mycophenolate mofetil is also indicated as treatment being injected into a vein(don't do that without a doctor!) so I guess it will work transdermally too.
Most supplements around "Molecular weight 500 g/mol" (I think it gets hard beyond 1000 g/mol) can be transported transdermaly via
DMSO directly to the
plaque site. (searching google with "Supplement XYZ + molecular weight gives you the weight)
Why Transdermal? Side effects are often high with oral medication.
But the most important reason for transdermal is the PLACE where the Peyronies plaques sit! Penis has not as much blood circulation as let's say your heart, biceps, brain, arms, legs, even your knee.. The
plaque also often is right in the Penis tunica which has even less blood circulation than the Penis smooth muscles. The
plaque itself has no direct blood supply..
That's why pde5 can help a lot, it increases blood circulation to the penis and allows supplements to go there..
Now imagine you take orally a supplement and it's half life in the blood is 20 minutes.. and your penis is just normal
flaccid, no blood in it.. the medication will float through your body getting used up, degraded, secreted into your bladder/urine.. possibly
nothing reaching the plaque/fibrosis.So transdermaly applied at and around your
plaque area
it will be right there(yes, some will miss/transported away by blood too)
Doing that 1 to X times daily you can see how this is much more effective than oral. IMO
this is also why oral has such wide range of results between people and studies. Hit or miss! (It still can be good to do both oral and transdermal -WATCH toxicity obviously)
That said..
The mean maximum plasma mycophenolic acid concentration (Cmax) after a mycophenolate mofetil 1g dose in healthy individuals was around 25 mg/L, occurred at 0.8 hours postdose, decayed with a mean apparent half-life (t1/2) of around 16 hours, and generated a mean total area under the plasma concentration-time curve
So not that bad of a chance but imo orally you would still need to take is often as possible(and healthy!) to get good concentrations to the
plaque site.
I'm no doctor though and maybe this logic only makes sense to me
I'm not sure on mycophenolate mofetil generally, sounds promising, I would have to investigate more(I won't cause I'd need a prescription to use it)