Of abrupt onset, in reference to a disease. Acute often also connotes a phase that is of short duration, rapidly progressive, and in need of urgent care. "Acute" is a measure of the time scale of a disease and is in contrast to "chronic." which indicates indefinite duration with little change.
Abbreviation for: Advanced Glycation End products. AGE products are the result of sugar being heated outside of the body or being metabolized inside of the body. AGE has been identified as a factor in many disorders.
Acetyl L-Carnitine an over-the-counter nutritional supplement.
Abnormal response of the immune system that causes antibodies and other defenses of the body that normally attack invaders to attack the body's own tissue.
Prescription drugs that block the stimulating effect of adrenaline thereby relieving stress on the heart. Many beta blocker drugs list Peyronie's disease as a possible side effect.
Usually a mixture of papaverine and phentolamine self-injected into the penis as a treatment for ED. Unlike Viagra the erection results directly from the injection and usually requires no physical or psychological stimulation.
Blind or blinded refers to a condition where the patient in a clinical study does not know whether they are being given the treatment being studied or the control (another treatment or placebo). Double blinded means neither the patients or the medical team know. This helps assure objective results.
Benign Prostatic Hyperplasia. A common condition as men get older resulting in enlargement of the prostate gland. Prostate gland enlargement can cause bothersome urinary symptoms. Untreated prostate gland enlargement can block the flow of urine out of the bladder and can cause bladder, urinary tract or kidney problems.
Bone Pressed Streched Flaccid Length A standardized method to measure penis length used to chart progress. Ruler pressed against pubic bone and flaccid penis is stretched straight out from the body at a 90 degree angle. Some doctors refer to a less accurate term, Stretched Flaccid Length (SFL)
Abbreviation for Corpus Cavernosum, one of a pair of sponge-like columns of erectile tissue which contain most of the blood in the penis during penile erection. The two corpora cavernosa lie along the penis shaft, from the pubic bones to the head of the penis, where they join.
in reference to a disease. Chronic often connotes a phase that is of infinite duration, and relatively stable. It is in contrast to acute that is of rapid onset and development, and requiring immediate attention.
Prescription medication used for suppressing the inflammation in acute gout (arthritis). It was also sometimes used in the treatment of the inflammatory phase Peyronie’s disease although there is little objective data that supports its effectiveness considering potentially significant side-effects.
the main protein of connective tissue and the most abundant protein in our bodies. There are well over a dozen types of collagen and these types are the main component of cartilage, ligaments, tendons, bone, teeth, blood vessels, and skin. Collagen actually acts as a mesh scaffolding for our bodies and controls cell shape, determining the type of structure that is rebuilt.
A type of protein that breaks down collagen.
A condition that is present at birth, whether or not it is inherited.
One of a pair of sponge-like columns of erectile tissue which contain most of the blood in the penis during penile erection. The two corpora cavernosa lie along the penis shaft, from the pubic bones to the head of the penis, where they join.
A third much smaller column of spongy tissue that receives a small amount of blood during erection. It surrounds the urethra and runs the length of the underside of the penis ending with its end cap, the glans or head of the penis. The corpus spongiosum functions to prevent the urethra from collapsing during erection and causes the head to swell, but contributes little to the erection itself.
chronic pelvic pain syndrome - Sometime called cp/cpps for chronic prostatitis/chronic pelvic pain syndrome.
Dupuytren’s Contracture, a condition involving abnormal build-up of collagen in the hand, causing the fingers to permanently bend toward the palm. It is usually first noticed in the little and ring fingers.
Dimethyl Sulfoxide is a Colorless liquid used to dissolve or extract organic compounds.
Because DMSO increases the rate of absorption of some compounds through organic tissues, including skin, it can be used as a drug delivery system. It is frequently compounded with antifungal medications, enabling them to penetrate, skin, toe nails etc..
Refers to the top surface. A dorsal curve is an upward curve.
condition involving an abnormal build-up of collagen in the hand, causing the fingers to permanently bend toward the palm. It is usually first noticed in the little and ring fingers.
An abreviation for Erectile Dysfunction A condition where the penis either cannot gain or maintain an erection sufficient for normal intercourse. ED has many possible causes. It is a somewhat common symptom and even possibly a cause of Peyronies Disease.
A condition where the penis either cannot gain or maintain an erection sufficient for normal intercourse. ED has many possible causes. It is a somewhat common symptom and even possibly a cause of Peyronies Disease.
Extracorporeal Shockwave Therapy A treatment where ultrasound shock waves bombard an area of tendonitis, frozen shoulder, painful heel, and in some instances Peyronies Disease. There are some studies that show pain reduction. Changes in curve have not been reported. This is not FDA approved in the U.S. ESWT has never grown to the status of a mainstream treatment for Peyronies Disease.
The formation of collagen based scar tissue that can be spurred by injury or other factors.
Not stiff or rigid. Limp
The distance around something.
localized collection of blood in soft tissue resulting from damaged blood vessels. The lay term is "bruise"
Human Growth hormone is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. HGH would seem to battle peyronies (nerve regeneration, NO increase, lower BP, more flexible, improves libido, ect) EXCEPT that HGH increases Collagen Synthesis.
Hyperbaric Oxygen Therapy involves breathing pure oxygen in a pressurized room. Hyperbaric oxygen therapy is used for the treatment of conditions including serious infections and wounds that won't heal as a result of diabetes or radiation injury. The treatment elevates the amount of oxygen in the blood over breathing pure oxygen at normal air pressure. Your blood carries this oxygen throughout your body, stimulating the release of growth factors and stem cells, which promote healing.
The process by which soft tissue responds to injury with swelling, redness, warmth, and often pain. Inflammatory processes can often be the cause of a host of age related diseases rather than just the response to an injury. Many factors can cause or reduce the inflammatory processes.
A technique that relies on active transportation using a small electric charge to deliver a medicine through the skin trans-dermally.
Induratio Penis Plastica - The European (latin) name for Peyronies Disease. As Dr Peyronie was a French doctor, the french call it: Maladie de la Peyronie.
An amino acid found naturally in meats/dairy, but is also taken as a supplement; It is a vasodilator used by athletes, weight lifters, cardiology patients, and those suffering from ED; It increases blood flow to tissue, by increasing nitric oxides which in turn dilates blood vessels. L-Arginine is 1 of the ingredients of The PAV cocktail recommended by many urologists. Warning, taken with Viagra and other PDE5 inhibitors it could cause an unsafe drop in blood pressure due to relaxing the blood vessels.
Nesbit Plication - tuck
Named for the doctor to first use the procedure in 1965. This procedure shortens the side of the penis that doesn't have scar tissue.1) The outer skin of the penis is pulled back. 2)The penis is straightened, and the excess tissue on what had been the long side of the curve is cinched together with sutures. (3) The penis is somewhat shorter after this procedure.
Abbreviation for night time erections. These erections are now believed to use different nerve pathways than psychologically or physically stimulated erections; NTE's can occur in individuals that have physically based erectile dysfunction. NTE's are considered essential for oxygenation of the penis and for good penile health.
An abbreviation for Pentox, L-Arginine, Viagra. This cocktail trio of substances has recently been used as an oral treatment for Peyronies Disease with some promising results. It was first prescribed by Dr Levine.
Phosphodiesterase type 5 inhibitors refers to a group of drugs are used in the treatment of erectile dysfunction, and were the first effective oral treatment available for the condition. PDE5 inhibitors help to sustain an erection by inhibiting the the process that causes an erection to diminish. This is why physical stimulation is still required to cause the erection. Common PDE5 inhibitors include Viagra, Livitra, and Cialis.
A tear in the tunica albuginea resulting from abrupt bending trauma to the erect penis. Penile fracture requires immediate emergency medical attention.
a technique to fix a curved penis by adding tissue to the shorter side where the plaque is most prominent. After careful dissection neurovascular bundles, the scar is incised/excised, and a graft tissue is used to fill the void to lengthen the short side. Many graft materials can be used. This is a complex surgery requiring a very skilled surgeon.
There are several types, but the modern implant is likely to be a 3 piece inflatable implant. 1)the cavernosia are totally destroyed to implant the inflatable chambers. 2)a miniature pump hidden in the scrotum between the testicles, 3) a fluid reservoir inserted in lower abdomen near the bladder. Most implants increase only in girth from deflated to inflated although there is a model that gives some increase in length when inflated.
Is short for the prescription drug Pentoxifylline. The original drug is sold under the trademark name of Trental. Today there are many other gerneric products.
In some European countries (except France) it is called Induratio Penis Plastica or IPP. It is a change in normal structures of the penis, transforming functional portions of penile tissue into scar tissue. This is a wound healing process gone awry somewhat like keloids. Once started, the process spreads across undamaged tissue, turning it to scar tissue.
Any dummy medication (sugar pill) or treatment. A placebo is often used in a control group to compare to the treatment actually being tested.
A painful inflammatory condition of the plantar fascia, the connective tissue on the sole (bottom surface) of the foot. PF be caused by strain or by abnormal build up of collagen in the foot.
In Peyronies, plaque is another word for scar tissue that is NON-elastic thus prevents normal expansion of the penis during erection. It is the essence of Peyronies and can overspread healthy uninjured tissue. It should not be confused with arterial plaque which is unrelated.
A prescription antifibrotic medication that has been used to treat skin disorders and PD. Stomach upset is a common side-effect. Clinical evidence is lacking in Potaba's benefit in PD treatment.
An artificial replacement of a part of the body; See Penile Implant
Platelet-rich plasma is blood plasma that has been enriched with platelets. As a concen- trated source of autologous platelets, PRP contains and releases several different growth factors that stimulate healing.
Penile Traction Therapy. PTT has traditionally been implemented to increase penile length but has recently been investigated for reducing the curvature associated with Peyronie's disease. There are several manufacturers of penile extension devices. These devices are designed to apply a pull or tension on the penis. Penile extenders usually require the penis being in traction for several hours a day for several months for any significant improvement.
In clinical studies, randomized refers to assigning patients to the study group or the control group in a totally random fashion. This prevents such things as assigning the patients most likely to respond to treatment to one group thus affecting the outcome and resulting in false conclusions.
Something that increases your chances of getting a disease. Sometimes this risk comes from something you do. For example, penile fracture increases the chance of Peyronies. Other risk factors are beyond your control and there's nothing you can do about the risk. The risk just exists, such as age or heredity.
The loose visible sack surrounding the the testicles. The scrotum is part of the external male genitalia.
Abbreviation for Tunica Albuginea, the fibrous envelope over the corpora cavernosa. It is white and consists of approximately 5% elastin and 95% collagen. The tunica albuginea is directly involved in maintaining an erection; due to Buck's fascia constricting the deep dorsal vein of the penis, preventing blood from leaving and thus sustaining the erection.
Transforming Growth Factor, Beta 1 -This gene encodes a member of the TGFB family of cytokines, that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors. This protein positively and negatively regulates many growth factors.
Generic name for Desyrel; Trazodone ia a VERY cheap prescription drug developed for depression at a dose of 150-400 mg daily. - It is used off label at a dosage of just 25 mg. for a sleep aid; At these very low dosages it enhances night time erections for most men and is therefore sometime used to enhance healthy blood flow. Should be taken with some food.
Something that either sets off a disease in people who are genetically predisposed to developing the disease, or that causes a certain symptom to occur in a person who has a disease. Example, sunlight can trigger rashes in people with lupus.
Usually a mixture of papaverine, phentolamine, and prostaglandin self-injected into the penis as a treatment for ED. Unlike Viagra the erection results directly from the injection and usually requires no physical or psychological stimulation.
Testosterone Replacement Therapy is the use of hormone replacement for men incapable of producing sufficient amounts of this hormone themselves. The medicine used to treat this ailment is testosterone and similar androgenic compounds. Levels are monitored by the reference laboratory used by their physician to maintain patients in the mid-range. Injectable formulations are available as are topical gel forms.
The Tunica Albuginea is the fibrous envelope over the corpora cavernosa. It is white and consists of approximately 5% elastin and 95% collagen. The tunica albuginea is directly involved in maintaining an erection, due to Buck's fascia constricting the deep dorsal vein of the penis, preventing blood from leaving and thus sustaining the erection.
A term sometime used on the PDS forum to describe significant shortening/contraction of the flaccid penis.
Urologist. One who is trained in the medical and surgical specialty that focuses on the urinary tracts of males and females. Urologists and are trained to diagnose, treat, and manage patients with with bladder or other urological disorders. Some urologists specialize in the treatment of Peyronie's Disease.
Blood vessels expanding and resulting in their engorgement with blood.
Vacuum Erection Device A cylinder device that slides over the penis. It has a mechanism for drawing the air out of the cylinder and forming a vacuum around the penis to draw blood into the penis causing an erection. It has been used both prior to intercourse to compensate for ED and as a treatment for Peyronies Disease although the techniques are are different.
Underside. A ventral curve is a downward curve.
Verapamil is a prescription calcium channel blocker and vasodilator taken orally for certain cardiac conditions. Verapamil injections (VI) are injected directly into the plaque of PD. Recent clinical observations indicate the incidence of improvement is only slightly better than the incidence of worsening or no improvement.
Verapimil Injection is a treatment approach that has demonstrated mixed results in a number of published studies. This treatment involves the injection of Verapamil directly into Peyronie’s plaques (scar tissue nodules or bands). Verapamil is a type of calcium channel blocker and is used for collagen degradation to reduce the plaque and scarring associated with Peyronie's Disease.
Gradually reducing the fullness and strength of the body or a body part: a wasting disease. (sometimes misused for hourglass deformity)
The brand name For the injectable drug collagenase that breaks down collagen. In the United States, Auxilium markets the drug. In Europe it is marketed by Pfizer.