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Author Topic: mycophenolate mofetil  (Read 10846 times)

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projectpd

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Re: mycophenolate mofetil
« Reply #100 on: May 12, 2020, 12:02:03 PM »

the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.
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Age 57, Onset 2010, 2” shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

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Re: mycophenolate mofetil
« Reply #101 on: May 12, 2020, 12:10:08 PM »

I would always go with the lower dose transdermally. 
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.

the problem with this transdermally could be that it's biphasic


Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

projectpd

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Re: mycophenolate mofetil
« Reply #102 on: May 12, 2020, 12:35:40 PM »

biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe)  ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.
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Age 57, Onset 2010, 2” shortening, shrinking and angulation of glans, weaker erections, 30 degree bend. Mild pain few months, but far from worst symptom. Tried many ideas, not just from here, but not consistently. Moderate improvement, maybe 40%

melting

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Re: mycophenolate mofetil
« Reply #103 on: May 12, 2020, 04:23:37 PM »

Thx! Learned something! Makes complete sense.
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Daily Transdermals and Traction/VED solved my Peyronies Disease https://www.peyroniesforum.net/index.php/topic,12587.0.html (DMSO+X)

drew67

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Re: mycophenolate mofetil
« Reply #104 on: May 20, 2020, 06:52:24 PM »

Just wanted to see if anyone is considering this either orally or transdermally.
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Michiganguy19

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Re: mycophenolate mofetil
« Reply #105 on: August 31, 2020, 09:44:29 PM »

For a lot of us it is an autoimmune disease causing it.

Whyisthishappening,

This isn't an autoimmune disease, it is an autoinflammatory one. The best bet is drugs like Colchicine or biologics that are used to lower certain types of inflammatory cytokines. I have had problems communicating with the doctors in that retrospect and taking immune suppressive drugs will not be the solution from what i know theoretically, as there isn't any antibody being produced if you have a negative autoimmune marker test. Its all about DAMP and PAMP overreaction and response and a bit of underlying genetics that makes you vulnerable to mutation and myofibroblast differentiation. But you can at least try it. Colchicine is a mixed drug for me as i am not sure if it actually helps, as i had severe side effects and had to stop the treatment right now for my own life's sake and i am not even sure if lower doses help by lowering inflammation or make it worse over time by delaying healing. I have realised while taking colchicine that i have a lot of minor scar spots in other places and i am not sure if colchicine is actually returning them back to acute to dissolve them or simply just creates them. First one has a higher chance of happening and i am just betting right now to be honest.
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

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Re: mycophenolate mofetil
« Reply #106 on: August 31, 2020, 09:45:22 PM »

What dose do I ask my doc for? I will try it. What about the IPF drug Ofev? Reversed my friends pulmonary fibrosis
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

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Re: mycophenolate mofetil
« Reply #107 on: August 31, 2020, 09:51:57 PM »

A lot of success treating pulmonary fibrosis with nintedanib and pirfenidone. Also ACE drug Lofarin been shown to stop and reverse fibrosis. Why no one trying it for Peyronie’s?
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Bent Ding Dong

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Re: mycophenolate mofetil
« Reply #108 on: September 01, 2020, 07:33:13 AM »

@Michiganguy19, I don't have access to those drugs otherwise I would try them but I bet they have nasty side effects also?

I've tried monk fruit extract which is supposed to reduce pulmonary fibrosis but that didn't do anything for my peyronies.

Here is the study: https://pubmed.ncbi.nlm.nih.gov/28280123/
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Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

hope794

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Re: mycophenolate mofetil
« Reply #109 on: September 01, 2020, 04:53:38 PM »

Anyone else have tried this?
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26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
Erectile Dysfunction for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

Michiganguy19

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Re: mycophenolate mofetil
« Reply #110 on: September 01, 2020, 07:44:36 PM »

I just messaged my doctor. He said he’d put me on it.
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

pey ron

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Re: mycophenolate mofetil
« Reply #111 on: September 02, 2020, 05:17:24 AM »

Did you have an easy reason to get it, or did you find a very understanding doctor who was willing to experiment?
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pey ron

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Re: mycophenolate mofetil
« Reply #112 on: September 02, 2020, 05:21:05 AM »

but do you have any condition for which mycophenolate mofetil has an on-label use?

also: how do you spell Lofarin? I can't find it...
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age, date of onset, symptoms, treatments tried,
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Bent Ding Dong

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Re: mycophenolate mofetil
« Reply #113 on: September 02, 2020, 06:14:12 AM »

@Michiganguy19, can you keep this post updated about how the drug goes for your peyronie's?
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Age, 40's.

Had peyronie's for more than 10 years. Developed glans lump, then had poor erections and soft glans.

Made a lot of progress over the years with diet and avoidance of sugar and high carbs. Still have the lump but it's much smaller now.

Asphyxia

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Re: mycophenolate mofetil
« Reply #114 on: April 09, 2021, 02:24:58 PM »

can i use mycophenolic acid instead?
anybody knows the difference?
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Age:23. Onset of symptoms: september 2020.
Curve mostly semi erect about 60 degrees, slight pain
Tried short & prolonged fasts, keto,carnivore, traction and most of the supplements.
Severe digestive issues, probably an autoimmune disorder

westerntown

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Re: mycophenolate mofetil
« Reply #115 on: November 08, 2021, 12:24:33 PM »

Any updates?
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20, late 2020 masturbation injury leads to semi erect hourglass, then try manual stretching leads to pudendal neuralgia like symptoms, corpus spongiosum and glans do not fill, severe Erectile Dysfunction- floppy unstable erections that feel like water balloon .
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