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Author Topic: Placental matrix-derived mesenchymal stem cells (PM-MSCs)in the management of Peyronies Disease  (Read 2244 times)

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hope794

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Hi guys,
to be honest i'm totally new to Peyronies Disease and i have a really mild form of it (a mild fibrosis near dorsal vein) that causes me a mild Erectile Dysfunction.
But as you can immagine, i'm really scared by this situation as it's new for me and i already began to cure with an urologist.

After doing some research, i found this:

https://www.ncbi.nlm.nih.gov/pubmed/26414724?dopt=Abstract

What do you think about it? Probably you're more experienced than me and speak english better than me, so you can give me more informations and share better opinions.
The study is from late 2015, about 2 years and half ago. But they claim to solve plaques on 7/10 patients. I think that's an incredible result: anyone has infos about this treatment going on?
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

tiagofil

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TonySa

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Osteopaths have all the same privelages of MD’s, are surgeons, all same specialities etc. although generally more wholistic and also are trained in manipulation (similar to chiropractic).
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PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

pey ron

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problem is: if the stem cells are not autologous you might need to live the rest of your life on immunosuppressants, just as if you were the recipient of an organ trasplant...
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hope794

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So guys, do you think this is fake?
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

Jack1909

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problem is: if the stem cells are not autologous you might need to live the rest of your life on immunosuppressants, just as if you were the recipient of an organ trasplant...

In any case, I would. No problem. We should stop saying ourselves in first place that there are many conditions worse than this. I have “lived” many years penisless and now I firmly claim that I would give both my limbs for a penis.
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suicidecomingsoon

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In any case, I would. No problem. We should stop saying ourselves in first place that there are many conditions worse than this. I have “lived” many years penisless and now I firmly claim that I would give both my limbs for a penis.
Same here
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JS1991

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pey ron, there is very small risk of this happening. At the clinic in Panama that I’ve spoken of (which uses umbilical cord cells), there have been zero cases of this disorder occurring. And the treatment I will be going for is autologous. Please link articles to back up your claims. And I suspect even if you provide said articles, they are based on shady clinics. But I appreciate your good intentions in trying to safeguard our members from potential hazards.

hope794, it is real.

Edit: Another thing on stem cell rejection. Fat and bone derived cells are autologous (from your own body) and are therefore not a concern. Regarding umbilical cord cells, here is quote from the clinic in Panama which you can find in the FAQ: “The body’s immune system is unable to recognize umbilical cord-derived mesenchymal stem cells as foreign and therefore they are not rejected.  These stem cells have been administered thousands of times at the Stem Cell Institute and there has never been a single instance rejection (graft vs. host disease).  As a matter of fact, mesenchymal stem cells are approved to treat graft vs. host disease in Canada and New Zealand.”
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Do your homework before attempting a prolonged fast. JS1991 Timeline - Peyronies Society Forums (updated)

hope794

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Thank you very much, JS!!
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

Werther

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To be totally honest, this study looks like scam. I once wrote to Zahalsky's office and I was answered that they're now injecting gwroth factors in plaques (something that sounds like prp to me).

This feeling is confirmed by the fact that one user of this forum approached Zahalsky to receive his stem cell treatment but only got a mixture of prp and something else, claiming that his plaque's size never reduced and erection quality didn't change during the treatment (the user is "krazylord" and you can find his posts on this subject by searching for it with the forum's bar).

The fact that stem cells were so successfull, based on his paper, should push him to plan further clinical trials and use them instead of prp, but it looks like he's doing the contrary, so I'm pretty suspicious about the reported results. Besides, Zahalsky is an urologist, but the paper was published nonetheless on an osteophatic journal (another circumstance that makes this "treatment" smell like snake oil).
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hope794

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Werther, your words seem legit. Probably you're right.
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.

JS1991

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Werther, Zahalsky uses amniotic fluid + PRP, not stem cells. Peyronies Gone - Peyronies Society Forums this is an account of a member of our own who received stem cells derived from his own fat. He received treatment from Dr. Landers, who has since updated his treatment to include shockwave therapy, followed by an injection of fat stem cells + PRP. That is essentially three treatments in one. I am going to compile a list of studies and trials and post it in the stem cell thread once it's done.
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Do your homework before attempting a prolonged fast. JS1991 Timeline - Peyronies Society Forums (updated)

Werther

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That's exactly what I've said: Zahalsky published a paper in 2015 regarding the use of stem cells to treat peyronie's and reported miracolous results (total disappearance of 7 plaques out of 10, based on the paper's claims), but despite having found the cure for an incurable disease (because fibrosis reversal would actually be nothing else but the cure), he's not planning further clinical trials (with a larger sample of patients) and he's not using this procedure in his office. All of this can only make me think that the results reported in his paper were practically made up.

The problem is that this paper is the only one that has been published so far with regards to the use of stem cells on humans to treat peyronie's (at least that's what I know), so I'm pretty concerned about the efficacy of any stem cell procedure for penile fibrosis as of today.

Nonetheless this is a very interesting subject and I look forward to hear from you or anybody to know what results (and from what procedure) you can actually get.

I wish you the best of luck for this and I hope you'll let us know how it goes.
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pey ron

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Placental must not be homologous. That scares the sh*t out of me.
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ConcernedandWorried

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What really gets me, Werther, is that, like most of the experimental treatments, it seems to be most effective in the acute phase.
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maximus99

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That's exactly what I've said: Zahalsky published a paper in 2015 regarding the use of stem cells to treat peyronie's and reported miracolous results (total disappearance of 7 plaques out of 10, based on the paper's claims), but despite having found the cure for an incurable disease (because fibrosis reversal would actually be nothing else but the cure), he's not planning further clinical trials (with a larger sample of patients) and he's not using this procedure in his office.

I just had a visit with him and he was explaining it to me. I pretty sure hes still doing it and says he has another paper coming out.
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samsung

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He is not using mesenchymal cells.
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45 y.o. Single. Onset of symptoms (pain-stinging like a wasp) @ 6/2018. No sudden injury. Curve developed slowly. 40 deg. dorsal. Hourglassing. Torsion to left flaccid. 4 rounds xiaflex. Restorex, DMSO+, heat, arginine, cialis, lipoic acid, vit. K2

hope794

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I just had a visit with him and he was explaining it to me. I pretty sure hes still doing it and says he has another paper coming out.

maximus, bro, can you please explain further? What did he tell you? Please let us know, what's the news?
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26 yo from Italy.Peyronie's probably since 2014.Since then,penis bends of about 20-25°, with a moderate twist to the left. Erectile Dysfunction since 4 years and things getting worse.From pornstar-like to moderately depressed,but still fighting for a solution.
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