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Welcome to Dr. Landon Trost - Directly answering member questions in the "Medical Professionals" section below the Treatment boards. https://www.peyroniesforum.net/index.php/topic,16512.0.html

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Author Topic: OTHER Possible Alternative Treatments  (Read 20188 times)

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Lancaster

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OTHER Possible Alternative Treatments
« on: January 08, 2010, 07:11:13 PM »

http://www.urotoday.com/3351/browse_categories/peyronies_disease/severe_disabling_andor_chronic_penile_pain_associated_with_peyronies_disease_management_with_subcutaneous_steroid_injection__abstract09022009.html

Above link is to UroToday.  Article is titled subcutaneous steroid injection.  The steroid used is Triamcinolone (50 mg).
The injection is  subcutaneous and non intralesional.  I have read the stories on other forums about folks who had triamcinolone injected into their leg, butt, back or arm.  Most of the time a large dimple, hole or divit develops.  

This uro does not penetrate the tunica.  Anybody have experience with triamcinolone to stop the pain of cronic tunica albugenia fibrosis.  I have had pain for four years and no sign of relenting.  
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Old Man

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Re: The steroid used is Triamcinolone (50 mg)
« Reply #1 on: January 18, 2010, 08:46:51 PM »

Lancaster:

I was prescribed an ointment by the same above name. It helps with rashes, but I don't have any idea it would help with Peyronies Disease symptoms if rubbed on ones dick!! You have to get the med into the penile shaft tissue for it to do any good.

Old Man
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Age 92. Peyronies Disease at age 24, Peyronies Disease after
stage four radical prostatectomy in 1995, Heart surgery 2004 with three bypasses/three stents.
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boston blacky

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Re: The steroid used is Triamcinolone (50 mg)
« Reply #2 on: January 19, 2010, 08:18:03 PM »

We have a doctor here in Boston that does that procedure you speak of.  And yes it is subcutanious, but does not puncture the tunica.  So the medicine makes direct contact with the inflamation on the tunica.

Doctor Munarriz is at Boston Medical center
720 Harrison Ave. 6th floor,
Boston, Ma  02118

1-617-638-8485

Lancaster, if you decide to get this procedure done please post your results here or private message me, as I have been thinking of visiting Munarriz also.
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j

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Re: The steroid used is Triamcinolone (50 mg)
« Reply #3 on: January 23, 2010, 12:55:19 PM »

Triamcinolone has been used for Dupuytren's for several years, with many people claiming positive results, although no dramatic cures.

http://www.ncbi.nlm.nih.gov/pubmed/11119679
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newguy

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Re: The steroid used is Triamcinolone (50 mg)
« Reply #4 on: January 23, 2010, 05:07:45 PM »

I think it's important to be very careful with injections. There's probably sme scope for use with related conditions in more durable areas of the body, but for peyronie's I don't think I'd consider anyinjections with the 'possible' exception of Xiaflex. As for topical applicatins, as has been pointed out, reaching where it counts might be problematic. Of course anything that might help is worth looking into though. I wish more peyronies studies were ongoing.
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allaaqui

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OTHER Possible Alternative Treatments
« Reply #5 on: March 07, 2010, 05:02:17 PM »

My doctor is suggesting Interferon alfa-2b - Intron A injection... Has anyone heard of this?  Results?  Side affects?
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BrooksBro

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #6 on: March 08, 2010, 05:37:30 AM »

Go this forum's home page:  http://www.peyroniesforum.net/index.php

Search on Interferon.

You will see some posts going back to 2005.

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allaaqui

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #7 on: March 08, 2010, 09:20:46 AM »

Thanks for the response.  However, I was not able to find any relevant data on your suggested web site.
Please any other suggestions?  
Allaaqui
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Old Man

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #8 on: March 08, 2010, 10:54:03 AM »

allaaqui:

Go to the home page of the forum which comes up when you first log in. In the right hand corner of the header portion above the topical index there is a search block. Type in interferon and click the search tab. You will find that it brings up many posts with the word interferon in them.

Surely; you can find something in these posts to help with your questions.

Old Man
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Age 92. Peyronies Disease at age 24, Peyronies Disease after
stage four radical prostatectomy in 1995, Heart surgery 2004 with three bypasses/three stents.
Three more stents in 2016. Hiatal hernia surgery 2017 with 1/3 stomach reduction. Many other surgeries too.

SSmithe

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #9 on: June 09, 2010, 02:36:33 PM »

I too have been trying to get any first hand experience on Interferon injections.  So far not one person on this forum has been able to offer anything up.  I find it hard to believe...  I have searched the site (as recommended by Old Man) and found many posts with "interferon" but none are from anyone who has actually used it.

If there is anyone out there who has tried interferon injections, please let us know.  There are a few of us that would appreciate any insight.
Thanks,
SSmithe
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32 years old.  Peyronies since 22. Stabilized peyronies plaque.  Erectile Dysfunction.  Trying to stay positive.

MikeSmith

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #10 on: June 14, 2010, 02:05:27 PM »

I don't think the main docs are using it anymore... I can ask my uro next week for you... but I think it is off the table.  Also, large doses have really tough side effects... though for Peyronies Disease I think people just get mild flu-like symptoms from what I read (forgot where I read it).
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zhukov

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Diprospan
« Reply #11 on: June 21, 2010, 04:17:43 PM »

I would like to know if anyone has any experience with injections of Diprospan? I have had Peyronies for 5 years and it has been stable all this time, no pain or complications at all, sex life is good but I have had a plaque for all this time and I recently changed urologist and he suggested I could try this medication. Does anyone know of any side effects? is it even worth trying this is my condition has been stable for so long? is there a chance it could trigger the creation of plaques again?
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james1947

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #12 on: February 08, 2011, 04:28:54 AM »

Interferon is used for treatment of Polycithemya Vera that is a blood disorder (high blood counts)
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
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Got amazing support on the forum

jmdcg

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Re: Interferon alfa-2b - - - Intron A injection
« Reply #13 on: February 10, 2011, 09:36:45 AM »

I have just gone through a course of interferon injections.  I am scheduled for my first followup after the interferon today.  They did seem to help somewhat. 

The injections were not as bad as you would expect.  The side effects were mild in my case and pretty much disappeared after the third or fourth (of ten) injections.

It did not do away with the plaque -- it's still there.  However, the bend seems to be less and any pain is pretty much gone.
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dioporcolorisolvo

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Criopass Therapy
« Reply #14 on: May 13, 2011, 09:07:18 PM »

Few days ago an italian urologist grants an interview where asserted that there is a new valid treatmente for peyronie disease: the criopass therapy. But on the web i didn't find any published studies or experiences of this treatment. I have looked for the email of this urologist to ask informations but there isn't his email contact on the web.
Do you know something about this?
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George999

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Re: Criopass Therapy
« Reply #15 on: May 13, 2011, 09:57:55 PM »

Criopass appears to be a new, very cool, method of placing medication at precise points in the body by using the power of photons to drive medication molecules into tissue.  This technology was recently developed by an Italian company, thus there is no information out there currently in the English language.  Because of the precision this allows in inserting medications into tissue in a very non-invasive manner, there are all sorts of applications being explored.  They basically freeze the medication they are using and then blast it, molecule by molecule, into the tissue using a high powered computer guided laser.  It will be interesting to see where this goes.  Imagine the potential possibilities if it were combined with a drug like Xiaflex!  - George
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mike49

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HGH - Help or hurt? Collagen Issue.
« Reply #16 on: July 10, 2011, 03:00:26 PM »

Okay so first off I have have what I believe is collagen throughout the CC, not one single spot. The penis has lost very significant girth, and is hard when flaccid (if anyone has read this never-ending thread on MedHelp), and feels like it has piano cords as veins. I get no engorgement of the corpus spogiousum - it's like I don't even have one. While the corpus cavernosums used to inflate like a ballon, now it inflates more like a bike tire - all of a sudden it only expands so far and then there is no give and only pain, which is what I get when I inject tri-mix because that is the only way to get an erection for me now. Now to my dilemma.


So basically everything that HGH does would seem to battle peyronies (nerve regeneration, NO increase, lower BP, more flexible, improves libido, ect) EXCEPT that HGH increases Collagen Synthesis.

And Collagen is what I am trying to battle. Should this automatically eliminate HGH as a possible option? Would I just be aiding my body in producing fibrous tissues?

On another note, there are many types of callagen - I don't know which types are increased by exogenous hgh.


Please chime in with any ideas or comments to help me out with some ideas as this is about my last hope.
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mike49

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #17 on: July 10, 2011, 03:13:20 PM »

Okay so it seems that Collagen 1 is most responsible for the peyronies effects. Now I need to see if that is what hgh increases and unfortunately it likely does.
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rd

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #18 on: July 10, 2011, 08:43:07 PM »

I tried HGH for my peyronies with in the first 6 months. I didn't notice any benefits. I was doing 2IU's 4 days a week for 6 months. I didn't have worsening or any benefit maybe I needed to go longer.
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mike49

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #19 on: July 10, 2011, 10:33:10 PM »

Thanks for the response. And yeah if I tried it I would go longer and with a slightly higher dose, maybe 3-4iu a day for 6 months. If I saw no benefit I could live with that, but if it made my penis tougher and less flexible by strengthening the fibers then that would ruin me.

I tried doing about 3iu's/day about 6 months ago for only one month and believed that it was making the penis have a harder time expanding in girth, but 1) I don't think hgh can even kick in this quicky and 2) it has gotten worse even since so it may have been getting worse for other reasons besides hgh.

I just don't know if this could be my miracle cure as it is so well known for rejuvenating organs and nerve issues or if it is going to solidify my fibers to the point of no return.   
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mike49

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #20 on: July 10, 2011, 10:47:43 PM »

And I've read that with hgh, it would increase type-1 Collagen (BAD I THINK) but would "speed healing and scar would be more flexible as healing was when you were young" (PERHAPS GOOD? - looser more "giving" fibers allow tunica to stretch more?) Any ideas?

My other option could be Testosterone as it supposedly (can't find a scientific source) can decrease collagen synthesis 50-80%. At what dose this would take effect I don't know..
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rd

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #21 on: July 11, 2011, 08:03:17 AM »

All your reasons are why I tried it. Also from what I have read and people I have talked to that did it. The younger you are the less effects you will feel from hgh. I have also thought about testosterone replacement. Let me know what you find with that. I haven't done to much research on it yet. But I have read some people say it will help other say it could make it worse but I haven't looked into it enough.
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mike49

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #22 on: July 11, 2011, 07:16:53 PM »

As far as Testosterone I have tried it in combination with another steroid, Equipoise which increases collagen synthesis (which at 3 mg/kg will increase procollagen III by approximately 340% - again supposedly, no scientific source). The test dose was very low and the EQ dose high, as I then thought I WANTED increased collagen synthesis. I do feel that during this time my morning erections were just as firm but that the girth decreased. Again less like a balloon and more like a bike tire when "inflated." I think that the test made me hornier (more erections) but that the EQ strengthened the tunica and left me with less girth.

Or maybe the increase in erections is even decreasing girth. maybe every time i get an erection it toughens the fibers or collagen or whatever and makes it smaller? i dk for sure- probably never will.

I know that I want to try testosterone alone again at a higher dose - maybe enough to decrease collagen synthesis.

I'm researching mostly on HGH before trying that again though so if you can squeeze any more information out of or point me into the direction of people with Peyronies Disease who have tried HGH that'd be great.
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George999

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #23 on: July 11, 2011, 08:38:25 PM »

I would just issue this warning about HORMONES in general:  If you are going to supplement hormones, that *can* be a good thing ... *BUT* ... you had better be getting blood tests regularly at the beginning to find out what your actual levels are, otherwise you are shooting in the dark and can end up doing more damage than good.  Focusing on a given hormone's effect on collagen is a *huge* mistake.  These hormones *each* affect so many metabolic functions it would make your head spin.  You can get things *really* out of whack by administering therapeutic doses without keeping close tabs on your levels.  AND ... that goes for HGH as well.  People who crash and burn on HGH do so because they are not using common sense as to how much they are taking.  You want to methodically bring all these hormones into a healthy range in an orchestrated manner, NOT haphazardly.
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crashbandit

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #24 on: July 11, 2011, 10:59:59 PM »

Okay so first off I have have what I believe is collagen throughout the CC, not one single spot. The penis has lost very significant girth, and is hard when flaccid (if anyone has read this never-ending thread on MedHelp), and feels like it has piano cords as veins. I get no engorgement of the corpus spogiousum - it's like I don't even have one. While the corpus cavernosums used to inflate like a ballon, now it inflates more like a bike tire - all of a sudden it only expands so far and then there is no give and only pain, which is what I get when I inject tri-mix because that is the only way to get an erection for me now. Now to my dilemma.

Hi mike,

I'm sorry I can't give you any insight about hormone injections but I was wondering if you could give alittle more history to your Peyronies disease. Can you give a timeline of your Peyronies progression if you dont mind and the symptoms that occured during the progression.

Thanks
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trevorrr

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Re: HGH - Help or hurt? Collagen Issue.
« Reply #25 on: July 11, 2011, 11:40:04 PM »

hey im a college athlete lots of experience with that stuff playing with hgh could have devastating consquences as far the as the test replacemnt therapy could help with blood flow if your levels are lower than normal other wise its not recomended if your levels are indeed normal, I didnt catch your age. I know levine outa chicago was experimenting with some of that but didnt have any good results. HGH and or sterioids do affect cellular death and could stop your body from getting rid of the stuff we want gone.
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james1947

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Re: Criopass Therapy
« Reply #26 on: March 26, 2012, 03:04:57 PM »

dioporcolorisolvo
 
I made a search by the Internet to see if have something new regarding Criopass therapy.
All I find is in Italian. Your post in the subject is from May 2011. Maybe have some news?
Can you take a look in the subject?

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
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dioporcolorisolvo

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Re: Criopass Therapy
« Reply #27 on: March 26, 2012, 07:08:08 PM »

dioporcolorisolvo
 
I made a search by the Internet to see if have something new regarding Criopass therapy.
All I find is in Italian. Your post in the subject is from May 2011. Maybe have some news?
Can you take a look in the subject?

James

no news, but it seemed more a publicity stunt...
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Audreyhuntsman

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Re: Criopass Therapy
« Reply #28 on: June 07, 2012, 01:07:36 PM »

dioporcolorisolvo
 
I made a search by the Internet to see if have something new regarding Criopass therapy.
All I find is in Italian. Your post in the subject is from May 2011. Maybe have some news?
Can you take a look in the subject?

James

no news, but it seemed more a publicity stunt...


Couldn't agree more.
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Luciano

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Re: Criopass Therapy
« Reply #29 on: June 08, 2012, 01:12:58 AM »

Very strange.. i took a look, and the only thing i could find (except the italian stuff) was something called cryotherapy - used for prostate cancers:
Now in ancient Greek cryo means cold.
So anything called cryo-something or crio-something has to do with cold.

the prostate cancer therapy is relatively new. its treatment by cold instead of radiation:
http://www.prostate-cancer.com/cryotherapy/treatment-description/prostate-cryotherapy-description.html

thats my 2 cents

Luc
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stuartmar

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Re: OTHER Possible Alternative Treatments
« Reply #30 on: July 15, 2012, 05:54:28 AM »

People who crash and burn on HGH do so because they are not using common sense as to how much they are taking. 

Tim_

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Might sound rediculous, could ice help in some way?
« Reply #31 on: July 30, 2012, 11:28:22 AM »

I know it might sound rediculous, but when you think about it ice is used for a suprisingly wide amount of things. A swollen eye, a pimple, so why not to try and get rid of some plaque because according to the diagrams I've seen the plaque is essentially trying to cause some swelling which acts like a 'pinch' and therefore restricts bloodflow etc. Hell, next time I have an erection I'll give it a try and see what it does. I would imagine no harm no foul, I don't expect immediate results but maybe it'll do something.

Anyone ever try this or know of its results?
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Skjaldborg

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Re: Might sound rediculous, could ice help in some way?
« Reply #32 on: July 30, 2012, 05:47:10 PM »

If you are in the inflammation stage and experiencing pain, ice may help reduce pain or swelling. But if you are in the stable phase ice will not help since scar tissue will have already been deposited.

Ice probably won't harm you. Be sure to put a cloth barrier between you and the icepack so you don't hurt your skin. Medications like pentox can help reduce scar tissue size and would probably be a better choice.

Good luck,

-Skjaldborg
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LWillisjr

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Re: Might sound rediculous, could ice help in some way?
« Reply #33 on: July 30, 2012, 08:08:59 PM »

according to the diagrams I've seen the plaque is essentially trying to cause some swelling which acts like a 'pinch' and therefore restricts bloodflow etc.
Anyone ever try this or know of its results?

Tim,
I don't know if the ice would work or not, but maybe not as you think. The plaque isn't a swollen spot. It is fibroid like tissue and affects an area of the Tunica. The Tunica is the tough sheathlike organ tissue the surrounds your penis. And it stretches when the corpora chambers expand and fill with blood. But the plaque on the Tunica doesn't allow that area to expand as it should. It isn't really pinching off blood flow into the corpora chambers.

I'm not stating that ice won't have an effect, just trying to clarify the Peyronies mechanism.
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PablitoNJ

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Re: Might sound rediculous, could ice help in some way?
« Reply #34 on: July 31, 2012, 12:24:17 PM »

When my acute phase pain was really bad I used an ice pack to help relieve the pain. It did provide some relief. Actually it was the only thing that provided relief at that point.
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james1947

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EDTA Chelation Therapy
« Reply #35 on: September 13, 2012, 05:19:44 PM »

As I have mentioned in my post on the "Off Topics" board, my uro just come back from a Peyronies seminar.
He have talked with me about the subject as one of the uro's that participated in the seminar briefed about using EDTA Chelation Therapy (intravenous) for Peyronies with some success in reducing the plaques size.
The process is used to clean the calcium deposits from arteries and as some Peyronies plaques are calcified this process will eliminate the calcification of the plaques making them more flexible and as a result reducing the bent and increasing the blood flow to the penis.
I will make an appointment within a month with my uro friend (uro also) that have a private clinic and would like to experiment with the treatment.
Maybe I will be his first Guinean pig ;D

Bellow an article from Extrem Health USA in the subject:
EDTA Chelation: Intravenous vs. Oral

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Abbar

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Re: OTHER Possible Alternative Treatments
« Reply #36 on: October 17, 2012, 12:01:20 PM »

Warning

Post deleted for double posting!

You have one thread for this.  Do not post another!
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George999

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Re: OTHER Possible Alternative Treatments
« Reply #37 on: October 17, 2012, 12:59:48 PM »

People who crash and burn on HGH do so because they are not using common sense as to how much they are taking.

The problem with HGH is that it impacts other hormone levels in a long sequence.  IF you attempt to raise HGH to youthful levels via supplementation, you will drive other hormones way too high.  So it IS OK to use HGH, you just have to monitor the whole hormone spectrum, not just your HGH levels.  HGH therapy under the supervision of a qualified endocrinologist is actually very beneficial.  - George
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Jonbinspain

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Re: OTHER Possible Alternative Treatments
« Reply #38 on: October 27, 2012, 07:00:28 AM »

I've just bought 1kg of 100% pharma grade Acetyl-L-Canitine powder from a UK supplier for £32.50 or a little over $50. At the moment, I'm not sure if they supply outside of the UK but if there was enough interest we can always ask. Anybody from the UK who's interested, please let me know. I'm happy to supply the name.
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