearing about it. Thanks in advance. This is a bitch of a disease for a single unattached guy.
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peyrosucks

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #51 on: May 17, 2011, 05:23:43 PM »

I had 6 of them and am convinced it made my peyronies worse.  Let me explain.  The original plaque seemed to have been reduced in size (which may have happened on its own).  However, the numbing shots added a new larger plaque right below the initial plaque.  It started to develop after the 3rd injection (out of 6).  I'm pretty confident it was the shot that did it because the numbing needle was being poked in several locations.  I went to see Dr. Levine on a trip to Chicago to get his opinion.  He injected me with some solution to get me erect for the exam.  Three months later I have a small plaque at that injection site.  I don't think it is worth the risk.  Search this forum and you will find more negative posts about it than positive. 
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Brightdog

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #52 on: May 20, 2011, 02:45:50 PM »

Disastrous for me.
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dioporcolorisolvo

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #53 on: May 20, 2011, 02:57:32 PM »

i've made 12 infusions. I noticed an improvment on erection quality but no benefits for curvature and pain. The progession has not been arrested.
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ComeBacKid

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #54 on: May 21, 2011, 01:24:42 AM »

The last three posts have echoed what I've heard dozens of people tell me over the last couple of years.  I have no interest in proving verapamil injections work or don't work.  When we took a look at topical verapamil in our PDLabs report we couldn't conclude it worked there either.  No one has yet to show me any study that proves verapamil does anything to dissolve the plaque or do anything positive for peyronies sufferers.  With Pentox we at least have a few studies showing it works.  I wouldn't inject anything into my penis until I saw at least a handfull of studies that showed the drug being injected actually worked.  I think the injection itself could cause minor damage, but would be worth it if the drug being injected actually worked, thats my own personal view on the matter.

Comebackid
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MikeSmith0

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #55 on: May 23, 2011, 02:17:36 AM »

You can search the forum and it is 90% negative.

I have nothing but negative things to say about my VI experience.  It was expensive (insurance didn't cover it very well - I spent over 1k in copays), painful, and I only got worse after it... scar tissue seemed to grow and narrowing worsened.  Length is probably similar - but the overall size is embarrassing & the curve is unchanged.

Pain was worse while i was undergoing it... until at least 3 months after I stopped.  This off label crap should be banned.  1 paper by Levine with 20 subjects and no control group is nonsense.  Xiaflex is working and FDA approved... it's just ridiculous why nobody can get that off label when the FDA NEVER APPROVED VERAPAMIL for peyronie's disease either.

It's another vitamin E.  In 20 years, nobody will be doing it.  Many docs already have a very negative opinion of it and will not do it.  It's a big money maker for them though.  VIs are cheap and they can charge a lot.
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peyrosucks

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #56 on: May 24, 2011, 01:59:53 AM »

I agree it VI's should be banned.  Those jackasses at the FDA make it difficult to get drugs that actually work and make the manufacturer of Xiaflex have a placebo group when there is no need for that.  It's total bull.  I can't believe that I even listened to my uro when he said it has no negative side effects.  I guess I was looking for the any answer that could help.  Nothing is worse that having an issue with your dick.
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Woodman

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #57 on: May 24, 2011, 03:56:51 AM »

Guys- I had 12 VIs and I had NO results. I noticed after the 8th injection my first signs of decrease in length and girth. I went over with the Doc and PA several times and they laughed and told me if it does get worse it was happening anyhow and that the injections wouldn't make it worse. I already had Peyronies Disease for over two yrs at that point right then my condition progressed. Coincidence maybe......for me with experience and time I say it was not. At the time I was soo desperate to try and reduce the pain also the progression it was non stop from the beginning till that point in time. That was there only suggestion saying it would help with the pain at the very least well gotta call bull on that count too. Like Mike mentioned it was very expensive insurance covered a little less then half and I came out of pocket approx. about 2K plus travel and loss time off work.

I had bruising from the injections for well over a year. I even went and seen Levine about 3 to 4 months afterwards and he seen the bruising and I asked him if it was normal. He said it can happen and seen it once or twice before he told me it could take up to a year to go away. Well it did about 15 months all told.

When I went back for my folllow up after the injections the PA not the doc. told me the obvious that there wasn't any change. I asked him what else I could do. He told me very quickly well we could try another 6 VIs I knew right then and there I had been taken for a ride. I told him I am not interested in that and I haven't even heard or read having that many injections. If 12 didn't work then why? I got no sound ansewer. His second option was to wait six months and see where I was at cause changes can happen up till then. Third he could give me a plication or an implant. I told him I don't want a wired back penis my pain is terrible already also I ve had three penis surgeries before in my life and the condition hasn't stopped. Then I proceeded to ask why would I need an implant when I can function. This part was said kinda sarcastic. I couldn't get a strait ansewer. I am always business when at the doc. polite refined strait forward so I can't see where the ending came from.....but that's ok. I left and made an appointment to Levine 3 months later. He said that I did the right thing not taking the additional 6 injections cause if I was gonna get any milage out of them I would of already seen it.

Sorry for the rant but the VIs IMO are not worth it. I held back my thoughts on it for a long time here so as not to interfere with others decisions who have to decide. Now I have read so many others here on the forum I decided to add my 2 cents for what its worth.
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ohjb1

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #58 on: May 24, 2011, 05:06:01 PM »

I would like to add my opinion as to verapamil injections.  Had them with Dr. Mulhall and I would recommend - Do not have this treatment!
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MikeSmith0

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #59 on: May 25, 2011, 06:53:30 AM »

Guys- I had 12 VIs and I had NO results. I noticed after the 8th injection my first signs of decrease in length and girth. I went over with the Doc and PA several times and they laughed and told me if it does

Sorry for the rant but the VIs IMO are not worth it. I held back my thoughts on it for a long time here so as not to interfere with others decisions who have to decide. Now I have read so many others here on the forum I decided to add my 2 cents for what its worth.

Glad u posted...and everyone else.   Over a year ago, I was out desperately searching for doctors who would give me the VIs.  I truly believed they were the "cure" based on the Levine research.  I basically called offices and asked if they did VIs and hung up if they did not.  One of my old posts talks about a doctor who wanted me to take Vitamin E and said that verapamil can cause scar tissue to increase due to the needle trauma.  Well, this was over a year ago - and I have to say he was half right.  The vit E does nothing but the plaques certainly got worse after the VIs.

I also sort of gave my opinion "lightly" on the VI issue...saying "well it didn't help but it progressed - and maybe that's due to the disease and not the VIs...etc"  Now, we have a critical mass of unhappy people here who have gone to top docs with VIs.  Maybe levine does something that works better than others in his technique since he published the 1 paper supporting them - but even one of Levine's pts had no results from it who posts here (blanking on the screen name now).  

One other doc says there was a multi-center study of VIs (2-3 docs doing it) that failed, and they called it off  half way thru - never publishing the data on the failure.  Another doc who people like on this board told me the sample sizes are too small in the studies, and he won't do them.

I had heard that it is better to do it earlier, before the plaques form, but when had the series of shots, I developed new plaques, and the plaques I had got harder.  I don't think the "natural progression of the disease" excuse holds up any more.  At best, we  all should've improved.  At worst, we should've had minimal progression of the disease - not significant progression.  With Xiaflex in the pipeline, VIs may soon be a thing of the past.
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pvpey

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #60 on: May 28, 2011, 02:44:13 PM »

Okay, I'm going to see uro next Friday and voice my concerns (he has me scheduled to start Verapamil injections). It would seem that the majority here saw no improvement with Verapamil injections although a few did. I am going to have a serious discussion as to the probability of them helping my condition. He had already mentioned that if not, that surgery may be the only other option. However I'm reading that there are many options from fellow sufferers here.

I'm leaning towards not getting the injections. For one, in my uro's office supposedly a nurse administers them and I am not com foratable with that after reading here. However I am willing to give the 6 shot procedure a chance if done properly and in hopes that I may be one of the minority that it does have a positive effect on. As long as there is no possibility of it having an adverse effect and cause my condition to worsen.

My condition is less than a year old and I'm hoping to slow the progression and decrease the upward curvature as it seems to be getting more severe slowly, but surely and now interfering with positions that I can have sex in.

I'd like more info on VEDs if possible and the reality of that being a viable alternative option of treatment. The last thing I want to do is cause more trauma and scarring that will worsen my condition. And what's the realistic possibility of getting these Xia... injections in the near future before further deterioration? I want to start some kind of treatment regimen immediately and need to hear from the experts, fellow patients here who have had success or not, and not doctors who simply treat the condition with the flavor of the month.
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LWillisjr

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #61 on: May 28, 2011, 03:37:45 PM »

I went to Levine. His nurse will do the initial injection for numbing you up. But Levine always did the actual VI's. I would only trust the doctor to do this properly. There definitely is a certain skill and technique for this.
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Les - 10 yrs Peyronies Disease free
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YMENOW

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #62 on: May 28, 2011, 04:41:06 PM »

I didn't have the injections but I am glad I read what you wrote.  I was thinking of going to Mulhall since I live in NYC.  Too much trouble going to Chicago.....I have the dents and have lost the spongy part on both sides of my shaft.  I don't know if I will ever get it back and was hoping Mulhall would help.  I had open heart surger at Mt Sinai with the top surgeon there but i don't think I want to see Mulhall. 

YMN
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nycsurfer

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #63 on: May 30, 2011, 10:06:56 PM »

I had 6 VIs and condition worsened plus Muhall had his assistant do all injections.  I must have seen home for a total of five minutes over the course of four months.  Never saw me erect.  I would suggest NO VI's and ESPECIALLY non through Mulhall!!
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Woodman

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Re: Has Anybody Had Verapamil Injections-Results?
« Reply #64 on: June 01, 2011, 02:42:05 AM »

I had 12 VIs by Dr. Lipshultzs. His PA administered them all and also did the follow up after all the injections were completed. I only seen the doctor maybe 2 out of the 3 times I had a regular appointments. His PA did most of the work. Once the PA took all the info for the appointment then the doctor would come in the room for 2 to 5 mins tops. I had to practically put my foot on his tale to get him to try and ansewer a few of my questions.

I only put up with this kind of service because there isn't another doctor versed in Peyronies in my whole geographical area. This is very ironic too considering I live in Houston where the population in our city is 6 million people now.

When the injections were described to me it was mentioned as more fact then experimentation. Once the injections got underway I noticed and realized I got more steam piped up my stack! When I started getting questions and protocol changing consistently. I remember one day in particular when the PA came in and told me " today the doctor wants me to start modeling after the injections are administered " I asked what modeling meant he explained. I told him I ve been here for 6 months to a year complaining of very bad pain and the injections hurt and bruise so bad that I can't even follow the VED protocol that suppose to go along with the injections. So if the doctor advise to do that for MY case then it makes no sense and I am not comfortable doing it. I can't see the doctor reading my history then prescribing modeling. After some coaxing and telling the PA this he told me " well, its just not for you he is now doing it with all the VI patients but I will not perform it on you since you are having pain issues" I already had the feeling I was being taken for a ride but after that day I knew I was paying them to use me for a pin cushion and a guinea pig.

Like I ve said before here, after I had all 12 injections and no results I asked what could we do next and he said right off the hip " well we can try 6 more and see if that works " I told him I am not doing that no thanks. When he told me that and didn't look me in the eye I felt like I got suckered by a sleazy used car salesman. 
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KAC

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Here I go again with Verapamil
« Reply #65 on: October 03, 2011, 08:54:56 AM »

An update on my situation. I had a series of six verapamil injections last year, but stopped because I couldn't tell if they had made any difference. The pain was gone, though the plaque kept growing.  I've been on Pentox since then and have used a VED.  Over the last few months the site of the plaques has changed--moved to one near the head and one near the base.  Meanwhile the site of the original plaque has gotten thinned out--I can tell it's a bit harder along the top side of the shaft.

In any case, at my uro's suggestion, I decided on another course of six injections.  It's hard to know if the progress I've made is the result of the pentox or VED (or all the other things I've tried taking like ALC, L-Arginine, PABA).  I tend to think the Pentox has been the most effective, as has re-organizing my life to decrease stress. 

I don't know if this is anyone else's experience, but my plaques seemed to start in one place (about 3/4's the way up the shaft), then turned into two points of inflammation that have traveled in opposite directions.  The site of current inflammations are slightly painful and large (kind of like wads of wax; it feels like a sphere in the head and a oval that wraps around the urethra near the base).  As the inflammation moves it seems to leave a thin track of moderately hardened tissue--sometimes I feel it, sometimes I don't.  The curvature has improved (from almost 90 degrees to 45) as the inflammation moved away from the center.  I've had some shortening, but not too much.  I don't have trouble getting erections and sex is usually fine despite the curvature

Anyway, since it didn't seem to hurt me last time, I'm going to try the Verapamil again.  I had the first shots last week.  I'm a lot more familiar with this area of my body now, so I may be better able to judge when/if it's helping.  Already the pain went away, though the size of the plaques seemed to increase slightly.

I'm sure I'm not the only one who finds the whole injection thing extremely stressful. I get very uptight about it and find it painful and embarrassing.  (Listening to music and especially some relaxation wavelength entrainment effects put out by ambiscience for iphones seems to help.)  I sometimes have swelling afterward--I think this depends on which blood vessels are in the way.  Also, when the doctor is trying to feel the contours of the plaque around the base it sometimes involves a lot of manipulation, which occasionally gives me a partial erection which I find pretty embarrassing. Does that happen to others?  I figure that is normal, but there is very little about this disease or being treated for it that feels normal.

Anyway, I'm just contributing some of my experience since I've appreciated others doing so on this site.

KAC
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LWillisjr

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Re: Here I go again with Verapamil
« Reply #66 on: October 04, 2011, 07:42:58 PM »

Thanks for posting this. There is support both for and against VI's. But it seems you are seeing positive results. So in my opinion, it they are helping, then continue the treatment.
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Les - 10 yrs Peyronies Disease free
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Woodman

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Re: Here I go again with Verapamil
« Reply #67 on: October 05, 2011, 09:58:27 PM »

KAC

I had 12 VI injections and it made my plaques larger too. I asked the doc and he told me it happens and is temporary. A little while after the injections the palques went back down in size to there normal diameter.

Good luck with your treatments I know they are physically and mentally taxing.
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PablitoNJ

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Thoughts on continuing Verapamil injections
« Reply #68 on: November 04, 2011, 12:15:25 PM »

Hi all,

I'm a newbie to Peyronies, started in July '11. On the advice from a Urology specialist in NYC I've started the Verapamil injections. I've had 5 injections so far. I've noticed that it seems to have helped with the overall pain I was experiencing. Daily pain has gone from sharp constant to a dull ache. Even erection pain has limited a bit. Only problem is that the curvature has gotten worse.  :(

During my initial examination the specialist was surprised my curvature wasn't worse due to the extent of the plaque I have. So I'm assuming that it's just caught up with me? But that was the reason I decided to go with Verapamil in the first place - to lessen the curve.

My question to the group - has anyone noticed that Verapamil caused an increase in curvature? If so, did that curvature lessen after the treatments stopped?

I've read on the forum about Pentox and supplements for pain, so I'll take that route as well. Just trying to get a gauge of those that have gone through this whether it's worth it to continue. I'm leaning towards addressing the pain with other measures and discontinuing the shots. But would like to hear other success stories if possible.

Thanks,

Paul

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KAC

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Re: Thoughts on continuing Verapamil injections
« Reply #69 on: November 04, 2011, 03:22:28 PM »

Paul,
My curvature got worse during shots as well--so much so that we quit after a series of 6.  But then after a few months the plaque seemed to diminish from large, hard nodes of inflammation to kind of a painless and not very noticeable rope along the top of the shaft, and the curvature lessened.  I've now returned for another set of 6 shots in hopes that the the two remaining nodes (now one in the head, one at the base) will turn more into the rope-like plaque.  That I can just live with no problem.  The uro did put one shot into the middle rope-like plaque on this last round as an experiment.  It did seem to puff up during the week and resemble more of a node, and now, about 10 days later it's almost back to where it was.  My hope is that over time that will shrink even smaller. If that happens I'll continue with shots--I think that will be evidence that it's actually working.

But most of this is really to say, who really knows.  I've gone through a lot of stages and finally decided I just have to trust my gut and not be too cautious.  I feel worst when I'm not trying anything.  I do take the pentox as well as ALC and L-Arginine, ubiquinol, and use a VED.  My biggest question for my uro has been whether the verapamil has immediate verses long term effect.  He says he just doesn't know.  If its true effect is immediate, then I think I'm making a mistake; if the true effect is long-term, then I would say it's diminished my curve from 90 to 45 degrees.

I don't really understand the every 2 weeks thing either.  It seemed to me that every shot came just when swelling from the last shot diminished.  Makes me wonder if a little more space--even a month between shots might have been better.

Hope that's helpful in some way.  KAC
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rd

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Re: Here I go again with Verapamil
« Reply #70 on: November 17, 2011, 02:50:20 PM »

I haven't had VI injections but I did notice my plaque seems to over time moved. Mine started out as one peace under the head on the right side of my shaft then over time its been a little over a year it moved to about just above the half way point of my shaft has changed shapes and spit into what at times has felt like 3 peaces. Right now I can only find one and that was after i had the Stem Cell treatment. But I am not free of pain/discomfort and deformaty from the remaining plaque. I never had a curve but a dent which turned into hour glassing as the plaque changed shape and moved.
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charlie44

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UPDATED....Some changes (and questions) after second round...
« Reply #71 on: February 21, 2012, 06:28:07 PM »

Had my second round of VI's a week ago. A decent amount of bruising this time, but not really painful after the injections. Still, I did not have sex till six days later (yesterday). One thing I have noticed in the last couple days is that the nodules do seem smaller. However, my penis as a whole seems more firm/dense when flaccid than usual. So I am not sure if the nodules have gotten smaller, or if there is anything going on under the skin (bruising? etc) that might make it harder for me to actually feel the nodules, therefore the impression is that they are smaller? Something has definitely changed since the last shots, it's just too early for me to say definitively if it is improvement or some temporary change that has not actually affected nodule size.

I welcome anyone with any insight or similar experience feedback. Thanks.
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LWillisjr

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Re: Some changes (and questions) after second round...
« Reply #72 on: February 21, 2012, 07:51:13 PM »

It's been some time now since I had my VI's. I also had quite a bit of bruising. And I think I recall the "firmer" feeling when flaccid. After several weeks after the VI's were completed it seems all was back to normal. But I still had the curvature as the VI's did not provide any improvement for me.
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Les - 10 yrs Peyronies Disease free
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charlie44

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Re: (Updated).....Some changes (and questions) after second round...
« Reply #73 on: March 12, 2012, 02:35:33 PM »

I have my fourth round of VI tomorrow.....per my earlier post, the "changes" were not improvement...it was just a different feeling of overall tissue density for a while. But after 6 months of Pentox and 3 rounds of VI, no real improvement. That being said, would my disease be worse if I had not done either of these things or one or the other? Nobody knows, right? Therefore you have to take the medicine and the painful shots....cause it's all you have.....at least in my case (hourglassing). So you are doing treatment without knowing if it does any good or not. There is no other treatment besides this for hourglassing except surgery, and they only do that (appropriately so) if sex is impossible. Thank god I am not there yet.

I try not to get depressed about this....I am in my early 40's, and obviously this is a depressing issue....but I have had friends pass away lately who were my age, and I always think of them and what their families deal with versus my problem to try and keep perspective. It could be worse.....but it still weighs in the back of my mind of course.

I am very interested in hearing back from anyone else who has hourglassing and the treatment they are taking and if it's doing any good or not?
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james1947

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #74 on: March 12, 2012, 08:36:08 PM »

Charlie44
I understand you getting depressed about this...Peyronie's. I was depressed for a long time, but I am not anymore. I make myself busy and yes, thinking about others that they situation is bad than mine, not just with Peyronie's.
People life are affected bad from many diseases and other events so I thank God that is as it is.

Sorry that the VI didn't help you. In any case I suppose you have not expected too much.
Personally after reading on the forum almost everything regarding VI I decided that I will not do.

I do have hourglassing. I don't see yet benefits with VED that I ma doing for 6 months by now but I will continue because I think is helping keeping the penis more healthy with the forced blood flow.
I begin Pentox just two months ago and also just 2*400mg daily, I have benefits not connected to Peyronie's and some Peyronie's benefits like my flaccid state is more full. I read on the forum that should not expect Pentox benefits before 6 months or longer of using it and also higher dosage is more benefitting.
James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

charlie44

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #75 on: March 13, 2012, 10:41:30 AM »

James1947, thanks for your post. Regarding Pentox and higher dosage, I was prescribed 400mg three times a day. Good luck moving forward!
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LWillisjr

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #76 on: March 13, 2012, 09:44:19 PM »

charlie44,
I understand what you are saying about the VI's. I too did not see improvement but also wondered if it kept my situation from getting worse. I think it helped me mentally to approach my whole situation in that I felt like I was trying something to try to help myself. I was determined to stay positive and try whatever it took to beat this.

Les
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Les - 10 yrs Peyronies Disease free
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charlie44

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #77 on: March 13, 2012, 11:32:57 PM »

Les...your approach and mindset, and mine is the exact same. I feel I have to do what I can. Maybe it's working, maybe not, but have to stay positive.

Did you ever see any improvement, and if so, what was the reason for it?
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LWillisjr

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #78 on: March 14, 2012, 05:05:48 PM »

I went through a series of  VI's. Didn't get any better but didn't get any worse. During this time I was doing traction (per doctor's recommendation) and using Pentox the whole time. Once I was beyone the 12-18 month acute phase and stable, both the doc and I agreed that there was no improvement and it was time to try something different. This eventually led to surgery which worked out well or me.

Les
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Les - 10 yrs Peyronies Disease free
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charlie44

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #79 on: March 19, 2012, 03:07:31 PM »

What surgery did you have...and I assume it was to correct curvature?
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LWillisjr

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #80 on: March 20, 2012, 08:58:05 PM »

charlie44,
If you click on the "my history" link at the bottom of my post it will provide more details. I eventually had excision and grafting surgery to correct a 70+ degree dorsal curve. The surgery was successful and corrected the curve.

Les
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Les - 10 yrs Peyronies Disease free
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charlie44

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Re: UPDATED....Some changes (and questions) after second round...
« Reply #81 on: March 21, 2012, 10:15:55 AM »

Thanks Les!
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trevorrr

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Re: Here I go again with Verapamil
« Reply #82 on: April 16, 2012, 09:20:20 PM »

Had my first VI injections with doctor Brock in London, went very well no bruising or anything just minor swelling, The injections were at the distal tip under the glands. I have noticed very minor improvements and am going to continue with the injections.



Trevor
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charlie44

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #83 on: April 29, 2012, 05:52:04 PM »

I just finished my set of six injections a couple weeks ago. The disease worsened some during the process, so I cannot say that VI has helped at all. But that is like every treatment for Peyronies Disease. Unless you see something dramatic, you hang on to the hope that maybe you are mitigating worse progression than what you currently experience.
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james1947

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #84 on: April 29, 2012, 08:07:37 PM »

Personally I am against sticking a needle or anything else in my dick, but I know from reading the topics related to Verapamil injections that some people see positive results a few months, even six months after they finish the first six VI and decided to go on.

Some on the forum had also very positive results fro VI. :)

I know is very difficult to wait, wait and wait, but with Peyronie's you have to wait to see results from a certain treatmet.
The only thing with Peyronie's not to wait long is to have a bionic dick (implant I mean) and be better than we ever was ;D

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #85 on: May 04, 2012, 10:45:12 PM »

trevorrr

I have posted my question to you to the wrong person on the wrong topic. Here is my post:

How was the injection? It was painfull?
The doctor injected it in the plaque?
When you are scheduled for the next? How many injections in the plan?
Many questions, sorry, answer when you will feel OK.

Wish you it will work  :)

James
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Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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trevorrr

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #86 on: May 05, 2012, 12:12:00 AM »

How ya doin James.

They put a numbing agent just inside the skin on the base of penis and under the glands and its fell likes a little be sting which is the worst part after that its fine, Anxiety through the 45 seconds of the injections was my only problem. My uro who is top in canada for peyronies who is currently doing studies with Tom Lue was very accurate with his injections and was going directly into my scars and to be quite honest I enjoyed the sensation it was if I was fighting back against peyronies with this verapmil being injected directly into my scars. I have noticed very minor improvements which are encouraging knock on wood so we are going to continue, no limit on the injections have been discussed. Plus they are free in Canada so as long as its not making my my situation worse I'm going to continue.

Trevor
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yyy

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #87 on: June 15, 2012, 08:20:23 AM »

Hi trevorrr,

I have not understood if you are doing injections in Canada or in London

Can you tell me the name of the doctor? thank you
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trevorrr

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #88 on: June 15, 2012, 05:12:13 PM »

London Ontario Canada, Dr Gerald Brock.
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mike67

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #89 on: June 15, 2012, 05:32:15 PM »

Good luck with the injections Trevorrr
I believe you are in good hands ( so to speak) with Dr. Brock.
For any members reading this thread , don't forget that Dr. Ethan Grober at Mt. Sinai , in Toronto , is in the same class of expertise as Brock. Handier if you are closer to Toronto area.
Mike
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james1947

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #90 on: June 15, 2012, 05:57:14 PM »

Good luck Trevorrr with the injections.
Keep us updated regarding the results.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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charlie44

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #91 on: June 18, 2012, 10:58:02 PM »

Comeback....how long were you on Pentox before it improved your condition?
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First six done, six more to follow
« Reply #92 on: June 21, 2012, 04:02:41 PM »

I finished my first six verapamil injections on June 7.  #5 was by a urology fellow, rather than the more experienced PA.  The injections by the fellow were much more unpleasant during and afterwards.  During my ultrasound evaluation this past Monday, the technician said some urologists are trained to repeatedly perforate the plaque with the needle as a way to mechanically break it up.  He said the studies show this technique with verapamil is no more effective than if it was done with saline.  The reason is that the verapamil never gets a chance to "bathe" the plaque and be absorbed, like water on a sponge.  Instead, it shoots through and back out of the holes made by the needle.  I was sore and the plaque felt like it was inflamed for more than a week later.

The forced erection and ultrasound exams were informative.  Because I did not have a baseline measurement, he could not quantify a plaque volume reduction.  Subjectively, I can feel that it has slightly changed in shape and volume.  The plaque has compressed the main artery, which reduced blood flow in.  During the 2+ years I have been on pentox, nightly 25 mg viagra, and L-arginine, collateral circulation has improved, resulting in erections of near normal volume and firmness.

So far, there has not been any noticeable improvement in my curve.  This has now officially been measured and entered into my medical record as 90 degrees.  Sigh.  Penetration attempts after injection #6, both without and using the VED and band, were not successful.

I have another round of six injections scheduled early July to mid-September.  Unless these (by the PA!) result in a curve reduction of at least 30 degrees (I think I could live with a 60 degree curve), there probably won't be any more injections for me.

I have not found time in my day to regularly wear the Fastsize extender the recommended 3+ hours.

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LWillisjr

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #93 on: June 21, 2012, 05:35:37 PM »

If the first 6 didn't see any improvement, I question why they think 6 more will do anything.
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james1947

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #94 on: June 21, 2012, 07:03:12 PM »

BrooksBro

As lwillisjr has said, why your uro think that additional Verapamil injections will help if the fist six don't helped?
Interesting to know his answer.

Even that the oral medications not straitened your curve, is encouraging that your erections are
Quote
near normal volume and firmness

I will be happy to achieve that also!
What is the daily dosage of the Pentox and L-Arginine?

James
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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #95 on: June 22, 2012, 11:21:16 AM »

The normal dosage of Pentox is 400 mg tablet 3x daily, with food.  I take 2g (2,000 mg) L-Arginine, usually in the evening at the same time as my nightly 25 mg viagra, on an empty stomach.

The PA (not the urologist) said their patients getting VI fall into three broad categories.  Those for whom the first six did nothing, those for whom there was some improvement, and those for whom there was significant improvement.  I am in the second category.  After six, I can feel my plaque is a slightly different shape than it was before the first injection.  Does reduction in the plaque shape or volume translate to a reduction in curve?  In my experience, not yet.

The best description I recently read about the plaque is that it is a change in the structure of the tunica albuginea itself.  The analogy being to replace a section of a latex balloon with a piece of non-expanding plastic.

With this condition, I have not found any "good" solutions.  I tried oral therapy.  I tried traction therapy.  I tried VED therapy.  I am now trying verapamil injection therapy.  Should the next six injections not reduce the curve to where I can penetrate my wife, with a 90 degree curve, the only practical solution left is an implant.  Nesbit plication is not an option for a curve that severe.  I think I can endure 12 more shots (6 to numb, and 6 of verapamil).

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james1947

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #96 on: June 22, 2012, 08:16:27 PM »

BrooksBro

Thank you for the answer. I am taking the L-Arginine 1g one in the morning one in the evening with 4mg Cialis after meal.
I will change to 2g L-Arginine in the evening together with the 4mg Cialis on empty stomach. Hope will help something.

Maybe if as you say your erections are firm a incision with grafting surgery will be enough.
I think implant is mainly to solve Erectile Dysfunction problems and to gain back some length and girth lost to the Peyronies.
Just thinking, not trying to advise in the subject.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #97 on: June 22, 2012, 09:03:59 PM »

Thanks for the thought.  Most of what I have read about grafting is that the long term (over 5 years) satisfaction is low, even when there was the best possible procedure.  My erections are firm, with medication or VED assistance.  Venous leakage is still present, even though the collateral circulation has partially overcome the arterial blockage from the plaque.  Achieving an erection is not the same as sustaining it long enough.

Maybe if as you say your erections are firm a incision with grafting surgery will be enough.
I think implant is mainly to solve Erectile Dysfunction problems and to gain back some length and girth lost to the Peyronies.
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LWillisjr

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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #98 on: June 22, 2012, 09:07:30 PM »

I had excision and grafting 4 years ago next month. And it is equally as good today as it was post surgery.
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Les - 10 yrs Peyronies Disease free
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Re: VERAPAMIL Injections results (Positive & Negative)
« Reply #99 on: June 23, 2012, 02:00:47 AM »

I suppose from reading this forum and other information that lwillisjr is not the only one that can say:
Quote
I had excision and grafting 4 years ago next month. And it is equally as good today as it was post surgery.

BrooksBro you are right that:
Quote
Achieving an erection is not the same as sustaining it long enough.
This can be fixed with an implant if all the other treatments don't help anymore.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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