The results of multiple studies are now showing that NON-DIABETIC blood sugar levels can CAUSE Diabetic Neuropathy. (See my posts on Causes->New Theory thread for more details on this). This is a major smoking gun. IF such NON-DIABETIC blood sugar levels can cause Diabetic Neuropathy which is MISDIAGNOSED as IDIOPATHIC because the patient passes the Diabetes tests, then it seems to me HIGHLY LIKELY that the Peyronie's many of us are experiencing is actually DIABETIC Peyronie's, in which case lowering blood sugar levels could easily be an effective treatment, especially since lowering blood sugar levels effectively treats Neuropathy in such a situation. (I have NEVER tested Diabetic AND I am seeing MAJOR relief from neuropathy by carefully managing my blood sugar levels.)
ADDITIONALLY, there are demonstrated pathways by which blood sugar levels can 1) damage your genes and/or 2) induce autoimmune processes. These are mediated by insulin. When insulin rises too high it can cause genetic damage which can result in all sorts of maladies up to and including cancer. Higher than normal insulin levels also result in lower DHEA levels which produces an imbalance between DHEA and Cortisol and, in turn, destabilizes the immune system opening the door for autoimmune syndromes.
One way to more closely assess your risk in terms of blood sugar is to get an OGTT (Oral Glucose Tolerance Test). This test is MUCH more sensitive in terms of detecting glucose metabolism/insulin resistance problems that the conventional fasting glucose and A1C tests.
The first level of response is, of course, diet and exercise. The second is drug therapy. Drug therapy should consist of either Metformin or Berberine or perhaps lesser treatments like Gymnema Silvestre or traditional blood sugar adjuncts like Cinnamon. What should be avoided are Sulfonylureas which actually reduce blood sugar by increasing insulin production. Since insulin is an intrinsic part of the problem, increasing it will only make matters worse.
Doing this successfully REQUIRES the use of a glucose meter. The ONLY way to control your glucose levels is by testing your glucose levels rigorously, sometimes as often as every 15-30 minutes, to evaluate how your specific diet and specific oral routine is actually affecting your glucose levels (which are EXTREMELY dynamic) in real time. To ensure safety, it also requires the assistance of a medical doctor as well. But there is no doubt whatsoever any longer in my mind that lowering glucose levels would bring significant relief to many, especially those with "acute
phase" symptoms. Lowering serum glucose can radically reduce inflammation
levels and should be considered as an option to attack Peyronie's symptoms.