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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: cyclophosphamide and dexamethasone treatment showing success  (Read 1714 times)

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Michiganguy19

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cyclophosphamide and dexamethasone treatment showing success
« on: December 30, 2018, 10:33:23 PM »

Peyronie's disease treated with oral weekly dexamethasone and continuous low-dose cyclophosphamide Gupta R, Gupta S - Indian J Dermatol

Has anyone tried this? What about colchicine?

This is shortening my flaccid penis to the point I can barely walk or sleep on my stomach. For some reason erect length is still 6-6.5 though. Just keeps getting thinner. I need to stop this.

Did anyone else get this from Reactive arthritis? From q chlamydia infection causing inflammation. Even though it's been gone 3 years. Idk what to do. I've been in the active phase for 3 years and suicide seems like the only option. I lost my job because walking like this is uncomfortable. Thinking of going to er. Idk what to say though. Last time I tried the doc just said my penis was bigger than her husband erect so don't worry about it. Was kinda funny at the time but no doc wants to help. Urologist says no way to stop besides stopping as arthritis, and rheumatologist says inflammation levels are low so no need to be treated.

Tried 8 different doctors. All say the same thing
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

TonySa

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Re: cyclophosphamide and dexamethasone treatment showing success
« Reply #1 on: December 31, 2018, 04:40:07 PM »

Sounds like you really need to consult w a peyronies specialist.  Meanwhile, you could get started w low dose daily cialis, traction, VED, etc.  please check out the survival guide as well: Peyronies Survival Guide - Information for New Members - Peyronies Society Forums
Please hang in there, you’re in the right place for support and can tackle this!
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PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Michiganguy19

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Re: cyclophosphamide and dexamethasone treatment showing success
« Reply #2 on: January 01, 2019, 12:56:38 AM »

Already tried all that
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Michiganguy19

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Re: cyclophosphamide and dexamethasone treatment showing success
« Reply #3 on: March 02, 2019, 08:54:49 PM »

Has anyone tried this yet?
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Peyronies Disease December 2015.
Caused by Reactive Arthritis, November 2015.
Length before erect: 7.2in
Girth before erect: 6.5in? Just a guess. Was 5.9 after loosing girth/having hourglass and first measuring.
Length erect. 6.2in
Girth erect: 4.1

Whyisthishappening

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Re: cyclophosphamide and dexamethasone treatment showing success
« Reply #4 on: March 07, 2019, 09:12:53 PM »

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019676/
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alc ,vitamin e, propolis,pde5,NAC,nsaids,olive oil massage,nsaids,aspirin,essential oils cockteils,keto,IF,green tea,coffee
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