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Author Topic: mycophenolate mofetil  (Read 4146 times)

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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #50 on: August 30, 2019, 01:58:43 PM »

mofetil healed rats in just 5 days  and not in a crazy dose but human therapeutic one
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jj21

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Re: mycophenolate mofetil
« Reply #51 on: September 01, 2019, 12:21:43 AM »

any update?
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Age:30 - Symptoms for 6-7 months no improvement or worsening.... Prominent Left + Upwards curve when half erect.. Fully erect - approx 20-25 degree curve... No noticeable plaque. Waiting on Ultrasound results.. Mild Erectile Dysfunction..

Fix This

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Re: mycophenolate mofetil
« Reply #52 on: September 01, 2019, 02:51:46 PM »

Yes I've just seen this and I'm very interested to hear of an update on this now too!...
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

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Re: mycophenolate mofetil
« Reply #53 on: September 01, 2019, 06:27:09 PM »

Also, whyhisishappening. Can you tell me where exactly you get thie SU MU tea from?  I have found several MU teas, but no SU MU?


Thanks

Fix
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #54 on: September 02, 2019, 11:45:08 AM »

bought it from a chinese traditional medicine shop  su mu (caesalpinia sappan)
https://tcmwiki.com/wiki/su-mu
please take reishi powder 1 tea spoon two times a day very helpful
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Re: mycophenolate mofetil
« Reply #55 on: September 02, 2019, 11:54:26 AM »

Thanks Whythisishappening. I'll look at that for sure

Have you had any success treating your peyronies with this tea?

Any news on the Mofetil yet ?
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #56 on: September 02, 2019, 01:31:27 PM »

i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago  i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
 considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it
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Re: mycophenolate mofetil
« Reply #57 on: September 03, 2019, 05:09:14 AM »

Do you think the reishi poweder might have helped ratehr than the su mu tea?

I've looked on Amazon here in the UK and there are quite a few reishi options - tablets, powder etc. But I'm not sure what doseage we shoud be looking at ? I haven't heard of this as a treatment or supplement before.

Whic country are you in Whythisishappening? If you don't mind me asking? It may be that some Easter countries such as China have different methods of dealing with peyronies which we in the West and even on this forum may not have such general knowledge of
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #58 on: September 03, 2019, 06:34:13 AM »

i do not know Fix maybe both ,try them they do not harm you,just take reishi up to a gram per day not less .Buy reishi in bulk powder form costs less and take a tea spoon twice a day
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Re: mycophenolate mofetil
« Reply #59 on: September 08, 2019, 05:32:15 AM »

Thanks, Su Mu in powder form or the red bark is better?

Also any update on the Mofetil?..
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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Hope77

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Re: mycophenolate mofetil
« Reply #60 on: September 09, 2019, 01:30:49 PM »

i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago  i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
 considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it

Hello, I have 3 lumps amd with pain around the area. Are these lump/swelling the same as plaques? Could I be in acute peyronie? What do u recommend at this stage apart from survival guide.

Thank you
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Curve to the right (healed) and two new lumps on the left (acute)
25,  Peyronies possibly (2 huge lumps by the left), sex without 100% erection  Erectile Dysfunction and pain
Current Treatment: Pentox, L Arginnine, COQ10

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #61 on: September 10, 2019, 09:40:49 AM »

fix this i took bark ,i also just got mofetil today but will wait for some days before i take it
 hope 77 try reishi mushroom powder apart from that i do not know this is the mofetil thread.. ,take care man and welcome to the forum
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JohnnyDoe

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Re: mycophenolate mofetil
« Reply #62 on: September 10, 2019, 05:19:38 PM »

Good luck with the Mofetil. I look forward to read about your results!
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Re: mycophenolate mofetil
« Reply #63 on: September 10, 2019, 06:42:06 PM »

Thanks Whythis , I'll try the bark :)

Also looking forward to your results with Mofetil

Are you going to try a 5 day course as per the rat tests?


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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #64 on: September 12, 2019, 05:30:28 PM »

 i will try  500mg  for 5 days and if does not work 2000mg for 5 days like the rat study
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Re: mycophenolate mofetil
« Reply #65 on: September 13, 2019, 04:17:31 AM »

Make sure to take before/after photos! In case it works, it would be good to have some proof :)
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pey ron

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Re: mycophenolate mofetil
« Reply #66 on: September 17, 2019, 01:10:43 AM »

@Whyisthishappening: can you send me a private message with the source you bought it from?
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Re: mycophenolate mofetil
« Reply #67 on: September 18, 2019, 04:12:45 AM »

Have you completed the 5 days at 500mg yet Whythisishappening?  Any improvements?

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44 , penis trauma July 2018 leading to Peyronies. I'm attacking it though, and I will fix this!

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Re: mycophenolate mofetil
« Reply #68 on: September 18, 2019, 01:14:48 PM »

hi ron i bought mofetil from a pharmacy in my city with a special prescription from a reummatologist
fix i have not started my treatment yet i am planning to start tomorrow or monday
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samsung

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Re: mycophenolate mofetil
« Reply #69 on: September 23, 2019, 11:13:46 AM »

Anything to report?
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 2 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

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Re: mycophenolate mofetil
« Reply #70 on: September 25, 2019, 02:04:19 PM »

hi guys i am on mofetil treatment  day 2 nothing so far to report i will finish my treatment on saturday
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pey ron

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Re: mycophenolate mofetil
« Reply #71 on: September 27, 2019, 04:11:00 AM »

best of luck!!!!!

what country are you in?
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Re: mycophenolate mofetil
« Reply #72 on: September 28, 2019, 06:45:57 AM »

mofetil day 5 i have switched yesterday to 2 grams per day so will take it for 4 more days and report about the results ,so far no results.
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Re: mycophenolate mofetil
« Reply #73 on: September 28, 2019, 08:31:01 AM »

Just don't overuse it man, there are serious risks of rare uncurable cancers with the use of mofetil. From my perspective its not a risk worth taking however i give you props for being the one with the biggest balls. I just think thrice before using something potent since it can also make you worse in theory... Now i am gonna mix up raloxifene and tadalafil and will let you know about the results. We gonna get through this man
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #74 on: September 30, 2019, 08:04:04 AM »

guys it did nothing so far so i quit it
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Re: mycophenolate mofetil
« Reply #75 on: September 30, 2019, 04:00:13 PM »

Respect for trying. Who knows, it will take some time to have an effect.
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #76 on: October 01, 2019, 01:00:41 AM »

guys i want to thank everybody for your best wishes mofetil at least in theory sounded promising the doctor told me that it takes time to build in your system and work but i followed the rat study protocol with no results and didn't want to try it longer
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #77 on: October 03, 2019, 02:42:29 PM »

guys great news

   i have no curvature while i had minimal curvature before
    and my two dents are better
 
 i should mention that i had NO FIBROSIS established on MRI BEFORE I TOOK MOFETIL
  i have soft non palpable plaques so my case is considered very mild

 also i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
 i will try again for five days at 2000mg per day in the near future and report back
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Re: mycophenolate mofetil
« Reply #78 on: October 03, 2019, 04:50:42 PM »

Great to hear. So after 2 days you saw improvements happening?
How many degrees are we talking about?
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Re: mycophenolate mofetil
« Reply #79 on: October 03, 2019, 05:18:23 PM »

Pickatures
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 2 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #80 on: October 04, 2019, 06:10:33 AM »

i saw improvement 3 days after the last pills i had 5-10 degrees curvature i have no pictures
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hope794

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Re: mycophenolate mofetil
« Reply #81 on: October 04, 2019, 05:03:15 PM »

Hello, can you please be more accurate bro?

Answer these questions please..

1. Curvature degrees BEFORE and AFTER the treatment?
2. How long did the treatment last?
3. How were your erections BEFORE and AFTER the treatment?
4. Which effects did you notice (if you had any) on other deformities, like dents, hourglassing, and so on?
5. What about penile lenght and girth? any improvements?

Thank you!!!
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24 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 10-15°, with a slight twist to the left.Moderate Erectile Dysfunction since 2 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

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Re: mycophenolate mofetil
« Reply #82 on: October 04, 2019, 05:21:01 PM »

Sorry for me saying to provide pics. Don't mean to be aggressive. You understand we are all just anxious for any positive results.
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 2 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #83 on: October 05, 2019, 09:11:05 AM »

 i have no curvature while i had minimal curvature before (5-10 degrees)
   
 my two dents are better
 
 i had NO FIBROSIS  on MRI BEFORE I TOOK MOFETIL
 
 i have soft non palpable plaques so my case is considered very mild
 
 i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
 
i never had and i do not have any erection problems
 
 i will try again for five days at 2000mg per day in the near future and report back
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JohnnyDoe

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Re: mycophenolate mofetil
« Reply #84 on: October 05, 2019, 03:52:24 PM »

I assume by "dents are better" you mean not completely healed yet, but better than before.
Do you want to do it again because you believe you can get further improvements?
Did you experience any side effects during or after this treatment?
And most importantly, would you recommend this treatment to the rest of us?

I believe this sounds pretty amazing.
As you can imagine, 5 days of taking a few pills sounds to good to be true.
But I am open to trying if it works this well, especially because my case sounds very similar to yours.
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #85 on: October 06, 2019, 06:21:53 AM »

I assume by "dents are better" you mean not completely healed yet, but better than before
 yes
Do you want to do it again because you believe you can get further improvements?
yes i will for 5 days at 2000mg per day
Did you experience any side effects during or after this treatment?
no nothing
And most importantly, would you recommend this treatment to the rest of us?
 i CANNOT RECOMMEND A DANGEROUS DRUG I AM NOT A DOCTOR VISIT ONE BEFORE YOU TAKE IT
  WHEN ON MOFETIL YOU HAVE TO AVOID UV AND SUN EXPOSURE AND MANY OTHER THINGS LIKE INFECTIONS AND SORE THROAT READ THE MANUAL
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Re: mycophenolate mofetil
« Reply #86 on: October 07, 2019, 04:17:40 PM »

Thanks for answering, yeah speaking to a doctor makes sense.
If I understand correctly, if you went from 10 degrees to 0, that means your plaque must have softened or (partially) went back to normal tissue.
Which both sounds pretty impressive.

MMF weakens the immune system, could halt auto immune processes, therefore could stop myofibroblasts.
Also it restores the collagen ratios according to the article. But why does it have an anti-fibrotic effect though?
Restoring the balance of the different elements initiates the process of restoring the damaged tissue?
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Re: mycophenolate mofetil
« Reply #87 on: October 15, 2019, 09:36:56 PM »

Quote deleted by moderator. Please read the forum rules.

I'm eager to see what the follow up run will do, any idea how soon you'll do it? And are you planning to take pictures?
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Re: mycophenolate mofetil
« Reply #88 on: October 22, 2019, 11:29:02 AM »

Any plans on doing additional dose? Anything to report?
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44 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 2 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

Whyisthishappening

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Re: mycophenolate mofetil
« Reply #89 on: October 22, 2019, 11:56:41 AM »

as of today nothing new to report guys do not know when i am going to take it again
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Patientxyz1992

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Re: mycophenolate mofetil
« Reply #90 on: October 22, 2019, 12:44:56 PM »

Hey whyisthishappening im closely watching on this thread, congratulations on improvement and on balls to do this, did you finished second round and if you can calculate what was your percentage of improvement before and after drug if 100% is perfect healthy erection, thank you and i hope that soon enaugh we will get rid of peyronies..
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Re: mycophenolate mofetil
« Reply #91 on: October 23, 2019, 03:20:05 AM »

Whyisthishappening, this is so exciting to hear!!!

do you have:
1) an old ultrasound?
2) before pictures?
3) after pictures?

...

4) suppose you get to the point where you believe you are 100% healed, will you go and do a follow-up ultrasound?

thank you!!! and good luck!
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Re: mycophenolate mofetil
« Reply #92 on: October 23, 2019, 07:11:55 AM »

guys i have no pictures
 
had an MRI with NO FIBROSIS  BEFORE i took  MOFETIL

 I BELIEVE REISHI MUSHROOM OR MY BODY DID THE JOB FOR FIBROSIS I CANNOT TELL
 
I WILL TRY CHLORELLA BECAUSE OF WOUNDVITE
 
MOFETIL DID SOMETHING FOR MY MINIMAL CURVATURE AND IMPROVED SLIGHTLY MY TWO DENTS
 
reply#83
 
 " i have no curvature while i had minimal curvature before (5-10 degrees)
   
 my two dents are better
 
 i had NO FIBROSIS  on MRI BEFORE I TOOK MOFETIL
 
 i have soft non palpable plaques so my case is considered very mild
 
 i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
 
i never had and i do not have any erection problems
 
 i will try again for five days at 2000mg per day in the near future and report back"
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #93 on: October 31, 2019, 07:00:51 AM »

i just finished mofetil treatment 2000mg per day for 5 days will report back if i have any benefits
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Dabbydu

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Re: mycophenolate mofetil
« Reply #94 on: October 31, 2019, 07:03:02 PM »

Look forward to your report whyisthishappening. Did you notice any I'll effects from the dosage with this run vs last run or still relatively easy on the body?
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #95 on: November 01, 2019, 07:16:09 AM »

i noticed no side effects
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #96 on: November 04, 2019, 08:18:01 AM »

guys no gains so far and i do not believe i will have any
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melting

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Re: mycophenolate mofetil
« Reply #97 on: November 04, 2019, 08:33:58 AM »

mycophenolate mofetil
Molecular Weight‎: ‎433.5 g/mol
Theoretically possible to shuttle in via transdermal application.(ask your doc)
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Whyisthishappening

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Re: mycophenolate mofetil
« Reply #98 on: November 04, 2019, 10:43:29 AM »

melting you believe its going to have an effect as a topical treatment and why better than oral the rat study was oral
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melting

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Re: mycophenolate mofetil
« Reply #99 on: November 04, 2019, 02:39:27 PM »

mycophenolate mofetil is also indicated as treatment being injected into a vein(don't do that without a doctor!) so I guess it will work transdermally too.

Most supplements around "Molecular weight 500 g/mol" (I think it gets hard beyond 1000 g/mol) can be transported transdermaly via DMSO directly to the plaque site. (searching google with "Supplement XYZ + molecular weight gives you the weight)

Why Transdermal? Side effects are often high with oral medication. 
But the most important reason for transdermal is the PLACE where the Peyronies plaques sit! Penis has not as much blood circulation as let's say your heart, biceps, brain, arms, legs, even your knee.. The plaque also often is right in the Penis tunica which has even less blood circulation than the Penis smooth muscles. The plaque itself has no direct blood supply..
That's why pde5 can help a lot, it increases blood circulation to the penis and allows supplements to go there..

Now imagine you take orally a supplement and it's half life in the blood is 20 minutes.. and your penis is just normal flaccid, no blood in it.. the medication will float through your body getting used up, degraded, secreted into your bladder/urine.. possibly nothing reaching the plaque/fibrosis.

So transdermaly applied at and around your plaque area it will be right there(yes, some will miss/transported away by blood too)
Doing that 1 to X times daily you can see how this is much more effective than oral. IMO this is also why oral has such wide range of results between people and studies. Hit or miss! (It still can be good to do both oral and transdermal -WATCH toxicity obviously)

That said..

Quote
The mean maximum plasma mycophenolic acid concentration (Cmax) after a mycophenolate mofetil 1g dose in healthy individuals was around 25 mg/L, occurred at 0.8 hours postdose, decayed with a mean apparent half-life (t1/2) of around 16 hours, and generated a mean total area under the plasma concentration-time curve

So not that bad of a chance but imo orally you would still need to take is often as possible(and healthy!) to get good concentrations to the plaque site.

I'm no doctor though and maybe this logic only makes sense to me ;)

I'm not sure on mycophenolate mofetil generally, sounds promising, I would have to investigate more(I won't cause I'd need a prescription to use it)


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