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Quote from: Tristen on October 21, 2011, 03:08:43 PMMy Urologist believes it to be genetic, and not AI. But I have other arthritic syndrome type things happening that lead me to believe it's AI. Valuable info.
Quote from: KAC on October 21, 2011, 04:57:54 PMI'm curious what your other arthritic syndromes are. I had Reiter's syndrome when I was 18--I was on crutches for about 6 months--and have wondered if Peyronie's is related. Perhaps the syndrome made me more susceptible. Has anyone else had Reiter's syndrome in their youth?
Quote from: George999 on October 21, 2011, 08:38:17 PMQuote from: Tristen on October 21, 2011, 03:08:43 PMMy Urologist believes it to be genetic, and not AI. But I have other arthritic syndrome type things happening that lead me to believe it's AI. Valuable info.Genetic and AI are NOT mutually exclusive. Genetic damage can and will cause AI activity. When a cell is genetically damaged the immune system will attack it. That is how the healthy body gets rid of cancer. And when enough cells in a given tissue are uniformly damaged, they will trigger an immune response that will reinforce itself as it progresses. Even the smallest physical or chemical trauma can unleash this cascade by bringing inflammation to a tipping point. The cytokines released against the damaged cells in turn damage other weakened cells and the whole process snowballs to the point that large areas of tissue are involved. This is where the medical profession gets it wrong. Instead of viewing health problems holistically, they try to buttonhole everything to simplistically fit their theories. Its like the blind men examining the elephant. The animal is a sum of its pieces, but all the blind me perceive is the pieces. Similarly physicians always try to find the ONE pill or procedure that fixes the symptom rather than trying to address the underlying upstream physiology that is causing the problem in the first place. - George
QuoteDHEA: Low levels of DHEA are seen in many of the autoimmune diseases, and higher daily intake of DHEA is associated with improvement of symptoms in many. A typical daily dose of DHEA for autoimmunity would be 50-200mg per day. However, since DHEA is a hormone, doses in excess of 50mg per day should be supervised by a physician. A male hormone profile or female hormone profile which includes evaluation of DHEA should be performed at the beginning of treatment to monitor hormone levels.
QuoteResearch has pinpointed low DHEA levels as a marker for many degenerative diseases and accelerated aging. The hormone has been implicated as a contributing factor in a host of health problems, including Alzheimer's disease, autoimmune disease and other immunological disorders, cancer, chronic fatigue syndrome, diabetes, heart disease, high cholesterol, memory problems, obesity, osteoporosis, and stress disorders.What's more, the collective indirect evidence from more than 5,000 published studies overwhelmingly supports DHEA's anti-aging role. Scientists now have proof that DHEA: * Enhances immunity
QuoteIn a study of ten women with the autoimmune disease Sjogren's syndrome, all were shown to have decreased serum concentrations of DHEA-S and an increased cortisol/DHEA-S ratio compared with healthy controls (Valtysdottir et al. 2001).
QuoteDecreased levels of DHEA have been found in people with autoimmune disorders like lupus and immune deficiency syndrome. ... In patients with lupus, an autoimmune disease where the body attacks itself, studies show that DHEA helps regulate the immune system and may reduce the need for medication and slow the frequency of flare-ups. Clinical tests are ongoing to test how DHEA treats other diseases as well as autoimmune disorders.
QuoteNestler showed, in several different ways, that increased levels of insulin drive DHEA levels down. Nestler also cited evidence obtained in his laboratory that insulin inhibits the adrenal 17,20-lyase activity in man that is needed for DHEA synthesis (JCEM 74: 362-7, 1992) In addition, according to Peter Hornsby's talk, insulin increases the activity of the 3HSD enzyme that destroys DHEA. Thus, insulin both inhibits the synthesis of DHEA and accelerates the breakdown of DHEA. However, DHEA has no effect on insulin levels, and has no effect on insulin sensitivity (type II diabetes) in humans.
QuoteInsulin is used to lower blood sugar. Insulin can also lower the amount of DHEA in the body. By lowering DHEA in the body, insulin might lower the effectiveness of DHEA supplements.
QuoteIn vitro studies showed that insulin induced the number of AP sites (apurinic/apyrimidinic sites, a bio-marker of DNA damage), and this effect was dependent on high FASN expression. NMU (DNA alkylating agent)-induced colon cancer cell apoptosis was enhanced by the silencing of FASN. These collaborative results suggest that SPI diet decreases circulating insulin levels, colon FASN expression, and insulin-induced DNA damage, and attenuates FASN-mediated anti-apoptosic activity, to exert its cancer-preventive actions in the colon.