mycophenolate mofetil

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projectpd

the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.  
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

I would always go with the lower dose transdermally.  
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.

Quote from: projectpd on May 12, 2020, 12:02:03 PM
the problem with this transdermally could be that it's biphasic

Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe)  ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.  
Age 57, Onset 2010, 2" shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

Thx! Learned something! Makes complete sense.
Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

drew67

Just wanted to see if anyone is considering this either orally or transdermally.

Michiganguy19

For a lot of us it is an autoimmune disease causing it.

Quote from: Hontas on August 30, 2019, 09:01:38 AM
Whyisthishappening,

This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

What dose do I ask my doc for? I will try it. What about the IPF drug Ofev? Reversed my friends pulmonary fibrosis
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

A lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie's?
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Bent Ding Dong

@Michiganguy19, I don't have access to those drugs otherwise I would try them but I bet they have nasty side effects also?

I've tried monk fruit extract which is supposed to reduce pulmonary fibrosis but that didn't do anything for my peyronies.

Here is the study: https://pubmed.ncbi.nlm.nih.gov/28280123/
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

hope794

26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Michiganguy19

I just messaged my doctor. He said he'd put me on it.  
Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

pey ron

Did you have an easy reason to get it, or did you find a very understanding doctor who was willing to experiment?
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pey ron

but do you have any condition for which mycophenolate mofetil has an on-label use?

also: how do you spell Lofarin? I can't find it...
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
age, date of onset, symptoms, treatments tried,
relationship status, etc
** You will waste less time and get better answers **

Bent Ding Dong

@Michiganguy19, can you keep this post updated about how the drug goes for your peyronie's?
Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

Asphyxia

can i use mycophenolic acid instead?
anybody knows the difference?
Age:23. Onset of symptoms: september 2020.
Curve mostly semi erect about 60 degrees, slight pain
Tried short & prolonged fasts, keto,carnivore, traction and most of the supplements.
Severe digestive issues, probably an autoimmune disorder

westerntown

20, late 2020 masturbation injury leads to semi erect hourglass, then try manual stretching leads to pudendal neuralgia like symptoms, corpus spongiosum and glans do not fill, severe ed- floppy unstable erections that feel like water balloon .