My doctor just told me I have Peyronies Disease (on penis and both hands) and has ordered a cream containing pentoxifylline. Has anyone had success with this treatment? Any side effects?
What you have on your hands is not technically Peyronie's (though the conditions are seen to be related) - it's called Dupuytren's Contracture.
I have never heard of Pentox being available in cream form and am slightly concerned that your information is off to begin with. Are you certain this is what he has prescribed? What is the name of the medication?
Nemo
My doctor is having the cream specially formulated and prepared to his specifications by a comppending pharmacy so there is no brand name.
Thanks for enlightening me about the situation with my hands.
Hi Perplexed,
Pentox containing cream has not been studied, and it is not something any of us have heard of. This is big news to us (to me at least).
While it may have a positive effect, please stick to the standard treatments, these are oral Pentox, daily low dose Cialis, and supplements such as Citrulline, CoQ10, Acetyl-L-Carnitine. Also consider the physical therapy options which include traction and VED therapy, which are both to be done with extreme caution, but still have a very positive effect on Peyronie's. The treatments I outlined above are effective for many of us given enough time.
By all means try the pentox cream, I know I would, but first I would take it orally. Studies on pentox and cialis and other supplements on penis health and fibrosis are good.
Thanks for the heads up, let us know how it goes!
I have a rather serious heart condition (cardiomyopathy) so my urologist is loath to prescribe anything orally that could possibly inimically counteract the stabilizing therapeutic regimen my cardiologist has had me on for several years. The urologist wants to try the cream initially to assess the results and will move to a more aggressive approach (in consult with my cardiologist) if necessary to treat the Peyronies.
Perplexed;
Presumably, this compound will include something like DMSO to allow the other ingredients to penetrate the dermis?
Yes, the prescribed compound has 10% DMSO for dermal penetration.
I just started to use an ointment formulated by my doctor for Peyronies. The ointment was prepared by a compounding pharmacy to my doctor's specifications. The ointment is to be applied to the affected area twice a day and I have applied it for three days so far. I will let you know if I experience any improvement. My doctor told me that the formula containes very minimal quantities of the active ingredients and my have to be modified if positive results are not attained.
Sounds intriguing. topical transdermal makes the most sense as it goes where it is needed in contrary to oral meds.
I think it should work better then if you took it oraly.
Quote from: Perplexed on March 09, 2015, 11:21:21 PM
The ointment was prepared by a compounding pharmacy to my doctor's specifications.
Do you have the possibility to describe the ingredients and their amounts?
Sorry for the delay in replying to your posts regarding the ointment for my Peyronies. Here are the components and quantities:
Pentoxifylline 5%
Verapamil 5%
Vitamin E 1%
Potassium Iodide 8%
DMSO 10%
The doctor agrees that using the ointment topically has a better chance of effectiveness than an oral medication. The doctor said I won't notice any remarkable improvement for at least 4-6 weeks. I'm in my second week right now.
I don't see how Pentox would be useful in a topical compound. Pentox works by making the red blood cells "squishier" so they can better bring oxygen and nutrients through smaller capillaries. It also has a mild anti-fibrotic effect. You really need to ingest significant quantities on a daily basis for several months to see results with it. I don't know if it's absorbed well through the skin.
-Skjald
I will second Skjaldborg regarding Pentox.
Regarding Verapamil, proposing you to read the Verapamil board, not helped too many (if at all)
What is/are the rest of 71% of the compound? (5+5+1+8+10=29%)
James
I have no idea what the additional 71% is composed of but I believe it is a benign cream ointment to contain the medicinal components.
Perplexed
QuoteI have no idea what the additional 71% is composed
Also an answer. If it was me, I was asking the doctor before using it.
James
James:
I have all the faith in the world in my doctor. I believe if there were any other medicinal components they would have had to be listed along with the other active ingredients. I only know one thing -- its working!
Perplexed
How so?
When I first developed Peyronies my urine flow had a 45 degree angle to the right. Now it is flowing straight from the urethra. Also, the plaque is diminishing in size and firmness. Erections are straighter.
Quote removed by moderator - James,
Please read the forum rules!!!
If that's really true that sounds promising. Please post more updates, I'm very interested to see if it's actually working.
I have had excellent results from the treatment that I have been using for about three weeks. Plaque has been reduced by 75% and I am confident that it will be totally gone with another several weeks of medicine application.
Sounds like excellent results Perplexed :)
Please keep us updated.
James
Perplexed, not to be a wiseguy, but I'm a bit perplexed by your case. Your doctor felt it would be 4-6 weeks before you might notice major results, and in only 3 weeks you've seen a 75% reduction in the plaque! If accurate, that is nothing short of astounding, especially for an apparently ad hoc concoction of topical agents.
If these results are 100% legit, I would ask that you invite your Urologist to join the discussion here so that he may share his treatment protocol or any research that gives rise to it with us. While it's impossible to draw any general conclusions from one isolated case, if he has experience with this treatment and has seen similar results, he really needs to share this with others.
Not to draw too sharp a comparison, but we had a similar topical treatment blow up several years ago, all based on what one guy somewhere was supposedly given by his grandfather, a doctor. The so-called "Thacker's Formula" (which was DMSO based) simply didn't pan out for anyone, save for this one guy (who was only accessible to ONE member of the forum), who swore it cured him. Eventually "Thacker" disappeared and a lot of empty bottles of DMSO, apple cider vinegar and castor oil went into landfills across America.
Additionally, no one is going to be able to go to their Uro and say, "Hey I read about this guy on the internet who had results mixing this and this and this - can you order me some of that?" But if your doctor makes his presence known here, the treatment could be given much more substance. I say I'm perplexed, because here you have the largest collection of men on the internet suffering with Peyronies Disease, and none of us have ever heard of using Pentox topically in solution with anything. Your doc is tilling new soil here and we need to know more than an isolated anecdotal report of improvement like "my plaque shrunk 75% in 3 weeks." I'm not trying to cast doubt on your results; frankly, I hope like heck they're 100% accurate.
Your doctor's participation here would be greatly appreciated by the Peyronies Disease sufferers, I guarantee.
Thanks and continued success,
Nemo
Perplexed,
This is much welcomed news. I can see you are new here so you may not know about all of the "dry holes" people have dug. False hopes, etc..... skepticism becomes a natural reaction to something simple, fast and effective.
Again...keep us informed.
Can you share your Doctors name, city and state?
Perplexed
I would like also to have the doctor name, location etc', it may help other forum members if they will decide to go in your way.
James
I have been reading much of the forum posts and can well understand much of the skepticism, but I can only relate my personal experienced. When I quoted my doctor as saying the results may take 4-6 weeks I interpreted that to mean it would take about that long for full issue resolution. I find things are favorably progressing as he anticipated.
The name of my physician is Dr. Lee Dennis, ND and you can find him at his website: namastenaturalhealing.com. He is located in Portland, Oregon but would, I believe, be willing to consult with you personally over the phone. As you would expect the Doctor's professional consultations are not without compensation but very reasonable.
Perplexed
Perplexed, thanks very much for sharing that information.
Again, let me say, I don't mean to doubt the results you are claiming, but if I may be perfectly honest, the source of your treatment is a bit discouraging to me. Most of us don't even live in a state where so-called Naturopath doctors can be licensed (I think about 17 states currently recognize the degree and allow them to practice medicine). The fact that your doctor is not a board certified Urologist, but rather a Naturopath general practitioner, and also gave you to believe that something like Peyronie's Disease, which has baffled medical science for centuries, could find "full resolution" period, much less in 3-4 weeks, gives me to wonder if he is not simply throwing several things at the wall in the form of a topical solution and hoping something sticks. If this were an effective strategy, or based in sound science, I have to believe some of our leading Uro's like Leu or Levine or others would have tried it before (maybe they have - if so, they don't currently).
However, the single most important thing here is that you feel your condition is improved, and that being the case, whatever the nature of that improvement, I congratulate you. But the fuller picture, admittedly, leaves me less inclined to believe we're dealing with a practitioner forging a new breakthrough in the treatment of Peyronies Disease.
I'm only offering one man's opinion, of course. And as I've said many times, I would LOVE to be proved wrong, especially if it comes in the form of a fellow sufferer being "healed" - so continued progress to you.
Thanks again,
Nemo
It has always made sense to me that, if and when an effective treatment is found for this, it would be in the form of something applied directly to the problem, rather than anything taken orally. Most oral medication, supplements, etc are used up in the body before they get to the intended target.
Like Nemo I would love to believe that this actually works. However, reading of the ingredients, I'm sceptical. I don't doubt the sincerity of Perplexed, but suspect that his improvement may just be coincidental. If more people were to come forward saying that this treatment had helped them, I might start to believe.
hi all my name is steve and about 15 years ago i had pain in my penis and it was painful to have a orgasam so i when to a uralagest sorry about the spelling he said i had peyronies but i had no curveature and he told me about what the onitment with veraparil in it it cam from a lab i dont know what all was in it but i can tell you that it worked but here i am 15 years later with the same problem due to to much masterbation so i know it does work just saying
You're referring to Topical Verapamil from "PDLabs" in San Antonio, Texas. In the years since its introduction, that treatment has been overwhelmingly discredited both by anecdotal experience from the many of us who used it (myself included) and by direct surgical tissue examination by doctors (Levine, for instance), who found the Verapamil simply did not penetrate the tunica at all. If you believe TV cured you, you're welcome to that belief, but I'd tell you the overwhelming majority of its users feel we wasted a lot of time and money.
Nemo
Perplexed,
Thanks for sharing the ND you are working with. I think it is great you are having beyond remarkable results. If you had a 25% improvement in 4-6 weeks I would say that would be remarkable. You are doing great!
As I mentioned before I can fully understand the skepticism.
Did your Doctor share with you his overall experience with this topical cream? i.e. How long has he been working with it, how many men have used it and how many had good results? I am sure, Like everything the results fall on a scale from none to very good.
Did he warn you of any potential side effects?
I would not discount this approach because it is being used by a ND. They take a different approach than MD's. In some cases ND's help a lot of people where main stream MD's fail. The fact that they may not be approved for license in some states is just politics.
Perplexed
I added the doctor to our list.
Keep us updated on your progress. :)
James
I will be flying to Oregon later this month to see Dr. Dennis. I will let you guys know how it goes.
Youngdude22,
Please do come back and give us an update. Like many I am skeptical but also hopeful you will posting good results in the weeks ahead.
Leland
Just a quick update, visited my Urologist this afternoon. After the examination I showed him the listing of the topical ingredients given here. He said we see two items we know might work verapamil and pentoxifylline, and then commented on the DMSO penetrating ability. He told me if I started seeing more positive reports here on this mixture, and I wanted him to he would have it compounded for me. Basically nothing about the compound alarmed him.
Leland
leland_mack
You have stated:
QuoteI showed him the listing of the topical ingredients given here
Please remember this forum is not advising or promoting this compound in any way or form. It is a compound that one forum member use it successfully from his report.
James
OK James, I understand. I won't post my experiences with my doctor again.
leland_mack
You can post your experience with your treatment, but a sentence that sounds like the treatment is endorsed by the forum is not appropriate as the treatment is not endorsed by the forum.
Such a statement misleads other members.
I am sure many members, including myself, reading your posts with eagerness as we all are interested to learn everything we can to fight this horrible disease.
James
James1947
Thanks for the clarification, never thought I was endorsing anything, just wanted to make the point that one medical doctor, my Urologist was not alarmed by the contents.
So my point is before putting anything in or on yourself that does not have a well established efficacy, it would be wise to seek the council of an M.D.!
Don't gamble with your health, stakes are too high.
leland_mack
I agree, do not gamble with your health, any time you are choosing to try something new with a medication or herbal product vitamin of any kind always consult your physician, you never know what it can counteract with that you may already be taking, even though it may be safe on its own, mixed with something else could be hazardous.
hugs, Mamma
Stabler
During my last physical 6 months ago, I presented a complete list of all the supplements and vitamins I take. The Dr. cautioned me about excessive Vitamin E just as an example and told me to limit Vitamin E to 1000 I.U. a day. After running a full blood panel the Dr. added Vitamin D to my list.
During my initial visit to my Urologist, I took the same list and the Urologist issued the same warning as the GP about excessive E.
Unfortunately many people think that because it is a "vitamin" that "the more the better" but that is not the case, vitamins need to be a well balanced combination. you CAN have to much when it comes to even a vitamin so everyone please make sure you are watching what you put in your bodies.
Hugs Mamma
It has been about 4 months now since Perplexed told us about his great initial results.
Perplexed, are you out there? How are you dong now?
Please chime in and let us know your status.
[Full quote remove - Admin]
Agree. The more the better policy can not be applied into vitamin consumption. The over absorption of some type of vitamin can be very harmful to our bodies. So the suggestion is taking vitamin as the doctor suggests.
[Commercial site link removed]
I am hoping we will get a good report from Youngdude22. If we do I will make an appointment with my Urologist to get the mix compounded. Perplexed hasn't posted since April, I wonder why.
Hello Everyone
Sorry for my lack of alacrity responding to your questions. My peyronies has been resolved by about 90%. There is still a very small nodule but the curvature is essentially gone and there are no other effects or indications from the disease. My doctor said that the prescription he gave me can not penetrate the shaft entirely and he is reluctant to increase the strength of the formula to capture the last 10%. I was pleased that the prescription was topically administered rather than orally since I do not like taking medications of any sort -- except for those needed for therapeutic purposes for treating my hypothyroid and cardiac issues.
Perplexed
I have postponed my trip to see Dr. Dennis until December. I want to give the pentox/COQ10 a fair shot before I pursue other lines of treatment. Also I tried a MSM/DSMO gel for a few days and had an adverse reaction, which made me concerned about trying this DSMO based gel Dr. Dennis prescribes. I skipped using it for one day and I noticed an immediate reduction in girth, which was enough for me to stop it. My girth returned back to normal over the next week thankfully. If the pentox doesn't achieve the results I'm looking for then I will probably take a trip to see Dr. Dennis to give it a shot. By the way Perplexed, what stage of peyronie's were you at when you began using the topical from Dennis?
Its December Youngdude22, let's us know what happens if you visit Dr. Dennis.
Hello Everyone.
Sorry for my absence from the forum, but I've had several major medical issues to deal with. In June I was diagnosed with prostate cancer -- luckily it was found in the very early stages and had not migrated from the gland. A prostatectomy was performed robotically in September. My PSA after six months is 0.01 which is non-detectable, but the lab will never give a reading less than that. After quickly recovering from the prostate surgery, I was diagnosed with two hernias -- one left and one right. I had them repaired in January and have fully recovered. I'm hopeful my medical issues have subsided for the time being.
The Peyronies has not improved beyond the 90% level since I last posted. I have a very small module just behind the glans but the large module left side mid-shaft is gone. I have also been putting the ointment Dr. Lee prescribed on my hands (as suggest by my nephew who is an orthopedic surgeon specializing in hands). The left hand Dupuytren's Contracture is about 80% resolved while the right had as not responded quite as well -- about 40% resolution.
I hope this information is helpful and somewhat encouraging.
Perplexed
Perplexed
Happy to hear that your problems solved very good.
Your results with Dr. Lee DMSO based cream are remarkable. I wish I was living closer and can get my hands on that cream :)
James
Hi Perplexed, nice to have you back :)
Your positivity is inspiring in the face of cancer, I wish you all the best, it at least (for me) puts into perspective the benign condition of Peyronie's.
I hope you will keep in touch :)
Applying transdermaly locally makes so much more sense with peyronies. Orally can be supplementally but chances that it reaches the site of peyronies are small.
Actually DMSO could deliver anti cancer medicine too. Keep that in mind if anything bugs you again.
Thanks for updating us and good luck with staying healthy!
There needs to be a study done with this cream. Hmmm...
Pentoxifylline has a Molecular Weight: 278.31
This makes it a good candidate for transdermal delivery with DMSO.
We know that Pentox is widely used and described for Peyronies Disease. Many had no improvement with it. Im pretty sure that most oral supplements can have only marginal impact for the condition.
The plaque is sitting in the tunica at a place that hasn't much blood supply. So anything going systemical through the blood will only affect the site of the Peyronies Disease marginally and possibly urinated out of the system before doing any impact. This is simple logic.
I guess it makes sense, to be blunt, if you would throw a Peyronies Disease-plaque into a 24hour/7days solution of Pentox or any other said to help drug, the pentox would have more impact then eating some pills.
Verapamil hydrochloride has a Molecular Weight: 454.611 g/mol.
So also able to be shuttled transdermal by DMSO.
Some good and some useless reports about it. The most useless obviously oral supplementation of it. Some bad reports cause injections created more scar tissue.
It also might work best on new plaques as a calcium channel blocker stopping the plaque from hardening.(calcification)
Vitamin E and Potassium Iodide are also able to shuttle through by DMSO.
It makes sense that this creme is possibly working. I used DMSO and VE and Iodine already in a DMSO solution and they softened my plaques.
To make it work Im also pretty sure that you have to use it as often as possible for the simple logic already laid out above. The more you "bath" the Peyronies Disease plaque in a helpful solution the more success.
10% dmso seemed to have worked for Perplexed, not sure if that isnt a bit on the low end.
What is DMSO's maximum carrier limit for molecular weight?
Through reading this thread I have gotten very interested in this topical application of Pentox. I started looking up pentox cream in google and came across this article which I found interesting. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228656/ This guy seems to very much support pentox even through a cream. I also came across this http://www.podiatrytoday.com/blogged/how-topical-compounding-has-worked-my-patients so I am hopeful towards this pentox cream and ways to get it leading me to this place Compounded Scar Cream | IPS Compounding (http://ipscompounding.com/scar-cream/) . I still plan to do more investigating into this but I'm sure it'll give some ppl something interesting to check out
It would be challenging to find compounded pentox cream.
Hi livinghell, I also found below link, may interest you as it mentions Pentox along with DMSO
A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. compound analgesic cream (CAC)
ketamine 10%, pentoxifylline 6%, clonidine 0.2%, and dimethyl sulfoxide 6% to 10%.
https://www.ncbi.nlm.nih.gov/pubmed/26547813
Hi, guys...
isn't it a little peculiar how doctors, like -for example- Dr. Levine who prescribes the PAV, etc. and he is supposedly works with companies for a cream solution, have not tried or recommended something like a pentox based cream, up to now ?
Unfortunately, this disease has a lot of ''try and see'' procedures, by the patients themselves ...
We are taking pentox or other medicine, without a clue ... if we see no betterness, then (I do it) we feel that perhaps, in case we didn't get these things, the situation could be worsened .. and then, we keep on trying everything under the same concept.
For the time, it is 6 months now that i do ved every day, I take one or two pentox pills, and 1000 mgs of arginine ... no results ... but keep trying ... nothing better to do ...
Good find Paolo. It seems like there are small studies that support pentox in topical cream form yet there has not been a larger study. Which makes me wonder why. Is there not an effective ailment that this can properly be marketed for or does it simply not work in cream format. It seems to have worked in some capacity for Perplexed so I would hope to see others to benefit from it as well. So yes the skeptics are out why leading Peyronies Disease urologists haven't implemented pentox in cream form but I hope it has some merit and maybe we'll see it out soon. But spyrosg i just started my 26 week program a couple days ago and before I use the ved I usually heat up with a rice sock and gently massage the plaque areas with a sonicare for a good 10-15 mins before I put it in the ved. After my shower I then apply castor oil. This will be my go to routine for when I use the ved for the next six months and onwards towards recovery. I'm with you man just wish there was an idiot's guide to getting rid of peyronies.
After reading this topic, I had done two things, firstly, I had written to Dr. Dennis to verify the validity of this post (this is the internet after all), he confirmed to me that this was indeed an actual case he had seen for a patient (no details discussed obviously beyond me asking him to confirm that this actually happened). He also told me that the dosage was actually very low and could be increased, but he suggested that (the dosage) as a preliminary "test run" initially to see if the patient responded. However, he did warn that the patient's success wasn't what would be considered typical, so there's that.
Upon having this confirmation I had a discussion with my doctor (showed him this topic and the email - cause you know, asking your doctor about "some guy online" usually doesn't work that well) on the possibility of him prescribing this medication for me to try out. After reviewing, he agreed that it had the potential to work simply based on the vera+pentox+DMSO mix, and further told me that the dosage could be increased (he settled on roughly double of what the OP's dosage was) and that is what I have received.
As I have only started the treatment this week it presumably should take some time before - if any - results are seen.
Let's see how things go.
Side note:
There really are a lot of dissenting opinions in the medical community about Peyronies Disease it seems... my doc hasn't put me on anything oral aside from 2.5mg cialis daily - in his words "just in case you have problems obtaining erections", yet on this board I've read that most are put on various oral regimes. Of course my question would be, of the ingested medication, what percentage would even reach the affected area due to low circulation of said area? Trans-dermal delivery of drugs right to the affected area in theory makes a lot more sense than ingesting but there seems to be very little interest in developing such medication mainstream?
Quote deleted by moderator. Read the forum rules
Haven't been here or posted for a while now. My treatment consisted of the usual, Vitamins, Pentox, Vacuum, used traction also. I feel I had my most improvement using traction and VED and saw no change with Pentox or Vitamin E or anything else.
I tried to have my doctor prescribe Dr. Dennis' formulation, at first he seemed receptive, on my next visit I brought formula and he balked saying he needed a more precise description than 10% this and 5% that.
This seemed strange to me, since one would think that all that is needed is to decide the total amount of medication you will make then compound the actives by percentage with the base carrier.
Made me think he was more interested in treating me than curing me. Less money to be made by curing I suppose so I have not been back to him.
Still hoping to hear another success story from Dr. Dennis' compound.
If I do I am headed to Oregon, I have plenty of air miles available to use.
Well it's been some 4 months almost, I had wanted to give a bit of an update sometime ago but never got around to doing that, apologies for anyone who was interested.
Around the 3 month mark of using the aforementioned formula I had started to see some improvement, in that (don't get this wrong) erections were becoming a bit... strange (as in you can feel some sort of stretch where the plaque is). Keep in mind that my Peyronies Disease started and resolved almost a decade ago (that's what my doctor figures and I never knew what the curvature was till my SO asked about it randomly) due to multiple injuries sustained. Now I've yet to check with my doctor about this development as it's not really a bother, but I figure that the plaque is being softened gradually and that it's about time that I tried to squeeze time in for traction to further develop on this.
That's about all that's happened to far. I believe this formula has been somewhat effective, my case is certainly not a 1 month cure as was the case for the OP, but I do think it's working.
Noting there hasn't been any more posts on this I wonder if anyone else has tried this topical cream? Is there any update?
I want to try it, but do not know how to find someone who can prescribe this compounded formula.
Any medical provider (MD, DO, NP, PA, etc) who can prescribe can call in a Rx to a compounding pharmacy for you. Just have to find a willing provider. Most who describe their practice as "integrative medicine" are likely to do so. As it will be generic, the cost can be quite reasonable.
HAs anyone else tried this?)
I am wondering if the OP, z01, or anyone else who has used the cream has experienced any further success? If so, please keep us updated.
Wow Perplexed your doctor sounds amazing. He literally created a cream specifically to help with your illness, very rare that a doc would go out on a limb.
Curious, what state is he in? Also is he a urologist or a GP?
Wow I actually live 2 hours away from Portland, Oregon. What are the odds? Unfortunately it appears that Dr. Dennis Lee is no longer practicing. Is that true, Perplexed?
I am going to talk to my doctor about this as soon as we get more confirmation from members long term results. Side effects etc. I can see where this would be a lot better than oral. I still need more improvement. Sometimes it looks 90%. Sometimes it looks 70 % improved from xiaflex treatments. Looks very promising. I wonder why there is no xiaflex penetrating cream?
One year on with no new report.
Two possibilities (maybe more)
* Cured himself and now he is rich from patenting the formula
* Didn't cured himself and I don't know...
James
why doesnt anyone actually come back and post what happened
I recently had my dr. call in a script to a compounding pharmacy for DMSO+pentox, verapamil and vit. E.
If I have any results (don't hold your breath) I will report back. I doubt I will be able to use this because Pentox makes me crazy and with DMSO, it will probably accumulate in my system and make me discontinue using it. We'll see.
I am also going to ask if he can do another formulation with mofetil.
yo i dunno i just have an injury or acute stage peyronies but i have pain and a curve when half hard but not barely at all when fully hard. if it is just an injury or acute stage, would it beneficial to do dmso? i figure the same concept would apply regardless of peyronies, acute stage peyronies or just a penis injury, right? isnt dmso just about penetrating the tissue to get stuff in there directly
DMSO is the transporting agent. You'd need to add a compound you believe would be therapeutic. A few guys here are trying it. I'd start reading the survival guide here. Seek out a specialist who can diagnose you w an ultrasound. Consider getting started w pentox, low dose nightly PDE5i and traction or VED to halt any progress and remodel the plaque to healthy tissue.
https://www.peyroniesforum.net/index.php/topic,3180.msg44057.html#msg44057
ya my uro laughed and said for what?? when i said what about doing an ultrasound. i just signed up for insanely good insurance coverage for 2020 so i dont think i can access a good uro until then. so they can tell with an ultrasound if its acute peyronnies or not? ive had like 8 appointments and theyve ran every test and said im fine, but i have pain enough that i cant really do anything - bumps while driving are pretty bad after a few miles
also im reading that long ass 10 page dmso thread to educate myself and i think im just gonna use the thackers formula, and then also dmso + vit c and dmso + vit e at separate times
i dont have any plaque that i can feel i just have pain and a slight curve, the uro said no plaque but that was just by feel. im debating going to a uro in the mean time in my current network and asking about pentox or just simply ordering it online as some other ppl posted recently it seems i either have acute peyronies or some type of penis injury, but all advice ive gotten says the protocol is the same. im eating super healthy and supplementing with vit e ubiquinol propolis blueberry extract and milk thistle. would you suggest just adding pentox and the dmso on my own and then also seeing a new uro? thx
ive also read the entire survival guide
Quote from: buzzin2 on November 30, 2019, 06:42:36 PM
so they can tell with an ultrasound if its acute peyronnies or not?
The problem with many uros is that they will only label it peyronies when there's an established hard palpable plaque.
So many say "to wait" until you have a bent, hourglass or any other established peyronies form.
The Ultrasound, which is their nr.1 way to diagnose it also, in most cases, will only show faulty tissue when it's hardened.
So in that context what your doc says "for what" makes sense.
But if you have reason to believe you had an injury or inflammed tissue that is basically the start of the peyronies condition the doc should be able to give you some option to AVOID it resulting in a hard plaque. Like anti inflammatories, healthy tissue formation etc.
I think verapamil and pentox could help to avoid hard plaques forming. (so could some dmso + x formations, like I talk about in the DMSO + X thread.)
My hunch is that the doc you have right now is not good for your case and you might check for another one that understands your worries.
For the pain I'd try a NSAID and diclofenac sodium gel applied to penis.
Quote from: melting on December 03, 2019, 06:28:36 AM
The problem with many uros is that they will only label it peyronies when there's an established hard palpable plaque.
So many say "to wait" until you have a bent, hourglass or any other established peyronies form.
do you mean bent, hourgless or another form when erect? i have a curve thats most prominent when its half hard, but when its fully hard in the morning its essentially 100% straight. when its half erect its like maybe 15% to the left and the pain is on the right side of the shaft. i find it weird in my case that the pains on the right side but the curve is to the left, and again the harder i get the straighter it gets. i thought that in peyronies the plaque prevents blood flow and the curve goes to the same side as the plaque.
so everyone has essentially told me the same thing, that it could be an injury or acute stage peyronies but that i wont know until it does or does not develop - and that the protocol to treat both is the same. do u think i should research and find what i think drugs are most apprortiate and suggest that in the appointment or just see what the new uro says? or i guess i could do both...
and then im gonna get dmso and do those applications too. should i ask the uro for a ultrasound or would that be a waste of time at this point? thx
If you look at Penis anatomy depending on where you have the injury or faulty tissue it can influence your erection differently.
Without a hardened plaque I can imagine that during a full erection the blood pressure and erection mechanisms are strong enough to mitigate/"overpower" the "weakness"/bad tissue.
I think anti-inflammatory should be the focus during an acute phase. Then it needs to heal properly.(healthy collagen formation vs. scar formation).
Once you have faulty tissue I think things change. The tissue needs to be stretched/"broken" and/or dissolved(or other medical treatments)
I think many had good Uros who listen and think outside the box and then you have 1 dimensional ones. You need to gauge if the doc is good yourself.
I'm not 100% sure on the different imagining procedures and what they can show but that can surely be found somewhere. The doppler/ultrasound might help even if its just shows what's not there...
Sadly with this penis stuff it seems we need to either have a really great doc or turn into experts ourselves.
so, is there a chance itll just heal properly and not scar up if i act appropriately and take all precautions? also when you say the blood pressure overpowers the weakness/bad tissue does this mean that the comrpmised tissue is just restricting blood flow? i wonder if the fact the erections are still full means its not that bad, or that the tissue can be repaired with some work and the right meds and treatments during acute
It seems like this guy got his problems completely solved with DMSO + X
Can anyone recall what the mix consisted of? Or why it isn't a well known and used treatment for the disease? His claims are totally legit, right?
And it seems like he got cured, basically.
It may be real for him...but if it was really the solution we would have heard from lots of guys as many tried it over the years.
Quote from: buzzin2 on December 04, 2019, 08:01:48 PM
so, is there a chance itll just heal properly and not scar up if i act appropriately and take all precautions? also when you say the blood pressure overpowers the weakness/bad tissue does this mean that the comrpmised tissue is just restricting blood flow?
I don't know what's going on exactly with you. Just semi educated speculation ;) That's why I can lay out my thoughts but can't make individual definite statements.
It really depends where the site of "injury"/faulty tissue is. Look at an anatomy picture and then you can imagine what faulty tissue could do in different spots..
The problem with peyronies bends mostly happens when the site gets hardened/calcified.
In many cases that's within the tunica layers. The tunica can expand to a certain degree. In acute phase a site of injury or with a fibrous inflammatory mass might still be flexible and a straight erection possible. The body "repairs" or isolates the injured site with harder tissue and that takes time(weeks/months). This tissue is then less flexible than tunica which results in bends and hourglass symptoms.
But let's say the faulty tissue is near an artery or smooth muscle cells and is not yet hard/calcified..
In flaccid state the tissue is compressed. So any swelling/inflammation might constrict more % of the total diameter
Imagine a hose that has only low water pressure and a hair tie around it. That would influence the shape and function of the hose.
Now imagine the hose has high pressure water in it,.. it would expand normally as the hair tie isn't a hard constriction vs. the pressure.
During an erection arteries, and smooth muscle cells which are supplied by artieries, fill with blood and expand and the pressure goes up a lot.
If I had a penis injury today, I would stop any strain on the tissue, no masturbation, no sex. Good bloodflow but no prolonged erections.
I would eat healthy, lot's of good air/oxygen. I would take pentox and other oral medications that lower inflammation.
I would apply everyday DMSO+vitamin C and DMSO+anti inflammatories and DMSO + other supplements that aid in HEALTHY COLLAGEN FORMATION, and do that for many months..
It's quiet established how the body deals with injuries to various tissues. Timeframes and what behavior and supplements helps and what helps not.
The penis tissue in it's isolated parts is not much different to other body parts. The big problem with Penis tissue is the "volatile" place. Low blood circulation, trapping inflammation, and erections stretching inflammed tissue, aggravating it.
If you have an injury in your knee or arm and take medications it will with high probability reach that site of injury circulating.(after you took it oral)
Not so much with the penis. That's why using transdermal DMSO applications directly to the site of injury makes logically sense.
Quote from: TonySa on December 05, 2019, 01:09:13 PM
It may be real for him...but if it was really the solution we would have heard from lots of guys as many tried it over the years.
Not many tried it all and for everyone trying you have dozens of people disparaging them with empty statements that have nothing to do with the logic of the treatment at hand.
How many tried in open forums? 20? For how long and how often did they use it? Which combination of supplements for which type and stage of peyronies? Did they use VED and traction along with it?
You are very keen on scientific accountability, so maybe you investigate this in detail with sources etc. before making generalized statements acting as if you knew?
Many insecure men will never try it anyway or give up fast cause of the variables of this as a DIY treatment. Perplexed doctor is a blessing. Only possible in America and surely not in europe where the only official option is oral meds and to get sliced up.
Most people end up with doctors repeating the "come back when your dick bends, let's see from there" mantra. Quiet sad state of affairs.
How great it would be if Perplexed doctor could help them with his open mind and simple application of logic towards a solution.
Melting, it's not about putting down unorthodox treatments. But, when guys have tried them and have had success...more and more try and have even more success. Traction is a good example, as more tried it and had success, more tried and it even began to become included in medical studies. That didn't happen w DSMO, but it's great for guys to try things...just be sure to do that to the exclusion of treatments w some success records. Hope this makes sense. Your excited about this treatment and that's great, good luck!