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Author Topic: mycophenolate mofetil  (Read 6337 times)

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projectpd

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Re: mycophenolate mofetil
« Reply #100 on: May 12, 2020, 12:02:03 PM »

the problem with this transdermally could be that it's biphasic - I posted about it, see https://www.journal-of-hepatology.eu/article/S0168-8278(07)61934-5/pdf, so transdermally we wouldn't have any idea on safe dosage.
also @WhyThis, according to that, 500mg was optimal, 2000mg was slightly too much for an average human.
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melting

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Re: mycophenolate mofetil
« Reply #101 on: May 12, 2020, 12:10:08 PM »

I would always go with the lower dose transdermally. 
So much we intake orally get's lost in the stomach and other transfers through the blood and organs, that a 1-1 comparison might not apply. Though with most substances toxic amounts are known.

the problem with this transdermally could be that it's biphasic


Could you say what biphasic in relation to transdermal delivery means in a rather simple way? ;)
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projectpd

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Re: mycophenolate mofetil
« Reply #102 on: May 12, 2020, 12:35:40 PM »

biphasic means that at sufficiently low doses, it is effective, but as the dose increases, the response changes, it starts to have the opposite effect and gets worse. Like alcohol (maybe)  ;) Transdermally, if it works, you would be delivering a vastly higher tissue concentration to the local tissue for a dose meant to be used orally. So it would need to be scaled down, but how much is impossible to quantify.
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melting

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Re: mycophenolate mofetil
« Reply #103 on: May 12, 2020, 04:23:37 PM »

Thx! Learned something! Makes complete sense.
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drew67

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Re: mycophenolate mofetil
« Reply #104 on: May 20, 2020, 06:52:24 PM »

Just wanted to see if anyone is considering this either orally or transdermally.
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