Topic: mycophenolate mofetil (Read 5352 times)

Whyisthishappening · « **Reply #50 on:** August 30, 2019, 01:58:43 PM »

mofetil healed rats in just 5 days and not in a crazy dose but human therapeutic one

jj21 · « **Reply #51 on:** September 01, 2019, 12:21:43 AM »

any update?

Fix This · « **Reply #52 on:** September 01, 2019, 02:51:46 PM »

Yes I've just seen this and I'm very interested to hear of an update on this now too!...

Fix This · « **Reply #53 on:** September 01, 2019, 06:27:09 PM »

Also, whyhisishappening. Can you tell me where exactly you get thie SU MU tea from? I have found several MU teas, but no SU MU?

Thanks

Fix

Whyisthishappening · « **Reply #54 on:** September 02, 2019, 11:45:08 AM »

bought it from a chinese traditional medicine shop su mu (caesalpinia sappan)
https://tcmwiki.com/wiki/su-mu
please take reishi powder 1 tea spoon two times a day very helpful

Fix This · « **Reply #55 on:** September 02, 2019, 11:54:26 AM »

Thanks Whythisishappening. I'll look at that for sure

Have you had any success treating your peyronies with this tea?

Any news on the Mofetil yet ?

Whyisthishappening · « **Reply #56 on:** September 02, 2019, 01:31:27 PM »

i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it

Fix This · « **Reply #57 on:** September 03, 2019, 05:09:14 AM »

Do you think the reishi poweder might have helped ratehr than the su mu tea?

I've looked on Amazon here in the UK and there are quite a few reishi options - tablets, powder etc. But I'm not sure what doseage we shoud be looking at ? I haven't heard of this as a treatment or supplement before.

Whic country are you in Whythisishappening? If you don't mind me asking? It may be that some Easter countries such as China have different methods of dealing with peyronies which we in the West and even on this forum may not have such general knowledge of

Whyisthishappening · « **Reply #58 on:** September 03, 2019, 06:34:13 AM »

i do not know Fix maybe both ,try them they do not harm you,just take reishi up to a gram per day not less .Buy reishi in bulk powder form costs less and take a tea spoon twice a day

Fix This · « **Reply #59 on:** September 08, 2019, 05:32:15 AM »

Thanks, Su Mu in powder form or the red bark is better?

Also any update on the Mofetil?..

Hope77 · « **Reply #60 on:** September 09, 2019, 01:30:49 PM »

Quote from: Whyisthishappening on September 02, 2019, 01:31:27 PM

i do not know man my TWO DENTS ARE smaller but STILL THERE i had an MRI and i have NO FIBROSIS at the moment while a year ago i had ,so reishi or my body helped i stoped su mu after a month of use and i am on reishi powder only
considering mofetil today i called another reummatologist and is willing to prescribe it so i hope in a few days to have it

Hello, I have 3 lumps amd with pain around the area. Are these lump/swelling the same as plaques? Could I be in acute peyronie? What do u recommend at this stage apart from survival guide.

Thank you

Whyisthishappening · « **Reply #61 on:** September 10, 2019, 09:40:49 AM »

fix this i took bark ,i also just got mofetil today but will wait for some days before i take it
hope 77 try reishi mushroom powder apart from that i do not know this is the mofetil thread.. ,take care man and welcome to the forum

JohnnyDoe · « **Reply #62 on:** September 10, 2019, 05:19:38 PM »

Good luck with the Mofetil. I look forward to read about your results!

Fix This · « **Reply #63 on:** September 10, 2019, 06:42:06 PM »

Thanks Whythis , I'll try the bark

Also looking forward to your results with Mofetil

Are you going to try a 5 day course as per the rat tests?

Whyisthishappening · « **Reply #64 on:** September 12, 2019, 05:30:28 PM »

i will try 500mg for 5 days and if does not work 2000mg for 5 days like the rat study

JohnnyDoe · « **Reply #65 on:** September 13, 2019, 04:17:31 AM »

Make sure to take before/after photos! In case it works, it would be good to have some proof

pey ron · « **Reply #66 on:** September 17, 2019, 01:10:43 AM »

@Whyisthishappening: can you send me a private message with the source you bought it from?

Fix This · « **Reply #67 on:** September 18, 2019, 04:12:45 AM »

Have you completed the 5 days at 500mg yet Whythisishappening? Any improvements?

Whyisthishappening · « **Reply #68 on:** September 18, 2019, 01:14:48 PM »

hi ron i bought mofetil from a pharmacy in my city with a special prescription from a reummatologist
fix i have not started my treatment yet i am planning to start tomorrow or monday

samsung · « **Reply #69 on:** September 23, 2019, 11:13:46 AM »

Anything to report?

Whyisthishappening · « **Reply #70 on:** September 25, 2019, 02:04:19 PM »

hi guys i am on mofetil treatment day 2 nothing so far to report i will finish my treatment on saturday

pey ron · « **Reply #71 on:** September 27, 2019, 04:11:00 AM »

best of luck!!!!!

what country are you in?

Whyisthishappening · « **Reply #72 on:** September 28, 2019, 06:45:57 AM »

mofetil day 5 i have switched yesterday to 2 grams per day so will take it for 4 more days and report about the results ,so far no results.

Hontas · « **Reply #73 on:** September 28, 2019, 08:31:01 AM »

Just don't overuse it man, there are serious risks of rare uncurable cancers with the use of mofetil. From my perspective its not a risk worth taking however i give you props for being the one with the biggest balls. I just think thrice before using something potent since it can also make you worse in theory... Now i am gonna mix up raloxifene and tadalafil and will let you know about the results. We gonna get through this man

Whyisthishappening · « **Reply #74 on:** September 30, 2019, 08:04:04 AM »

guys it did nothing so far so i quit it

JohnnyDoe · « **Reply #75 on:** September 30, 2019, 04:00:13 PM »

Respect for trying. Who knows, it will take some time to have an effect.

Whyisthishappening · « **Reply #76 on:** October 01, 2019, 01:00:41 AM »

guys i want to thank everybody for your best wishes mofetil at least in theory sounded promising the doctor told me that it takes time to build in your system and work but i followed the rat study protocol with no results and didn't want to try it longer

Whyisthishappening · « **Reply #77 on:** October 03, 2019, 02:42:29 PM »

guys great news

i have no curvature while i had minimal curvature before
and my two dents are better

i should mention that i had NO FIBROSIS established on MRI BEFORE I TOOK MOFETIL
i have soft non palpable plaques so my case is considered very mild

also i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day
i will try again for five days at 2000mg per day in the near future and report back

JohnnyDoe · « **Reply #78 on:** October 03, 2019, 04:50:42 PM »

Great to hear. So after 2 days you saw improvements happening?
How many degrees are we talking about?

samsung · « **Reply #79 on:** October 03, 2019, 05:18:23 PM »

Pickatures

Whyisthishappening · « **Reply #80 on:** October 04, 2019, 06:10:33 AM »

i saw improvement 3 days after the last pills i had 5-10 degrees curvature i have no pictures

hope794 · « **Reply #81 on:** October 04, 2019, 05:03:15 PM »

Hello, can you please be more accurate bro?

Answer these questions please..

1. Curvature degrees BEFORE and AFTER the treatment?
2. How long did the treatment last?
3. How were your erections BEFORE and AFTER the treatment?
4. Which effects did you notice (if you had any) on other deformities, like dents, hourglassing, and so on?
5. What about penile lenght and girth? any improvements?

Thank you!!!

samsung · « **Reply #82 on:** October 04, 2019, 05:21:01 PM »

Sorry for me saying to provide pics. Don't mean to be aggressive. You understand we are all just anxious for any positive results.

Whyisthishappening · « **Reply #83 on:** October 05, 2019, 09:11:05 AM »

i have no curvature while i had minimal curvature before (5-10 degrees)

my two dents are better

i had NO FIBROSIS on MRI BEFORE I TOOK MOFETIL

i have soft non palpable plaques so my case is considered very mild

i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day

i never had and i do not have any erection problems

i will try again for five days at 2000mg per day in the near future and report back

JohnnyDoe · « **Reply #84 on:** October 05, 2019, 03:52:24 PM »

I assume by "dents are better" you mean not completely healed yet, but better than before.
Do you want to do it again because you believe you can get further improvements?
Did you experience any side effects during or after this treatment?
And most importantly, would you recommend this treatment to the rest of us?

I believe this sounds pretty amazing.
As you can imagine, 5 days of taking a few pills sounds to good to be true.
But I am open to trying if it works this well, especially because my case sounds very similar to yours.

Whyisthishappening · « **Reply #85 on:** October 06, 2019, 06:21:53 AM »

I assume by "dents are better" you mean not completely healed yet, but better than before
yes
Do you want to do it again because you believe you can get further improvements?
yes i will for 5 days at 2000mg per day
Did you experience any side effects during or after this treatment?
no nothing
And most importantly, would you recommend this treatment to the rest of us?
i CANNOT RECOMMEND A DANGEROUS DRUG I AM NOT A DOCTOR VISIT ONE BEFORE YOU TAKE IT
WHEN ON MOFETIL YOU HAVE TO AVOID UV AND SUN EXPOSURE AND MANY OTHER THINGS LIKE INFECTIONS AND SORE THROAT READ THE MANUAL

JohnnyDoe · « **Reply #86 on:** October 07, 2019, 04:17:40 PM »

Thanks for answering, yeah speaking to a doctor makes sense.
If I understand correctly, if you went from 10 degrees to 0, that means your plaque must have softened or (partially) went back to normal tissue.
Which both sounds pretty impressive.

MMF weakens the immune system, could halt auto immune processes, therefore could stop myoﬁbroblasts.
Also it restores the collagen ratios according to the article. But why does it have an anti-fibrotic effect though?
Restoring the balance of the different elements initiates the process of restoring the damaged tissue?

Dabbydu · « **Reply #87 on:** October 15, 2019, 09:36:56 PM »

Quote deleted by moderator. Please read the forum rules.

I'm eager to see what the follow up run will do, any idea how soon you'll do it? And are you planning to take pictures?

samsung · « **Reply #88 on:** October 22, 2019, 11:29:02 AM »

Any plans on doing additional dose? Anything to report?

Whyisthishappening · « **Reply #89 on:** October 22, 2019, 11:56:41 AM »

as of today nothing new to report guys do not know when i am going to take it again

Patientxyz1992 · « **Reply #90 on:** October 22, 2019, 12:44:56 PM »

Hey whyisthishappening im closely watching on this thread, congratulations on improvement and on balls to do this, did you finished second round and if you can calculate what was your percentage of improvement before and after drug if 100% is perfect healthy erection, thank you and i hope that soon enaugh we will get rid of peyronies..

pey ron · « **Reply #91 on:** October 23, 2019, 03:20:05 AM »

Whyisthishappening, this is so exciting to hear!!!

do you have:
1) an old ultrasound?
2) before pictures?
3) after pictures?

...

4) suppose you get to the point where you believe you are 100% healed, will you go and do a follow-up ultrasound?

thank you!!! and good luck!

Whyisthishappening · « **Reply #92 on:** October 23, 2019, 07:11:55 AM »

guys i have no pictures

had an MRI with NO FIBROSIS BEFORE i took MOFETIL

I BELIEVE REISHI MUSHROOM OR MY BODY DID THE JOB FOR FIBROSIS I CANNOT TELL

I WILL TRY CHLORELLA BECAUSE OF WOUNDVITE

MOFETIL DID SOMETHING FOR MY MINIMAL CURVATURE AND IMPROVED SLIGHTLY MY TWO DENTS

reply#83

" i have no curvature while i had minimal curvature before (5-10 degrees)

my two dents are better

i had NO FIBROSIS on MRI BEFORE I TOOK MOFETIL

i have soft non palpable plaques so my case is considered very mild

i took mofetil for 3 days at 500mg per day and then for 3 days at 2000mg per day

i never had and i do not have any erection problems

i will try again for five days at 2000mg per day in the near future and report back"

Whyisthishappening · « **Reply #93 on:** October 31, 2019, 07:00:51 AM »

i just finished mofetil treatment 2000mg per day for 5 days will report back if i have any benefits

Dabbydu · « **Reply #94 on:** October 31, 2019, 07:03:02 PM »

Look forward to your report whyisthishappening. Did you notice any I'll effects from the dosage with this run vs last run or still relatively easy on the body?

Whyisthishappening · « **Reply #95 on:** November 01, 2019, 07:16:09 AM »

i noticed no side effects

Whyisthishappening · « **Reply #96 on:** November 04, 2019, 08:18:01 AM »

guys no gains so far and i do not believe i will have any

melting · « **Reply #97 on:** November 04, 2019, 08:33:58 AM »

mycophenolate mofetil
Molecular Weight‎: ‎433.5 g/mol
Theoretically possible to shuttle in via transdermal application.(ask your doc)

Whyisthishappening · « **Reply #98 on:** November 04, 2019, 10:43:29 AM »

melting you believe its going to have an effect as a topical treatment and why better than oral the rat study was oral

melting · « **Reply #99 on:** November 04, 2019, 02:39:27 PM »

mycophenolate mofetil is also indicated as treatment being injected into a vein(don't do that without a doctor!) so I guess it will work transdermally too.

Most supplements around "Molecular weight 500 g/mol" (I think it gets hard beyond 1000 g/mol) can be transported transdermaly via DMSO directly to the plaque site. (searching google with "Supplement XYZ + molecular weight gives you the weight)

Why Transdermal? Side effects are often high with oral medication.
But the most important reason for transdermal is the PLACE where the Peyronies plaques sit! Penis has not as much blood circulation as let's say your heart, biceps, brain, arms, legs, even your knee.. The plaque also often is right in the Penis tunica which has even less blood circulation than the Penis smooth muscles. The plaque itself has no direct blood supply..
That's why pde5 can help a lot, it increases blood circulation to the penis and allows supplements to go there..

Now imagine you take orally a supplement and it's half life in the blood is 20 minutes.. and your penis is just normal flaccid, no blood in it.. the medication will float through your body getting used up, degraded, secreted into your bladder/urine.. possibly nothing reaching the plaque/fibrosis.

So transdermaly applied at and around your plaque area it will be right there(yes, some will miss/transported away by blood too)
Doing that 1 to X times daily you can see how this is much more effective than oral. IMO this is also why oral has such wide range of results between people and studies. Hit or miss! (It still can be good to do both oral and transdermal -WATCH toxicity obviously)

That said..

Quote

The mean maximum plasma mycophenolic acid concentration (Cmax) after a mycophenolate mofetil 1g dose in healthy individuals was around 25 mg/L, occurred at 0.8 hours postdose, decayed with a mean apparent half-life (t1/2) of around 16 hours, and generated a mean total area under the plasma concentration-time curve

So not that bad of a chance but imo orally you would still need to take is often as possible(and healthy!) to get good concentrations to the plaque site.

I'm no doctor though and maybe this logic only makes sense to me

I'm not sure on mycophenolate mofetil generally, sounds promising, I would have to investigate more(I won't cause I'd need a prescription to use it)

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Author Topic: mycophenolate mofetil (Read 5352 times)

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