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Author Topic: mycophenolate mofetil  (Read 7035 times)

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projectpd

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Re: mycophenolate mofetil
« Reply #100 on: May 12, 2020, 12:02:03 PM »

the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.
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melting

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Re: mycophenolate mofetil
« Reply #101 on: May 12, 2020, 12:10:08 PM »

I would always go with the lower dose transdermally. 
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.

the problem with this transdermally could be that it's biphasic


Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

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Re: mycophenolate mofetil
« Reply #102 on: May 12, 2020, 12:35:40 PM »

biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe)  ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.
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melting

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Re: mycophenolate mofetil
« Reply #103 on: May 12, 2020, 04:23:37 PM »

Thx! Learned something! Makes complete sense.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

drew67

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Re: mycophenolate mofetil
« Reply #104 on: May 20, 2020, 06:52:24 PM »

Just wanted to see if anyone is considering this either orally or transdermally.
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Michiganguy19

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Re: mycophenolate mofetil
« Reply #105 on: August 31, 2020, 09:44:29 PM »

For a lot of us it is an autoimmune disease causing it.

Whyisthishappening,

This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
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Peyronies Disease November 2015.
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Length before erect: 7.2in
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Michiganguy19

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Re: mycophenolate mofetil
« Reply #106 on: August 31, 2020, 09:45:22 PM »

What dose do I ask my doc for? I will try it. What about the IPF drug Ofev? Reversed my friends pulmonary fibrosis
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

Michiganguy19

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Re: mycophenolate mofetil
« Reply #107 on: August 31, 2020, 09:51:57 PM »

A lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie’s?
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

Bent Ding Dong

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Re: mycophenolate mofetil
« Reply #108 on: September 01, 2020, 07:33:13 AM »

@Michiganguy19, I don't have access to those drugs otherwise I would try them but I bet they have nasty side effects also?

I've tried monk fruit extract which is supposed to reduce pulmonary fibrosis but that didn't do anything for my peyronies.

Here is the study: https://pubmed.ncbi.nlm.nih.gov/28280123/
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hope794

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Re: mycophenolate mofetil
« Reply #109 on: September 01, 2020, 04:53:38 PM »

Anyone else have tried this?
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

Michiganguy19

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Re: mycophenolate mofetil
« Reply #110 on: September 01, 2020, 07:44:36 PM »

I just messaged my doctor. He said he’d put me on it.
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Peyronies Disease November 2015.
Caused by Reactive Arthritis, caused by chlamydia October 2015.
Length before erect: 7.2in
Girth before erect: 6in? Just a guess.
Length erect. 6.1in
Girth erect: 4.1in
That's what I get for touching a stripper.

pey ron

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Re: mycophenolate mofetil
« Reply #111 on: September 02, 2020, 05:17:24 AM »

Did you have an easy reason to get it, or did you find a very understanding doctor who was willing to experiment?
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pey ron

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Re: mycophenolate mofetil
« Reply #112 on: September 02, 2020, 05:21:05 AM »

but do you have any condition for which mycophenolate mofetil has an on-label use?

also: how do you spell Lofarin? I can't find it...
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Bent Ding Dong

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Re: mycophenolate mofetil
« Reply #113 on: September 02, 2020, 06:14:12 AM »

@Michiganguy19, can you keep this post updated about how the drug goes for your peyronie's?
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